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Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

François De Guio, Eric Jouvent, Geert Jan Biessels, Sandra E Black, Carol Brayne, Christopher Chen, Charlotte Cordonnier, Frank-Eric De Leeuw, Martin Dichgans, Fergus Doubal, Marco Duering, Carole Dufouil (+29 others)
2016 Journal of Cerebral Blood Flow and Metabolism  
This review focuses on the main SVD-related markers on MRI including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds and brain volume.  ...  Several magnetic resonance imaging (MRI) markers have therefore emerged, providing new information on the diagnosis, progression and mechanisms of SVD.  ...  The authors declare no conflict of interest. Supplementary material for this paper can be found at  ... 
doi:10.1177/0271678x16647396 pmid:27170700 pmcid:PMC4976752 fatcat:62yvvbsgorgnbnlgv6v3w3j3bu

Episodic memory decline in Parkinson' s disease: relation with white matter hyperintense lesions and influence of quantification method

Vincent Dunet, Mario Joao Fartaria, Jeremy Deverdun, Emmanuelle Le Bars, Florence Maury, Giovanni Castelnovo, Tobias Kober, Meritxell Bach Cuadra, Christian Geny, Benedicte Marechal, Nicolas Menjot de Champfleur
2018 Brain Imaging and Behavior  
Free recall performance was negatively correlated with the total white matter hyperintense lesions volume, either manually or automatically delineated, but not with the age-related white matter changes  ...  Performance during episodic memory testing, age-related white matter changes score, total manual and automated white matter hyperintense lesions volume and lobar white matter hyperintense lesions volumes  ...  . 1 Examples of manual and automated segmentation of white matter hyperintense lesions according to age-related white matter changes score (ARWMC) on FLAIR images Dalaker et al. (2009) who found no  ... 
doi:10.1007/s11682-018-9909-x pmid:29948903 fatcat:gwvdbdalpfdn3p4ifi5wgswg2u

Limited One-time Sampling Irregularity Age Map (LOTS-IAM): Automatic Unsupervised Detection of Brain White Matter Abnormalities in Structural Magnetic Resonance Images [article]

Muhammad Febrian Rachmadi, Maria Valdés Hernández, Hongwei Li, Ricardo Guerrero, Jianguo Zhang, Daniel Rueckert, Taku Komura
2018 bioRxiv   pre-print
We propose a novel unsupervised approach of detecting and segmenting white matter abnormalities, using limited one-time sampling irregularity age map (LOTS-IAM).  ...  LOTS-IAM is a fully automatic unsupervised approach to extract brain tissue irregularities in magnetic resonance images (MRI) (e.g. T2-FLAIR white matter hyperintensities (WMH)).  ...  All supervised segmentation methods used in this study were trained and tested using 5-fold cross validation.  ... 
doi:10.1101/334292 fatcat:ouw5mtiobjeghi6zqs56v7payq

Automatic segmentation of White Matter Hyperintensities: validation and comparison with state-of-the-art methods on both Multiple Sclerosis and elderly subjects

Philippe Tran, Urielle Thoprakarn, Emmanuelle Gourieux, Clarisse Longo dos Santos, Enrica Cavedo, Nicolas Guizard, François Cotton, Pierre Krolak-Salmon, Christine Delmaire, Damien Heidelberg, Nadya Pyatigorskaya, Sébastian Ströer (+3 others)
2022 NeuroImage: Clinical  
Evaluation and comparison results suggest that WHASA-3D is a reliable and easy-to-use method for the automated segmentation of white matter hyperintensities, for both MS lesions and age-related WMH.  ...  in clinical practice for the detection of both MS lesions and age-related WMH in the brain, using both 3D T1-weighted and T2-FLAIR images.  ...  or age-related WMH, but none is validated on both WMH types.  ... 
doi:10.1016/j.nicl.2022.102940 pmid:35051744 pmcid:PMC8896108 fatcat:tcjpnabttbhvvpwgmnacb36chy

Multicentre imaging measurements for oncology and in the brain

P S Tofts, D J Collins
2011 British Journal of Radiology  
Sources of variation that are generic to any imaging method and analysis parameters include MR sequence mismatch, B 1 errors, CT effective tube potential, region of interest generation and segmentation  ...  Normal white matter forms an excellent standard for some MRI parameters (e.g. diffusion or magnetisation transfer) because the normal biological range is low (,2-3%) and the measurements will reflect this  ...  Acknowledgments Dr Laura Parkes (University of Manchester, UK) kindly supplied the material on CBF measured using ASL.  ... 
doi:10.1259/bjr/74316620 pmid:22433831 pmcid:PMC3473901 fatcat:tjmigfvftbcj7k7tbmai5swi2u

