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Advances in functional neuroimaging in dementias and potential pitfalls

Katherine Standley, Charles Brock, Michael Hoffmann
2012 Neurology International  
Structural imaging has given way to functional, metabolic and receptor imaging.  ...  Neuroimaging is continuously advancing at a rapid rate and has progressed from excluding relatively uncommon secondary causes (stroke, tumor) to assisting with early diagnosis and subtype of dementia.  ...  Acknowledgments: presented in part at the 2011 Annual Meeting of the Florida Society of Neurology Lake Buena Vista, Florida September  ... 
doi:10.4081/ni.2012.e7 pmid:22593811 pmcid:PMC3349962 fatcat:adid33psabfbrkit6omtbhhi5q

What can imaging tell us about cognitive impairment and dementia?

Leela Narayanan, Alison Dorothy Murray
2016 World Journal of Radiology  
glucose positron emission tomography (PET), amyloid PET, tau PET, are currently within the realm of dementia research but are available for clinical use.  ...  Advanced magnetic resonance imaging (MRI) techniques, such as functional connectivity MRI, diffusion tensor imaging and magnetic resonance spectroscopy, and molecular imaging techniques, such as 18F fluoro-deoxy  ...  Amyloid positron emission tomography imaging has recently been introduced into clinical practice and is likely to be most useful in early onset Alzheimer's disease.  ... 
doi:10.4329/wjr.v8.i3.240 pmid:27029053 pmcid:PMC4807333 fatcat:jt6vq7lyjbgfvoih4gph5is32u

Potential neuroimaging biomarkers of pathologic brain changes in Mild Cognitive Impairment and Alzheimer's disease: a systematic review

Qingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Zhijun Bao, Antonio Greco, Zhuowei Yu
2016 BMC Geriatrics  
The dynamic measures of these imaging biomarkers are used to predict the disease progression in the early stages and improve the assessment of therapeutic efficacy in these diseases in future clinical  ...  Conclusions: The panel of noninvasive neuroimaging-biomarkers reviewed provides a set methods to measure brain structural and functional pathophysiological changes in vivo, which are closely associated  ...  Diffusion MRI The diffusion tensor imaging (DTI) metrics including fractional anisotropy (FA), mean diffusivity, axial diffusivity and radial diffusivity (RA), can assess the connectivity between brain  ... 
doi:10.1186/s12877-016-0281-7 pmid:27184250 pmcid:PMC4869390 fatcat:spci42k24rarvkagqslsivbfd4

Imaging as a biomarker in drug discovery for Alzheimer's disease: is MRI a suitable technology?

Emilio Merlo Pich, Andreas Jeromin, Giovanni B Frisoni, Derek Hill, Andrew Lockhart, Mark E Schmidt, Martin R Turner, Stefania Mondello, William Z Potter
2014 Alzheimer's Research & Therapy  
application in multimodal approaches which include other imaging technologies, such as positron emission tomography, electroencephalography, and magnetoencephalography.  ...  This review provides perspectives on the utility of magnetic resonance imaging (MRI) as a neuroimaging approach in the development of novel treatments for Alzheimer's disease.  ...  Acknowledgments We thank the participants of the Wellcome Trust meeting on Brain Disorders for discussion, the Wellcome Trust for support, and Treasan Creavin and Lucy Criddle for their help in organizing  ... 
doi:10.1186/alzrt276 pmid:25484927 pmcid:PMC4255417 fatcat:oauvmaotwvbepcbsjzgwtiyxhi

Imaging Brain Metabolism and Pathology in Alzheimer 's Disease with Positron Emission Tomography

Riddle WR Claassen D
2014 Journal of Alzheimer's Disease & Parkinsonism  
Current Positron Emission Tomography (PET) biomarkers for Alzheimer's disease (AD) assess either neuronal function, or associated pathological features of this common neurodegenerative disease.  ...  Already, amyloid PET imaging is a tool that allows in vivo imaging of extracellular beta-amyloid levels.  ...  Alzheimer's Disease and Metabolism Current Positron Emission Tomography (PET) biomarkers for Alzheimer's disease (AD) assess either neuronal function, or associated pathological features of this common  ... 
doi:10.4172/2161-0460.1000143 pmid:25343059 pmcid:PMC4204649 fatcat:3v6l6lhojbbwbkfw6yrkgt7zia

