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Fully automated brain resection cavity delineation for radiation target volume definition in glioblastoma patients using deep learning

Ekin Ermiş, Alain Jungo, Robert Poel, Marcela Blatti-Moreno, Raphael Meier, Urspeter Knecht, Daniel M. Aebersold, Michael K. Fix, Peter Manser, Mauricio Reyes, Evelyn Herrmann
2020 Radiation Oncology  
We evaluated the segmentation method in terms of Dice coefficient (DC) and estimated volume measurements.  ...  We did not detect a statistically significant difference of the measured RC volumes for the different raters and the automated method (Kruskal-Wallis test: chi-square = 1.46, p = 0.69).  ...  Fully automatic segmentation, where no interaction of the user is required, has the potential to substantially limit the time for target volume and OAR definition.  ... 
doi:10.1186/s13014-020-01553-z pmid:32375839 fatcat:psazmvptejfjhoyuysjg2sh37y

Atlas-Based Segmentation of the Brain for 3-Dimensional Treatment Planning in Children with Infratentorial Ependymoma [chapter]

Pierre-François D'Haese, Valerie Duay, Thomas E. Merchant, Benoit Macq, Benoit M. Dawant
2003 Lecture Notes in Computer Science  
The greatest difference was noted for smaller structures which were located along the midline and in the gradient of dose.  ...  To test this hypothesis, we compared the integrated average dose for three small (chiasm, pituitary, hypothalamus) and three large (temporal lobes and total brain) normal tissue structures from ten patients  ...  Supported in part by grants from the National Institutes of Health NIH/NCI 1R21 CA89657-01A2, American Cancer Society RPG-99-25201CCE and the American Lebanese Syrian Associated Charities (ALSAC).  ... 
doi:10.1007/978-3-540-39903-2_77 fatcat:5djtrpwn45bdzlrset6hvw7yg4

Evaluation of an atlas-based automatic segmentation software for the delineation of brain organs at risk in a radiation therapy clinical context

Aurélie Isambert, Frédéric Dhermain, François Bidault, Olivier Commowick, Pierre-Yves Bondiau, Grégoire Malandain, Dimitri Lefkopoulos
2008 Radiotherapy and Oncology  
Materials and methods: Automatic and manual segmentations of the eyes, optic nerves, optic chiasm, pituitary gland, brain stem and cerebellum of 11 patients on T1-weighted magnetic resonance, 3-mm thick  ...  Results: Automatic segmentation of OAR was achieved in 7-8 min. Excellent agreement was obtained between automatic and manual delineations for organs exceeding 7 cm 3 : the DSC was greater than 0.8.  ...  Coulot, Institut Gustave Roussy, for editorial advice and L. Saint Ange for editing.  ... 
doi:10.1016/j.radonc.2007.11.030 pmid:18155791 fatcat:ois2mcqykvfizdswqa2krgbc6q

Application of volumetric modulated arc therapy (VMAT) in a dual-vendor environment

Barbara Dobler, Karin Weidner, Oliver Koelbl
2010 Radiation Oncology  
VMAT planning was conducted for three typical target types of prostate cancer, hypopharynx/larynx cancer and vertebral metastases, and compared to standard IMRT with respect to plan quality, number of  ...  and Purpose: The purpose of this study was to assess plan quality and treatment time achievable with the new VMAT optimization tool implemented in the treatment planning system Oncentra MasterPlan® as  ...  Acknowledgements The authors would like to thank David Robinson (Nucletron, Columbia, MD) and Markus Rankl (Theranostic, Solingen, Germany) for valuable discussions.  ... 
doi:10.1186/1748-717x-5-95 pmid:20973977 pmcid:PMC2987940 fatcat:bh7iikhgrvexvlujee6coebpoa

Treatment Volume Determination for Irradiation Ofrecurrent Nasopharyngeal Carcinoma with Multimodality Imaging: An Original Article

