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Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease

Yi-Yu Chou, Natasha Leporé, Greig I. de Zubicaray, Owen T. Carmichael, James T. Becker, Arthur W. Toga, Paul M. Thompson
2008 NeuroImage  
We examined genotyped healthy subjects with the goal of detecting subtle effects of a gene that confers heightened risk for Alzheimer's disease.  ...  We averaged the meshes extracted for each 3D MR data set, and combined the automated segmentations with a radial mapping approach to localize ventricular shape differences in patients.  ...  Acknowledgments This work was funded by grants from the National Institute for Biomedical Imaging and Bioengineering, the National Center for Research Resources, and the National Institute on Aging (EB01651  ... 
doi:10.1016/j.neuroimage.2007.11.047 pmid:18222096 pmcid:PMC2720413 fatcat:s6rrvfeahfdzvcqugilaw6ehsq

Ventricular maps in 804 subjects correlate with cognitive decline, CSF pathology, and imminent Alzheimer's disease

Yi-Yu Chou, Natasha Lepore, Priya Saharan, Sarah K. Madsen, Xue Hua, Clifford R. Jack, Leslie M. Shaw, John Q. Trojanowski, Michael W. Weiner, Arthur W. Toga, Paul M. Thompson
2010 2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro  
Here we used our multi-atlas fluid image alignment method (MAFIA [1]), to automatically segment parametric 3D surface models of the lateral ventricles in brain MRI scans from 184 AD, 391 MCI, and 229 healthy  ...  There is an urgent need for neuroimaging biomarkers of Alzheimer's disease (AD) that correlate with cognitive decline, and with accepted measures of pathology detectable in cerebrospinal fluid (CSF).  ...  Here we used a high-throughput method, known as multi-atlas fluid image alignment (MAFIA [1] ), to create detailed surface-based maps of ventricular anatomy in 804 subjects, comparing groups of AD and  ... 
doi:10.1109/isbi.2010.5490368 pmid:28316758 pmcid:PMC5354306 fatcat:rp4rvmz7z5a5hcbu6hcx5kvgba

Quantitative genetic modeling of lateral ventricular shape and volume using multi-atlas fluid image alignment in twins

Yi-Yu Chou, Natasha Lepore, Marina Barysheva, Ming-Chang Chiang, Katie McMahon, Greig de Zubicaray, Matthew Meredith, Margaret Wright, Arthur W. Toga, Paul M. Thompson
2008 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro  
We applied our multi-template segmentation approach ("Multi-Atlas Fluid Image Alignment") to fluidly propagate hand-labeled parameterized surface meshes into 116 scans of twins (60 identical, 56 fraternal  ...  We developed an automated system to identify and map genetic and environmental effects on brain structure in large brain MRI databases 1 .  ...  Computational morphometry studies of disease routinely use 3D statistical maps to localize regions with greatest effects.  ... 
doi:10.1109/isbi.2008.4541031 dblp:conf/isbi/ChouLBCMZMWTT08 fatcat:txtcjqkmibh4zhk4jbz3ytckum

A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly

Florence Roussotte
2013 Frontiers in Aging Neuroscience  
We first examined a large sample of 738 elderly participants with neuroimaging and genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI1).  ...  Despite a lack of alcohol consumption data in this study cohort, these findings, combined with earlier functional imaging investigations of the same gene, suggest the existence of reciprocal interactions  ...  Segmentation of the lateral ventricles Prior methods for ventricular segmentation have used semiautomated, automated (Chou et al., 2008) , and single-atlas or multi-atlas methods (Chou et al., 2009 )  ... 
doi:10.3389/fnagi.2013.00093 pmid:24409144 pmcid:PMC3867747 fatcat:3iqinxqomvf4xe2kxjcagbgk3m

Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls

Yi-Yu Chou, Natasha Leporé, Christina Avedissian, Sarah K. Madsen, Neelroop Parikshak, Xue Hua, Leslie M. Shaw, John Q. Trojanowski, Michael W. Weiner, Arthur W. Toga, Paul M. Thompson
2009 NeuroImage  
Ventricular expansion maps correlate with pathological and cognitive measures in AD, and 38 may be useful in future imaging-based clinical trials. 39 Introduction 43 Alzheimer's disease^(AD) is the commonest  ...  Around 4.5 million people in the 47 United States have AD, with an estimated cost to society of $100 48 billion per year, and up to 14 million people and their families may 49 be affected by AD by the  ...  A., Thompson, P., 2008 , Automated ventricular mapping with multi-atlas fluid image alignment 23 reveals genetic effects^in Alzheimer's^disease, NeuroImage 40(2): 615-^630.); with this method, we calculated  ... 
doi:10.1016/j.neuroimage.2009.02.015 pmid:19236926 pmcid:PMC2696357 fatcat:egt7iz2vmfhtpaeedbxqna5hhi

