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Deep Learning based Retinal OCT Segmentation [article]

Mike Pekala, Neil Joshi, David E. Freund, Neil M. Bressler, Delia Cabrera DeBuc, Philippe M Burlina
2018 arXiv   pre-print
comparable with human annotation of retinal layers from OCT when there is only mild retinopathy.  ...  For each image, two expert graders each manually annotated five retinal surfaces (i.e. boundaries between pairs of retinal layers).  ...  Jun Kong for interesting discussions on OCT.  ... 
arXiv:1801.09749v1 fatcat:474syzsyp5cxfljj646ecbtq6m

Identification of Age-Related Macular Degeneration Using OCT Images

Punal M Arabi, Nanditha Krishna, V Ashwini, H M Prathibha
2018 IOP Conference Series: Materials Science and Engineering  
Age-related Macular Degeneration is the most leading retinal disease in the recent years. Macular degeneration occurs when the central portion of the retina, called macula deteriorates.  ...  The Healthy and AMD affected OCT images are classified by extracting the Retinal Pigmented Epithelium (RPE) layer of the images using the image processing technique.  ...  Acknowledgement The authors thank the Management and Principal of ACS College of Engineering, Mysore road, Bangalore for permitting and supporting to carry out the research work.  ... 
doi:10.1088/1757-899x/310/1/012096 fatcat:wmmiujn3e5baln2xrouquclfve

OCTID: Optical Coherence Tomography Image Database [article]

Peyman Gholami, Priyanka Roy, Mohana Kuppuswamy Parthasarathy, Vasudevan Lakshminarayanan
2019 arXiv   pre-print
OCT images are capable of visualizing deep retinal layers which is crucial for early diagnosis of retinal diseases.  ...  The image classes include Normal (NO), Macular Hole (MH), Age-related Macular Degeneration (AMD), Central Serous Retinopathy (CSR), and Diabetic Retinopathy (DR).  ...  Girija for providing the images and diagnosing pathological conditions. This research is supported by an NSERC discovery grant to VL.  ... 
arXiv:1812.07056v2 fatcat:psiszrotcvegbju4f6ju7yzoam

Comparison of OCT Angiography Review Strategies to Identify Vascular Abnormalities in the AVATAR Study

Amy S. Babiuch, Mehnaz Khan, Ming Hu, Peter K. Kaiser, Sunil K. Srivastava, Rishi P. Singh, Allison Watts, Jamie L. Reese, Justis P. Ehlers
2018 Ophthalmology Retina  
In this study, OCT-A report using automated segmentation was comparable to continuous slab descent review for identifying microvascular abnormalities of the retina and choroid.  ...  A single report using automated segmentation within the Avanti software to represent the superficial retina capillary plexus, deep retina capillary plexus, outer retina, and choroid capillary layer was  ...  The most frequent underlying pathologies included diabetic retinopathy (n =110), neovascular age-related macular degeneration (n = 75, and non-neovascular age-related macular degeneration (n = 91), Table  ... 
doi:10.1016/j.oret.2017.10.009 pmid:30035246 pmcid:PMC6053057 fatcat:aca72ijmlzbwxhrgertdygg6j4

Repeatability of swept-source optical coherence tomography retinal and choroidal thickness measurements in neovascular age-related macular degeneration

Daren Hanumunthadu, Tomas Ilginis, Marie Restori, Mandeep S Sagoo, Adnan Tufail, Kamaljit S Balaggan, Praveen J Patel
2016 British Journal of Ophthalmology  
tomography (SS-OCT) derived retinal and choroidal thickness measurements in eyes with neovascular age related macular degeneration (nAMD).  ...  choroidal thickness measurements in eyes with neovascular age related macular degeneration. 3 ABSTRACT Background: The aim was to determine the intrasession repeatability of swept-source optical coherence  ...  patients with neovascular age-related macular degeneration.  ... 
doi:10.1136/bjophthalmol-2016-308999 pmid:27491359 fatcat:np6xg2moxzhzjog2vc2kbcs33i

Differential Vulnerability of Retinal Layers to Early Age-Related Macular Degeneration: Evidence by SD-OCT Segmentation Analysis