FLAIR-only joint volumetric analysis of brain lesions and atrophy in clinically isolated syndrome (CIS) suggestive of multiple sclerosis

O. Goodkin, F. Prados, S.B. Vos, H. Pemberton, S. Collorone, M.H.J. Hagens, M.J. Cardoso, T.A. Yousry, J.S. Thornton, C.H. Sudre, F. Barkhof
2020 NeuroImage: Clinical  
MRI assessment in multiple sclerosis (MS) focuses on the presence of typical white matter (WM) lesions.  ...  Age-associated change in cortical GM volume was a significant covariate in both T1 (p = 0.001) and FLAIR-only (p = 0.005) methods, confirming the expected relationship between age and GM volume for FLAIR-only  ...  Lesions were defined as all areas of abnormal white matter hyperintensity consistent with CIS apparent on T2-FLAIR images and larger than 3 mm diameter.  ... 
doi:10.1016/j.nicl.2020.102542 pmid:33418171 pmcid:PMC7804983 fatcat:hrg7djmrvfhhbg6gxjcabbbnae

FlowReg: Fast Deformable Unsupervised Medical Image Registration using Optical Flow [article]

Sergiu Mocanu, Alan R. Moody, April Khademi
2021 arXiv   pre-print
A battery of quantitative novel registration validation metrics are proposed that focus on the structural integrity of tissues, spatial alignment, and intensity similarity.  ...  In total, 4643 FLAIR MR imaging volumes are used from dementia and vascular disease cohorts, acquired from over 60 international centres with varying acquisition parameters.  ...  Yu (York University, Computer Science Dept.) which included methodological input on the optical flow network and on the use of the penalty function, in addition to editing of the manuscript.  ... 
arXiv:2101.09639v2 fatcat:j7z37iaejzddpbfgjpffoxuguu

Contrast-Based Fully Automatic Segmentation of White Matter Hyperintensities: Method and Validation

Thomas Samaille, Ludovic Fillon, Rémi Cuingnet, Eric Jouvent, Hugues Chabriat, Didier Dormont, Olivier Colliot, Marie Chupin, Karl Herholz
2012 PLoS ONE  
This paper introduced WHASA (White matter Hyperintensities Automated Segmentation Algorithm), a new method for automatically segmenting WMH from FLAIR and T1 images in multicentre studies.  ...  White matter hyperintensities (WMH) on T2 or FLAIR sequences have been commonly observed on MR images of elderly people.  ...  Discussion We have presented WHASA, a new method for automatically segmenting white matter hyperintensities from FLAIR and T1 images in multi centre studies.  ... 
doi:10.1371/journal.pone.0048953 pmid:23152828 pmcid:PMC3495958 fatcat:d4odvpsiifgkzjcebarjj3qeje

Noninvasive Grading of Glioma Tumor Using Magnetic Resonance Imaging with Convolutional Neural Networks

Saed Khawaldeh, Usama Pervaiz, Azhar Rafiq, Rami Alkhawaldeh
2017 Applied Sciences  
and segmentation.  ...  The unhealthy images of brain tumors are categorized also into low grades and high grades.  ...  Conflicts of Interest: None of the authors of this paper have a financial or personal relationship with other people or organizations that could influence or bias the content of the paper.  ... 
doi:10.3390/app8010027 fatcat:y7tftfzzf5bxnmrxfs57npim64

MRI Radiomic Signature of White Matter Hyperintensities Is Associated with Clinical Phenotypes [article]

Martin Bretzner, Anna K. Bonkhoff, Markus D. Schirmer, Sungmin Hong, Adrian Dalca, Kathleen L. Donahue, Anne-Katrin Giese, Mark R. Etherton, Pamela M. Rist, Marco Nardin, Razvan Marinescu, Clinton Wang (+41 others)
2021 bioRxiv   pre-print
Methods: Our analyses were based on a multi-site cohort of 4,163 acute ischemic strokes (AIS) patients with T2-FLAIR MR images and corresponding deep-learning-generated total brain and WMH segmentation  ...  We built a radiomic signature of WMH with the most stable selected features predictive of WMH burden and then related this signature to clinical variables (age, sex, hypertension (HTN), atrial fibrillation  ...  MRE is supported by the American Academy of Neurology and MGH Executive Council on Research. TT was supported by the Helsinki University Central Hospital, Sigrid  ... 
doi:10.1101/2021.01.24.427986 fatcat:oemzvexwuner3p2yam3whqzpdi

