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Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults

Wei Li, Christian Langkammer, Ying-Hui Chou, Katja Petrovic, Reinhold Schmidt, Allen W. Song, David J. Madden, Stefan Ropele, Chunlei Liu
2015 NeuroImage  
Independent of gender, age, and global cognitive function, increasing magnetic susceptibility in the globus pallidus and red nuclei was associated with decreasing manual dexterity.  ...  In this study, we explored the correlation between magnetic susceptibility--a surrogate marker of brain iron--of these gray matter structures with behavioral measures of motor and cognitive abilities,  ...  Acknowledgment The study is supported by the National Institutes of Health (NIH) through grant R01 MH096979 to C. L. C. L. and A.W.  ... 
doi:10.1016/j.neuroimage.2014.10.009 pmid:25315786 pmcid:PMC4339282 fatcat:p3jriuquzrbzbdjibuwyt3lwxm

Age-related magnetic susceptibility changes in deep grey matter and cerebral cortex of normal young and middle-aged adults depicted by whole brain analysis

Romana Burgetova, Petr Dusek, Andrea Burgetova, Adam Pudlac, Manuela Vaneckova, Dana Horakova, Jan Krasensky, Zsoka Varga, Lukas Lambert
2021 Quantitative Imaging in Medicine and Surgery  
Our goal was to conduct a detailed analysis of iron deposition patterns in the cerebral deep grey matter and cortex using region-based and whole-brain analyses of brain magnetic susceptibility.  ...  Thalamic susceptibility increased until the fourth decade and decreased thereafter with the exception of the pulvinar where susceptibility increase was observed throughout the adult lifespan.  ...  Discussion In this study, we quantified age-related changes of magnetic susceptibility in deep grey matter structures and the cerebral cortex in a cohort of adult healthy individuals using whole-brain  ... 
doi:10.21037/qims-21-87 pmid:34476177 pmcid:PMC8339659 fatcat:xvgh7xiszrbpte7jb3fhw4vmjm

Quantitative susceptibility mapping to evaluate brain iron deposition and its correlation with physiological parameters in hypertensive patients

Xin Li, Dayong Jin, Yinhu Zhu, Liyao Liu, Yanqiang Qiao, Yifan Qian, Juan Tian, Boyuan Jiang, Chunkai Hou, Jigang Geng, Xiaoshi Li, Xiaohua Gao (+4 others)
2021 Annals of Translational Medicine  
These results are indicative of the role of overload brain iron in deep brain gray matter nuclei in HP and suggest that HP is associated with excess brain iron in certain deep gray matter regions.  ...  Differences in brain iron deposition in deep gray matter nuclei of participants were compared between HP and HC.  ...  Our results show that excessive iron in the deep gray matter nuclei of the brain plays a role in HP, which suggests HP is associated with excess brain iron in certain deep gray matter regions.  ... 
doi:10.21037/atm-21-5170 pmid:34790788 pmcid:PMC8576670 fatcat:gj7ejqenwzabppxwjqbivkx7tq

Characterization of Iron Accumulation in Deep Gray Matter in Myotonic Dystrophy Type 1 and 2 Using Quantitative Susceptibility Mapping and R2* Relaxometry: A Magnetic Resonance Imaging Study at 3 Tesla

Sevda Ates, Andreas Deistung, Ruth Schneider, Christian Prehn, Carsten Lukas, Jürgen R. Reichenbach, Christiane Schneider-Gold, Barbara Bellenberg
2019 Frontiers in Neurology  
In this prospective, explorative study the iron accumulation in deep gray matter nuclei (DGM) in myotonic dystrophy type 1 (DM1) and 2 (DM2) and its clinical and neuro-cognitive relevance using susceptibility  ...  Quantitative mapping of the magnetic susceptibility and the effective transverse relaxation rate (R2*) are suitable to assess the iron content in distinct brain regions.  ...  Likewise, we thank all healthy volunteers for taking part in the MRI examinations. We also thank the staff of the Neurological Clinic (St.  ... 
doi:10.3389/fneur.2019.01320 pmid:31920940 pmcid:PMC6923271 fatcat:7s7zdk5yp5aqti3b5b2pw6w7ty

Iron Content in Deep Gray Matter as a Function of Age Using Quantitative Susceptibility Mapping: A Multicenter Study

