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OncoNet: Weakly Supervised Siamese Network to automate cancer treatment response assessment between longitudinal FDG PET/CT examinations
[article]
2021
arXiv
pre-print
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Automated assessment of radiographic response from FDG PET/CT with OncoNet could provide clinicians with a valuable tool to rapidly and consistently interpret change over time in longitudinal multi-modal ...
OncoNet demonstrates an AUROC of 0.86 and 0.84 on internal and external institution test sets respectively for determination of change between scans while also showing strong agreement to clinical scoring ...
The top row shows the emergence of a new tumor (progression) in the bottom left part of the scan and the saliency focuses on the region of the change. ...
arXiv:2108.02016v1
fatcat:xv63gckiangrdjafnq2rhm6lem
FDG-PET/CT for Response Monitoring in Metastatic Breast Cancer: The Feasibility and Benefits of Applying PERCIST
2021
Diagnostics
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Reasons for progression were (a) more than 30% increase in SULpeak of the hottest lesion (n = 7, 15.9%), (b) detection of new metastatic lesions (n = 28, 63.6%), or both (a) and (b) (n = 9, 20.5%). ...
Methods: Response monitoring FDG-PET/CT scans in 37 women with MBC were retrospectively screened for PERCIST standardization and measurability criteria. ...
Acknowledgments: We want to acknowledge the two patient representatives, Marie Lykke Rasmussen and Susanne Geneser, who have served as co-researchers in this study for valuable discussions of the study ...
doi:10.3390/diagnostics11040723
pmid:33921580
fatcat:fq2isjg67becppscxjirjytjhy
In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model
2016
PLoS ONE
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With 1-2 minutes scanning by a high speed in vivo micro-CT scanner (Quantum CT), and injection of a highly efficient contrast agent (Exitron nano 12000), vasculature and organ structure were semi-automatically ...
and cancer, would be critical to the development and evaluation of new therapies for the same. ...
Acknowledgments We are grateful to Michael Philcock, General Manager of AnalyzeDirect Inc., for providing his guidance and advanced knowledge with respect to image and post-image processing using the AnalyzeDirect ...
doi:10.1371/journal.pone.0150085
pmid:26910759
pmcid:PMC4765930
fatcat:yoik7dugdncanbb6zruovvkrsy
Variability in Assessing Treatment Response: Metastatic Colorectal Cancer as a Paradigm
2014
Clinical Cancer Research
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A subset of patients' CT images of chest, abdomen, and pelvis were randomly chosen from a multicenter clinical trial evaluating insulin-like growth factor receptor type 1-targeted therapy in mCRC. ...
Using Response Evaluation Criteria in Solid Tumors (RECIST), three radiologists selected target lesions and measured "uni" (maximal diameter), "bi" (product of maximal diameter and maximal perpendicular ...
from longitudinal CT examinations. ...
doi:10.1158/1078-0432.ccr-14-0245
pmid:24780294
pmcid:PMC4337392
fatcat:74vnw7f56zf5xm7rj545uodczq
Quantitative monitoring of mouse lung tumors by magnetic resonance imaging
2012
Nature Protocols
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However, detection of mouse pulmonary tumors and their subsequent response to therapy in situ is challenging. ...
research tool for preclinical investigation of therapeutic strategies for treatment of pulmonary malignancies, and it may be valuable in evaluating new compounds targeting lung cancer in vivo. protocol ...
Values of relative tumor burden can be compared between animals and across time points of a longitudinal, time-course study.
? ...
doi:10.1038/nprot.2011.424
pmid:22222788
pmcid:PMC3870466
fatcat:xfxg6jhkzzbpvcwlzfww2qqbtm
AI-Based Detection, Classification and Prediction/Prognosis in Medical Imaging: Towards Radiophenomics
[article]
2022
arXiv
pre-print
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This work reviews AI-based techniques, with a special focus on oncological PET and PET/CT imaging, for different detection, classification, and prediction/prognosis tasks. ...
AI-based detection searches the image space to find the regions of interest based on patterns and features. ...
Acknowledgements This project was in part supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant RGPIN-2019-06467, and the Canadian Institutes of Health Research ...
arXiv:2110.10332v4
fatcat:vmpxhoolarbrve5ddyfn5umfim
Response rate and safety in patients with hepatocellular carcinoma treated with transarterial chemoembolization using 40-µm doxorubicin-eluting microspheres
2020
Journal of Cancer Research and Clinical Oncology
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Images of the treated lesions were analyzed before and after each treatment according to mRECIST (modified Response Evaluation Criteria in Solid Tumors). ...
Additional endpoints were progression-free survival (PFS) and time to progression (TTP). In the target tumors, a therapy response rate of 63.1% and a disease control rate of 95.7% were achieved. ...
It was necessary to use the portal venous phase in 13 CT (5.1%) scans (n = 13/255) and the venous phase in 6 CT (2.3%) scans (n = 6/255). ...
doi:10.1007/s00432-020-03370-z
pmid:32880029
fatcat:xarzfu3fqrcoxfx4kgvgt37wgu
Radiology in Transplant
2014
Current Transplantation Reports
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There have been several advances in liver imaging that have affected liver transplantation, with the adoption of new policies for hepatocellular carcinoma (HCC) and exploration of new imaging techniques ...
This review also comments on the use of CT and MRI for evaluating living donor candidates, and the use of elasticity imaging with MRI or ultrasound for graft fibrosis after liver transplantation. ...