Segmentation of white matter lesions in multicentre FLAIR MRI

April Khademi, Adam Gibicar, Giordano Arezza, Justin DiGregorio, Pascal N. Tyrrell, Alan R. Moody
2021 Neuroimage: Reports  
In total 252 imaging volumes (~13 K image slices) with annotations, from 5 multicentre datasets (33 imaging centres) were used to train, validate and test the WML segmentation methods.  ...  White matter lesions (WML) in the brain are thought to be related to ischemic processes, demyelination, and axonal degeneration.  ...  support from the Canadian Consortium on Neurodegeneration and Aging (CCNA) for data from the COMPASS-ND study, data storage, and management and standardized MRI protocols.  ... 
doi:10.1016/j.ynirp.2021.100044 fatcat:4zv2p3j34rbdzaj5kflgxyjdbq

Close Correlation between Quantitative and Qualitative Assessments of White Matter Lesions

Maria del C. Valdés Hernández, Zoe Morris, David Alexander Dickie, Natalie A. Royle, Susana Muñoz Maniega, Benjamin S. Aribisala, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
2013 Neuroepidemiology  
Conclusions: WML rating scores and volumes provide near-equivalent estimates of WML burden, therefore either can be used depending on research circumstances.  ...  Even closer agreement could result from improved computational detection of subtle WML and modified visual ratings to differentiate prominent ventricular caps from thin periventricular linings, and small  ...  Acknowledgements We thank the LBC1936 participants, Catherine Murray for work on recruitment and the nurses, radiographers and other staff at the Brain Research Imaging Centre ( Disclosure Statement  ... 
doi:10.1159/000341859 pmid:23075702 fatcat:io2ug5ubo5h5pgpqx6ealjqady

MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes

Martin Bretzner, Anna K. Bonkhoff, Markus D. Schirmer, Sungmin Hong, Adrian V. Dalca, Kathleen L. Donahue, Anne-Katrin Giese, Mark R. Etherton, Pamela M. Rist, Marco Nardin, Razvan Marinescu, Clinton Wang (+44 others)
2021 Frontiers in Neuroscience  
clinical phenotypes.MethodsWe analyzed a multi-site cohort of 4,163 acute ischemic strokes (AIS) patients with T2-FLAIR MR images with total brain and WMH segmentations.  ...  ), and CV7 by CAD and diabetes.ConclusionRadiomics extracted from T2-FLAIR images of AIS patients capture microstructural damage of the cerebral parenchyma and correlate with clinical phenotypes, suggesting  ...  Advanced diffusion tensor imaging (DTI) studies have shown an age-related loss of parenchymal microstructural integrity in normal-appearing white matter (NAWM) (Etherton et al., 2017a) .  ... 
doi:10.3389/fnins.2021.691244 pmid:34321995 pmcid:PMC8312571 fatcat:ixzkolwa6jhxbbksyzuc3f34re

Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies

Iain D. Croall, Valerie Lohner, Barry Moynihan, Usman Khan, Ahamad Hassan, John T. O'Brien, Robin G. Morris, Daniel J. Tozer, Victoria C. Cambridge, Kirsty Harkness, David J. Werring, Andrew M. Blamire (+3 others)
2017 Clinical Science  
One hundred and nine patients (mean age =68 years) with symptomatic lacunar infarction and confluent white matter hyperintensities (WMH) on MRI was recruited across six sites as part of the PRESERVE DTI  ...  We investigate the associations between these metrics and cognition in a multicentre clinical trial of SVD. • In a cross-sectional analysis, significant associations were found between white matter DTI  ...  normal appearing white matter; NBV, normalised brain volume; QoL, quality of life; RAVLT, Rey auditory verbal learning test; SSQoL, stroke specific quality of life; SVD, small vessel disease; TMT, trail  ... 
doi:10.1042/cs20170146 pmid:28487471 pmcid:PMC5461938 fatcat:u5qprq2xbvc7fa5uh7vue5rtcy

Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: effect on cognition and associations with mineral deposition

Maria del C. Valdés Hernández, Lucia Ballerini, Andreas Glatz, Susana Muñoz Maniega, Alan J. Gow, Mark E. Bastin, John M. Starr, Ian J. Deary, Joanna M. Wardlaw
2019 Brain Imaging and Behavior  
risk factors, childhood intelligence and white matter hyperintensity volume.  ...  testing and multimodal brain MRI at mean age 72.7 years.  ...  Normal-appearing white matter (WM) masks are obtained from combining T1-and T2weighted images (T1W and T2W respectively), whilst white matter hyperintensity (WMH) masks are obtained from the FLAIR and  ... 
doi:10.1007/s11682-019-00128-1 pmid:31250262 fatcat:bhhzlw24mbckxkqci5kh5yq4x4
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