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Autaptic Modulation of Electrical Activity in a Network of Neuron-Coupled Astrocyte

Shengli Guo, Jun Tang, Jun Ma, Chunni Wang
2017 Complexity  
Autapse connection is considered on a biological neuron coupled by astrocyte, and the effect of autapse driving-induced response in electrical activities is investigated.  ...  In this paper, a simple network is developed on the Hodgkin-Huxley (HH) neuron coupled by astrocyte and the autapse effect is also considered.  ...  Acknowledgments This work is partially supported by the National Natural Science of Foundation of China under the Grant nos. 11672122, 11365014, and 11372122.  ... 
doi:10.1155/2017/4631602 fatcat:cwbvajyu6nb7jag4eh23il2yqi

The Astrocyte as a Gatekeeper of Synaptic Information Transfer

Vladislav Volman, Eshel Ben-Jacob, Herbert Levine
2007 Neural Computation  
This interaction enables the astrocyte to modulate the information flow from presynaptic to postsynaptic cells in a manner dependent on previous activity at this and other nearby synapses.  ...  We present a simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain.  ...  This work has been supported in part by the NSF-sponsored Center for Theoretical Biological Physics (grant numbers PHY-0216576 and PHY-0225630), by Maguy-Glass Chair in Physics of Complex Systems.  ... 
doi:10.1162/neco.2007.19.2.303 pmid:17206866 fatcat:b5dx55ovwbbkxdkuf3uffvacha

Astrocyte-Derived Thrombospondins Mediate the Development of Hippocampal Presynaptic Plasticity In Vitro

D. C. Crawford, X. Jiang, A. Taylor, S. Mennerick
2012 Journal of Neuroscience  
We found evidence that protein kinase A activity is abnormal in astrocyte-deprived neurons but restored by TSP1, so protein kinase A dysfunction may provide a mechanism by which muting is disrupted during  ...  Here we studied the role of astrocytes in the development of presynaptic muting at glutamatergic synapses in rat hippocampal neurons.  ...  Muting occurs in single-neuron networks in culture, but because these neurons contact astrocytes it is unclear whether muting is cell autonomous or whether astrocyte signals modulate or induce muting.  ... 
doi:10.1523/jneurosci.2604-12.2012 pmid:22993427 pmcid:PMC3475988 fatcat:b3742pf46bf73mbtboekdc6b3q

Neuron-Glial Interactions [article]

Maurizio De Pittà
2020 arXiv   pre-print
Although our understanding of the need of neuron-glial interactions in the brain is still at its infancy, being mostly based on predictions that await for experimental validation, simple general modeling  ...  arguments borrowed from control theory are introduced to support the importance of including such interactions in traditional neuron-based modeling paradigms.  ...  Neuron-glial interactions in neural networks The importance of uptake of neurotransmitters such as glutamate and GABA by astrocytes in setting the tone of neural network activity has only been partially  ... 
arXiv:2001.06881v1 fatcat:sus3rwcexferjpioq5txa5vn7y

Neuron-Glial Interactions [chapter]

Maurizio De Pittà
2020 Encyclopedia of Computational Neuroscience  
Synonyms neuron-glial interaction modeling, synapse-astrocyte bidirectional signaling, axon-glial signaling, microglia modeling, computational glioscience Definition Dependence of neuronal function on  ...  ranging from subcellular and synaptic levels to those of networks and whole-brain structures.  ...  Neuron-glial interactions in neural networks The importance of uptake of neurotransmitters such as glutamate and GABA by astrocytes in setting the tone of neural network activity has only been partially  ... 
doi:10.1007/978-1-4614-7320-6_100691-1 fatcat:kmusuo77ave5pcwvkpmkimmxma

