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The Maki-e technique with eggshell powder is one of techniques of Japanese traditional Urushi (Japanese lacquer) crafts. ... However, this technique is relatively new in the history of Maki-e, and there are no prior researches in terms of materials, structure, and properties. ... Powder which is used for Maki-e is usually gold and/or silver powder. ...doi:10.4236/msa.2013.42016 fatcat:3iazyju24fadxmstttgkkyte74
Nuclear receptor subfamily 5, group A, member 1 (NR5A1) is a nuclear receptor involved in gonadal and adrenal development. We identified a novel C-terminally truncating NR5A1 mutation, p.Leu423Trpfs*7, in dizygotic twins with 46,XY disorders of sex development. Our results highlight the functional importance of C-terminal region of NR5A1 and indicate that NR5A1 mutations can be associated with intrafamilial phenotypic variations, progressive testicular dysfunction, hypogonadotropic hypogonadism, and borderline adrenal dysfunction.doi:10.1038/hgv.2017.8 pmid:28326187 pmcid:PMC5352671 fatcat:5tzjtgheefbq7gpn7k5n5v5j54
This addition of EACA in the determination of fibrinogen was first described by Maki et al.5) and supported by Nilsson and Olow22). ...doi:10.1620/tjem.83.183 fatcat:o3wt456ebbfenhl4pxoe7kwfce
The human brain function measurement by light that applies near-infrared spectroscopy (NIRS) has accomplished rapid development in these 30 years. We developed the optical topography (OT) method to make an image of the brain activity by the multipoint measurement simultaneously based on NIRS (1995). OT has several features. 1) It can measure brain activity in the daily life naturally. 2) It can measure the brain activity only by putting on the optical fiber cap. 3) It can measure the neonataldoi:10.2184/lsj.40.4_241 fatcat:qohlavyh2rebjcrwcfzmnhpagq
more »... ain function because light level is safe for the baby brain. 4) The measurement signal can be used to know the autonomic nervous system. We have achieved the application to neurosurgery; the diagnosis of the epileptic focus and the dominant hemisphere for language. Moreover, we have found neonatal brain function concerning the language and sleep. Now, everyone can measure the brain function anytime and anywhere. It is expected to become an effective tool to the approach of a different research field and a new brain imaging. We need understanding of the meaning of the measurement signal, and to tie to new knowledge by the brain and the human function measurement in the future.
Imaging of Brain Function with Light: Optical Topography
Imaging of Brain Function with Light: Optical Topography
., Maki, A., Yoro, T., & Koizumi, H. (2005). ... Hb (Maki et al., 1995; , 1996) et al., 1993; Hoshi et al., 1993; Kato et al., 1993; Villringer et al., 1993) 2 (Maki et al., 1995; Yamashita et al., 1996) Lateralized activation in the inferior ...doi:10.11225/jcss.12.296 fatcat:7r65dyvdo5ddnp4exp3i2elxzm
達手術を行った未破裂脳動脈瘤 255 例 312 動脈瘤のうち術 中破裂をきたした 8 例 (Table 1) .出血を誘発した操作に 関しては手術ビデオおよび手術記録に基づき検討した.転 帰は Glasgow Outcome Scale (GOS) を用いて評価した. 結 果 術中破裂の頻度は 255 例中 8 例,312 動脈瘤中 8 動脈瘤 で,症例あたり 3.1%,動脈瘤あたり 2.6%であった.内訳 は女性 5 例,男性 3 例で,年齢は 46-71 歳 (平均 62.1 歳) , 動脈瘤サイズは 3.4-21.0 mm (平均 7.3 mm) であり,動脈瘤は 前交通動脈瘤 (anterior communicating artery aneurysm: 術中破裂をきたした未破裂脳動脈瘤 坂田 義則,波出石 弘,田中美千裕,門岡 慶介 齋藤 浩史,稲葉 眞貴,岩田 卓士,築山 敦 Summary: Most unruptured cerebral aneurysms are asymptomatic and associated with extremely lowdoi:10.2335/scs.49.247 fatcat:zflvjioltnhu5jxovcle4qisaa
more »... es of surgical complications. Therefore, the control of ruptures before clipping the aneurysmal neck should be of considerable prognostic significance. We retrospectively assessed data from 255 consecutive surgical patients with a total of 312 aneurysms treated between September 2006 and June 2019 , and selected eight aneurysms that ruptured before clipping. Of the eight intraoperative aneurysm ruptures, four (50%) were anterior communicating artery aneurysms (Acom Ans). The incidence of intraoperative aneurysm rupture was 3.1% of patients and 2.6% of aneurysms. The main contributor to aneurysm rupture was dissection around the aneurysms. The outcomes were favorable in all patients. We considered that the following factors might be involved in the likelihood of an Acom An rupture: the Acom is developmentally fragile, involves several blood vessels, is located deep in the brain, and adheres to the optic chiasma, in addition to the frontal lobe. These considerations indicate that direct surgical manipulation, especially for Acom Ans, can result in intraoperative ruptures and is thus very important for surgeons to bear in mind.