Maria Cristina Savastano, Angelo Maria Minnella, Antonello Tamburrino, Gaspare Giovinco, Salvatore Ventre, Benedetto Falsini
2014 Investigative Ophthalmology and Visual Science  
We evaluated layer-by-layer retinal thickness in spectral-domain optical coherence tomography (SD-OCT), determined by automated segmentation analysis (ASA) software in healthy and early age-related maculopathy  ...  The SD-OCT scans were transferred into a dedicated software program that performed automated segmentation of different retinal layers. RESULTS.  ...  Acknowledgments The authors alone are responsible for the content and writing of the paper.  ... 
doi:10.1167/iovs.13-12172 pmid:24408984 fatcat:3k5gpihwdjb3lk6yhusfxia3n4

Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images

Pratul P. Srinivasan, Leo A. Kim, Priyatham S. Mettu, Scott W. Cousins, Grant M. Comer, Joseph A. Izatt, Sina Farsiu
2014 Biomedical Optics Express  
We present a novel fully automated algorithm for the detection of retinal diseases via optical coherence tomography (OCT) imaging.  ...  The spectral domain OCT data sets used for cross-validation consisted of volumetric scans acquired from 45 subjects: 15 normal subjects, 15 patients with dry age-related macular degeneration (AMD), and  ...  stages of diseases such as diabetic macular edema (DME) and wet (exudative) age-related macular degeneration [23, 24] .  ... 
doi:10.1364/boe.5.003568 pmid:25360373 pmcid:PMC4206325 fatcat:qbl7eahzwndkvmc43cuhaytl5a


Ilkay Kilic Muftuoglu, Hema L. Ramkumar, Dirk-Uwe Bartsch, Amit Meshi, Raouf Gaber, William R. Freeman
2018 Retina  
Purpose-To characterize inner retinal damage in dry age-related macular degeneration (AMD) patients using high resolution spectral-domain optical coherence tomography (SD-OCT) images.  ...  SD-OCT images of these patients were quantified by manually correcting the segmentation of each retinal layer, including the retina nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform  ...  INTRODUCTION Age-related macular degeneration (AMD) is the leading cause of vision loss with an estimated prevalence of 6.5% among people 40 years of age and older in the United States. 1 Moreover, the  ... 
doi:10.1097/iae.0000000000001759 pmid:28650925 pmcid:PMC5742077 fatcat:p53s567tzzgchhf3mnq4kbegeq

Adaptive Optics Imaging Shows Rescue of Macula Cone Photoreceptors

Manickam Nick Muthiah, Pearse A. Keane, Joe Zhong, Carlos Gias, Gurmit Uppal, Peter J. Coffey, Lyndon da Cruz
2014 Ophthalmology (Rochester, Minn.)  
Advanced age-related macular degeneration and inherited macular diseases remain largely untreatable.  ...  and autologous retinal pigment epithelium (RPE), namely, choroidal transplantation 3 demonstrated rescue of visual function in severe neovascular age-related macular degeneration.  ...  Advanced age-related macular degeneration and inherited macular diseases remain largely untreatable.  ... 
doi:10.1016/j.ophtha.2013.10.008 pmid:24268491 fatcat:jovabso6pzc23czmuaak4eh5ya


Hema L. Ramkumar, Brian Nguyen, Dirk-Uwe Bartsch, Luke J. Saunders, Ilkay Kilic Muftuoglu, Qisheng You, William R. Freeman
2017 Retina  
Heidelberg scanning laser ophthalmoscope OCT images of the optic nerve and macula were obtained, and the Viewing module was used to manually calibrate retinal layer segmentation.  ...  PURPOSE-Geographic atrophy (GA) is a sequelae of macular degeneration.  ...  Introduction Geographic atrophy (GA) is a highly prevalent, devastating end-stage result of long standing age-related macular degeneration (AMD) characterized by loss of the retinal pigment epithelium  ... 
doi:10.1097/iae.0000000000001867 pmid:29117065 pmcid:PMC5938165 fatcat:awrgt5uamjbu3gqj3mias56cuy

Effects of subthreshold nanosecond laser therapy in age-related macular degeneration using artificial intelligence (STAR-AI Study)

