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Automated Detection of Cortical Lesions in Multiple Sclerosis Patients with 7T MRI [article]

Francesco La Rosa, Erin S Beck, Ahmed Abdulkadir, Jean-Philippe Thiran, Daniel S Reich, Pascal Sati, Meritxell Bach Cuadra
2020 arXiv   pre-print
The automated detection of cortical lesions (CLs) in patients with multiple sclerosis (MS) is a challenging task that, despite its clinical relevance, has received very little attention.  ...  For supervised training based on multimodal structural MRI at 7T, two experts generated ground truth segmentation masks of 60 patients with 2014 CLs.  ...  Conclusion In this work, we explore the capability of deep learning-based techniques for the automated detection of MS cortical lesions in advanced MRI sequences (MP2RAGE, T2*w EPI, and T2*w GRE) at 7T  ... 
arXiv:2008.06780v1 fatcat:nnqfbpgcurbtjk44hkfy2ey6iu

Imaging cortical multiple sclerosis lesions with ultra-high field MRI [article]

Mads Alexander Just Madsen, Vanessa Wiggermann, Stephan Bramow, Jeppe Romme Christensen, Finn Sellebjerg, Hartwig Roman Siebner
2021 medRxiv   pre-print
Cortical lesions are abundant in multiple sclerosis (MS), yet difficult to visualize in vivo.  ...  Ultra- high field (UHF) MRI at 7T and above provides technological advances suited to optimize the detection of cortical lesions in MS.  ...  Siebner has received honoraria as speaker from Sanofi Genzyme, Denmark and Novartis, Denmark, as consultant from Sanofi Genzyme, Denmark, Lophora, Denmark, and Lundbeck AS, Denmark, and as editor-in-chief  ... 
doi:10.1101/2021.06.25.21259363 fatcat:762dvtiwinevxglrean6ruq64i

Contribution of cortical lesion subtypes at 7T MRI to physical and cognitive performance in MS

A. S. Nielsen, R. P. Kinkel, N. Madigan, E. Tinelli, T. Benner, C. Mainero
2013 Neurology  
Patients also underwent anatomical 3T MRI for cortical thickness estimation, and neuropsychological testing within 1 week of the 7T scan.  ...  performance in a heterogeneous multiple sclerosis (MS) cohort.  ...  Benner contributed in extraction and analysis of radiographic data and revising the manuscript. Dr.  ... 
doi:10.1212/wnl.0b013e3182a08ce8 pmid:23864311 pmcid:PMC3775688 fatcat:5nnwnyam3zahjnnalnf522wqja

Multiple sclerosis cortical lesion detection with deep learning at ultra-high-field MRI [article]

Francesco La Rosa, Erin S. Beck, Josefina Maranzano, Ramona-Alexandra Todea, Peter van Gelderen, Jacco A. de Zwart, Nicholas J. Luciano, Jeff H. Duyn, Jean-Philippe Thiran, Cristina Granziera, Daniel S. Reich, Pascal Sati (+1 others)
2022 medRxiv   pre-print
In the future, CLAIMS may be useful to support clinical decisions at 7T MRI, especially in the field of diagnosis and differential diagnosis of multiple sclerosis patients.  ...  To accelerate this task, we developed a deep learning-based framework (CLAIMS: Cortical Lesion Artificial Intelligence-based assessment in Multiple Sclerosis) for the automated detection and classification  ...  Acknowledgments We thank members of the Translational Neuroradiology Section and the staff of the National Institute of Mental Health Functional MRI Facility for help with MRI acquisitions.  ... 
doi:10.1101/2022.03.02.22271269 fatcat:cpfr6ifkwzgidpnkgc2oumzeda

MRI postprocessing in presurgical evaluation

Irene Wang, Andreas Alexopoulos
2016 Current Opinion in Neurology  
This review summarizes recent developments in MRI post-processing in the context of epilepsy pre-surgical evaluation, with the focus on patients with unremarkable MRI by visual analysis (i.e., "nonlesional  ...  Recent Findings-Various methods of MRI post-processing have been reported to show additional clinical values in the following areas: (1) lesion detection on an individual level; (2) lesion confirmation  ...  Sehong Oh for his technical expertise on 7T MRI.  ... 
doi:10.1097/wco.0000000000000305 pmid:26900745 pmcid:PMC4932912 fatcat:wtuowhnkdrgv3bm6acdtdcwvwq

Malformations of cortical development: The role of 7-Tesla magnetic resonance imaging in diagnosis