2020 ARC Journal of Cancer Science  
Conclusion: Inclusion of MRI in RT planning proceduremay be considered for improving the therapeutic ratio through optimization of target and treatment volume definition for precise and accurate reirradiation  ...  Adequate coverage of treatmentvolumes with optimal sparing of critical structures were prioritized in RT planning.  ...  In conclusion, inclusion of MRI inRT planning proceduremay be considered for improving the therapeutic ratio through optimization of target and treatment volume definition for precise and accurate  ... 
doi:10.20431/2455-6009.0602004 fatcat:ngh2faecpngtdl7tpna6ochdxe

Anatomical Brain Barriers to Cancer Spread: Segmentation from CT and MR Images [article]

Nadya Shusharina, Thomas Bortfeld, Carlos Cardenas, Jinzhong Yang
2020 Zenodo  
The goal of this challenge is to identify best methods to segment brain structures that serve as barriers to cancer spread, for use in computer assisted target definition for radiotherapy plan optimization  ...  The barriers are brain structures that are not routinely outlined during the treatment planning for radiotherapy plan optimization.  ...  If necessary, differentiate between target and challenge cohort. Anatomical structures used for radiotherapy treatment plan optimization.  ... 
doi:10.5281/zenodo.3746561 fatcat:oshbjkk5jreojbm4yj2xbzpdce

Anatomical Brain Barriers to Cancer Spread: Segmentation from CT and MR Images [article]

Nadya Shusharina, Thomas Bortfeld, Carlos Cardenas, Jinzhong Yang
2020 Zenodo  
The goal of this challenge is to identify best methods to segment brain structures that serve as barriers to cancer spread, for use in computer assisted target definition for radiotherapy plan optimization  ...  The barriers are brain structures that are not routinely outlined during the treatment planning for radiotherapy plan optimization.  ...  If necessary, differentiate between target and challenge cohort. Anatomical structures used for radiotherapy treatment plan optimization.  ... 
doi:10.5281/zenodo.3714981 fatcat:hakzle6c3fgvxic5asjgv5gbra

Treatment volume definition for irradiation of primary lymphoma of the orbit: Utility of multimodality imaging

Demira Selcuk, Dincoglan Ferrat, Sager Omer, Beyzadeoglu Murat
2021 Journal of Surgery and Surgical Research  
Prioritization was given for encompassing of the target volumes with optimal sparing of critical structures in radiation treatment planning. Synergy (Elekta, UK) LINAC was used in RT delivery.  ...  Results: Available treatment planning systems at our tertiary referral institution were used for precise radiation treatment planning.  ...  Prioritization was given for encompassing of the target volumes with optimal sparing of critical structures in radiation treatment planning.  ... 
doi:10.17352/2455-2968.000138 fatcat:p5x5nb5cdjbcnmhqlzdc3yipny

A Method for Planning Safe Trajectories in Image-Guided Keyhole Neurosurgery [chapter]

Reuben R. Shamir, Idit Tamir, Elad Dabool, Leo Joskowicz, Yigal Shoshan
2010 Lecture Notes in Computer Science  
The trajectory risk is evaluated based on the tool placement uncertainty, on the proximity of critical brain structures, and on a predefined table of quantitative geometric risk measures.  ...  Our results on five targets show a significant reduction in trajectory risk and a shortening of the preoperative planning time as compared to the current routine method.  ...  While volume visualization and spatial segmentation of critical brain structures are sometimes used to help the neurosurgeon with spatial perception and planning, the insertion trajectory is currently  ... 
doi:10.1007/978-3-642-15711-0_57 fatcat:r244uu64cnfudpxtclvrlpxljm

Evaluation of Target Definition for Management of Myxoid Liposarcoma (MLS) with Neoadjuvant Radiation Therapy (RT)

Ferrat DINCOGLAN
2021 Biomedical Journal of Scientific & Technical Research  
Results : Priorities in RT planning included encompassing of target volumes adequately with optimal sparing of critical structures.  ...  Accurate RT target definition comprises an indispensable and critical component of successful MLS management.  ...  Priorities in RT planning included encompassing of target volumes adequately with optimal sparing of critical structures.  ... 
doi:10.26717/bjstr.2021.33.005458 fatcat:wy4fs5kkuvex5dgr47uig7iuly

