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A Case of Hypo-Responsiveness to Thyroid Hormone

Yumi Kitazawa, Tetsuo Mori, Yukio Sekiguchi, Shigeyuki Matsuzawa, Atsushi Baba, Kazuhiko Washizawa, Yasunobu Wakabayashi, Atsushi Komiyama, Akihiro Sakurai, Kiyoshi Hashizume
1996 Clinical Pediatric Endocrinology  
Although he was neg- ative in neonatal screening, his TSH level was significantly high, implying that his clinical Vo1.5INo.1 Kitazawa et al.  ... 
doi:10.1297/cpe.5.17 fatcat:hxowfxswnjfidnkmvhz4ffopty

Measuring of chiral susceptibility using gradient flow [article]

Atsushi Baba, Shinji Ejiri, Kazuyuki Kanaya, Masakiyo Kitazawa, Takanori Shimojo, Asobu Suzuki, Hiroshi Suzuki, Yusuke Taniguchi, Takashi Umeda
2019 arXiv   pre-print
In lattice QCD with Wilson-type quarks, the chiral symmetry is explicitly broken by the Wilson term on finite lattices. Though the symmetry is guaranteed to recover in the continuum limit, a series of non-trivial procedures are required to recover the correct renormalized theory in the continuum limit. Recently, a new use of the gradient flow technique was proposed, in which correctly renormalized quantities are evaluated in the vanishing flow-time limit. This enables us to directly study the
more » ... iral condensate and its susceptibility with Wilson-type quarks. Extending our previous study of the chiral condensate and its disconnected susceptibility in (2+1)-flavor QCD at a heavy u, d quark mass (m_π/m_ρ≃0.63) and approximately physical s quark mass, we compute the connected contributions to the chiral susceptibility in the temperature range of 178--348 MeV on a fine lattice with a≃0.07 fm.
arXiv:1901.02294v1 fatcat:k4dwnzdg7jc5pk3v4kdyoki424

Calculation of PCAC mass with Wilson fermion using gradient flow [article]

Atsushi Baba, Shinji Ejiri, Kazuyuki Kanaya, Masakiyo Kitazawa, Asobu Suzuki, Hiroshi Suzuki, Yusuke Taniguchi, Takashi Umeda
2020 arXiv   pre-print
We calculate the PCAC mass for (2+1) flavor full QCD with Wilson-type quarks. We adopt the Small Flow-time eXpansion (SFtX) method based on the gradient flow which provides us a general way to compute correctly renormalized observables even if the relevant symmetries for the observable are broken explicitly due to the lattice regularization, such as the Poincáre and chiral symmetries. Our calculation is performed on heavy u, d quarks mass (m_π/m_ρ≃0.63) and approximately physical s quark mass
more » ... th fine lattice a ≃ 0.07 fm. The results are compared with those computed with the Schrödinger functional method.
arXiv:2001.01524v1 fatcat:3satgkhb4nh2dptgf4ucju2uai

PEAK SHIFT ESTIMATION A novel method to estimate ranking of selectively omitted examination data [article]

Satoshi Takahashi and Masaki Kitazawa and Ryoma Aoki and Atsushi Yoshikawa
2021 arXiv   pre-print
In this paper, we focus on examination results when examinees selectively skip examinations, to compare the difficulty levels of these examinations. We call the resultant data 'selectively omitted examination data' Examples of this type of examination are university entrance examinations, certification examinations, and the outcome of students' job-hunting activities. We can learn the number of students accepted for each examination and organization but not the examinees' identity. No research
more » ... as focused on this type of data. When we know the difficulty level of these examinations, we can obtain a new index to assess organization ability, how many students pass, and the difficulty of the examinations. This index would reflect the outcomes of their education corresponding to perspectives on examinations. Therefore, we propose a novel method, Peak Shift Estimation, to estimate the difficulty level of an examination based on selectively omitted examination data. First, we apply Peak Shift Estimation to the simulation data and demonstrate that Peak Shift Estimation estimates the rank order of the difficulty level of university entrance examinations very robustly. Peak Shift Estimation is also suitable for estimating a multi-level scale for universities, that is, A, B, C, and D rank university entrance examinations. We apply Peak Shift Estimation to real data of the Tokyo metropolitan area and demonstrate that the rank correlation coefficient between difficulty level ranking and true ranking is 0.844 and that the difference between 80 percent of universities is within 25 ranks. The accuracy of Peak Shift Estimation is thus low and must be improved; however, this is the first study to focus on ranking selectively omitted examination data, and therefore, one of our contributions is to shed light on this method.
arXiv:2103.05479v1 fatcat:ntwnvbcrq5g3dalwtzwtrgawz4

