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Biohybrid Micro- and Nanorobots for Intelligent Drug Delivery

Jinhua Li, Lukas Dekanovsky, Bahareh Khezri, Bing Wu, Huaijuan Zhou, Zdenek Sofer
2022 Cyborg and Bionic Systems  
They can possess the advantages of onboard actuation, sensing, control, and implementation of multiple medical tasks such as targeted drug delivery, single-cell manipulation, and cell microsurgery.  ...  Leukocytes, also referred to as white blood cells (WBCs), are the cells of the body's immune system and participate in the protection of the body against neoplastic/infectious diseases and foreign invaders  ...  Recently, dual-targeting macrophage-based microrobots were developed with controllability by inherent chemotaxis and external magnetic field to implement NIR-responsive precision drug release at tumor  ... 
doi:10.34133/2022/9824057 fatcat:3az4nxey55dinbxyw2xwjuekeu

On the evolution of motility and intelligent tactic response

Laura M. Grabowski, Wesley R. Elsberry, Charles Ofria, Robert T. Pennock
2008 Proceedings of the 10th annual conference on Genetic and evolutionary computation - GECCO '08  
These experiments served as a stepping-stone and proof-ofconcept of the infrastructure needed for our future work on the evolution of simple intelligence.  ...  of a tactic response, both when provided with a hand-coded system to remember previous gradient concentrations and without this crutch where the organisms must determine how to store previous values on  ...  Taking their inspiration from a single cell, Onsum and Arkin [24] developed a collaborative control algorithm based on the behavior of a human neutrophil (white blood cell).  ... 
doi:10.1145/1389095.1389129 dblp:conf/gecco/GrabowskiEOP08 fatcat:x4kqyls7czcnrdjxih7gglb4xq

Mechanistic Understanding of Single-Cell Behavior is Essential for Transformative Advances in Biomedicine

Emmet A Francis, Volkmar Heinrich
2018 The Yale Journal of Biology and Medicine  
Most of the presented case studies are based on the controlled manipulation of nonadherent human immune cells using one or more micropipettes.  ...  The included studies have (i) examined one-on-one encounters of immune cells with real or model pathogens, (ii) assessed the physiological role of the expandable surface area of immune cells, and (iii)  ...  Consequently, the surface area of white blood cells invariably increases during cell deformations that accompany physiological functions such as chemotaxis and phagocytosis.  ... 
pmid:30258315 pmcid:PMC6153630 fatcat:rueh2zfpgje7tbvjtwejmb5ec4

Optimization of Nanoparticles for Smart Drug Delivery: A Review

Lina Jia, Peng Zhang, Hongyan Sun, Yuguo Dai, Shuzhang Liang, Xue Bai, Lin Feng
2021 Nanomaterials  
There have been many studies focusing on optimizing the structure of nanoparticles in recent years, and a series of achievements have been made.  ...  The DNA-based robot also can be used to separate the cargo and transport them to the target zone, or even walk on the cell membrane to drive the cell motility.  ...  Based on these characteristics, many research groups began to study the application of red blood cell membranes in cancer treatment.  ... 
doi:10.3390/nano11112790 pmid:34835553 pmcid:PMC8622036 fatcat:wqwcvhoyxven7m5ljuieuy5vnu

Development of micro- and nanorobotics: A review

Jia Yang, Chuang Zhang, XiaoDong Wang, WenXue Wang, Ning Xi, LianQing Liu
2018 Science China Technological Sciences  
First, the application of the robots is reviewed. Then, the key components of the robots are discussed separately, covering their actuation, design, fabrication and control.  ...  In the past 30 years, research on micro-and nanorobots has made considerable progress. This article provides a comprehensive overview of the development of these robots.  ...  The smart microrobot can identify target objects in time, such as identifying cancer cells and normal red blood cells, and autonomously select the best path to track cancer cells.  ... 
doi:10.1007/s11431-018-9339-8 fatcat:3xppd5lxpjd4fdtik3og33ak7i

A Supramolecular Approach to Nanoscale Motion: Polymersome-Based Self-Propelled Nanomotors

Isamar Ortiz-Rivera, Motilal Mathesh, Daniela A. Wilson
2018 Accounts of Chemical Research  
Our research has been focused on addressing the importance of motor architecture, motion activation, direction control, and biological integration.  ...  In this Account, we highlight the steps we have taken in order to understand and optimize the design of catalytically powered polymersome-based motors.  ...  Synthesis of micro-and nanosystems using this methodology is solely based on dynamic assembly of molecules or nanosized building blocks, providing better control over the physical and structural parameters  ... 
doi:10.1021/acs.accounts.8b00199 pmid:30179450 pmcid:PMC6150652 fatcat:pramrxzr3nemtia36are6dhane

Nano-and Micromotors Designed for Cancer Therapy

Luisa Sonntag, Juliane Simmchen, Veronika Magdanz
2019 Molecules  
Research on nano- and micromotors has evolved into a frequently cited research area with innovative technology envisioned for one of current humanities' most deadly problems: cancer.  ...  Macrophages are phagocytotic white blood cells that are responsible for the immune response by engulfing cancer cells and can therefore be considered an anti-cancer strategy that relies on the digestion  ...  (e) Bacteria-propelled red blood cells which are loaded with DOX (Alapan Science robotics 2018) [147] Reprinted with permission from AAAS.  ... 
doi:10.3390/molecules24183410 pmid:31546857 pmcid:PMC6767050 fatcat:iczk4ikvgnfktmgb7bcvjb2wee

