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Automated quantification of caudate atrophy by local registration of serial MRI: Evaluation and application in Huntington's disease

Nicola Z. Hobbs, Susie M.D. Henley, Edward J. Wild, Kelvin K. Leung, Chris Frost, Roger A. Barker, Rachael I. Scahill, Josephine Barnes, Sarah J. Tabrizi, Nick C. Fox
2009 NeuroImage  
Objective: Caudate atrophy rate measured from serial MRI is proposed as a biomarker of HD progression that may be of use in assessing putative disease-modifying agents.  ...  We describe and evaluate an automated technique based on a local registration and boundary shift integral (BSI) approach at the caudate-CSF and caudate-white matter boundaries; caudate boundary shift integral  ...  Acknowledgments The authors would like to thank the patients and controls who took part in this study. This study was funded by the Cure Huntington's Disease Initiative (CHDI), Inc.  ... 
doi:10.1016/j.neuroimage.2009.06.003 pmid:19523522 fatcat:oikhyqrdn5gnjltfovhgcpnkde

Distribution of grey matter atrophy in Huntington's disease patients: A combined ROI-based and voxel-based morphometric study

G. Douaud, V. Gaura, M.-J. Ribeiro, F. Lethimonnier, R. Maroy, C. Verny, P. Krystkowiak, P. Damier, A.-C. Bachoud-Levi, P. Hantraye, P. Remy
2006 NeuroImage  
The striatum, a subcortical structure, is the principal target of the neurodegenerative process in Huntington's disease (HD).  ...  changes in the head of the caudate nucleus.  ...  This study is part of the MIG-HD program and is supported by the Délégation Régionale à la Recherche Clinique (PHRC AOM0039), the Association Française contre les Myopathies and the Etablissement Français  ... 
doi:10.1016/j.neuroimage.2006.05.057 pmid:16875847 fatcat:unx3fgozgfgcdfeajan4ykmpra

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington's Disease

Ivan Rattray, Edward J. Smith, William R. Crum, Thomas A. Walker, Richard Gale, Gillian P. Bates, Michel Modo, Emmanuel Planel
2017 PLoS ONE  
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease.  ...  Experimental design and body weight measures. (A) Full experimental design from 8 to 94 weeks of age. In vivo MRI was taken, serially, at 8, 15, 23, 36, 52, 81 and 94 weeks.  ...  The lack of correlations between mHTT aggregation and neuron numbers with MRI measures further indicates that other factors contribute to macroscopic tissue changes in Huntington's disease.  ... 
doi:10.1371/journal.pone.0168556 pmid:28099507 pmcid:PMC5242535 fatcat:ipi2hmozsjelplbpzktro5g4ja

Efficient Morphometric Techniques in Alzheimer's Disease Detection: Survey and Tools

Vinutha N., P. Deepa Shenoy, P. Deepa Shenoy, K.R. Venugopal
2016 Neuroscience International  
of transformation and similarity measures to suit the required application.  ...  The development of advance techniques in the multiple fields such as image processing, data mining and machine learning are required for the early detection of Alzheimer's Disease (AD) and to prevent the  ...  The corresponding author confirms that all of the other authors have read and approved the manuscript and there are no ethical issues involved.  ... 
doi:10.3844/amjnsp.2016.19.44 fatcat:3zeb2s5pjzfv7mptqi7cy2a3au

Magnetic resonance imaging of Huntington's disease: preparing for clinical trials

S. Klöppel, S.M. Henley, N.Z. Hobbs, R.C. Wolf, J. Kassubek, S.J. Tabrizi, R.S.J. Frackowiak
2009 Neuroscience  
The known genetic mutation causing Huntington's disease (HD) makes this disease an important model to study links between gene and brain function.  ...  Despite its monogenetic cause, HD presents with a range of clinical manifestations, not explained by variation in the number of CAG repeats in the affected population.  ...  The brain boundary shift (BSI) integral is a semi-automated technique for measuring whole-brain volume change from serial MRI (Freeborough and Fox, 1997) , and can be used to capture the full extent of  ... 
doi:10.1016/j.neuroscience.2009.01.045 pmid:19409230 pmcid:PMC2771270 fatcat:ilnyxbbtuvbc5db6v3kap6qbmm

Metabolic network as a progression biomarker of premanifest Huntington's disease

Chris C. Tang, Andrew Feigin, Yilong Ma, Christian Habeck, Jane S. Paulsen, Klaus L. Leenders, Laura K. Teune, Joost C.H. van Oostrom, Mark Guttman, Vijay Dhawan, David Eidelberg
2013 Journal of Clinical Investigation  
The evaluation of effective disease-modifying therapies for neurodegenerative disorders relies on objective and accurate measures of progression in at-risk individuals.  ...  At each time point, the subjects were also scanned with [ 11 C]-raclopride PET and structural MRI to measure concurrent declines in caudate/putamen D 2 neuroreceptor binding and tissue volume.  ...  validation studies, and to James Brewer at the University of California San Diego for his invaluable guidance in the analysis of the volumetric MRI data.  ... 
doi:10.1172/jci69411 pmid:23985564 pmcid:PMC3754266 fatcat:ybcjdtpeyrdyxfceuh6vj4iqlq

Neuroreceptor Mapping 2000

2000 NeuroImage  
The aim of this study was to evaluate in rats and monkeys the suitability of MPP-PTP for the in vivo imaging of adenosine A 2A receptors.  ...  To this end we evaluated in rats and Macaca Nemestrina the metabolic degradation of [C-11]MPP-PTP, the time course of its cerebral distribution and the inhibitory effects of different drugs.  ...  A thermoplastic mask and MRI were used for PET localization and for partial volume correction (PVC) for the effect of atrophy on PET measurements.  ... 
doi:10.1006/nimg.2000.0622 fatcat:z7wjtrzb6jacva4vohw447zx2e

