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OncoNet: Weakly Supervised Siamese Network to automate cancer treatment response assessment between longitudinal FDG PET/CT examinations [article]

Anirudh Joshi, Sabri Eyuboglu, Shih-Cheng Huang, Jared Dunnmon, Arjun Soin, Guido Davidzon, Akshay Chaudhari, Matthew P Lungren
2021 arXiv   pre-print
Automated assessment of radiographic response from FDG PET/CT with OncoNet could provide clinicians with a valuable tool to rapidly and consistently interpret change over time in longitudinal multi-modal  ...  OncoNet demonstrates an AUROC of 0.86 and 0.84 on internal and external institution test sets respectively for determination of change between scans while also showing strong agreement to clinical scoring  ...  The top row shows the emergence of a new tumor (progression) in the bottom left part of the scan and the saliency focuses on the region of the change.  ... 
arXiv:2108.02016v1 fatcat:xv63gckiangrdjafnq2rhm6lem

FDG-PET/CT for Response Monitoring in Metastatic Breast Cancer: The Feasibility and Benefits of Applying PERCIST

Marianne Vogsen, Jakob Lykke Bülow, Lasse Ljungstrøm, Hjalte Rasmus Oltmann, Tural Asgharzadeh Alamdari, Mohammad Naghavi-Behzad, Poul-Erik Braad, Oke Gerke, Malene Grubbe Hildebrandt
2021 Diagnostics  
Reasons for progression were (a) more than 30% increase in SULpeak of the hottest lesion (n = 7, 15.9%), (b) detection of new metastatic lesions (n = 28, 63.6%), or both (a) and (b) (n = 9, 20.5%).  ...  Methods: Response monitoring FDG-PET/CT scans in 37 women with MBC were retrospectively screened for PERCIST standardization and measurability criteria.  ...  Acknowledgments: We want to acknowledge the two patient representatives, Marie Lykke Rasmussen and Susanne Geneser, who have served as co-researchers in this study for valuable discussions of the study  ... 
doi:10.3390/diagnostics11040723 pmid:33921580 fatcat:fq2isjg67becppscxjirjytjhy

In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model

Nanditha Mohan Das, Sarah Hatsell, Kalyan Nannuru, Lily Huang, Xialing Wen, Lili Wang, Li-Hsien Wang, Vincent Idone, Jeffrey A. Meganck, Andrew Murphy, Aris Economides, LiQin Xie (+1 others)
2016 PLoS ONE  
With 1-2 minutes scanning by a high speed in vivo micro-CT scanner (Quantum CT), and injection of a highly efficient contrast agent (Exitron nano 12000), vasculature and organ structure were semi-automatically  ...  and cancer, would be critical to the development and evaluation of new therapies for the same.  ...  Acknowledgments We are grateful to Michael Philcock, General Manager of AnalyzeDirect Inc., for providing his guidance and advanced knowledge with respect to image and post-image processing using the AnalyzeDirect  ... 
doi:10.1371/journal.pone.0150085 pmid:26910759 pmcid:PMC4765930 fatcat:yoik7dugdncanbb6zruovvkrsy

Variability in Assessing Treatment Response: Metastatic Colorectal Cancer as a Paradigm

B. Zhao, S. M. Lee, H.-J. Lee, Y. Tan, J. Qi, T. Persigehl, D. P. Mozley, L. H. Schwartz
2014 Clinical Cancer Research  
A subset of patients' CT images of chest, abdomen, and pelvis were randomly chosen from a multicenter clinical trial evaluating insulin-like growth factor receptor type 1-targeted therapy in mCRC.  ...  Using Response Evaluation Criteria in Solid Tumors (RECIST), three radiologists selected target lesions and measured "uni" (maximal diameter), "bi" (product of maximal diameter and maximal perpendicular  ...  from longitudinal CT examinations.  ... 
doi:10.1158/1078-0432.ccr-14-0245 pmid:24780294 pmcid:PMC4337392 fatcat:74vnw7f56zf5xm7rj545uodczq

Quantitative monitoring of mouse lung tumors by magnetic resonance imaging

Alexander Sasha Krupnick, Vanessa K Tidwell, John A Engelbach, Vamsi V Alli, Arye Nehorai, Ming You, Haris G Vikis, Andrew E Gelman, Daniel Kreisel, Joel R Garbow
2012 Nature Protocols  
However, detection of mouse pulmonary tumors and their subsequent response to therapy in situ is challenging.  ...  research tool for preclinical investigation of therapeutic strategies for treatment of pulmonary malignancies, and it may be valuable in evaluating new compounds targeting lung cancer in vivo. protocol  ...  Values of relative tumor burden can be compared between animals and across time points of a longitudinal, time-course study. ?  ... 
doi:10.1038/nprot.2011.424 pmid:22222788 pmcid:PMC3870466 fatcat:xfxg6jhkzzbpvcwlzfww2qqbtm