Yan Li, Sean K Sethi, Chunyan Zhang, Yanwei Miao, Kiran Kumar Yerramsetty, Vinay Kumar Palutla, Sara Gharabaghi, Chengyan Wang, Naying He, Jingliang Cheng, Fuhua Yan, Ewart Mark Haacke
2021 Frontiers in Neuroscience  
of deep gray matter (DGM) of the human brain using subjects from multiple sites; and to establish a susceptibility baseline as a function of age for each DGM structure using both a global and regional  ...  Eight subcortical gray matter nuclei were semi-automatically segmented using a full-width half maximum threshold-based analysis of the QSM data.  ...  Kofi (2015) assessed the reproducibility of brain QSM in healthy controls (HC) and Abbreviations: QSM, quantitative susceptibility mapping; DGM, deep gray matter; GRE, gradient echo; HC, healthy controls  ... 
doi:10.3389/fnins.2020.607705 pmid:33488350 pmcid:PMC7815653 fatcat:7q7smao4szhzzmn3jvgmfzptj4

Increased Magnetic Susceptibility in the Deep Gray Matter Nuclei of Wilson's Disease: Have We Been Ignoring Atrophy?

Xiao-Zhong Jing, Xiang-Zhen Yuan, Gai-Ying Li, Jia-Lin Chen, Rong Wu, Ling-Li Yang, Shu-Yun Zhang, Xiao-Ping Wang, Jian-Qi Li
2022 Frontiers in Neuroscience  
and total susceptibility of multiple deep gray matter nuclei in patients with WD were higher than those in healthy controls.  ...  BackgroundHistopathological studies in Wilson's disease (WD) have revealed increased copper and iron concentrations in the deep gray matter nuclei.  ...  In summary, significantly increased mean bulk susceptibility and total susceptibility were observed in the majority of deep gray matter nuclei of both patients with neuro-WD and patients with hep-WD.  ... 
doi:10.3389/fnins.2022.794375 pmid:35720701 pmcid:PMC9198485 fatcat:f3wth77hnrhmxlmikhfiptw5jy

Longitudinal Study of Iron Deposition and Volume in the Precentral Gyrus in Patients with Relapse-Remitting Multiple Sclerosis

Silin Du, Chun Zeng, Zhiwei Zhang
2020 Journal of Biosciences and Medicines  
The mean phase values (MPVs) and volumes in precentral gyrus gray matter (PGM) were measured, and change of iron content and its correlation with volume, clinical manifestations were analyzed.  ...  Methods: Thirty RRMS patients and thirty age-and sex-matched healthy controls were recruited and underwent ESWAN and 3D T 1 WI twice interval of one year with the same parameters.  ...  content increased and atrophy in deep brain gray matter nuclei, also concluded that iron deposition and atrophy in deep brain gray matter nuclei are more powerful influence than lesion load of white matter  ... 
doi:10.4236/jbm.2020.85008 fatcat:un75zc4w3ncnhby3kvx32ac6gm

Neonate and infant brain development from birth to 2 years assessed using MRI-based quantitative susceptibility mapping

Yuyao Zhang, Jingjing Shi, Hongjiang Wei, Victor Han, Wen-Zhen Zhu, Chunlei Liu
2019 NeuroImage  
The contrast between the gray and white matters on the QSM images did not change through brain development from neonate to adult.  ...  Also, the magnetic susceptibility values of the cerebral spinal fluid (CSF) exhibit a gradually decreasing trend from birth to 2 years old and to adulthood.  ...  Susceptibility in Deep Gray Matter (DGM) Fig. 6 shows the development of R2* and susceptibility in DGM nuclei at different ages.  ... 
doi:10.1016/j.neuroimage.2018.10.031 pmid:30315906 pmcid:PMC6292682 fatcat:uoj5pwvvxbf4znc7g7jxs4smu4

Age and sex related differences in subcortical brain iron concentrations among healthy adults

Ninni Persson, Jianlin Wu, Qing Zhang, Ting Liu, Jing Shen, Ruyi Bao, Mingfei Ni, Tian Liu, Yi Wang, Pascal Spincemaille
2015 NeuroImage  
Age and sex can influence brain iron levels. We studied the influence of these variables on deep gray matter magnetic susceptibilities.  ...  Women expected to be post menopause (+51 years) showed lower total magnetic susceptibility in the subcortical gray matter.  ...  Acknowledgments This work was supported in part by a grant: R01EB013443, from the National Institute on Aging to YW, Grants FOA11H-349 & FOA13H-090 from the Royal Swedish Society of Sciences, & Solstickan  ... 
doi:10.1016/j.neuroimage.2015.07.050 pmid:26216277 pmcid:PMC4737643 fatcat:4rkgsewrlbhpjenx3pkkv432g4

Correlation of dystonia severity and iron accumulation in Rett syndrome

Tz-Yun Jan, Lee-Chin Wong, Ming-Tao Yang, Chien-Feng Judith Huang, Chia-Jui Hsu, Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Wang-Tso Lee
2021 Scientific Reports  
In this study, we investigated the iron accumulation in deep gray matter of RTT and its correlation with dystonia severity.  ...  Abnormal iron accumulation in deep gray matter were reported in some Parkinsonian-related disorders.  ...  that accumulation of iron in deep brain nuclei may associate to extrapyramidal symptoms.  ... 
doi:10.1038/s41598-020-80723-1 pmid:33436916 fatcat:eh4wzplgb5cyjaa7nnprrfx46i

