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Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia

Katherine H. Karlsgodt, Daqiang Sun, Amy M. Jimenez, Evan S. Lutkenhoff, Rachael Willhite, Theo G. M. van Erp, Tyrone D. Cannon
2008 Development and Psychopathology  
This article reviews genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder.  ...  susceptibility genes that affect processes involved in establishing intra-and interregional connectivity.  ...  brain changes are associated with schizophrenia-related gene variations.  ... 
doi:10.1017/s095457940800062x pmid:18838043 fatcat:ri3ekde2wjb4rhibji7lbywe2m

Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach

Elliot Murphy, Antonio Benítez-Burraco
2016 Frontiers in Human Neuroscience  
Additionally, we will show that candidate genes for schizophrenia are overrepresented among the set of genes that are believed to be important for the evolution of the human faculty of language.  ...  These genes crucially include (and are related to) genes involved in brain rhythmicity.  ...  Accordingly, nearly 5% of the human genes are expected to be related to the disease [assuming that the human genome contains about 20,000 protein-coding genes and that about 1000 of them have been associated  ... 
doi:10.3389/fnhum.2016.00422 pmid:27601987 pmcid:PMC4993770 fatcat:kxzgapyzzrdgpkcmwsavvwzaom

Cortical white matter: beyond the pale remarks, main conclusions and discussion

DeFelipe
2010 Frontiers in Neuroanatomy  
One of the most promising schizophrenia-related genes is neuregulin 1 (NRG1) gene.  ...  The subcortical WM and its resident IN have been associated with a variety of neurological and psychiatric disorders.  ...  A commentary on Linking white and grey matter in schizophrenia: Oligodendrocyte and neuron pathology in the prefrontal cortex by Höistad, M., Segal, D., Takahashi, N., Sakurai, T., Buxbaum, J.  ... 
doi:10.3389/neuro.05.004.2010 pmid:20428509 pmcid:PMC2859874 fatcat:vpuvvsmpvbbgtprjulwh6muqty

The 3rd Schizophrenia International Research Society Conference, 14–18 April 2012, Florence, Italy: Summaries of oral sessions

Brandon Abbs, Rashmin M. Achalia, Adegoke O. Adelufosi, Ahmet Yiğit Aktener, Natalie J. Beveridge, Savita G. Bhakta, Rachael K. Blackman, Emre Bora, M.S. Byun, Maurice Cabanis, Ricardo Carrion, Christina A. Castellani (+25 others)
2012 Schizophrenia Research  
an update on current investigations ongoing in the field of schizophrenia research.  ...  The following report is a composite of these reviews.  ...  The information in these reports and the accuracy of each statement were the sole responsibility of each rapporteur and are based on personal interpretations of what was heard.  ... 
doi:10.1016/j.schres.2012.07.024 pmid:22910407 pmcid:PMC3877922 fatcat:kjoz7q232zejnfnvpuogpobsfa

The 2nd Schizophrenia International Research Society Conference, 10–14 April 2010, Florence, Italy: Summaries of oral sessions

Moogeh Baharnoori, Cali Bartholomeusz, Aurelie A. Boucher, Lisa Buchy, Christopher Chaddock, Bonga Chiliza, Melanie Föcking, Alex Fornito, Juan A. Gallego, Hiroaki Hori, Gisele Huf, Gul A. Jabbar (+20 others)
2010 Schizophrenia Research  
After the association studies, other findings implicated dysbindin and neuregulin 1 function in phenotypes associated with schizophrenia.  ...  Interestingly, they found that H3K4me3 peaks at several high risk loci such as transcription site for DARPP32 (a target gene in dopaminergic system) and also Neuregulin-1 (NRG1), a promising susceptibility  ...  Additionally, it has been shown that longer DUP is associated with smaller grey matter in cingulate, frontal, temporal and insular cortex (Lappin et al. 2006) . Dr.  ... 
doi:10.1016/j.schres.2010.09.008 pmid:20934307 pmcid:PMC4182935 fatcat:aca7cqdp35gotmhphwkqimwsre

Schizophrenia: from phenomenology to neurobiology

Albert Hung Choy Wong, Hubert H.M. Van Tol
2003 Neuroscience and Biobehavioral Reviews  
Schizophrenia is a complex genetic disorder in which many genes may be implicated, with the possibility of gene -gene interactions and a diversity of genetic causes in different families or populations  ...  Structural brain changes are present in vivo and post-mortem, with both histopathological and imaging studies in overall agreement that the temporal and frontal lobes of the cerebral cortex are the most  ...  [78] Decreased perfusion and metabolism in frontal regions Ingvar and Franzen [93] Gur et al. [94] Kurachi et al. [95] Gur [96] Berman et al. [97] Weinberger et al. [98] Geraud et al.  ... 
doi:10.1016/s0149-7634(03)00035-6 pmid:12788337 fatcat:lrlbw2qy4vh2pdajb6oemeslxq