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Daron Geldwert, J Madison Norris, Igor G Feldman, Joshua J Schulman, Myra P Joyce, Stephen Rayport
2016 BMC Neuroscience  
There, medium-spiny GABAergic neurons, which constitute about 95% of the neurons in the area, form a mutually inhibitory synaptic network that is modulated by dopamine.  ...  When put in culture, the neurons reestablish this network.  ...  Acknowledgements We thank Wei-Xing Shi for preliminary experiments, Marjorie A. Ariano for DA receptor antisera, Ling Lin for cell culture preparation, and Takeo Mizuno for critical discussion.  ... 
doi:10.1186/1471-2202-7-53 pmid:16813648 pmcid:PMC1538613 fatcat:zcdlyoqhrzfvfihmpzb2ddbbhi

Emitting waves from defects in network with autapses

Huixin Qin, Ying Wu, Chunni Wang, Jun Ma
2015 Communications in nonlinear science & numerical simulation  
The effect of autapse connected to a neuron is often described by using a self-feedback forcing current in a close loop, and the electric activities of neuron can be regulated by the autapse greatly.  ...  In the case of ring network, it is found that pulse can be blocked by the neurons with negative feedback in autapse, and the pulse also can keep alive in the ring network stably under appropriate coupling  ...  Acknowledgment This work was partially supported by the National Natural Science Foundation of China under the Grant Nos. 11265008, 11372122, 11365014.  ... 
doi:10.1016/j.cnsns.2014.11.008 fatcat:u6ezes3zeje6djtkfttwgwypuq

Progress of Induced Pluripotent Stem Cell Technologies to Understand Genetic Epilepsy

Bruno Sterlini, Floriana Fruscione, Simona Baldassari, Fabio Benfenati, Federico Zara, Anna Corradi
2020 International Journal of Molecular Sciences  
In addition, functional characterization of cerebral organoids enlightens neuronal network dynamics in a three-dimensional (3D) structure.  ...  At the two dimensional (2D) level, single-cell models of iPSC-derived neurons lead to a mature neuronal phenotype, and now allow a reliable investigation of synaptic transmission and plasticity.  ...  in a mass culture setting; then mature neurons are re-plated as single cells onto astrocytic micro-islands for a second autaptic culturing phase lasting a further 2 weeks.  ... 
doi:10.3390/ijms21020482 pmid:31940887 pmcid:PMC7013950 fatcat:gmfyw4kdjza4hpq7qg6nllol4y

Functional diversity on synaptic plasticity mediated by endocannabinoids

R. Cachope
2012 Philosophical Transactions of the Royal Society of London. Biological Sciences  
Endocannabinoids (eCBs) act as modulators of synaptic transmission through activation of a number of receptors, including, but not limited to, cannabinoid receptor 1 (CB1). eCBs share CB1 receptors as  ...  a common target with D 9 -tetrahydrocannabinol (THC), the main psychoactive ingredient in marijuana.  ...  The first effect of cannabinoids on electrical synapses described their modulation of intercellular communication between astrocytes in a CB1-receptor-independent fashion [91] .  ... 
doi:10.1098/rstb.2011.0386 pmid:23108543 pmcid:PMC3481528 fatcat:tnrtfycklbbxpkjrfk4pbr4jye

Mixed Stimulus-Induced Mode Selection in Neural Activity Driven by High and Low Frequency Current under Electromagnetic Radiation

Lulu Lu, Ya Jia, Wangheng Liu, Lijian Yang
2017 Complexity  
In this paper, different types of electrical stimulus impended with a high-low frequency current are imposed on new HR neuron model, and mixed stimulus-induced mode selection in neural activity is discussed  ...  behaviors of neuronal activities with electromagnetic induction being considered, and the mode transition of electrical activities in neuron is detected when external electromagnetic radiation is imposed  ...  This work was supported by the National Natural Science Foundation of China, under Grant nos. 11775091 and 11474117.  ... 
doi:10.1155/2017/7628537 fatcat:vzckwsvnlzctbhnovjxbwzv62a