Disease-Specific Brain Atlases [chapter]

Paul M. Thompson, Michael S. Mega, Arthur W. Toga
2000 Brain Mapping: The Disorders  
National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health (NINDS/NIMH NS38753), and by a Human Brain Project grant to the International Consortium for Brain Mapping  ...  Special thanks go to our colleagues Roger Woods, Colin Holmes, Jay Giedd, David MacDonald, Alan Evans, and John Mazziotta, whose advice and support have been invaluable in these investigations. …………………  ...  Population-Based Maps of Ventricular Anatomy in Normal Aging and Alzheimer's Disease. 3D parametric surface meshes were used to model the 14 ventricular elements, shown in Fig. 6 , in 3D MRI scans of  ... 
doi:10.1016/b978-012481460-8/50009-3 fatcat:63fa3fvfdbbf3hq6qm4dy5nwny

Subpopulation Brain Atlases [chapter]

Paul M. Thompson, Michael S. Mega, Arthur W. Toga
2002 Brain Mapping: The Methods  
Co-planar Stereotaxic Atlas of the Human Brain, New York: Thieme. Tao X, Han X, Rettmann ME, Prince JL, Davatzikos C (2001)  ...  , David MacDonald, Alan Evans, Roger Woods, Colin Holmes, and John Mazziotta, and many others whose support has been invaluable in these investigations. …………………………..  ...  This challenge has driven developments in automated image registration and warping methods (Woods Atlases in Brain Mapping Brain Maps and Atlases.  ... 
doi:10.1016/b978-012693019-1/50030-7 fatcat:jyb3d46vhbbp7nfqw3yothneia

Ventricular maps in 804 ADNI subjects: correlations with CSF biomarkers and clinical decline

Yi-Yu Chou, Natasha Leporé, Priyanka Saharan, Sarah K. Madsen, Xue Hua, Clifford R. Jack, Leslie M. Shaw, John Q. Trojanowski, Michael W. Weiner, Arthur W. Toga, Paul M. Thompson
2010 Neurobiology of Aging  
We used our multi-atlas fluid image alignment (MAFIA) method, to compute ventricular models automatically, without user intervention, from 804 brain MRI scans with 184 AD, 391 mild cognitive impairment  ...  Ideal biomarkers of Alzheimer's disease (AD) should correlate with accepted measures of pathology in the cerebrospinal fluid (CSF); they should also correlate with, or predict, future clinical decline,  ...  Hoffman-La Roche, Schering-Plough, Synarc, Inc., and Wyeth, as well as nonprofit partners the Alzheimer's Association and Alzheimer's Drug Discovery Foundation, with participation from the US Food and  ... 
doi:10.1016/j.neurobiolaging.2010.05.001 pmid:20620663 pmcid:PMC2904619 fatcat:qycwz7ixnnf2la4xufv3emgizq

Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation

Rolf A. Heckemann, Shiva Keihaninejad, Paul Aljabar, Daniel Rueckert, Joseph V. Hajnal, Alexander Hammers
2010 NeuroImage  
The modified approach (MAPER, multiatlas propagation with enhanced registration) extends the applicability of multi-atlas based automatic whole-brain segmentation to subjects with ventriculomegaly, as  ...  seen in normal aging as well as in numerous neurodegenerative diseases.  ...  The registration procedure aligned white matter in the atlas with ventricular CSF in these cases.  ... 
doi:10.1016/j.neuroimage.2010.01.072 pmid:20114079 fatcat:cjmekbkntjglbbudiorgtmo5li

Mapping genetic influences on ventricular structure in twins

Y CHOU, N LEPORE, M CHIANG, C AVEDISSIAN, M BARYSHEVA, K MCMAHON, G DEZUBICARAY, M MEREDITH, M WRIGHT, A TOGA
2009 NeuroImage  
We applied our multitemplate segmentation approach termed "Multi-Atlas Fluid Image Alignment" to fluidly propagate hand-labeled parameterized surface meshes, labeling the lateral ventricles, in 3D volumetric  ...  Here we developed an automated system to visualize genetic and environmental effects on brain structure in large brain MRI databases.  ...  N new ventricular models were then produced by fluid registration of each image to a different atlas.  ... 
doi:10.1016/j.neuroimage.2008.10.036 pmid:19041405 pmcid:PMC2773138 fatcat:lfywf3p3k5bd7bf6ivmcgn6vla

