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Front Matter: Volume 10140

Proceedings of SPIE, Metin N. Gurcan, John E. Tomaszewski
2017 Medical Imaging 2017: Digital Pathology  
Publication of record for individual papers is online in the SPIE Digital Library. SPIEDigitalLibrary.org Paper Numbering: Proceedings of SPIE follow an e-First publication model.  ...  Utilization of CIDs allows articles to be fully citable as soon as they are published online, and connects the same identifier to all online and print versions of the publication.  ...  (USA) Automated epidermis segmentation in histopathological images of human skin stained with hematoxylin and eosin 10140 0NAutomated cancer stem cell recognition in H and E stained tissue using convolutional  ... 
doi:10.1117/12.2270372 dblp:conf/midp/X17 fatcat:6yeb63ix6bau7jhipthayjih24

Automated segmentation of skin strata in reflectance confocal microscopy depth stacks [article]

Samuel Hames, Marco Ardigò, H. Peter Soyer, Andrew P. Bradley, Tarl W. Prow
2015 bioRxiv   pre-print
However, current use of RCM depends on qualitative examination by a human expert to look for specific features in the different strata of the skin.  ...  The probabilities predicted by the classifier in the test set showed that the classifier learned an effective model of the anatomy of human skin.  ...  by hematoxylin and eosin staining only a monochrome image showing variation in reflectance at one wavelength is available.  ... 
doi:10.1101/022137 fatcat:uq6ivoiofzbvtn4tfkf6jgfiiu

Automated Segmentation of Skin Strata in Reflectance Confocal Microscopy Depth Stacks

Samuel C. Hames, Marco Ardigò, H. Peter Soyer, Andrew P. Bradley, Tarl W. Prow, Konradin Metze
2016 PLoS ONE  
However, current use of RCM depends on qualitative examination by a human expert to look for specific features in the different strata of the skin.  ...  The probabilities predicted by the classifier in the test set showed that the classifier learned an effective model of the anatomy of human skin.  ...  by hematoxylin and eosin staining only a monochrome image showing variation in reflectance at one wavelength is available.  ... 
doi:10.1371/journal.pone.0153208 pmid:27088865 pmcid:PMC4835045 fatcat:yq6sdfl2ave7phy7tbjbh3skpi

A Texture Based Pattern Recognition Approach to Distinguish Melanoma from Non-Melanoma Cells in Histopathological Tissue Microarray Sections

Elton Rexhepaj, Margrét Agnarsdóttir, Julia Bergman, Per-Henrik Edqvist, Michael Bergqvist, Mathias Uhlén, William M. Gallagher, Emma Lundberg, Fredrik Ponten, Jürgen Schauber
2013 PLoS ONE  
Images representing immunostained melanoma tissue were then digitally processed to segment regions of interest, highlighting Melan-A positive and negative areas.  ...  Tedious manual assessment of immunohistochemically stained tissue needs to be fully automated to take full advantage of the potential for high throughput analyses enabled by tissue microarrays and digital  ...  Carolina Whä lby at Center for Image analysis, Uppsala University for the fruitful discussions on the data analysis and experimental design. Author Contributions  ... 
doi:10.1371/journal.pone.0062070 pmid:23690928 pmcid:PMC3656869 fatcat:dznfhjq6bbap3e5lzpddex7xxm

Electrochemical treatment of ex vivo human abdominal skin and potential use in scar management: A pilot study

Dana M Hutchison, Amir A Hakimi, Avin Wijayaweera, Soohong Seo, Ellen M Hong, Tiffany T Pham, Melissa Bircan, Ryan Sivoraphonh, Brandyn Dunn, Mark R Kobayashi, Sehwan Kim, Brian JF Wong
2021 Scars, Burns & Healing  
The width of dye color change for each dosimetry pair was calculated. Hematoxylin and eosin staining was used to evaluate samples.  ...  The purpose of this study is to examine the acid-base and histological changes in ex vivo human abdominal skin following ECT.  ...  Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article:  ... 
doi:10.1177/2059513120988532 pmid:33796338 pmcid:PMC7970177 fatcat:d63xptdodjastbxjhv2ogxkgti