True Gastric Carcinosarcoma with Rhabdomyosarcomatous Differentiation

Kazunori Tokuda, Atsushi Horiuchi, Shun Akehi, Ken Sakai, Sohei Kitazawa
2019 The Japanese Journal of Gastroenterological Surgery  
doi:10.5833/jjgs.2017.0151 fatcat:k7xmhsgy2fcedne6qym7zydetu

A New Series of Estrogen Receptor Modulators: Effect of Alkyl Substituents on Receptor-Binding Affinity

Atsushi Kamada, Atsushi Sasaki, Noritaka Kitazawa, Tadashi Okabe, Kazumasa Nara, Shinichi Hamaoka, Shin Araki, Hiroaki Hagiwara
2004 Chemical and pharmaceutical bulletin  
New types of selective estrogen receptor modulators (SERMs) were synthesized and evaluated for their binding affinity and biological effect on reproductive cells. A proposed lead structure (B) was derivatized to provide compounds 30 and 44, which showed good estrogen-receptor binding affinity (K i values: 6.3 and 10 nM, respectively), as well as minimal impact on mammary and uterine carcinoma cells. Introduction of an alkyl group in the core structure considerably enhanced receptor-binding
more » ... ity of the compounds tested. Synthesis and structure-activity relationships of these compounds are described.
doi:10.1248/cpb.52.79 pmid:14709872 fatcat:ci7kfzkyfjg2npvbpimlbjefyq

School Virus Infection Simulator for Customizing School Schedules During COVID-19 [article]

Satoshi Takahashi, Masaki Kitazawa, Atsushi Yoshikawa
2022 arXiv   pre-print
During the Coronavirus 2019 (the covid-19) pandemic, schools continuously strive to provide consistent education to their students. Teachers and education policymakers are seeking ways to re-open schools, as it is necessary for community and economic development. However, in light of the pandemic, schools require customized schedules that can address the health concerns and safety of the students considering classroom sizes, air conditioning equipment, classroom systems, e.g., self-contained or
more » ... compartmentalized. To solve this issue, we developed the School-Virus-Infection-Simulator (SVIS) for teachers and education policymakers. SVIS simulates the spread of infection at a school considering the students' lesson schedules, classroom volume, air circulation rates in classrooms, and infectability of the students. Thus, teachers and education policymakers can simulate how their school schedules can impact current health concerns. We then demonstrate the impact of several school schedules in self-contained and departmentalized classrooms and evaluate them in terms of the maximum number of students infected simultaneously and the percentage of face-to-face lessons. The results show that increasing classroom ventilation rate is effective, however, the impact is not stable compared to customizing school schedules, in addition, school schedules can differently impact the maximum number of students infected depending on whether classrooms are self-contained or compartmentalized. It was found that one of school schedules had a higher maximum number of students infected, compared to schedules with a higher percentage of face-to-face lessons. SVIS and the simulation results can help teachers and education policymakers plan school schedules appropriately in order to reduce the maximum number of students infected, while also maintaining a certain percentage of face-to-face lessons.
arXiv:2110.03615v2 fatcat:xbtzmi2uqne6nkoifk4chb6dzq