Imaging phenotypes of major depressive disorder: genetic correlates

J.B. Savitz, W.C. Drevets
2009 Neuroscience  
Concerning neuroreceptor PET imaging, decreased 5-HT 1A binding potential in the raphe, medial temporal lobe, and medial prefrontal cortex (mPFC) has been strongly associated with MDD, and may be impacted  ...  by a functional single nucleotide polymorphism in the promoter region of the 5-HT 1A gene (HTR1A: -1019C/G; rs6295).  ...  Variants of this gene class such as oligodendrocyte lineage transcription factor 2 (OLIG2), Neuregulin 1 (NRG1), and v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) have been directly  ... 
doi:10.1016/j.neuroscience.2009.03.082 pmid:19358877 pmcid:PMC2760612 fatcat:tq7cpwflwbgqdll7t5cfsk2xae

Poster Session II

2005 Neuropsychopharmacology  
These results will be discussed in light of other studies showing evidence of frontal-subcortical dysfunction in cocaine dependent subjects.  ...  Based on prior animal and human studies suggesting that demyelination increases diffusion normal to the direction of fiber tracts λ2 with minimal effect on λ1 our findings are consistent with a reduction  ...  Schizophrenia is Associated with Increased Synaptic Dopamine in Associative Rather than Limbic Regions of the Striatum Marc Laruelle*, Lawrence S Kegeles, Gordon W Frankle, Raj Narendran, Roberto Gil,  ... 
doi:10.1038/sj.npp.1300970 fatcat:ikayo4dkwrdrthgopr2hltn2hi

Poster Session I

2010 Neuropsychopharmacology  
paralleling what is observed in humans.  ...  Since its clinical efficacy is characterized by a lag in onset of 1-3 weeks, it is reasonable that the therapeutic effect requires reprogramming of gene expression.  ...  Discussion: Depression is associated with increased susceptibility of T-cells to the HIV virus ex-vivo.  ... 
doi:10.1038/npp.2010.216 fatcat:v3q2xjxc45b2hckv33pzz7mtee

Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring

K. E. Stephan, K. J. Friston, C. D. Frith
2009 Schizophrenia Bulletin  
Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal functional integration  ...  This article addresses these 3 issues in the framework of the dysconnection hypothesis.  ...  Johnstone for her comments on an earlier version of this article.  ... 
doi:10.1093/schbul/sbn176 pmid:19155345 pmcid:PMC2669579 fatcat:rpwss5sb3rbb7owar3hdycy3ca

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
In our presentation last year at the ACNP, we reported a) the pharmacological characterization of the COX-1 and COX-2 radioligands using in vitro enzymatic assays in monkey and human blood, and b) initial  ...  In contrast, COX-2 is minimally expressed at baseline in several peripheral tissues but markedly upregulated by inflammation at the level of both gene transcription and protein synthesis.  ...  Patient-specific iPS cells (Controls and Schizophrenics) were treated with Neuregulin-1(NRG1) ligands.  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

Poster Session III-Wednesday

2013 Neuropsychopharmacology  
tions about the sensory effects of meditation may be warranted. Abstracts S436 ACNP 52nd Annual Conference  ...  Many of the associated genes interact on a molecular level and, in combination with the results from our initial custom chip, provide strong evidence for the involvement of the glutamate and neuregulin-ErbB4  ...  A novel exon overlaps with the central part of exon 11, while many splicing events were also detected in the 3 0 end of the gene.  ... 
doi:10.1038/npp.2013.281 fatcat:n2o3tllrsrbyxgzsfwzhl5psua

Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012

2012 International Journal of Neuropsychopharmacology  
(GADD45b), somatostatin (SST), and serum/glucocorticoid regulated kinase 1 (SGK1), previously implicated in neurodegenerative and mood disorders, in the frontal cortex of a novel brain cohort from patients  ...  Methods : This current investigation assessed gene expression changes of fibroblast growth factor 2 (FGF2), microtubule-associate protein 2 (MAP2), growth arrest and DNA-damage-inducible protein 45 beta  ...  When multiple SNPs in a gene are associated with a trait, a gene-level test may be a powerful approach for detecting association with variation in the gene.  ... 
doi:10.1017/s1461145712000508 fatcat:ft6ipgmb45azzjxouthbqdn43i

The underlying mechanisms of mismatch negativity response in 22q11.2 deletion syndrome

Lucia-Manuela Cantonas, Christoph Michel, Tonia Rihs
2020
.; Abnormal auditory processing and underlying structural changes in 22q11.2Deletion Syndrome; Schizophrenia Bulletin. 2020, doi: 10.1093/schbul/sbaa104 In addition, some of the methods used here are based  ...  Seeber M, Cantonas LM, Hoevels M, Sesia T, Visser-Vandewalle V, Michel CM.; Subcortical electrophysiological activity is detectable with high-density EEG source imaging. Nature Communication 10, 753,  ...  Neuregulin-1 is one of susceptibility genes for schizophrenia involved in glutamatergic and GABAergic signalling [228] .  ... 
doi:10.13097/archive-ouverte/unige:149673 fatcat:qubgngfrbzbv5dk2zxk2egl4ju