Computational anatomical methods as applied to ageing and dementia

P M THOMPSON, L G APOSTOLOVA
2007 British Journal of Radiology  
Here, we review three computational approaches to map brain deficits in AD: cortical thickness maps, tensor-based morphometry, and hippocampal/ventricular surface modeling.  ...  Time-lapse maps can be built to show how the disease spreads in the brain, and where treatment affects the disease trajectory.  ...  Acknowledgments This work was supported by the National Institute on Aging (NIA), the National Library of Medicine, the National Institute for Biomedical Imaging and Bioengineering, the National Center  ... 
doi:10.1259/bjr/20005470 pmid:18445748 fatcat:b5l3zf7grnfovcf64hibfsjvrm

Tracking Alzheimer's Disease

P. M THOMPSON, K. M HAYASHI, R. A DUTTON, M.-C. CHIANG, A. D LEOW, E. R SOWELL, G. DE ZUBICARAY, J. T BECKER, O. L LOPEZ, H. J AIZENSTEIN, A. W TOGA
2007 Annals of the New York Academy of Sciences  
We report the first time-lapse maps of cortical atrophy spreading dynamically in the living brain, based on averaging data from populations of subjects with Alzheimer's disease and normal subjects imaged  ...  drug trials, and shed light on the neuroscience of brain degeneration in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI).  ...  This research was supported by the National Institute on Aging, the National Library of Medicine, the National Institute for Biomedical Imaging and Bioengineering, the National Center for Research Resources  ... 
doi:10.1196/annals.1379.017 pmid:17413023 pmcid:PMC3197831 fatcat:ztx5gpereze5fiujthiwuktr5q

Multi-atlas image registration of clinical data with automated quality assessment using ventricle segmentation [article]

Florian Dubost, Marleen de Bruijne, Marco Nardin, Adrian V. Dalca, Kathleen L. Donahue, Anne-Katrin Giese, Mark R. Etherton, Ona Wu, Marius de Groot, Wiro Niessen, Meike Vernooij, Natalia S. Rost, Markus D. Schirmer
2019 arXiv   pre-print
The automated ventricle segmentation reached a Dice coefficient with manual annotations of 0.89 in the single-site dataset, and 0.83 in the multi-center dataset.  ...  In this work, we demonstrated the utility of an automated tool for assessing image registration quality in clinical scans.  ...  Scans were selected with a semi-automated method that estimates ventricular volume using nonlinear registration to an atlas.  ... 
arXiv:1907.00695v2 fatcat:tgnn5dky3zcujkm4h5n2xpie74

The apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging

Florence F. Roussotte, Boris A. Gutman, Sarah K. Madsen, John B. Colby, Katherine L. Narr, Paul M. Thompson
2014 Neurobiology of Aging  
The apolipoprotein E epsilon 4 allele (ApoE-ε4) is the strongest known genetic risk factor for late onset Alzheimer's disease.  ...  ApoE genotyping is considered critical in clinical trials of Alzheimer's disease.  ...  Prior methods for ventricular segmentation have used semi-automated, automated (Chou et al., 2008) , and single-atlas or multi-atlas methods (Chou et al., 2009 ).  ... 
doi:10.1016/j.neurobiolaging.2013.11.030 pmid:24411483 pmcid:PMC3961511 fatcat:nwldgzwlfbcjvcudecrdi4avoi

A framework for computational anatomy

Paul M. Thompson, Arthur W. Toga
2002 Computing and Visualization in Science  
These atlases describe how the brain varies with age, gender, genetics, and over time.  ...  We review applications in Alzheimer's disease, schizophrenia and brain development, outlining some current challenges in the field.  ...  Mathematical/Computational Challenges in Creating Population-Based Brain Atlases, Human Brain Mapping 9(2), Feb. . Brain Warping, Academic Press. Toga AW, Mazziotta JC (1996).  ... 
doi:10.1007/s00791-002-0084-6 fatcat:cla6fnu5ybbpngc2gjmcijzavi
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