Geometry Design, Principles and Assembly of Micromotors

Huanpo Ning, Yan Zhang, Hong Zhu, Andreas Ingham, Gaoshan Huang, Yongfeng Mei, Alexander Solovev
2018 Micromachines  
This review summarizes recent achievements in the field of nano-/micromotors, and methods of their external control and collective behaviors, which may stimulate new ideas for a broad range of applications  ...  Figure 5 .Figure 5 . 55 Dynamic self-assembly system based on externally triggered/controlled and autonomous micro-/nanomotors. (a) TiO2 light driven reversible "microfireworks".  ...  Reproduced with permission from [235] , copyright (2013) American Chemical Society; Dynamic self-assembly system based on externally triggered/controlled and autonomous micro-/nanomotors.  ... 
doi:10.3390/mi9020075 pmid:30393351 pmcid:PMC6187850 fatcat:645lq22vrvdqnalzzymw56iwny

Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release

Haifeng Xu, Mariana Medina-Sánchez, Oliver G. Schmidt
2020 Angewandte Chemie International Edition  
of multiple motile sperm cells (ca. 50).  ...  The binding mechanism between the HA microflake and sperm rely on the interactions between HA and the corresponding sperm HA receptors, which are expressed on the sperm membrane when they are mature and  ...  Serial passaging and selective detachment was used to eliminate white blood cells and separate tumour fractions from stromal cells.  ... 
doi:10.1002/anie.202005657 pmid:32392393 fatcat:ddatyqlrefaqpa5l5gsifhq6bu

Transmission and detection techniques for Internet of Bio-Nano Things applications with static and mobile molecular communication: A survey

Amit K. Shrivastava, Debanjan Das, Neeraj Varshney, Rajarshi Mahapatra
2021 ITU Journal  
This paper, therefore, presents an exhaustive review of the existing literature on detection techniques along with their transmission schemes under various MC setups.  ...  transmitter and receiver in a pure-diffusive channel, (iv) mobile transmitter and receiver in a flow-induced diffusive channel.  ...  Cell-to-cell communication based on calcium signaling was proposed in [141] .  ... 
doi:10.52953/gxez7259 fatcat:ngxeejwlpna4nonxbup2xyiqia

Lévy walks

V. Zaburdaev, S. Denisov, J. Klafter
2015 Reviews of Modern Physics  
Remarkably, one specific model of random walks appears to be ubiquitous across many fields as a tool to analyze transport phenomena in which the dispersal process is faster than dictated by Brownian diffusion  ...  CD8 + T-cells are a special type of white blood cells which are responsible for killing cancer cells, those infected by viruses, or otherwise damaged or abnormal cells.  ...  First of all, it is a development of new natureinspired search algorithms for autonomous mobile robots (Fujisawa and Dobata, 2013; Keeter et al., 2012; Lenagh and Dasgupta, 2010; Nurzaman et al., 2009  ... 
doi:10.1103/revmodphys.87.483 fatcat:b7gd3tcg2vem5j4udcwcxfp3ka

A Survey of Molecular Communication in Cell Biology: Establishing a New Hierarchy for Interdisciplinary Applications

Dadi Bi, Apostolos Almpanis, Adam Noel, Yansha Deng, Robert Schober
2021 IEEE Communications Surveys and Tutorials  
relying on communication with MC signals at the Application level.  ...  , and manipulate signaling in cell biology.  ...  cells T-cell Type of white blood cell (leukocyte), part of the immune system Transcription factor A protein that can bind a specific DNA sequence, controlling the expression of a gene Transfer RNA (tRNA  ... 
doi:10.1109/comst.2021.3066117 fatcat:xd2o7fobtret3bc4vc5yqbckru

A Survey of Molecular Communication in Cell Biology: Establishing a New Hierarchy for Interdisciplinary Applications [article]

Dadi Bi, Apostolos Almpanis, Adam Noel, Yansha Deng, Robert Schober
2020 arXiv   pre-print
, and manipulate signaling in cell biology.  ...  To further demonstrate the proposed hierarchy, it is applied to case studies on quorum sensing, neuronal signaling, and communication via DNA.  ...  cells T-cell Type of white blood cell (leukocyte), part of the immune system Transcription factor A protein that can bind a specific DNA sequence, controlling the expression of a gene Transfer RNA (tRNA  ... 
arXiv:2009.00090v1 fatcat:5fhpk7dpmvc35b44ysr4srqbc4

Collective motion

Tamás Vicsek, Anna Zafeiris
2012 Physics reports  
The observations we report on include systems consisting of units ranging from macromolecules through metallic rods and robots to groups of animals and people.  ...  We review the observations and the basic laws describing the essential aspects of collective motion -- being one of the most common and spectacular manifestation of coordinated behavior.  ...  The proximity sensors on most mobile robots (such as ultrasound and IR-based systems) can sense only the range to the closest point of a neighboring robot and multiple range-readings can be returned from  ... 
doi:10.1016/j.physrep.2012.03.004 fatcat:qmnmww5lurhqrikozq674wtcce

The 2012 ESSR Congress, Lille, France, June 6–9, 2012, Lille, France

2013 European Surgical Research  
His blood test showed a significant increase in white blood cell count. Theabdominal ultrasonographywas normal.  ...  Recent research on cancer metastasis has explored on the intrinsic factors regulating the cell autonomous homing of the tumor cells to the metastatic site.  ...  Blood samples were collected 6h and 72h following SID to analyse the white blood cell count and corticosterone levels.  ... 
doi:10.1159/000351963 fatcat:2wfowtsnsrd25gfsukw2po37wu
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