The use of PET/MRI in Dementia: A Literature Review

Nicole Lorking, Alison D. Murray, John T. O'Brien
2021 International Journal of Geriatric Psychiatry  
Positron emission tomography-magnetic resonance imaging (PET/MRI) is an emerging hybrid imaging system in clinical nuclear medicine.  ...  A comprehensive literature search using the PubMed database was conducted to retrieve studies using PET/MRI in relation to the topics of mild cognitive impairment, dementia, or Alzheimer's disease between  ...  PET amyloid imaging in management of Alzheimer's disease‐review 52. Scherr M, Utz L, Tahmasian M, et al. Effective connectivity in the of literature and interesting images.  ... 
doi:10.1002/gps.5586 pmid:34490651 fatcat:qbw5i4egrfhcze36qwu2yygjue

Secondary prevention of Alzheimer's dementia: neuroimaging contributions

Mara ten Kate, Silvia Ingala, Adam J. Schwarz, Nick C. Fox, Gaël Chételat, Bart N. M. van Berckel, Michael Ewers, Christopher Foley, Juan Domingo Gispert, Derek Hill, Michael C. Irizarry, Adriaan A. Lammertsma (+9 others)
2018 Alzheimer's Research & Therapy  
In Alzheimer's disease (AD), pathological changes may arise up to 20 years before the onset of dementia. This pre-dementia window provides a unique opportunity for secondary prevention.  ...  We review available evidence for the use of neuroimaging in clinical trials in pre-dementia AD.  ...  disease, ASL arterial spin labelling, DTI diffusion tensor imaging, FDG fluorodeoxyglucose, MCI mild cognitive impairment, PET positron emission tomography, rs-fMRI resting state functional magnetic resonance  ... 
doi:10.1186/s13195-018-0438-z pmid:30376881 pmcid:PMC6208183 fatcat:rbbvlm6jajb2hnke62sxe576iy

An Algorithm for Preclinical Diagnosis of Alzheimer's Disease

Tapan K. Khan
2018 Frontiers in Neuroscience  
Functional MRI (fMRI), diffusion tensor imaging (DTI) MRI, arterial spin labeling (ASL) MRI, and advanced PET have potential application in preclinical AD diagnosis.  ...  Almost all Alzheimer's disease (AD) therapeutic trials have failed in recent years.  ...  Cassandra George for assisting in the preparation of this manuscript. The author is grateful to the honorable editor and reviewers for their valuable comments for the improvement of this article.  ... 
doi:10.3389/fnins.2018.00275 pmid:29760644 pmcid:PMC5936981 fatcat:7upo64ocv5dgvh6hn5znwhb7ze

Ischemic brain injury in cerebral amyloid angiopathy

Yael D Reijmer, Susanne J van Veluw, Steven M Greenberg
2015 Journal of Cerebral Blood Flow and Metabolism  
with diffusion tensor imaging.  ...  Widespread ischemic tissue injury may affect cognition by disrupting white-matter connectivity, thereby hampering communication between brain regions.  ...  emission tomography (PET).  ... 
doi:10.1038/jcbfm.2015.88 pmid:25944592 pmcid:PMC4758563 fatcat:f6esw3ui2be7jnsgsk6vvyyi2i

WHITE MATTER MICROSTRUCTURE AND AMYLOID AGGREGATION IN COGNITIVELY HEALTHY, ELDERLY IDENTICAL TWINS

Anouk den Braber, Kristine Stickney, Dennis van 't Ent, Mara ten Kate, Elles Konijnenberg, Jori Tomassen, Frederik Barkhof, Bart N.M. van Berckel, Dorret I. Boomsma, Eco de Geus, Philip Scheltens, Pieter Jelle Visser
2018 Alzheimer's & Dementia  
Given the pernicious effects of Alzheimer's disease (AD)-related neurodegeneration on functional capacity of multiple brain networks, AD pathophysiology may have implications for stress adaptation, which  ...  Methods: In the current study, we examined the relationship between self-perceptions of stress adaptation and the neurobiological response to a laboratory model of stress adaptation in amnestic mild cognitive  ...  One currently established biomarker is positron emission tomography (PET) measured amyloid b load.  ... 
doi:10.1016/j.jalz.2018.06.427 fatcat:elmoz72brjbbri23hkyye5kxzi