The significance of glycomic profiling has been highlighted by recent findings that structural changes of glycans are observed in many diseases, including cancer. Therefore, glycomic profiling of the whole body (glycome mapping) under different physiopathological states may contribute to the discovery of reliable biomarkers with disease-specific alterations. To achieve this, standardization of high-throughput and in-depth analysis of tissue glycome mapping is needed. However, this is a greatdoi:10.1038/srep43560 pmid:28262709 pmcid:PMC5337905 fatcat:eueza5qqlvar3au7iplfhl6kiq
more »... llenge due to the lack of analytical methodology for glycans on small amounts of endogenous glycoproteins. Here, we established a standardized method of lectin-assisted tissue glycome mapping. Formalin-fixed, paraffin-embedded tissue sections were prepared from brain, liver, kidney, spleen, and testis of two C57BL/6J mice. In total, 190 size-adjusted fragments with different morphology were serially collected from each tissue by laser microdissection and subjected to lectin microarray analysis. The results and subsequent histochemical analysis with selected lectins were highly consistent with previous reports of mass spectrometry-based N-and/or O-glycome analyses and histochemistry. This is the first report to look at both N-and O-glycome profiles of various regions within tissue sections of five different organs. This simple and reproducible mapping approach is also applicable to various disease model mice to facilitate disease-related biomarker discovery.
Completion lobectomy long after segmentectomy in the same lobe is extremely difficult because of severe adhesions around hilar structures, especially in cases involving video-assisted thoracoscopic surgery (VATS) completion lobectomy. We report and compare the surgical outcomes of patients who underwent VATS or thoracotomy completion lobectomy long after radical segmentectomy for lung cancer. Methods: We retrospectively evaluated the surgical outcomes of completion lobectomies performed at ourdoi:10.1186/s13019-019-0941-8 fatcat:3cydrxwey5fvvg4mbaba7zk3di
more »... nstitute long after radical segmentectomies for lung cancer in the same lobe. The efficacy and safety of VATS completion lobectomy was compared to that of thoracotomy completion lobectomy. Results: Ten of 228 patients who underwent radical segmentectomy for lung cancer between 2009 and 2018 underwent completion lobectomy at least a month after segmentectomy; five patients underwent VATS completion lobectomy. None of the patients underwent VATS left upper completion lobectomy, and conversion to thoracotomy was required in one patient. There were no significant differences between VATS and thoracotomy completion lobectomies in the median operative times (VATS 295 min, thoracotomy 339 min, p = 0.55), intraoperative blood loss volumes (VATS 350 mL, thoracotomy 500 mL, p = 0.84), intervals between initial segmentectomy and completion lobectomy (VATS 40 months, thoracotomy 48 months, p = 0.55), and number of patients with pulmonary artery injury (VATS 1, thoracotomy 2, p = 0.49). There was no operation-related mortality. Conclusions: VATS completion lobectomy long after segmentectomy for lung cancer could be performed without fatal complications unless severe adhesions are observed around each main pulmonary artery.
The Review of Laser Engineering
Optical topography, which visualizes brain activation, has been developed over the last several years. It uses near-infrared light to measure the blood-volume change associated with the brain activation in the cortex. The changes are measured at plural points, and topographic images, which show the distributions of the blood volume change, are obtained. In the current study, such optical topography was used to measure brain-functions. To improve spatial resolution of the topographical image,doi:10.2184/lsj.30.636 fatcat:shtnxgxro5bsreqj2fzvjssmia
more »... h-density optical fiber arrangement was proposed. Phantom experiment shows that the spatial resolution is improved by the high-density measurement.
Maki joined Hitachi, Ltd., R & D Group in April 1990. He was an invited researcher of University College London in 2002. He received his PhD in medical engineering. ...doi:10.1117/1.nph.3.1.010801 pmid:26788547 pmcid:PMC4707558 fatcat:oelacrdrpjchvj3ufed2j4ncyy
The mammalian target of the rapamycin (mTOR) system plays multiple, important roles in the brain, regulating both morphology, such as cellular size, shape, and position, and function, such as learning, memory, and social interaction. Tuberous sclerosis complex (TSC) is a congenital disorder caused by a defective suppressor of the mTOR system, the TSC1/TSC2 complex. Almost all brain symptoms of TSC are manifestations of an excessive activity of the mTOR system. Many children with TSC aredoi:10.3390/ijms22136677 pmid:34206526 pmcid:PMC8268912 fatcat:epziyxvtpvbfzm7bl5tb5bqaji
more »... d by intractable epilepsy, intellectual disability, and/or autism. In the brains of infants with TSC, a vicious cycle of epileptic encephalopathy is formed by mTOR hyperactivity, abnormal synaptic structure/function, and excessive epileptic discharges, further worsening epilepsy and intellectual/behavioral disorders. Molecular target therapy with mTOR inhibitors has recently been proved to be efficacious for epilepsy in human TSC patients, and for autism in TSC model mice, indicating the possibility for pharmacological treatment of developmental synaptic disorders.
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