Performance of a simple chromatin-rich segmentation algorithm in quantifying basal cell carcinoma from histology images

Kyle Lesack, Christopher Naugler
2012 BMC Research Notes  
Findings: Haematoxylin and eosin stained basal cell carcinoma histology slides were digitized and analyzed using the open source image analysis program ImageJ.  ...  The use of digital imaging and algorithm-assisted identification of regions of interest is revolutionizing the practice of anatomic pathology.  ...  and eosin stain components using the built-in H&E vector.  ... 
doi:10.1186/1756-0500-5-35 pmid:22251818 pmcid:PMC3398325 fatcat:4aitwbhj65c6vl7xkmp3hocbte

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

Julio Aguado, Agustin Sola-Carvajal, Valeria Cancila, Gwladys Revêchon, Peh Fern Ong, Corey Winston Jones-Weinert, Emelie Wallén Arzt, Giovanna Lattanzi, Oliver Dreesen, Claudio Tripodo, Francesca Rossiello, Maria Eriksson (+1 others)
2019 Nature Communications  
We also show in vivo that tASO treatment significantly enhances skin homeostasis and lifespan in a transgenic HGPS mouse model.  ...  In summary, our results demonstrate an important role for telomeric DDR activation in HGPS progeroid detrimental phenotypes in vitro and in vivo.  ...  Data availability The authors state that all data generated during this study are included in the article, its supplementary information file, and the Source Data file, and are available from the corresponding  ... 
doi:10.1038/s41467-019-13018-3 pmid:31740672 pmcid:PMC6861280 fatcat:4zqzzzwtxff33h3rzsjdg3lhlq

A New Approach to Border Irregularity Assessment with Application in Skin Pathology

Pawel Kleczek Grzegorz Dyduch, Agnieszka Graczyk-Jarzynka, Joanna Jaworek-Korjakowska
2019 Applied Sciences  
The proposed segmentation method has been tested on 25. skin whole slide images of common melanocytic lesions.  ...  Our method is particularly well suited for assessing the border irregularity of human epidermis and thus could help develop computer-aided diagnostic algorithms for skin cancer detection.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/app9102022 fatcat:7usgtjvgr5csbdm4unzj6jjkuu

Fully Convolutional Network for Melanoma Diagnostics [article]

Adon Phillips, Iris Teo, Jochen Lang
2018 arXiv   pre-print
Given the qualitative and quantitative results, it is possible to overcome the discriminative challenges of the skin and tumour anatomy for segmentation using modern machine learning techniques, though  ...  We provide gold standard annotations for three tissue types (tumour, epidermis, and dermis) which are important for the prognostic measurements known as Breslow thickness and Clark level.  ...  The gold standard for the diagnosis of melanoma requires full-thickness excisional biopsy of suspected lesions followed by the histopathologic analysis of hematoxylin and eosin (H&E) stained tissue sections  ... 
arXiv:1806.04765v1 fatcat:ssps2yurbzhzvj2kgkbrutfmdu

Semiquantitative histopathology and 3D magnetic resonance microscopy as collaborative platforms for tissue identification and comparison within teratomas derived from pedigreed primate embryonic stem cells

Carlos A. Castro, Ahmi Ben-Yehudah, John A. Ozolek, Parker H. Mills, Carrie J. Redinger, Jocelyn D. Mich-Basso, David A. McFarland, Stacie L. Oliver, Eric T. Ahrens, Gerald Schatten
2010 Stem Cell Research  
Teratomas were subsequently serially sectioned and tissue types identified, semiquantitated, and correlated with MRM images.  ...  MRM provides rapid quantitative imaging of intact teratomas that complements histology and identifies sites of interest for additional biological studies.  ...  of Pittsburgh for providing the tissue sections and immunohistochemistry presented in this paper.  ... 
doi:10.1016/j.scr.2010.07.005 pmid:20864427 pmcid:PMC2975385 fatcat:5mou6fsb4jalzn7swchbu3yyzu

Automatic detection of melanoma progression by histological analysis of secondary sites

