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Autaptic Modulation of Electrical Activity in a Network of Neuron-Coupled Astrocyte
2017
Complexity
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Autapse connection is considered on a biological neuron coupled by astrocyte, and the effect of autapse driving-induced response in electrical activities is investigated. ...
In this paper, a simple network is developed on the Hodgkin-Huxley (HH) neuron coupled by astrocyte and the autapse effect is also considered. ...
Acknowledgments This work is partially supported by the National Natural Science of Foundation of China under the Grant nos. 11672122, 11365014, and 11372122. ...
doi:10.1155/2017/4631602
fatcat:cwbvajyu6nb7jag4eh23il2yqi
The Astrocyte as a Gatekeeper of Synaptic Information Transfer
2007
Neural Computation
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This interaction enables the astrocyte to modulate the information flow from presynaptic to postsynaptic cells in a manner dependent on previous activity at this and other nearby synapses. ...
We present a simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain. ...
This work has been supported in part by the NSF-sponsored Center for Theoretical Biological Physics (grant numbers PHY-0216576 and PHY-0225630), by Maguy-Glass Chair in Physics of Complex Systems. ...
doi:10.1162/neco.2007.19.2.303
pmid:17206866
fatcat:b5dx55ovwbbkxdkuf3uffvacha
Astrocyte-Derived Thrombospondins Mediate the Development of Hippocampal Presynaptic Plasticity In Vitro
2012
Journal of Neuroscience
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We found evidence that protein kinase A activity is abnormal in astrocyte-deprived neurons but restored by TSP1, so protein kinase A dysfunction may provide a mechanism by which muting is disrupted during ...
Here we studied the role of astrocytes in the development of presynaptic muting at glutamatergic synapses in rat hippocampal neurons. ...
Muting occurs in single-neuron networks in culture, but because these neurons contact astrocytes it is unclear whether muting is cell autonomous or whether astrocyte signals modulate or induce muting. ...
doi:10.1523/jneurosci.2604-12.2012
pmid:22993427
pmcid:PMC3475988
fatcat:b3742pf46bf73mbtboekdc6b3q
Neuron-Glial Interactions
[article]
2020
arXiv
pre-print
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Although our understanding of the need of neuron-glial interactions in the brain is still at its infancy, being mostly based on predictions that await for experimental validation, simple general modeling ...
arguments borrowed from control theory are introduced to support the importance of including such interactions in traditional neuron-based modeling paradigms. ...
Neuron-glial interactions in neural networks The importance of uptake of neurotransmitters such as glutamate and GABA by astrocytes in setting the tone of neural network activity has only been partially ...
arXiv:2001.06881v1
fatcat:sus3rwcexferjpioq5txa5vn7y
Neuron-Glial Interactions
[chapter]
2020
Encyclopedia of Computational Neuroscience
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Synonyms neuron-glial interaction modeling, synapse-astrocyte bidirectional signaling, axon-glial signaling, microglia modeling, computational glioscience Definition Dependence of neuronal function on ...
ranging from subcellular and synaptic levels to those of networks and whole-brain structures. ...
Neuron-glial interactions in neural networks The importance of uptake of neurotransmitters such as glutamate and GABA by astrocytes in setting the tone of neural network activity has only been partially ...
doi:10.1007/978-1-4614-7320-6_100691-1
fatcat:kmusuo77ave5pcwvkpmkimmxma
:{unav)
2016
BMC Neuroscience
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There, medium-spiny GABAergic neurons, which constitute about 95% of the neurons in the area, form a mutually inhibitory synaptic network that is modulated by dopamine. ...
When put in culture, the neurons reestablish this network. ...
Acknowledgements We thank Wei-Xing Shi for preliminary experiments, Marjorie A. Ariano for DA receptor antisera, Ling Lin for cell culture preparation, and Takeo Mizuno for critical discussion. ...
doi:10.1186/1471-2202-7-53
pmid:16813648
pmcid:PMC1538613
fatcat:zcdlyoqhrzfvfihmpzb2ddbbhi
Emitting waves from defects in network with autapses
2015
Communications in nonlinear science & numerical simulation
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The effect of autapse connected to a neuron is often described by using a self-feedback forcing current in a close loop, and the electric activities of neuron can be regulated by the autapse greatly. ...
In the case of ring network, it is found that pulse can be blocked by the neurons with negative feedback in autapse, and the pulse also can keep alive in the ring network stably under appropriate coupling ...
Acknowledgment This work was partially supported by the National Natural Science Foundation of China under the Grant Nos. 11265008, 11372122, 11365014. ...
doi:10.1016/j.cnsns.2014.11.008
fatcat:u6ezes3zeje6djtkfttwgwypuq
Progress of Induced Pluripotent Stem Cell Technologies to Understand Genetic Epilepsy
2020
International Journal of Molecular Sciences
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In addition, functional characterization of cerebral organoids enlightens neuronal network dynamics in a three-dimensional (3D) structure. ...