AI-Based Detection, Classification and Prediction/Prognosis in Medical Imaging: Towards Radiophenomics [article]

Fereshteh Yousefirizi, Pierre Decazes, Amine Amyar, Su Ruan, Babak Saboury, Arman Rahmim
2022 arXiv   pre-print
This work reviews AI-based techniques, with a special focus on oncological PET and PET/CT imaging, for different detection, classification, and prediction/prognosis tasks.  ...  AI-based detection searches the image space to find the regions of interest based on patterns and features.  ...  Acknowledgements This project was in part supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant RGPIN-2019-06467, and the Canadian Institutes of Health Research  ... 
arXiv:2110.10332v4 fatcat:vmpxhoolarbrve5ddyfn5umfim

Response rate and safety in patients with hepatocellular carcinoma treated with transarterial chemoembolization using 40-µm doxorubicin-eluting microspheres

Katharina Carolin Albrecht, René Aschenbach, Ioannis Diamantis, Niklas Eckardt, Ulf Teichgräber
2020 Journal of Cancer Research and Clinical Oncology  
Images of the treated lesions were analyzed before and after each treatment according to mRECIST (modified Response Evaluation Criteria in Solid Tumors).  ...  Additional endpoints were progression-free survival (PFS) and time to progression (TTP). In the target tumors, a therapy response rate of 63.1% and a disease control rate of 95.7% were achieved.  ...  It was necessary to use the portal venous phase in 13 CT (5.1%) scans (n = 13/255) and the venous phase in 6 CT (2.3%) scans (n = 6/255).  ... 
doi:10.1007/s00432-020-03370-z pmid:32880029 fatcat:xarzfu3fqrcoxfx4kgvgt37wgu

Radiology in Transplant

Amy K. Kim, Michael L. Schilsky
2014 Current Transplantation Reports  
There have been several advances in liver imaging that have affected liver transplantation, with the adoption of new policies for hepatocellular carcinoma (HCC) and exploration of new imaging techniques  ...  This review also comments on the use of CT and MRI for evaluating living donor candidates, and the use of elasticity imaging with MRI or ultrasound for graft fibrosis after liver transplantation.  ...  Conclusion The many advances during this year in imaging techniques and their application to the evaluation of liver structure and anatomy, tumor detection, and the evaluation of liver tumor treatment  ... 
doi:10.1007/s40472-014-0034-5 fatcat:2hpnyvir7vcm7gkwsv5znhbate

Automatic Segmentation of Metastatic Breast Cancer Lesions on 18F-FDG PET/CT Longitudinal Acquisitions for Treatment Response Assessment

Noémie Moreau, Caroline Rousseau, Constance Fourcade, Gianmarco Santini, Aislinn Brennan, Ludovic Ferrer, Marie Lacombe, Camille Guillerminet, Mathilde Colombié, Pascal Jézéquel, Mario Campone, Nicolas Normand (+1 others)
2021 Cancers  
The aim of this work was to (1) propose networks to segment breast cancer metastatic lesions on longitudinal whole-body PET/CT and (2) extract imaging biomarkers from the segmentations and evaluate their  ...  From the automatic segmentations, four imaging biomarkers were computed and evaluated: SULpeak, Total Lesion Glycolysis (TLG), PET Bone Index (PBI) and PET Liver Index (PLI).  ...  The aim of this study was therefore to find a solution to automatically detect and segment breast cancer metastatic lesions on longitudinal whole-body PET/CT and obtain segmentations that can be used to  ... 
doi:10.3390/cancers14010101 pmid:35008265 pmcid:PMC8750371 fatcat:ue2cfj2nwzdw3fwdyf3yz4qrai

Morphological and functional MDCT: problem-solving tool and surrogate biomarker for hepatic disease clinical care and drug discovery in the era of personalized medicine

