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Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease

Claudia Plant, Stefan J. Teipel, Annahita Oswald, Christian Böhm, Thomas Meindl, Janaina Mourao-Miranda, Arun W. Bokde, Harald Hampel, Michael Ewers
2010 NeuroImage  
pattern matching for the prediction of the conversion from MCI to AD.  ...  Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical brain areas show atrophic changes in MCI, preceding the onset of AD-type dementia.  ...  Foundation Ireland (SFI) as part of the SFI Stokes Programme (to ALWB), a grant from the Hirnliga Foundation, Germany (to SJT), a grant from the German Center on Neurodegenerative Disorders (DZNE) within  ... 
doi:10.1016/j.neuroimage.2009.11.046 pmid:19961938 pmcid:PMC2838472 fatcat:w33gytmvjrhhzkgkot4prph6um

A list of publications describing new supervised learning pipelines to predict clinical variables from neuroimaging data in Alzheimer's disease

Alex F Mendelson
2016 Figshare  
This is a list of publications describing new classification and regression methods to predict clinical variables relevant to Alzheimer's disease using neurological images.  ...  It is intended as a companion document for my thesis.  ...  An intelligent technique for detecting Alzheimer's disease based on brain structural changes and hippocampal shape.  ... 
doi:10.6084/m9.figshare.3435752 fatcat:mdtfbkinjzfezcg6qhhwx43s4e

Quantitative structural MRI for early detection of Alzheimer's disease

Linda K McEvoy, James B Brewer
2010 Expert Review of Neurotherapeutics  
Objective evidence of ongoing brain atrophy will be critical for risk/benefit decisions once potentially aggressive, disease-modifying treatments become available.  ...  Recent advances have paved the way for the use of quantitative structural MRI in clinical practice, and initial clinical use has been promising.  ...  The advent of computer-based methods for quantitative MRI has allowed for efficient quantification of AD-related atrophy across the brain [51] [52] [53] [54] [55] .  ... 
doi:10.1586/ern.10.162 pmid:20977326 pmcid:PMC3182103 fatcat:7uqcwd77cfdgnhdpsvuxcg64vu

Tracking Alzheimer's Disease

P. M THOMPSON, K. M HAYASHI, R. A DUTTON, M.-C. CHIANG, A. D LEOW, E. R SOWELL, G. DE ZUBICARAY, J. T BECKER, O. L LOPEZ, H. J AIZENSTEIN, A. W TOGA
2007 Annals of the New York Academy of Sciences  
We report the first time-lapse maps of cortical atrophy spreading dynamically in the living brain, based on averaging data from populations of subjects with Alzheimer's disease and normal subjects imaged  ...  drug trials, and shed light on the neuroscience of brain degeneration in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI).  ...  This research was supported by the National Institute on Aging, the National Library of Medicine, the National Institute for Biomedical Imaging and Bioengineering, the National Center for Research Resources  ... 
doi:10.1196/annals.1379.017 pmid:17413023 pmcid:PMC3197831 fatcat:ztx5gpereze5fiujthiwuktr5q

Alliance for Aging Research AD Biomarkers Work Group: structural MRI

Clifford R. Jack
2011 Neurobiology of Aging  
In addition, AD biomarkers are an essential component of recently updated diagnostic criteria for AD from the National Institute on Aging -Alzheimer's Association.  ...  This article reviews evidence supporting the position that MRI is a biomarker of neurodegenerative atrophy.  ...  Acknowledgments The Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation, USA, and the Robert H. and Clarice Smith Alzheimer's Disease Research Program of the Mayo Foundation  ... 
doi:10.1016/j.neurobiolaging.2011.09.011 pmid:22078173 pmcid:PMC3661287 fatcat:kyu6vx6a6rezlb4j6laq5emgte

Efficient Morphometric Techniques in Alzheimer's Disease Detection: Survey and Tools