At the two dimensional (2D) level, single-cell models of iPSC-derived neurons lead to a mature neuronal phenotype, and now allow a reliable investigation of synaptic transmission and plasticity. ...
in a mass culture setting; then mature neurons are re-plated as single cells onto astrocytic micro-islands for a second autaptic culturing phase lasting a further 2 weeks. ...
doi:10.3390/ijms21020482
pmid:31940887
pmcid:PMC7013950
fatcat:gmfyw4kdjza4hpq7qg6nllol4y
Functional diversity on synaptic plasticity mediated by endocannabinoids
2012
Philosophical Transactions of the Royal Society of London. Biological Sciences
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Endocannabinoids (eCBs) act as modulators of synaptic transmission through activation of a number of receptors, including, but not limited to, cannabinoid receptor 1 (CB1). eCBs share CB1 receptors as ...
a common target with D 9 -tetrahydrocannabinol (THC), the main psychoactive ingredient in marijuana. ...
The first effect of cannabinoids on electrical synapses described their modulation of intercellular communication between astrocytes in a CB1-receptor-independent fashion [91] . ...
doi:10.1098/rstb.2011.0386
pmid:23108543
pmcid:PMC3481528
fatcat:tnrtfycklbbxpkjrfk4pbr4jye
Mixed Stimulus-Induced Mode Selection in Neural Activity Driven by High and Low Frequency Current under Electromagnetic Radiation
2017
Complexity
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In this paper, different types of electrical stimulus impended with a high-low frequency current are imposed on new HR neuron model, and mixed stimulus-induced mode selection in neural activity is discussed ...
behaviors of neuronal activities with electromagnetic induction being considered, and the mode transition of electrical activities in neuron is detected when external electromagnetic radiation is imposed ...
This work was supported by the National Natural Science Foundation of China, under Grant nos. 11775091 and 11474117. ...
doi:10.1155/2017/7628537
fatcat:vzckwsvnlzctbhnovjxbwzv62a
Erythropoietin enhances hippocampal long-term potentiation and memory
2008
BMC Biology
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Networks of EPOtreated primary hippocampal neurons develop lower overall spiking activity but enhanced bursting in discrete neuronal assemblies. ...
Conclusion: We conclude that EPO improves hippocampus dependent memory by modulating plasticity, synaptic connectivity and activity of memory-related neuronal networks. ...
LM was supported by a Lichtenberg Stipend of the State of Lower-Saxony. ...
doi:10.1186/1741-7007-6-37
pmid:18782446
pmcid:PMC2562991
fatcat:pmmcpkp72vezje7gipwcz43soq
Brain Energetics, Mitochondria, and Traumatic Brain Injury
[article]
2019
arXiv
pre-print
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In addition to summarizing current thinking in these disciplines, our goal is to suggest a framework for mechanisms and pathways based on optimal energetic decisions. ...
throughout the astrocytic network in response to neuronal activity. ...
additionally model the coupling between brain electrical activity, metabolism, and hemodynamics. ...
arXiv:1909.00012v1
fatcat:rsgo63vmyzevpmlaxoznks7r4a
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons
2017
eLife
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These results indicate that oxytocin controls the development of hippocampal excitatory neurons and contributes to the maintenance of a physiological excitation/inhibition balance, whose disruption can ...
We show that early, transient oxytocin exposure in vitro inhibits the development of hippocampal glutamatergic neurons, leading to reduced dendrite complexity, synapse density, and excitatory transmission ...
We thank V Tarabykin and C Rosemund (Charité , Berlin, Germany) for expression plasmids, H Taschenberger for advice regarding electrophysiological recordings in acute slices, and A Gü nter, S Bolte, I ...
doi:10.7554/elife.22466
pmid:28231043
pmcid:PMC5323041
fatcat:vt3i7jwaozfsdapiqtsunkllsm
Brain connexins in demyelinating diseases: Therapeutic potential of glial targets
2012
Brain Research
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Although mutations in connexins of the myelinating cells, Schwann cells and oligodendrocytes, were initially described, recent data have shown that astrocytes also play a major role in the demyelination ...
Alterations in astrocytic proteins directly affect the oligodendrocytes' ability to maintain myelin structure, and associated astrocytic proteins that regulate water and ionic fluxes, including aquaporins ...
Acknowledgments This work was supported by the National Institute of Neurological Disorders and Stroke/NIH ...
doi:10.1016/j.brainres.2012.07.003
pmid:22789906
pmcid:PMC3506183
fatcat:mcet73te4ra7di2rjrvv55cj3u
Comparative Effects of Heterologous TRPV1 and TRPM8 Expression in Rat Hippocampal Neurons
2009
PLoS ONE
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We found that activation of both channels with appropriate agonist caused large depolarizing currents in voltage-clamped hippocampal neurons, exceeding the amplitude responses to a calibrating 30 mM KCl ...
Therefore, by a number of criteria, TRPM8 proved the superior choice for control over neuronal membrane potential. ...
(D) Percentage of transfected autaptic neurons that did not respond to electrical stimulation with a detectable PSC. ...
doi:10.1371/journal.pone.0008166
pmid:19997638
pmcid:PMC2780724
fatcat:q27emd2webfphaknbbrqhrvtau
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