Serum thiamine level during the initiation term of hemodialysis

Shuji Ono, Junichi Hirata, Yasuhito Hakii, Tomoko Kaneda, Eri Ikeda, Atsushi Kitazawa, Kazuhiko Shibata
2012 Kidney Research and Clinical Practice  
http://dx.doi.org/10.1016/j.krcp.2012.04.511 188 SERUM THIAMINE LEVEL DURING THE INITIATION TERM OF HEMODIALYSIS Shuji Ono, Junichi Hirata, Yasuhito Hakii, Tomoko Kaneda, Eri Ikeda, Atsushi Kitazawa, Kazuhiko  ... 
doi:10.1016/j.krcp.2012.04.512 fatcat:ypcerrkow5e2dknd225yh7ewwa

Unexpectedly Good Neurological Outcome after Prolonged Cardiac Arrest

Kohei Ichinohashi, Tomoaki Natsukawa, Takahiro Ueda, Hirotaka Sawano, Yasuyuki Hayashi, Hironori Shigeoka, Yasuhide Kitazawa, Atsushi Hiraide
2019 Open Journal of Emergency Medicine  
Backgoround: Generally, neurological outcome of patients who have achieved return of spontaneous circulations (ROSC) with abnormal blood tests date and some severe organ complications is extremely poor. Because we experienced a case of good neurological outcome using two different types of extracorporeal membrane oxygenation (ECMO) in spite of prolonged cardiac arrest, we reported this case and reviewed the literature. Case presentation: A 36-year-old male suddenly collapsed at bar after
more » ... g. Initial ECG showed ventricular fibrillation (VF) and subsequently underwent advanced cardiovascular life support. On admission, the ECG still showed VF, but pupillary light reflex was faintly present. Then, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support was established 54 minutes after collapse. Blood tests showed lactate was 15.8 mmol/l and NH 3 of 251 μg/dl. To improve respiratory function after cardiogenic shock, we changed to veno-venous ECMO (VV-ECMO) and removed superabundant fluid using continuous hemodiafiltration. Patient was discharged on day-26 after a full functional recovery. Conclusion: In severe respiratory disorder, it would be more effective to change to VV-ECMO after recovering from cardiogenic shock while removing superabundant fluid using continuous hemodiafiltration. In predicting the neurological outcome of a post cardiac arrest patient, the presence of a pupillary light reflex may be more significant than NH 3 and lactate.
doi:10.4236/ojem.2019.71001 fatcat:p5ejkfuu2nazrhjtiidlkwyprm

AnalyzingIn-store Shopping Paths from Indirect Observation with RFIDTags Communication Data

Toshiki Fujino, Masaki Kitazawa, Takashi Yamada, Masakazu Takahashi, Gaku Yamamoto, Atsushi Yoshikawa, Takao Terano
2014 Journal on Innovation and Sustainability  
Toshiki Fujino, Masaki Kitazawa, Takashi Yamada, Masakazu Takahashi, Gaku Yamamoto, Atsushi Yoshikawa, Takao Terano  ... 
doi:10.24212/2179-3565.2014v5i1p88-96 fatcat:q2qe4w2psnbkzjgirugdgzlmym

Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling [article]

Satoshi Yoshinaga, Minkyung Shin, Ayako Kitazawa, Kazuhiro Ishii, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-ichiro Kubo, Kazunori Nakajima
2020 bioRxiv   pre-print
Kitazawa, K.I., and M.T.; Writing ---Original Draft, S.Y.; Writing --Editing, K.K. and K.N.; Visulalization, S.Y., M.T., and A. Kasai; Supervision, K.K. and K.N.Acquisition, S.Y., A.  ... 
doi:10.1101/2020.10.05.317925 fatcat:ykqmrnduf5fhnf33ry2eznam5q

Study of energy-momentum tensor correlation function in N_f=2+1 full QCD for QGP viscosities [article]