Abstracts from HSG 2019

2019 Neurotherapeutics  
Lay Summary: This project identifies gaps in care that are experienced by people with Huntington's Disease and their families.  ...  The next phase of this project will seek solutions to reduce the burden of care for all people affected by Huntington's Disease.  ...  PET scan and an MRI for anatomical localization.  ... 
doi:10.1007/s13311-019-00788-3 pmid:31595435 pmcid:PMC6985315 fatcat:z36763kxpfabvnn532hxglmvxe

Inflammation after trauma: Microglial activation and traumatic brain injury

Anil F. Ramlackhansingh, David J. Brooks, Richard J. Greenwood, Subrata K. Bose, Federico E. Turkheimer, Kirsi M. Kinnunen, Steve Gentleman, Rolf A. Heckemann, Karen Gunanayagam, Giorgio Gelosa, David J. Sharp
2011 Annals of Neurology  
of Objectives: Neurodegeneration is an important pathological component hallmark of many neurological illnesses.  ...  Effective management demands a greater understanding of the changes taking place at a neuronal level.  ...  MRI image acquisition All subjects underwent volumetric T1 and T2-weighted MRI for the identification of any underlying structural lesions and for the subjective quantification of cerebro-vascular disease  ... 
doi:10.1002/ana.22455 pmid:21710619 fatcat:lrrjyvf5tnfjfl43fkmhnqed5e

Investigating the spinal cord atrophy measurement on MRI from two aspects : physiological variations and longitudinal measurement methods

Chunfang Wang
Measurement of spinal cord atrophy on MRI may be possibly confounded by fluctuations in water content, and the high measurement variance in previous longitudinal studies can be possibly reduced by registration-based  ...  and artifacts and by regularization of the registration to constrain the degrees of freedom.  ...  s study [63] and 2.90(1.60)% for caudate nucleus volume of 16 patients with Huntington's disease in Hobbs et al.'s study MRI images used in our experiments.  ... 
doi:10.14288/1.0165586 fatcat:xzm4ozkeyve4lhvvkceozxog4e

Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice

Sveinung Lillehaug, Gry H. Syverstad, Lars N.G. Nilsson, Jan G. Bjaalie, Trygve B. Leergaard, Reidun Torp
2014 Neurobiology of Aging  
Acknowledgements This work was supported by the Letten Centre, University of Oslo to RT, Anders Jahres stiftelse, Helse Sør-Øst, and Swedish Research Council (#2009e4389) to LNGN, and The Research Council  ...  Professor Lars Lannfelt and the Uppsala University Transgenic Facility are acknowledged for their support in developing the tg-ArcSwe mouse model.  ...  deformation algorithms applied to human brain MRI registration.  ... 
doi:10.1016/j.neurobiolaging.2013.09.013 pmid:24126157 fatcat:nayvhizomnaaxaz6gwjfbstiiq

Segmentation of neuroanatomy in magnetic resonance images

Andrew Simmons, Simon R. Arridge, G. J. Barker, Paul S. Tofts, Murray H. Loew
1992 Medical Imaging VI: Image Processing  
In the unlikely e v e n t that the a u thor did not send a c o m p le te m anuscript and there are missing pages, these will be noted.  ...  All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is d e p e n d e n t upon the quality of the copy subm itted.  ...  MRI has shown atrophy of the caudate nuclei and with progression of dementia and disease duration and also increasing generalised cerebral atrophy [JOLLES89].  ... 
doi:10.1117/12.59406 fatcat:rbchl46uffcj5cysrho2pr2ewy

The Following are Abstracts from the Second International Conference of the European Society for Molecular Imaging in Naples, Italy June 14-15, 2007

2007 Molecular Imaging  
Such a set of ligand-receptor interactions can encompass applications in different organ-specific vascular beds in health and diseased conditions.  ...  Topics covered in this lecture include-but are not limited to-vascular and lymphatic targeting, molecular-genetic imaging, and other applications of toolkits of scientific and medical value.  ...  The results show that in vivo imaging of NF-kB activation can be used for early and sensitive detection of autoimmune disease in experimental autoimmune models and should offer new possibilities for evaluation  ... 
doi:10.2310/7290.2007.00032 fatcat:hl2ynabt3bez7bt6vllibmsy3y

Abstracts of the German Congress on Parkinson's Disease and Movement Disorders (Deutscher Kongress für Parkinson und Bewegungsstörungen), 7–9 March 2019, Düsseldorf, Germany

2019 Journal of neural transmission  
Reduced atrophy in MRI (exploratory endpoint) indicates that treatment approaches with more effective anti-aggregative compounds may be considered for future disease modifying studies in MSA.  ...  In addition to the general study procedures, a subset of patients was examined by MRI. Results: 127 participants were screened, 92 were randomized and 67 (72.8%) completed treatment.  ...  Hereby we provide proof of concept for single data types and the evaluation decision system of the application as a whole by comparison to medical evaluation as gold standard.  ... 
doi:10.1007/s00702-019-01978-1 fatcat:qd4vebobrjcxxma7tqtlu63xoq

ePresentation Sessions

2018 European Journal of Neurology  
the age of diagnosis of Huntington's disease (HD).  ...  Tissue segmentation, image registration and white matter (WM) lesion filling were also evaluated.  ...  Disclosure: Nothing to disclose Background and aims: To evaluate the presence of RBD and its characteristics in 5 cases with IgLON5 disease.  ... 
doi:10.1111/ene.13700 fatcat:xk5co6xixzbs3n7wnhc5xjkpv4
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