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Predicting COVID-19 Vaccine Efficacy from Neutralizing Antibody Levels [article]

Majid R. Abedi, Samuel Dixon, Timothy Guyon, Serene Hsu, Aviva R. Jacobs, Lakshmi Nair, Robert Terbrueggen
2021 medRxiv   pre-print
Analysis was performed using R code adapted from code published by the Khoury group 23 .  ...  Figure 2C shows a plot of log transformed mean NAb titer versus mean of Probit IC50 by vaccine and prior infection with an excellent correlation (R 2 = 0.95).  ... 
doi:10.1101/2021.10.13.21264921 fatcat:jm7wilx3xrckjcvgu7iee7hvwq

Characterization ofDrosophilaInsulin Receptor Substrate

Rachel M. Kulansky Poltilove, Aviva R. Jacobs, Carol Renfrew Haft, Pin Xu, Simeon I. Taylor
2000 Journal of Biological Chemistry  
Endogenous dIRS has an M r Ϸ144,000, whereas transfected dIRS in COS-7 cells has an M r Ϸ132,000.  ...  It is likely that the low M r band corresponds to the proteolytically cleaved isoform lacking the Cterminal extension, whereas the high M r band corresponds to the full-length isoform.  ... 
doi:10.1074/jbc.m003579200 pmid:10801879 fatcat:wsnt5javbjh4pic32r4xd7i6le

Insulin Receptor Substrate-1 Pleckstrin Homology and Phosphotyrosine-binding Domains Are Both Involved in Plasma Membrane Targeting

Aviva R. Jacobs, Derek LeRoith, Simeon I. Taylor
2001 Journal of Biological Chemistry  
The localization of insulin receptor substrate (IRS) molecules may be responsible for the differential biological activities of insulin and other peptides such as platelet-derived growth factor. The subcellular localization of IRS-1 is controversial, with some reports suggesting association with the cytoskeleton and other studies reporting membrane localization. In this study, we used immunofluorescence microscopy to define the localization of IRS-1. In the basal state, recombinant IRS-1 was
more » ... alized predominantly in the cytoplasm. In response to insulin, recombinant IRS-1 translocated to the plasma membrane. We have also studied the localization of green fluorescent protein (GFP) fusion proteins. Unlike native IRS-1, a fusion protein containing GFP plus fulllength IRS-1 appeared to localize in inclusion bodies. In contrast, when GFP was fused to the N terminus of IRS-1 (i.e. the pleckstrin homology and phosphotyrosine-binding domains), this fusion protein was targeted to the plasma membrane. Mutations of phosphoinositide-binding sites in both the pleckstrin homology and phosphotyrosine-binding domains significantly reduced the ability of Myc-tagged IRS-1 to translocate to the plasma membrane following insulin stimulation. However, these mutations did not cause a statistically significant impairment of tyrosine phosphorylation in response to insulin. This raises the possibility that IRS-1 tyrosine phosphorylation may occur prior to plasma membrane translocation.
doi:10.1074/jbc.m105194200 pmid:11526109 fatcat:dyacqt42gff5rdsjjioq5xytji

Interaction of Insulin Receptor Substrate 3 with Insulin Receptor, Insulin Receptor-related Receptor, Insulin-like Growth Factor-1 Receptor, and Downstream Signaling Proteins

Pin Xu, Aviva R. Jacobs, Simeon I. Taylor
1999 Journal of Biological Chemistry  
Insulin receptor substrates (IRS) mediate biological actions of insulin, growth factors, and cytokines. All four mammalian IRS proteins contain pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains at their N termini. However, the molecules diverge in their C-terminal sequences. IRS3 is considerably shorter than IRS1, IRS2, and IRS4, and is predicted to interact with a distinct group of downstream signaling molecules. In the present study, we investigated interactions of IRS3 with
more » ... arious signaling molecules. The PTB domain of mIRS3 is necessary and sufficient for binding to the juxtamembrane NPXpY motif of the insulin receptor in the yeast two-hybrid system. This interaction is stronger if the PH domain or the C-terminal phosphorylation domain is retained in the construct. As determined in a modified yeast two-hybrid system, mIRS3 bound strongly to the p85 subunit of phosphatidylinositol 3-kinase. Although high affinity interaction required the presence of at least two of the four YXXM motifs in mIRS3, there was not a requirement for specific YXXM motifs. mIRS3 also bound to SHP2, Grb2, Nck, and Shc, but less strongly than to p85. Studies in COS-7 cells demonstrated that deletion of either the PH or the PTB domain abolished insulin-stimulated phosphorylation of mIRS3. Insulin stimulation promoted the association of mIRS3 with p85, SHP2, Nck, and Shc. Despite weak association between mIRS3 and Grb2, this interaction was not increased by insulin, and may not be mediated by the SH2 domain of Grb2. Thus, in contrast to other IRS proteins, mIRS3 appears to have greater specificity for activation of the phosphatidylinositol 3-kinase pathway rather than the Grb2/Ras pathway.
doi:10.1074/jbc.274.21.15262 pmid:10329736 fatcat:t2tssnh2cre5rcx33oa4ymu6xi