AGE AND APOE GENOTYPE INTERACTION ON WHITE MATTER MYELIN IN COGNITIVELY NORMAL MIDDLE-AGED PARTICIPANTS

Grégory Operto, Jose Luis Molinuevo, Carles Falcon, Raffaele Cacciaglia, Anna Brugulat-Serrat, Oriol Grau-Rivera, Marc Suárez-Calvet, Juan Domingo Gispert
2019 Alzheimer's & Dementia  
integrity (i.e., diffusion tensor imaging [DTI] measures of fractional anisotropy [FA] and mean  ...  ) and diffusion tensor im- Danielle June, Owen A.  ... 
doi:10.1016/j.jalz.2019.06.2748 fatcat:xbwvmc6olfahxhwgwel2qyyewm

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer's disease [article]

Alexa Pichet Binette, Guillaume Theaud, François Rheault, Maggie Roy, D. Louis Collins, John C.S. Breitner, Judes Poirier, Maxime Descoteaux, Sylvia Villeneuve, PREVENT-AD Research Group
2020 bioRxiv   pre-print
Combining diffusion imaging and positron emission tomography, we investigated associations between Aβ, tau and white matter microstructure specifically in bundles connecting brain regions in which AD pathology  ...  Beta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer's disease (AD), are believed to spread through connected regions.  ...  Positron emission tomography (PET) can image both proteins in vivo Klunk et al., 2004; Schöll et al., 2016) , and thus help identifying the earliest brain changes associated with such pathologies.  ... 
doi:10.1101/2020.08.27.266551 fatcat:tc5lv4ryszfzngoto56uvuo7iy

Neurological update: neuroimaging in dementia

Timothy Rittman
2020 Journal of Neurology  
This review covers some updates in the understanding of dementia using structural imaging, positron emission tomography (PET), structural and functional connectivity, and using big data and artificial  ...  There are challenges in translating novel imaging techniques to clinical practice, particularly in developing standard methodologies and overcoming regulatory issues.  ...  Positron emission tomography (PET) The pathology of dementia in vivo promises to be revealed by the fastest growing player in dementia imaging: Positron Emission Tomography (PET).  ... 
doi:10.1007/s00415-020-10040-0 pmid:32638104 fatcat:ubm324kkyrgq3kf6fiiyv7gjxu

ANALYSIS OF ALZHEIMER DISEASE PREDICTION USING MACHINE LEARNING TECHNIQUES

B. Hemalatha, Dr. M. Renukadevi
2021 Information Technology in Industry  
Various imaging methods are used to diagnose AD, and image modes play a key role in the diagnosis of AD. This paper uses a Positron Emission Tomography (PET) image to detect AD early.  ...  Alzheimer's Disease (AD) is referred to as one of the highest non-unusual neurodegenerative disorders that inflict eternal harm to the memory-associated brain cells and wonder skills.  ...  RELATED WORK Medical imaging data comes in a number of forms, such as structural or functional MRI, Diffusion Tensor Imaging (DTI), Positron Emission Tomography (PET), Computed Tomography (CT scan).  ... 
doi:10.17762/itii.v9i1.165 fatcat:sskgxiaqnrdlznebdr6mgsf5s4

Emerging Biomarkers in Cognition

Meredith Wicklund, Ronald C. Petersen
2013 Clinics in Geriatric Medicine  
This article focuses on biomarkers for mild cognitive impairment caused by Alzheimer disease, structural magnetic resonance imaging, fluorodeoxyglucose positron emission tomography (PET) or single-photon  ...  emission computed tomography, and PET with dopamine ligands.  ...  PET Amyloid Imaging Amyloid imaging via a positron emission tomography (PET) tracer binding to fibrillar amyloid was introduced around 2004, using the carbon 11 Pittsburgh compound B (PiB). 13 The short  ... 
doi:10.1016/j.cger.2013.07.006 pmid:24094298 pmcid:PMC3968430 fatcat:qppzzenrfzer5htaypbgmwy56m
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