Vinutha N., P. Deepa Shenoy, P. Deepa Shenoy, K.R. Venugopal
2016 Neuroscience International  
The development of advance techniques in the multiple fields such as image processing, data mining and machine learning are required for the early detection of Alzheimer's Disease (AD) and to prevent the  ...  progression of the disease to the later stages.  ...  The corresponding author confirms that all of the other authors have read and approved the manuscript and there are no ethical issues involved.  ... 
doi:10.3844/amjnsp.2016.19.44 fatcat:3zeb2s5pjzfv7mptqi7cy2a3au

Role of structural MRI in Alzheimer's disease

Prashanthi Vemuri, Clifford R Jack
2010 Alzheimer's Research & Therapy  
and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology.  ...  Alzheimer's disease (AD) is a multifaceted disease in which cumulative pathological brain insults result in progressive cognitive decline that ultimately leads to dementia.  ...  One of the most sensitive global measures for measuring the rates of brain atrophy is the ventricular change measure using BSI [24] .  ... 
doi:10.1186/alzrt47 pmid:20807454 pmcid:PMC2949589 fatcat:ua2c6ky2prdzpp42kxq4rlmp2q

Science to Practice: Translating Automated Brain MRI Volumetry in Alzheimer's Disease from Research to Routine Diagnostic Use in the Work-Up of Dementia

Bharath Gopal Rathakrishnan, P. Murali Doraiswamy, Jeffrey R. Petrella
2014 Frontiers in Neurology  
Atrophy of the MTL is particularly important because it can be detected earlier than generalized whole brain atrophy in AD.  ...  Impairment of declarative memory is one of the earliest symptoms of Alzheimer's disease (AD), the most common form of dementia.  ... 
doi:10.3389/fneur.2013.00216 pmid:24409168 pmcid:PMC3885875 fatcat:tdmq6exjrjgnxavzmtzmactc4u

An Overview of Quantitative Magnetic Resonance Imaging Analysis Studies in the Assessment of Alzheimer's Disease [chapter]

Stephanos Leandrou, Styliani Petroudi, Panicos A. Kyriacou, Constantino Carlos Reyes-Aldasoro, Constantinos S. Pattichis
2016 International Federation for Medical and Biological Engineering Proceedings  
CONFLICT OF INTEREST "The authors declare that they have no conflict of interest  ...  help on the detection of neuronal loss in the initial stages of the disease.  ...  The challenge for modern neuroimaging is to help in the early diagnosis of Alzheimer's disease and structural MRI is one of the biomarkers that could be selected in the assessment of early AD.  ... 
doi:10.1007/978-3-319-32703-7_56 fatcat:ryyepcaberbxhhxgjutojtnae4

Proceeding and abstracts,second meeting of the Alzheimer's imaging consortium,Stockholm,Fairgrounds,Stockholm,Sweden,July20,2002

2004 Neurobiology of Aging  
detecting the presence of Alzheimer's disease.  ...  Order of the scans was randomized, correction for persisting activity of the first scan was performed. Atrophy correction was done in the activation group PET scans based on individual MRI.  ...  Background: Previous investigators have measured longitudinal change of brain structure in Alzheimer's disease (AD) and normal aging using different methods, on different populations.  ... 
doi:10.1016/s0197-4580(03)00003-4 fatcat:ceywsycy2vappownkwlltj5lxi

Anatomically Standardized Detection of MRI Atrophy Patterns in Early-Stage Alzheimer's Disease

Lukas Lenhart, Stephan Seiler, Lukas Pirpamer, Georg Goebel, Thomas Potrusil, Michaela Wagner, Peter Dal Bianco, Gerhard Ransmayr, Reinhold Schmidt, Thomas Benke, Christoph Scherfler
2021 Brain Sciences  
MRI studies have consistently identified atrophy patterns in Alzheimer's disease (AD) through a whole-brain voxel-based analysis, but efforts to investigate morphometric profiles using anatomically standardized  ...  These morphologically distinct subtypes are based on standardized brain regions, which are anatomically defined and freely accessible so as to validate its diagnostic accuracy and enhance the prediction  ...  MRI data.  ... 
doi:10.3390/brainsci11111491 pmid:34827490 pmcid:PMC8615991 fatcat:ojmjkcjrvrgl3iu3ljy32lew7q