The COG database: an updated version includes eukaryotes

Roman L Tatusov, Natalie D Fedorova, John D Jackson, Aviva R Jacobs, Boris Kiryutin, Eugene V Koonin, Dmitri M Krylov, Raja Mazumder, Sergei L Mekhedov, Anastasia N Nikolskaya, B Sridhar Rao, Sergei Smirnov (+5 others)
2003 BMC Bioinformatics  
-----------------6 S -COG1795 Uncharacterized conserved protein 12 --|-----||--| ---||-------------|-----|------------------------------|--||--| ------------------------|----------------------------6 R  ...  The numbers were obtained after subtracting the COGs that consisted entirely of proteins from unicellular eukaryotes from the COG collection. 0% 5% 10% 15% 20% 25% 30% A B C D E F G H I J K L M N O P Q R  ... 
doi:10.1186/1471-2105-4-41 pmid:12969510 pmcid:PMC222959 fatcat:xuukptdqqnf3bfyb6zpg2gsdfi

A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes

Eugene V Koonin, Natalie D Fedorova, John D Jackson, Aviva R Jacobs, Dmitri M Krylov, Kira S Makarova, Raja Mazumder, Sergei L Mekhedov, Anastasia N Nikolskaya, B Sridhar Rao, Igor B Rogozin, Sergei Smirnov (+6 others)
2004 Genome Biology  
R Most bacteria and some archaea (COG0628) 0 1 2488 Predicted N- acetyltransferase ? R Most archaea and bacteria (COG0454) 1 X Putative role in ribosomal maturation?  ...  R Most archaea and bacteria (COG0697) 1 X 2647 Multitransmembrane protein, potential transporter ?  ... 
doi:10.1186/gb-2004-5-2-r7 pmid:14759257 pmcid:PMC395751 fatcat:4ouczx4zlrdphluvj4vfxe4the

Improved reference genome of Aedes aegypti informs arbovirus vector control

Benjamin J. Matthews, Olga Dudchenko, Sarah B. Kingan, Sergey Koren, Igor Antoshechkin, Jacob E. Crawford, William J. Glassford, Margaret Herre, Seth N. Redmond, Noah H. Rose, Gareth D. Weedall, Yang Wu (+60 others)
2018 Nature  
7 5 b D m e lI r7 5 d D m el Ir8 4a A g a m I r 1 6 4 N A a e g I r 1 5 2 A a e g Ir 1 1 6 N D m e lI r 3 1 a A a e g Ir 4 1 f Dm elI r60 d A g a m I r 1 2 7 N A a e g Ir 1  ...  tip Foreleg Midleg Hindleg 0 0 0 96 R e c e p t o r t y p e 0 96 Ovary N e w g e n e s Ors Grs Irs 0 4 log 10 (TPM+1) Article reSeArcH d c Assembly Min r 2 Mean r 2 Median  ... 
doi:10.1038/s41586-018-0692-z pmid:30429615 pmcid:PMC6421076 fatcat:n7jkptp76fcszea4his54rsege

Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control [article]

Benjamin J Matthews, Olga Dudchenko, Sarah Kingan, Sergey Koren, Igor Antoshechkin, Jacob E Crawford, William J Glassford, Margaret Herre, Seth N Redmond, Noah H Rose, Gareth D Weedall, Yang Wu (+60 others)
2017 bioRxiv   pre-print
AaegIr75a-l, AaegIr7a-r, AaegIr41a-q, and AaegIr100a-d).  ...  Annu Rev Entomol 59, 205-224 (2014). 48 Bourtzis, K., Lees, R. S., Hendrichs, J. & Vreysen, M. J.  ... 
doi:10.1101/240747 fatcat:kizr7mcjhnespaxi2tydebifua

Page 47 of Cornell Law Forum Vol. 19, Issue 2 [page]

1992 Cornell Law Forum  
Mandel§ Aviva A. Orenstein§ Paul C. Pawlowski Andrew C. Pickett§J Barry W. Rashkover§ George R. Rhodes Ronald B. Sann§ Kevin P. Sweeney Daniel M. Taitz John R. Taylor Kathleen T. Tobin Marianne C.  ...  Carman§7 Michael R. Clarke Ben T. Clements Kathleen M. Dillon§ Kenneth L. Doroshow Rodney S. Dowell§ Arthur D. Goldman Daniel C. Gordy§ Marla L. Hassner§ Aviva Jezer Page M. Kaufman Marcia K.  ... 