Neuroimaging of Basal Ganglia in Neurometabolic Diseases in Children

Justyna Paprocka, Magdalena Machnikowska-Sokołowska, Katarzyna Gruszczyńska, Ewa Emich-Widera
2020 Brain Sciences  
Neuroimaging of basal ganglia in neurometabolic diseases is helpful in early diagnosis and monitoring of changes for optimal therapy.  ...  This review focuses on neuroimaging of basal ganglia and its role in the differential diagnosis of inborn errors of metabolism.  ...  Changes in deep nuclei are more typical of infantile GM2, whereas juvenile and adult forms present with cerebellar hypo/atrophy.  ... 
doi:10.3390/brainsci10110849 pmid:33198265 pmcid:PMC7697699 fatcat:bqrdtocxjzcwbf3iuzeyrzk7ha

Brain iron and metabolic abnormalities in C19orf12 mutation carriers: A 7.0 tesla MRI study in mitochondrial membrane protein–associated neurodegeneration

Petr Dusek, Ralf Mekle, Marta Skowronska, Julio Acosta‐Cabronero, Till Huelnhagen, Simon Daniel Robinson, Florian Schubert, Marcus Deschauer, Antje Els, Bernd Ittermann, Gudrun Schottmann, Vince I. Madai (+6 others)
2019 Movement Disorders  
The aim of this study was to quantify iron concentrations in deep gray matter structures using quantitative susceptibility mapping MRI and to characterize metabolic abnormalities in the pyramidal pathway  ...  MR spectroscopy revealed significantly increased levels of glutamate, taurine, and the combined concentration of glutamate and glutamine in membrane protein-associated neurodegeneration, which may be a  ...  Volumetric analysis of deep gray matter nuclei did not show any significant differences between C19orf12 mutation heterozygotes and age-matched controls.  ... 
doi:10.1002/mds.27827 pmid:31518459 fatcat:q5yg364acjbjrnfzvgoh4sbzse

R2 * and quantitative susceptibility mapping in deep gray matter of 498 healthy controls from 5 to 90 years

Sarah Treit, Nashwan Naji, Peter Seres, Julia Rickard, Emily Stolz, Alan H. Wilman, Christian Beaulieu
2021 Human Brain Mapping  
This study reports both transverse relaxation rate (R2*) and quantitative susceptibility mapping (QSM) of four primary deep gray matter regions (thalamus, putamen, caudate, and globus pallidus) in 498  ...  Putative MRI markers of iron in deep gray matter have demonstrated age related changes during discrete periods of healthy childhood or adulthood, but few studies have included subjects across the lifespan  ...  Only a limited number of studies have reported both QSM and R2* in deep gray matter of healthy populations, and include studies of infants , adolescents (Peterson et al., 2019) or adults (Betts, Acosta-Cabronero  ... 
doi:10.1002/hbm.25569 pmid:34184808 pmcid:PMC8410539 fatcat:gtjypmeevrcw3jx5s3onjp2gyy

Quantitative Susceptibility Mapping: Contrast Mechanisms and Clinical Applications

2015 Tomography  
This article reviews the mechanism that generates susceptibility contrast within tissues and some associated applications.  ...  More importantly, magnetic susceptibility directly reflects the molecular composition and cellular architecture of the tissue.  ...  For instance, OEF decreased by 40% in the straight sinus and in the internal cerebral veins that drain the deep gray matter (110) .  ... 
doi:10.18383/j.tom.2015.00136 pmid:26844301 pmcid:PMC4734903 fatcat:asrfxxhhcrbpnobdc3hjkhnlfq

T2 Shortening in the Visual Cortex

Y Korogi, T Hirai, Y Komohara, T Okuda, I Ikushima, M Kitajima, Y Shigematu, T Sugahara, M Takahashi
1999 Journal of neuro-ophthalmology  
The signal intensity of the motor cortex decreased rapidly after the age of 50 years.  ...  On T2-weighted spin-echo images, the signal intensity of the visual, motor, and sensory cortices was divided into three grades and compared with the signal intensity of the frontal subcortical white matter  ...  In healthy adults, decreased signal intensity on T2-weighted images is seen in the globus pallidi, red nuclei, substantia nigra, and dentate nuclei (4 -6) .  ... 
doi:10.1097/00041327-199906000-00035 fatcat:zrq4e3w3h5gfpbp3ukafk2ha4i
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