Conclusion The many advances during this year in imaging techniques and their application to the evaluation of liver structure and anatomy, tumor detection, and the evaluation of liver tumor treatment ...
doi:10.1007/s40472-014-0034-5
fatcat:2hpnyvir7vcm7gkwsv5znhbate
Automatic Segmentation of Metastatic Breast Cancer Lesions on 18F-FDG PET/CT Longitudinal Acquisitions for Treatment Response Assessment
2021
Cancers
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The aim of this work was to (1) propose networks to segment breast cancer metastatic lesions on longitudinal whole-body PET/CT and (2) extract imaging biomarkers from the segmentations and evaluate their ...
From the automatic segmentations, four imaging biomarkers were computed and evaluated: SULpeak, Total Lesion Glycolysis (TLG), PET Bone Index (PBI) and PET Liver Index (PLI). ...
The aim of this study was therefore to find a solution to automatically detect and segment breast cancer metastatic lesions on longitudinal whole-body PET/CT and obtain segmentations that can be used to ...
doi:10.3390/cancers14010101
pmid:35008265
pmcid:PMC8750371
fatcat:ue2cfj2nwzdw3fwdyf3yz4qrai
Morphological and functional MDCT: problem-solving tool and surrogate biomarker for hepatic disease clinical care and drug discovery in the era of personalized medicine
2010
Hepatic Medicine : Evidence and Research
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State-of-the-art MDCT depicts and quantifies hepatic disease over conventional CT for not only depicting lesion location, size, and extent but also detecting changes in tumor biologic behavior caused by ...
MDCT holds incremental value to World Health Organization response criteria and Response Evaluation Criteria in Solid Tumors in liver disease management. ...
Diagnostic sensitivity and accuracy of MDCT are significantly improved and result in better detection of hepatic lesions, thus decreasing the number of biopsies. 23 Evaluation of diffuse liver disease ...
doi:10.2147/hmer.s9052
pmid:24367211
pmcid:PMC3846718
fatcat:ctkfxlk6ojd2jo554imcrqa5rm
Positron Emission Tomography (PET) in Oncology
2014
Cancers
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FDG-PET/CT proved more sensitive than contrast-enhanced CT scan in staging of several type of lymphoma or in detecting widespread tumor dissemination in several solid cancers, such as breast, lung, colon ...
Moreover, the continuous technological progress of image generation and the introduction of sophisticated software to use PET scan as a biomarker paved the way to calculate new prognostic markers such ...
Such a relationship, however, is not linear and seems lost for very small tumor burden where the entity of the residual tracer uptake by the tumor is beyond the detection power of FDG-PET/CT scan. ...
doi:10.3390/cancers6041821
pmid:25268160
pmcid:PMC4276948
fatcat:sj3mcp2odbhj3cdb5mar4n54ou
Imaging and liquid biopsy in the prediction and evaluation of response to PRRT in neuroendocrine tumors: implications for patient management
2021
European Journal of Nuclear Medicine and Molecular Imaging
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Peptide radio receptor therapy (PRRT) is a prospectively evaluated and approved therapy option in neuroendocrine tumors (NETs). ...
The aim of this narrative review is to give an overview on current and emerging imaging methods and liquid biopsy for prediction and evaluation of response to PRRT. ...
MRI Overall, CE MRI has a higher sensitivity than CE-CT in detecting NET metastases and allows for a more accurate detection of liver metastases compared to CT and ultrasound [24] . ...
doi:10.1007/s00259-021-05359-3
pmid:33903926
pmcid:PMC8484222
fatcat:st2hd4pecvamnbvtfdi27klng4
Imaging-Based Tumor Treatment Response Evaluation: Review of Conventional, New, and Emerging Concepts
2012
Korean Journal of Radiology
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This review elucidates morphologic and functional or metabolic approaches, and new concepts in the evaluation of tumor response in the era of personalized medicine (targeted chemotherapy). ...
Tumor response may be assessed readily by the use of Response Evaluation Criteria in Solid Tumor version 1.1. However, the criteria mainly depend on tumor size changes. ...
facilitates multicenter and longitudinal studies. ...
doi:10.3348/kjr.2012.13.4.371
pmid:22778559
pmcid:PMC3384819
fatcat:f2sgxu6divb6xdwmzysrrtms2q
EBONI: A Tool for Automated Quantification of Bone Metastasis Load in PSMA PET/CT
2017
Journal of Nuclear Medicine
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Here, we introduce EBONI (Evaluation of Bone Involvement), a software tool to automatically quantify the bone metastasis load in PSMA PET/CT. ...
Prostate-specific membrane antigen (PSMA) PET/CT has a high diagnostic accuracy for lesion detection in metastatic prostate cancer, including bone metastases. ...
Automated software has been developed for quantifying the total skeletal tumor burden in planar scintigraphy (18, 35) , and a study recently proved that software-based determination of the bone-scan index ...
doi:10.2967/jnumed.117.203265
pmid:29242401
fatcat:52dtd24fzba4vd4qh7wqmrvrli
Quantitative image analysis for evaluation of tumor response in clinical oncology
2018
Chronic Diseases and Translational Medicine
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Conflicts of interest The authors declare that they have no conflicts of interest. ...
is defined as a reduction in lesion size by 10% as shown in CT or a reduction in the tumor CT value of 15% without the appearance of new lesions. ...
Computer-assisted volumetric measurement becomes clinically available with the advent of recent improvements in CT and MRI scanning technology and the developments in image-segmentation software. ...
doi:10.1016/j.cdtm.2018.01.002
pmid:29756120
pmcid:PMC5938243
fatcat:qv6gh4km4nbhdixxaezmcu7yra
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