Ledipasvir and Sofosbuvir in the Treatment of Early Hepatitis C Virus Infection in HIV-Infected Men

Paari M Palaniswami, Ahmed El Sayed, Benjamin Asriel, Jesse R Carollo, Daniel S Fierer, Bisher Akil, Juan Bailey, Paul Bellman, Daniel Bowers, Krisczar Bungay, Susanne Burger, Aviva Cantor (+55 others)
2018 Open Forum Infectious Diseases  
Treatment of HIV-infected men during early hepatitis C virus (HCV) infection with interferon results in a higher cure rate with a shorter duration of treatment than during chronic HCV infection. We recently demonstrated that this phenomenon applied to interferon-free treatment as well, curing most participants with short-course sofosbuvir and ribavirin. Due to the significantly higher potency of the ledipasvir/sofosbuvir (LDV/SOF) combination, we hypothesized that we would be more successful in
more » ... curing early HCV infections using a shorter course of LDV/SOF than that used for treating chronic HCV infections. We performed a prospective, open-label, consecutive case series study of 8 weeks of LDV/SOF in HIV-infected men with early genotype 1 HCV infection. The primary end point was aviremia at least 12 weeks after completion of treatment. We treated 25 HIV-infected men with early sexually acquired HCV infection with 8 weeks of LDV/SOF, and all 25 (100%) were cured. Twelve (48%) reported sexualized drug use with methamphetamine. Eight weeks of LDV/SOF cured all 25 HIV-infected men with early HCV infection, including those who were actively using drugs. Based on these results, we recommend treatment of newly HCV-infected men during early infection, regardless of drug use, to both take advantage of this 8-week treatment and to decrease further HCV transmission among this group of men.
doi:10.1093/ofid/ofy238 pmid:30349848 pmcid:PMC6189631 fatcat:qj2tr3t7bfcudikwz3z3bkrqhq

Page 34 of German Social Report Vol. 5, Issue 1 [page]

1930 German Social Report  
Rosen, Miss Aviva Russell, Charles J. Sichel, Robert Ridley Park—Ferguson, Mrs. B. Wayne—Cajori, Florian A. Waynesboro— Weller, D. C.  ...  Brogueville—Jones, Jacob Columbia—Boliinger, O. P. Duersmith, Leonard Zerger, Harry F. Lancaster—Shubrooks, G. E. Tanger, Mrs. Charles Y. Philadelphia—Allen, Paul W.  ... 

Page 33 of Cornell Law Forum Vol. 23, Issue 2 [page]

1996 Cornell Law Forum  
Jacob ’72 Arthur J. Jacobs ’67 David B. Jacobsohn 68 Nancy A. Janes ’84 W. Garth Janes ’83 John P. Jehu ’37 Aviva Jezer ’89 Stuart R. Johnson ’65 Walter G.  ...  Perillo Jr. 55 Rocco R. Perna ’41 Russell O. Pettibone ’35 John R. Phelps ’52 November 1996 33  ... 

Page 40 of Cornell Law Forum Vol. 21, Issue 2 [page]

1994 Cornell Law Forum  
Hawes David R. Hermenze David B. Howlett§ John B. Kassel§ Scot L. Kline§ Barbara L. Krause§ Martin S. Lipman Laura Berkowitz Lokker Christopher J. Lord Aviva A. Orenstein§ David A. Pasqualini Paul C.  ...  Jacobs§ Daniel C. Johnson David T. Kettig Frederick L. Kobb§ Robin D. Leonard§ Thomas P. Livingston§ Jennifer T. Lum Blythe W. Marston§ Carl H. Osaki Michael D. Pinnisi§ Michael J.  ... 

Les illustrations

2015 Circuit Musiques contemporaines  
Photo : Patrick Jacobs, © Tzadik ; John Zorn, The Goddess -Music for the Ancient of Days (TZ 7383, 2010). Photo : Akino Kondoh, © Tzadik.  ...  r é su m é s / a b s t r ac t sGuillaume Boutard et François-Xavier FéronArcana : les méandres de la pensée créatrice Édités par John Zorn, les sept volumes qui composent la série de livres Arcana nous  ... 
doi:10.7202/1034503ar fatcat:g2jk4z2tvnd2znp636vtzwezwm

Page 1995 of Cornell Law Forum Vol. 26, Issue 2 [page]

1999 Cornell Law Forum  
A.B. 733 Renee Kirsch Bergner, A.B. ’55 A.B. "51 Brandes, A.B. ’85 Bennett, Phyllis Fein Bobrow, Aviva J. Florence Swank Britting, B.S. ’52 Jessica R. Carrow Mr. & Mrs.  ...  Trager Michael R.  ... 
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