Verina Hanna, Jonathan Oakley, Daniel Russakoff, Netan Choudhry, Sanjoy Bhattacharya
2021 PLoS ONE  
Purpose To investigate changes in retinal thickness, drusen volume, and visual acuity following subthreshold nanosecond laser (SNL) treatment in patients with age-related macular degeneration (ARMD).  ...  Retinal layers were segmented using the artificial intelligence-enabled Orion® software (Voxeleron LLC, San Francisco, USA).  ...  Introduction Age-Related Macular Degeneration (ARMD) affects between 7.4-30% of those aged 45 to 85, and is a common cause of blindness [1] .  ... 
doi:10.1371/journal.pone.0250609 pmid:33914797 fatcat:dlnstrkk2bdy5cdaly7uracckq

Automated Retinal Layer Segmentation in CLN2-Associated Disease: Commercially Available Software Characterizing a Progressive Maculopathy

Kyle D. Kovacs, Anton Orlin, Dolan Sondhi, Stephen M. Kaminsky, Donald J. D'Amico, Ronald G. Crystal, Szilárd Kiss
2021 Translational Vision Science & Technology  
LEXEO had no role, financial or otherwise, in the design, conduct, analysis, or write-up of this study.  ...  All authors note intellectual property related to gene and cellular therapy belonging to Weill Cornell/Cornell University; however, this factor was not relevant for the execution of the present study.  ...  For each eye on each examination date, images had automated segmentation lines generated by the Heidelberg Spectralis software for each B scan raster of a macular cube scan.  ... 
doi:10.1167/tvst.10.8.23 fatcat:lvasrrrx2jdcbjj7ryzeowluzi

A Method for En Face OCT Imaging of Subretinal Fluid in Age-Related Macular Degeneration

Fatimah Mohammad, Justin Wanek, Ruth Zelkha, Jennifer I. Lim, Judy Chen, Mahnaz Shahidi
2014 Journal of Ophthalmology  
The purpose of the study is to report a method for en face imaging of subretinal fluid (SRF) due to age-related macular degeneration (AMD) based on spectral domain optical coherence tomography (SDOCT).  ...  En face OCT images of a retinal layer anterior to the retinal pigment epithelium were generated. Validity, repeatability, and utility of the method were established.Results.  ...  Acknowledgments This study was supported by NIH Grants EY014275 and EY001792, Department of VA, a Senior Scientific Investigator award to Mahnaz Shahidi, and an unrestricted departmental grant from Research  ... 
doi:10.1155/2014/720243 pmid:25478209 pmcid:PMC4244942 fatcat:7a4q2wdc2vdrjogsfegynln2n4

Fully Automated Robust System to Detect Retinal Edema, Central Serous Chorioretinopathy, and Age Related Macular Degeneration from Optical Coherence Tomography Images

Samina Khalid, M. Usman Akram, Taimur Hassan, Ammara Nasim, Amina Jameel
2017 BioMed Research International  
It mostly occurs due to retinal edema (RE), central serous chorioretinopathy (CSCR), or age related macular degeneration (ARMD).  ...  Optical coherence tomography (OCT) imaging is the latest eye testing technique that can detect these syndromes in early stages. Many researchers have used OCT images to detect retinal abnormalities.  ...  They are also grateful to the panel of expert ophthalmologists for annotating the dataset and for cross-verifying 14 BioMed Research International the results of the self-diagnosis decision support system  ... 
doi:10.1155/2017/7148245 pmid:28424788 pmcid:PMC5382397 fatcat:56ylmqhkfjd3dnfarbnnty5qtq

Advances in Optical Coherence Tomography Angiography

Talisa E de Carlo
2016 US Ophthalmic Review  
The technology has been used to image a variety of chorioretinal disorders including choroidal neovascularization in age-related macular degeneration, diabetic retinopathy, retinal arterial occlusion,  ...  Continued advances in the software will improve the quality of OCTA and reduce image artifacts.  ...  [13] [14] [15] Finally, the deeper choroidal vessels appear dark (instead of white) due to fringe washout and a stromal decorrelation signal is seen on the OCT angiogram. 14 Age-related Macular Degeneration  ... 
doi:10.17925/usor.2016.09.01.37 fatcat:bnv7upmi6rewxhpswvn5qixvai
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