Evaluation of Treatment Volume Determination for Irradiation of chordoma: an Original Article

Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Murat Beyzadeoglu
2020 International Journal of Research Studies in Medical and Health Sciences  
Results: Optimal target coverage and sparing of normal tissues was prioritized in radiation treatment planning.  ...  Incorporation of MRI in treatment volume determination procedure can be considered for improving the optimization of target volume definition for precise radiation delivery despite the need for further  ...  IGRT techniques may offer improved target localization, and combined use of registered CT and MR images may assist in optimization of treatment volume definition for precise RT delivery.  ... 
doi:10.22259/ijrsmhs.0510002 fatcat:cwsv43rq6zbnjouazthyt3yqqa

Impact of Multimodality Imaging to Improve Radiation Therapy (RT) Target Volume Definition for Malignant Peripheral Nerve Sheath Tumor (MPNST)

Ferrat Dincoglan
2021 Biomedical Journal of Scientific & Technical Research  
Primary objectives of RT planning included adequate coverage of target volumes with optimal sparing of critical structures.  ...  Incorporation of MRI in target volume definition is strongly recommended for improved accuracy and precision in radiotherapeutic management of MPNST despite the need for further supporting evidence.  ...  Primary objectives of RT planning included adequate coverage of target volumes with optimal sparing of critical structures.  ... 
doi:10.26717/bjstr.2021.34.005549 fatcat:xlyu5s2itjfmbfgzo5kh64aypa

Web-based tool for visualization of electric field distribution in deep-seated body structures and planning of electroporation-based treatments

Marija Marčan, Denis Pavliha, Bor Kos, Tadeja Forjanič, Damijan Miklavčič
2015 BioMedical Engineering OnLine  
The basis of the treatment planning process consists of two complex tasks: medical image segmentation, and numerical modeling and optimization.  ...  Methods: In addition to previously developed segmentation algorithms for several tissues (human liver, hepatic vessels, bone tissue and canine brain) and the algorithms for numerical modeling and optimization  ...  treatment plans for electroporation-based treatments.  ... 
doi:10.1186/1475-925x-14-s3-s4 pmid:26356007 pmcid:PMC4565468 fatcat:7mo2qwybjjhvrohgpw6xgta2wq

Improved plan quality with automated radiotherapy planning for whole brain with hippocampus sparing: a comparison to the RTOG 0933 trial

J. Krayenbuehl, M. Di Martino, M. Guckenberger, N. Andratschke
2017 Radiation Oncology  
Availability of data and material The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Funding None.  ...  Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.  ...  histogram, monitor units and treatment time for hippocampus sparing whole brain irradiation Abbreviations: PTV: planning target volume, D98%: dose to 98% of the volume, V95%: volume covered by 95% of  ... 
doi:10.1186/s13014-017-0896-7 pmid:28969706 pmcid:PMC5625717 fatcat:udpnxeuy3ncy5lviipmyq77vzu

Vision 20/20: Perspectives on automated image segmentation for radiotherapy

Gregory Sharp, Karl D. Fritscher, Vladimir Pekar, Marta Peroni, Nadya Shusharina, Harini Veeraraghavan, Jinzhong Yang
2014 Medical Physics (Lancaster)  
Manual delineation of target volumes and organs at risk is still the standard routine for most clinics, even though it is time consuming and prone to intra-and interobserver variations.  ...  Due to rapid advances in radiation therapy (RT), especially image guidance and treatment adaptation, a fast and accurate segmentation of medical images is a very important part of the treatment.  ...  address the target volume definition needs, including focal segmentation within the target volume to enable dose boosting in the areas of most aggressive disease.  ... 
doi:10.1118/1.4871620 pmid:24784366 pmcid:PMC4000389 fatcat:4chtxzqojfeyfan5fjloq6e7p4
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