Automated identification of dementia using medical imaging: a survey from a pattern classification perspective

Chuanchuan Zheng, Yong Xia, Yongsheng Pan, Jinhu Chen
2015 Brain Informatics  
Since most of those algorithms consist of both feature extraction and classification, we provide a survey on three categories of feature extraction methods, including the voxel-, vertex-and ROI-based ones  ...  In this review paper, we summarized the automated dementia identification algorithms in the literature from a pattern classification perspective.  ...  Recently, Liu et al. proposed a simulation method to predict the longitudinal brain morphological changes in neurodegenerative brains based on VBM [52] .  ... 
doi:10.1007/s40708-015-0027-x pmid:27747596 pmcid:PMC4883162 fatcat:yefc226j4za75afkkkolg4m5n4

Prediction of Amyloid Positivity in Mild Cognitive Impairment Using Fully Automated Brain Segmentation Software

Kang KM, Sohn CH, Byun MS, Lee JH, Yi D, Lee Y, Lee JY, Kim YK, Sohn BK, Yoo RE, Yun TJ, Choi SH (+2 others)
2020 Neuropsychiatric Disease and Treatment  
of KoreaTel +82-2-2072-2205Fax +82-2-744-7241Email selfpsy@snu.ac.krObjective: To assess the predictive ability of regional volume information provided by fully automated brain segmentation software for  ...  cerebral amyloid positivity in mild cognitive impairment (MCI).Methods: This study included 130 subjects with amnestic MCI who participated in the Korean brain aging study of early diagnosis and prediction  ...  Materials and Methods Participants This study is based on the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), 20 an ongoing, prospective, community-based cohort  ... 
doaj:73031b65eb5345b5867a838aad1f99d7 fatcat:tsre6su4rvggretb4ikpok6bi4

Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

Clifford R. Jack, Josephine Barnes, Matt A. Bernstein, Bret J. Borowski, James Brewer, Shona Clegg, Anders M. Dale, Owen Carmichael, Christopher Ching, Charles DeCarli, Rahul S. Desikan, Christine Fennema-Notestine (+31 others)
2015 Alzheimer's & Dementia  
The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders.  ...  metrics; deriving sample size estimates for future trials based on those outcomes; and  ...  Introduction The overarching objective for the Alzheimer's Disease Neuroimaging Initiative (ADNI) magnetic resonance imaging (MRI) core has been to improve methods for clinical trials in Alzheimer's disease  ... 
doi:10.1016/j.jalz.2015.05.002 pmid:26194310 pmcid:PMC4523217 fatcat:xf473xlapvgbvekh4oxvkyk5wy

Biomarkers for Early Detection of Alzheimer Pathology

C.M. Clark, C. Davatzikos, A. Borthakur, A. Newberg, S. Leight, V.M.-Y. Lee, J.Q. Trojanowski
2007 Neurosignals  
Strategies to accomplish this include the detection of altered levels of tau and amyloid in cerebrospinal fluid, the use of structural MRI to identify disease-specific patterns of regional atrophy and  ...  Success will facilitate the ability to reliably diagnose Alzheimer's disease while the symptoms of brain failure are mild and may provide objective measures of disease-modifying treatment efficacy.  ...  Support for research summarized here comes from the NIH (AG10124), the Pennsylvania Department of Health (SAP4100027296), the James Previti Family Fund and Marian S. Ware.  ... 
doi:10.1159/000109754 pmid:18097155 pmcid:PMC2866153 fatcat:t7wofsgo6vc4fnnaque2cpdj2i
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