Yusuke Taniguchi, Atsushi Baba, Shinji Ejiri, Kazuyuki Kanaya, Masakiyo Kitazawa, Takanori Shimojo, Asobu Suzuki, Hiroshi Suzuki, Takashi Umeda
2019 arXiv   pre-print
We study correlation functions of the energy-momentum tensor (EMT) in (2+1)-flavor full QCD to evaluate QGP viscosities. We adopt nonperturbatively improved Wilson fermion and Iwasaki gauge action. Our degenerate u, d quark mass is rather heavy with m_π/m_ρ≃0.63, while the s quark mass is set to approximately its physical value. Performing simulations on lattices with N_t=16 to 6 at a fine lattice spacing of a=0.07 fm, the temperature range of T≃174--464 MeV is covered using the fixed-scale
more » ... oach. We attempt to compute viscosities by three steps: (1) calculate two point correlation functions of non-perturbatively renormalized EMT applying the gradient flow method, (2) derive the spectral function from correlation function, and (3) extract viscosities from the spectral function applying the Kubo formula. We report on the status of the project and present preliminary results for the shear viscosity in the high temperature phase.
arXiv:1901.01666v1 fatcat:22yb42whfbcqrpujw6fo33ou7i

Identification of microRNAs involved in acute rejection and spontaneous tolerance in murine hepatic allografts

Miwa Morita, Jiajie Chen, Masayuki Fujino, Yusuke Kitazawa, Atsushi Sugioka, Liang Zhong, Xiao-Kang Li
2014 Scientific Reports  
Graft acceptance without the need for immunosuppressive drugs is the ultimate goal of transplantation therapy. In murine liver transplantation, allografts are accepted across major histocompatibility antigen complex barriers without the use of immunosuppressive drugs and constitute a suitable model for research on immunological rejection and tolerance. MicroRNA (miRNA) has been known to be involved in the immunological responses. In order to identify mRNAs in spontaneous liver allograft
more » ... e, miRNA expression in hepatic allografts was examined using this transplantation model. According to the graft pathological score and function, miR-146a, 15b, 223, 23a, 27a, 34a and 451 were upregulated compared with the expression observed in the syngeneic grafts. In contrast, miR-101a, 101b and 148a were downregulated. Our results demonstrated the alteration of miRNAs in the allografts and may indicate the role of miRNAs in the induction of tolerance after transplantation. Furthermore, our data suggest that monitoring the graft expression of novel miRNAs may allow clinicians to differentiate between rejection and tolerance. A better understanding of the tolerance inducing mechanism observed in murine hepatic allografts may provide a therapeutic strategy for attenuating allograft rejection.
doi:10.1038/srep06649 pmid:25323448 pmcid:PMC5377586 fatcat:xwuene5ru5cs7dvd76vfg7nm7e

Determination of the endpoint of the first order deconfiniement phase transition in the heavy quark region of QCD [article]

Shinji Ejiri, Shota Itagaki, Ryo Iwami, Kazuyuki Kanaya, Masakiyo Kitazawa, Atsushi Kiyohara, Mizuki Shirogane, Yusuke Taniguchi, Takashi Umeda
2019 arXiv   pre-print
We study the endpoint of the first order deconfinement phase transition of 2 and 2+1 flavor QCD in the heavy quark region. We perform simulations of quenched QCD and apply the reweighting method to study the heavy quark region. The quark determinant for the reweighting is evaluated by a hopping parameter expansion. To reduce the overlap problem, we introduce an external source term of the Polyakov loop in the simulation. We study the location of critical point at which the first order phase
more » ... sition changes to crossover by investigating the histogram of the Polyakov loop and applying the finite-size scaling analysis. We estimate the truncation error of the hopping parameter expansion, and discuss the lattice spacing dependence and the spatial volume dependence in the result of the critical point.
arXiv:1912.11426v1 fatcat:ikzyuuuwr5gn5iuwgotqjuxkqy

Effects of High Temperature Treatment on the Sprouting and Elongation Rate of Asparagus Spears

Shin-ichi Watanabe, Masanori Matsuo, Hiroaki Kitazawa, Machiko Fukuda, Atsushi Yamasaki, Atsuko Uragami
2019 The Horticulture Journal  
et al., 2014 (Kitazawa et al., , 2016 .  ...  Low concentrations of oxygen (Kitazawa et al., 2014) or high concentrations of carbon dioxide in combination with low oxygen (Kitazawa et al., 2016) suppress spear sprouting.  ... 
doi:10.2503/hortj.okd-161 fatcat:4ffczzyznnefredl54ltg5u5pe
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