Liang Wang
2010 Hepatic Medicine : Evidence and Research  
State-of-the-art MDCT depicts and quantifies hepatic disease over conventional CT for not only depicting lesion location, size, and extent but also detecting changes in tumor biologic behavior caused by  ...  MDCT holds incremental value to World Health Organization response criteria and Response Evaluation Criteria in Solid Tumors in liver disease management.  ...  Diagnostic sensitivity and accuracy of MDCT are significantly improved and result in better detection of hepatic lesions, thus decreasing the number of biopsies. 23 Evaluation of diffuse liver disease  ... 
doi:10.2147/hmer.s9052 pmid:24367211 pmcid:PMC3846718 fatcat:ctkfxlk6ojd2jo554imcrqa5rm

Positron Emission Tomography (PET) in Oncology

Andrea Gallamini, Colette Zwarthoed, Anna Borra
2014 Cancers  
FDG-PET/CT proved more sensitive than contrast-enhanced CT scan in staging of several type of lymphoma or in detecting widespread tumor dissemination in several solid cancers, such as breast, lung, colon  ...  Moreover, the continuous technological progress of image generation and the introduction of sophisticated software to use PET scan as a biomarker paved the way to calculate new prognostic markers such  ...  Such a relationship, however, is not linear and seems lost for very small tumor burden where the entity of the residual tracer uptake by the tumor is beyond the detection power of FDG-PET/CT scan.  ... 
doi:10.3390/cancers6041821 pmid:25268160 pmcid:PMC4276948 fatcat:sj3mcp2odbhj3cdb5mar4n54ou

Imaging and liquid biopsy in the prediction and evaluation of response to PRRT in neuroendocrine tumors: implications for patient management

Wolfgang Roll, Matthias Weckesser, Robert Seifert, Lisa Bodei, Kambiz Rahbar
2021 European Journal of Nuclear Medicine and Molecular Imaging  
Peptide radio receptor therapy (PRRT) is a prospectively evaluated and approved therapy option in neuroendocrine tumors (NETs).  ...  The aim of this narrative review is to give an overview on current and emerging imaging methods and liquid biopsy for prediction and evaluation of response to PRRT.  ...  MRI Overall, CE MRI has a higher sensitivity than CE-CT in detecting NET metastases and allows for a more accurate detection of liver metastases compared to CT and ultrasound [24] .  ... 
doi:10.1007/s00259-021-05359-3 pmid:33903926 pmcid:PMC8484222 fatcat:st2hd4pecvamnbvtfdi27klng4

Imaging-Based Tumor Treatment Response Evaluation: Review of Conventional, New, and Emerging Concepts

Hee Kang, Ho Yun Lee, Kyung Soo Lee, Jae-Hun Kim
2012 Korean Journal of Radiology  
This review elucidates morphologic and functional or metabolic approaches, and new concepts in the evaluation of tumor response in the era of personalized medicine (targeted chemotherapy).  ...  Tumor response may be assessed readily by the use of Response Evaluation Criteria in Solid Tumor version 1.1. However, the criteria mainly depend on tumor size changes.  ...  facilitates multicenter and longitudinal studies.  ... 
doi:10.3348/kjr.2012.13.4.371 pmid:22778559 pmcid:PMC3384819 fatcat:f2sgxu6divb6xdwmzysrrtms2q

EBONI: A Tool for Automated Quantification of Bone Metastasis Load in PSMA PET/CT

Jochen Hammes, Philipp Täger, Alexander Drzezga
2017 Journal of Nuclear Medicine  
Here, we introduce EBONI (Evaluation of Bone Involvement), a software tool to automatically quantify the bone metastasis load in PSMA PET/CT.  ...  Prostate-specific membrane antigen (PSMA) PET/CT has a high diagnostic accuracy for lesion detection in metastatic prostate cancer, including bone metastases.  ...  Automated software has been developed for quantifying the total skeletal tumor burden in planar scintigraphy (18, 35) , and a study recently proved that software-based determination of the bone-scan index  ... 
doi:10.2967/jnumed.117.203265 pmid:29242401 fatcat:52dtd24fzba4vd4qh7wqmrvrli

Quantitative image analysis for evaluation of tumor response in clinical oncology

Wen-Li Cai, Guo-Bin Hong
2018 Chronic Diseases and Translational Medicine  
Conflicts of interest The authors declare that they have no conflicts of interest.  ...  is defined as a reduction in lesion size by 10% as shown in CT or a reduction in the tumor CT value of 15% without the appearance of new lesions.  ...  Computer-assisted volumetric measurement becomes clinically available with the advent of recent improvements in CT and MRI scanning technology and the developments in image-segmentation software.  ... 
doi:10.1016/j.cdtm.2018.01.002 pmid:29756120 pmcid:PMC5938243 fatcat:qv6gh4km4nbhdixxaezmcu7yra
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