M. Guye, F. Bartolomei, J.-P. Ranjeva
2019 Revue neurologique (Paris)  
Therefore, 7T MRI can be considered as a useful tool in the presurgical evaluation of drug-resistant partial epilepsies, particularly, but not exclusively, in cases of normal appearing conventional MRI  ...  Postprocessing of multiparametric ultra-high resolution and quantitative data may also be used to improve automated detection of MCD via machine learning.  ...  Declarations of interest The author declare that they no conflict of interest concerning this article.  ... 
doi:10.1016/j.neurol.2019.01.393 fatcat:d3nxch6wbnb3pgdcrghgk62vyq

Neuroinflammatory component of gray matter pathology in multiple sclerosis

Elena Herranz, Costanza Giannì, Céline Louapre, Constantina A. Treaba, Sindhuja T. Govindarajan, Russell Ouellette, Marco L. Loggia, Jacob A. Sloane, Nancy Madigan, David Izquierdo-Garcia, Noreen Ward, Gabriel Mangeat (+8 others)
2016 Annals of Neurology  
Objective-In multiple sclerosis (MS), using simultaneous magnetic resonance-positron emission tomography (MR-PET) imaging with 11 C-PBR28, we quantified expression of the 18kDa translocator protein (TSPO  ...  MS WM lesions showed relatively modest TSPO increases. With the exception of cortical lesions, where TSPO expression was similar, 11 C-PBR28 uptake across the brain was greater in SPMS than in RRMS.  ...  Albrecht for their help with quality control of the blood data.  ... 
doi:10.1002/ana.24791 pmid:27686563 pmcid:PMC5115951 fatcat:ypqdp4djyvg4lohly2ze5j5uz4

Ultra-high-field arterial spin labelling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis

Richard J. Dury, Yasser Falah, Penny A. Gowland, Nikos Evangelou, Molly G. Bright, Susan T. Francis
2018 European Radiology  
in cortical lesions (CLs) in multiple sclerosis (MS).  ...  Key Points • Perfusion can be quantified within cortical lesions in multiple sclerosis using an optimised high spatial resolution arterial spin Labelling MRI acquisition at ultra-high-field. • The majority  ...  Introduction Cortical lesions (CLs) in patients with multiple sclerosis (MS) are associated with physical disability [1] and cognitive impairment [2] ; however, little is known about the formation and  ... 
doi:10.1007/s00330-018-5707-5 pmid:30280247 fatcat:64mjip3ebfarbklz2xfxndqnym

Detection of Hippocampal Subfield Asymmetry at 7T With Automated Segmentation in Epilepsy Patients With Normal Clinical Strength MRIs

Akila Pai, Lara V. Marcuse, Judy Alper, Bradley N. Delman, John W. Rutland, Rebecca E. Feldman, Patrick R. Hof, Madeline Fields, James Young, Priti Balchandani
2021 Frontiers in Neurology  
The advent of novel techniques including ultra-high field 7T magnetic resonance imaging (MRI) and automated subfield volumetry have further enabled detection of hippocampal pathology in patients with epilepsy  ...  , however, studies combining both 7T MRI and automated segmentation in epilepsy patients with normal-appearing clinical MRI are limited.  ...  ORIGINAL RESEARCH article Detection of Hippocampal Subfield Asymmetry at 7T With Automated Segmentation in Epilepsy Patients With Normal Clinical Strength MRIs 1 Icahn School of Medicine at Mount  ... 
doi:10.3389/fneur.2021.682615 pmid:34867703 pmcid:PMC8634833 fatcat:lhgdutqpsjawhgtm4nzx5ot37m

7T Epilepsy Task Force Consensus Recommendations on the use of 7T in Clinical Practice

Giske Opheim, Anja van der Kolk, Karin Markenroth Bloch, Albert J. Colon, Kathryn A. Davis, Thomas R. Henry, Jacobus F.A. Jansen, Stephen E. Jones, Jullie W. Pan, Karl Rössler, Joel M. Stein, Maria C. Strandberg (+32 others)
2020 Neurology  
Over the last decade, studies have demonstrated the added value of 7T MRI in patients with and without known epileptogenic lesions from 1.5 and/or 3T.  ...  management of patients with epilepsy.  ...  Moreover, the absence of an MRI-detectable lesion in approximately one-third of patients with DRFE is a major limitation to surgical candidacy.  ... 
doi:10.1212/wnl.0000000000011413 pmid:33361257 pmcid:PMC8055334 fatcat:oonxogokevbzbcpy36ujjd7sby