Nikita V. Orlov, Ashani T. Weeraratna, Stephen M. Hewitt, Christopher E. Coletta, John D. Delaney, D. Mark Eckley, Lior Shamir, Ilya G. Goldberg
2012 Cytometry Part A  
We present results from machine classification of melanoma biopsies sectioned and stained with hematoxylin/eosin (H&E) on tissue micro-arrays (TMA).  ...  In our experiments we constructed an HE color space by digitally deconvolving the RGB images into separate H (hematoxylin) and E (eosin) channels.  ...  Acknowledgments This research was supported by the Intramural Research Program of the NIH, National Institute on Aging (Z01: AG000685-02). Literature Cited  ... 
doi:10.1002/cyto.a.22044 pmid:22467531 pmcid:PMC3331954 fatcat:443mj6zu7nfylgnw4jivk3eefe

The Effect of Projection Microstereolithographic Fabricated Implant Geometry on Myocutaneous Revascularization

Ross M. Clark, Kirsten N. Cicotte, Paul G. McGuire, Elizabeth L. Hedberg-Dirk, Thomas R. Howdieshell
2014 Surgical Science  
Laser speckle contrast imaging demonstrated flap revascularization in (SP) mice, and markedly reduced distal flap reperfusion in (S) mice.  ...  Clark et al. communication between recipient bed and flap with lack of bridging inflammatory cells and neovasculature and resultant distal tissue necrosis.  ...  Note the regenerating epidermis and viable panniculus carnosus muscle (Hematoxylin and eosin stain, 100× magnification); (B) Hematoxylin and eosin stain (100× magnification) of corresponding region of  ... 
doi:10.4236/ss.2014.512079 fatcat:4lrle2pycjfepfzfd2gbquhrsa

The Effect of Projection Microstereolithographic Fabricated Implant Geometry on Myocutaneous Revascularization

R.M. Clark, K.N. Cicotte, P.G. McGuire, E.L. Hedberg-Dirk, T.R. Howdieshell
2014 Journal of Surgical Research  
Laser speckle contrast imaging demonstrated flap revascularization in (SP) mice, and markedly reduced distal flap reperfusion in (S) mice.  ...  Clark et al. communication between recipient bed and flap with lack of bridging inflammatory cells and neovasculature and resultant distal tissue necrosis.  ...  Note the regenerating epidermis and viable panniculus carnosus muscle (Hematoxylin and eosin stain, 100× magnification); (B) Hematoxylin and eosin stain (100× magnification) of corresponding region of  ... 
doi:10.1016/j.jss.2013.11.716 fatcat:ugo2avthabakxl4nfzen4ve6ra

Classification of basal cell carcinoma in human skin using machine learning and quantitative features captured by polarization sensitive optical coherence tomography

Tahereh Marvdashti, Lian Duan, Sumaira Z. Aasi, Jean Y. Tang, Audrey K. Ellerbee Bowden
2016 Biomedical Optics Express  
We report the first fully automated detection of basal cell carcinoma (BCC), the most commonly occurring type of skin cancer, in human skin using polarization-sensitive optical coherence tomography (PS-OCT  ...  Our classifier achieved 95.4% sensitivity and specificity, validated by leave-one-patient-out cross validation (LOPOCV), in detecting BCC in human skin samples collected from 42 patients.  ...  Acknowledgments We would like to thank Owen Ma, Jamaica Jensen, Samantha Rodriguez, and Katherine Ransohoff of the Stanford dermatology clinic for their help in collecting human samples.  ... 
doi:10.1364/boe.7.003721 pmid:27699133 pmcid:PMC5030045 fatcat:takyff6msvf5nmowdqe6lpqdta

Optimization of multimodal spectral imaging for assessment of resection margins during Mohs micrographic surgery for basal cell carcinoma

Sho Takamori, Kenny Kong, Sandeep Varma, Iain Leach, Hywel C. Williams, Ioan Notingher
2014 Biomedical Optics Express  
sample preparation and subjective interpretation of stained frozen-sections.  ...  In this study, the MSI algorithm was optimized to maximize the diagnosis accuracy while minimizing the number of Raman spectra: the segmentation of the auto-fluorescence images was optimized according  ...  The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.  ... 
doi:10.1364/boe.6.000098 pmid:25657878 pmcid:PMC4317116 fatcat:od7bjkjmara73nlpnhtaqzyu4y
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