Erythropoietin enhances hippocampal long-term potentiation and memory

Bartosz Adamcio, Derya Sargin, Alicja Stradomska, Lucian Medrihan, Christoph Gertler, Fabian Theis, Mingyue Zhang, Michael Müller, Imam Hassouna, Kathrin Hannke, Swetlana Sperling, Konstantin Radyushkin (+8 others)
2008 BMC Biology  
Networks of EPOtreated primary hippocampal neurons develop lower overall spiking activity but enhanced bursting in discrete neuronal assemblies.  ...  Conclusion: We conclude that EPO improves hippocampus dependent memory by modulating plasticity, synaptic connectivity and activity of memory-related neuronal networks.  ...  LM was supported by a Lichtenberg Stipend of the State of Lower-Saxony.  ... 
doi:10.1186/1741-7007-6-37 pmid:18782446 pmcid:PMC2562991 fatcat:pmmcpkp72vezje7gipwcz43soq

Brain Energetics, Mitochondria, and Traumatic Brain Injury [article]

Haym Benaroya
2019 arXiv   pre-print
In addition to summarizing current thinking in these disciplines, our goal is to suggest a framework for mechanisms and pathways based on optimal energetic decisions.  ...  throughout the astrocytic network in response to neuronal activity.  ...  additionally model the coupling between brain electrical activity, metabolism, and hemodynamics.  ... 
arXiv:1909.00012v1 fatcat:rsgo63vmyzevpmlaxoznks7r4a

Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

Silvia Ripamonti, Mateusz C Ambrozkiewicz, Francesca Guzzi, Marta Gravati, Gerardo Biella, Ingo Bormuth, Matthieu Hammer, Liam P Tuffy, Albrecht Sigler, Hiroshi Kawabe, Katsuhiko Nishimori, Mauro Toselli (+3 others)
2017 eLife  
These results indicate that oxytocin controls the development of hippocampal excitatory neurons and contributes to the maintenance of a physiological excitation/inhibition balance, whose disruption can  ...  We show that early, transient oxytocin exposure in vitro inhibits the development of hippocampal glutamatergic neurons, leading to reduced dendrite complexity, synapse density, and excitatory transmission  ...  We thank V Tarabykin and C Rosemund (Charité , Berlin, Germany) for expression plasmids, H Taschenberger for advice regarding electrophysiological recordings in acute slices, and A Gü nter, S Bolte, I  ... 
doi:10.7554/elife.22466 pmid:28231043 pmcid:PMC5323041 fatcat:vt3i7jwaozfsdapiqtsunkllsm

Brain connexins in demyelinating diseases: Therapeutic potential of glial targets

Maria Luisa Cotrina, Maiken Nedergaard
2012 Brain Research  
Although mutations in connexins of the myelinating cells, Schwann cells and oligodendrocytes, were initially described, recent data have shown that astrocytes also play a major role in the demyelination  ...  Alterations in astrocytic proteins directly affect the oligodendrocytes' ability to maintain myelin structure, and associated astrocytic proteins that regulate water and ionic fluxes, including aquaporins  ...  Acknowledgments This work was supported by the National Institute of Neurological Disorders and Stroke/NIH  ... 
doi:10.1016/j.brainres.2012.07.003 pmid:22789906 pmcid:PMC3506183 fatcat:mcet73te4ra7di2rjrvv55cj3u

Comparative Effects of Heterologous TRPV1 and TRPM8 Expression in Rat Hippocampal Neurons

Devon C. Crawford, Krista L. Moulder, Robert W. Gereau, Gina M. Story, Steven Mennerick, Louis S. Premkumar
2009 PLoS ONE  
We found that activation of both channels with appropriate agonist caused large depolarizing currents in voltage-clamped hippocampal neurons, exceeding the amplitude responses to a calibrating 30 mM KCl  ...  Therefore, by a number of criteria, TRPM8 proved the superior choice for control over neuronal membrane potential.  ...  (D) Percentage of transfected autaptic neurons that did not respond to electrical stimulation with a detectable PSC.  ... 
doi:10.1371/journal.pone.0008166 pmid:19997638 pmcid:PMC2780724 fatcat:q27emd2webfphaknbbrqhrvtau
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