Magnetic Resonance Imaging in Multiple Sclerosis

Christopher C. Hemond, Rohit Bakshi
2018 Cold Spring Harbor Perspectives in Medicine  
The use of 7T MRI has markedly boosted the sensitivity in the detection of cortical lesions in MS with the ability to reach ∼80%-90% of ground truth detection versus histology (Pitt et al. 2010) .  ...  (B) White matter lesions in a patient with relapsing-remitting multiple sclerosis, showing deep white matter and periventricular lesions with central veins (red arrows).  ... 
doi:10.1101/cshperspect.a028969 pmid:29358319 fatcat:ytdy4yzrsbabnejyqbwof4nefe

Thalamic lesions in multiple sclerosis by 7T MRI: Clinical implications and relationship to cortical pathology

Daniel M Harrison, Jiwon Oh, Snehashis Roy, Emily T Wood, Anna Whetstone, Michaela A Seigo, Craig K Jones, Dzung Pham, Peter van Zijl, Daniel S Reich, Peter A Calabresi
2015 Multiple Sclerosis  
Conclusions-7T MRI allows identification of thalamic lesions in MS, which are associated with disability, progressive disease, and cortical lesions.  ...  Objective-Pathology in both cortex and deep gray matter contribute to disability in multiple sclerosis (MS).  ...  Wood are supported by the Intramural Research Program of NINDS. Time for data analysis was supported by NIH Mentored Grant K23NS072366 (Harrison).  ... 
doi:10.1177/1352458514558134 pmid:25583851 pmcid:PMC4499502 fatcat:uqpp62lyu5bzrbbvwgmbfykhkm

Radiological and Clinical Value of 7T MRI for Evaluating 3T-Visible Lesions in Pharmacoresistant Focal Epilepsies

Z Irene Wang, Se-Hong Oh, Mark Lowe, Mykol Larvie, Paul Ruggieri, Virginia Hill, Volodymyr Statsevych, Doksu Moon, Jonathan Lee, Todd Emch, James Bena, Ingmar Blümcke (+4 others)
2021 Frontiers in Neurology  
This study aims at accessing the radiological and clinical value of 7T in patients with pharmacoresistant focal epilepsy and 3T-visible lesions.  ...  Results: A total of 47 patients were included, with the main pathology types of focal cortical dysplasia (FCD), hippocampal sclerosis, periventricular nodular heterotopia (PVNH), tumor and polymicrogyria  ...  Ken Sakaie for the acquisition of 7T studies.  ... 
doi:10.3389/fneur.2021.591586 pmid:33737901 pmcid:PMC7960771 fatcat:44bcsjasurdc3fguwzy5wwv2my

Predictive MRI Biomarkers in MS—A Critical Review

Vlad Eugen Tiu, Iulian Enache, Cristina Aura Panea, Cristina Tiu, Bogdan Ovidiu Popescu
2022 Medicina  
and Objectives: In this critical review, we explore the potential use of MRI measurements as prognostic biomarkers in multiple sclerosis (MS) patients, for both conventional measurements and more novel  ...  Results: There are numerous MRI metrics that have been proven by clinical studies to hold important prognostic value for MS patients, most of which can be readily obtained from standard 1.5T MRI scans.  ...  Cortical lesion accrual was greater in patients with secondary progressive multiple sclerosis (SPMS) than in those with relapse-remitting multiple sclerosis (RRMS), and total cortical lesion volume independently  ... 
doi:10.3390/medicina58030377 pmid:35334554 pmcid:PMC8949449 fatcat:5sd7rehjfvbq7m24kkzirr3gni

MRI Prognostic Factors in Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, and Myelin Oligodendrocyte Antibody Disease

Rosa Cortese, Antonio Giorgio, Gianmarco Severa, Nicola De Stefano
2021 Frontiers in Neurology  
Several MRI measures have been developed in the last couple of decades, providing a number of imaging biomarkers that can capture the complexity of the pathological processes occurring in multiple sclerosis  ...  Moreover, the process of identifying new effective therapies for MS patients has been supported by the use of serial MRI examinations in order to sensitively detect the sub-clinical effects of disease-modifying  ...  Increased cortical grey matter lesion detection in multiple sclerosis with 7 T MRI: a post-mortem verification study. Brain.  ... 
doi:10.3389/fneur.2021.679881 pmid:34867701 pmcid:PMC8636325 fatcat:hktdfscaevfz3pppabwiba7nla
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