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Elderly Acute Myeloid Leukemia: Assessing Risk

Heidi D. Klepin
2015 Current Hematologic Malignancy Reports  
Measurable patient characteristics such as comorbidity and physical function can reflect the heterogeneity of physiologic aging among older patients and help predict resilience during and after the stress  ...  To improve outcomes for older adults with AML it will be critical to investigate the predictive utility of patient characteristics in parallel with tumor biology to improve decisionmaking, inform trial  ...  However, optimal assessment of physical function for older adults with adequate performance status (ECOG 0-2) may be best assessed with objective measures.  ... 
doi:10.1007/s11899-015-0257-2 pmid:25939828 pmcid:PMC4466909 fatcat:cctebfjqsnbbnl5oafex23rxmu

Wearable activity monitors to assess performance status and predict clinical outcomes in advanced cancer patients

Gillian Gresham, Andrew E. Hendifar, Brennan Spiegel, Elad Neeman, Richard Tuli, B. J. Rimel, Robert A. Figlin, Curtis L. Meinert, Steven Piantadosi, Arvind M. Shinde
2018 npj Digital Medicine  
Real-time, objective activity data may allow for a more accurate assessment of PS and physical function, while reducing the subjectivity and bias associated with current assessments.  ...  An objective evaluation of patient performance status (PS) is difficult because patients spend the majority of their time outside of the clinic, self-report to providers, and undergo dynamic changes throughout  ...  INTRODUCTION Cancer patients require an accurate assessment of performance status and physical function to inform treatment decisions and determine eligibility into clinical trials.  ... 
doi:10.1038/s41746-018-0032-6 pmid:31304309 pmcid:PMC6550281 fatcat:jfxanqs2ybfjdawonudnlwrqfy

Ready for prime time: role for geriatric assessment to improve quality of care in hematology practice

Heidi D. Klepin
2019 Hematology ASH Education Program  
Older adults represent the growing majority of patients diagnosed with hematologic disorders, yet they remain underrepresented on clinical trials.  ...  This article will highlight available evidence to support the role of geriatric assessment measures to enhance quality of care for older adults diagnosed with hematologic malignancies.  ...  investigating the independent role of specific vulnerabilities, such as comorbidity, physical function, cognitive function, and nutritional status.  ... 
doi:10.1182/hematology.2019001299 pmid:31808878 pmcid:PMC6913467 fatcat:l7iedlmijze4rirsgptumupk4a

Are patient-reported outcomes of physical function a valid substitute for objective measurements?

J. A.J. Douma, H. M.W. Verheul, L. M. Buffart
2018 Current Oncology  
The pro-pf cannot, therefore, be used in clinical practice as a substitute for objective measures of physical function.  ...  To determine whether pros for physical function (pro-pf) accurately predict physical function, we studied their interrelationships with objective measures of physical activity and fitness in patients with  ...  Physical activity and fitness can be assessed objectively, providing an estimate of a patient's physical function.  ... 
doi:10.3747/co.25.4080 pmid:30464699 pmcid:PMC6209559 fatcat:d4kyp34vufatjkhsnxc626afwa

Functional Outcomes for Clinical Trials in Frail Older Persons: Time To Be Moving: Working Group on Functional Outcome Measures for Clinical Trials

2008 The journals of gerontology. Series A, Biological sciences and medical sciences  
Appendix: Working Group on Functional Outcome Measures for Clinical Trials  ...  Acknowledgements FDA representatives participated in and contributed to this meeting, but this document should not be construed as an FDA policy statement.  ...  of measures of functional status that may reflect the overall health status of an individual.  ... 
doi:10.1093/gerona/63.2.160 pmid:18314451 pmcid:PMC2645663 fatcat:6fdqaqlp3vccxexrzrhgjyrj4q

Moving beyond Karnofsky and ECOG Performance Status Assessments with New Technologies

Ciara M. Kelly, Armin Shahrokni
2016 Journal of Oncology  
The potential ability of electronic activity monitoring systems to provide an objective, accurate measurement of patient functional performance is explored.  ...  This paper reviews the past, present, and potential future of functional performance status assessment in an oncology setting.  ...  Competing Interests The authors declare that there is no conflict of interests regarding the publication of this paper.  ... 
doi:10.1155/2016/6186543 pmid:27066075 pmcid:PMC4811104 fatcat:242lpo22dne5hnu463smhnhche

Associations of objectively measured moderate-to-vigorous physical activity and sedentary behavior with quality of life and psychological well-being in prostate cancer survivors

Cadeyrn J. Gaskin, Melinda Craike, Mohammadreza Mohebbi, Jo Salmon, Kerry S. Courneya, Suzanne Broadbent, Patricia M. Livingston
2016 Cancer Causes and Control  
We determined the extent to which objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary behavior were independently associated with quality of life, anxiety, and depressive symptoms  ...  Independent of MVPA, decreases in sedentary behavior of 119 and 107 min/day were associated with clinically important (but not statistically significant) improvements in physical functioning and role functioning  ...  , and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ... 
doi:10.1007/s10552-016-0787-5 pmid:27469939 pmcid:PMC4983284 fatcat:m2ezqzztn5hjjevewskvsdi6t4

Geriatric perspective: how to assess fitness for chemotherapy in acute myeloid leukemia

H. D. Klepin
2014 Hematology ASH Education Program  
However, many older adults with adequate performance status and absence of major comorbidity are "vulnerable" and may experience clinical and functional decline when stressed with intensive therapies.  ...  Available evidence is strongest in identifying those older adults who are frail at the time of diagnosis by characterizing performance status and comorbidity burden.  ...  The most promising predictors are measures of physical function (task specific or objectively measured), cognition, and symptoms.  ... 
doi:10.1182/asheducation-2014.1.8 pmid:25696829 fatcat:z4b3k2dmv5gtxhf5sxfzkufo7e

Association of Functional and Health Status Measures in Heart Failure

Jonathan Myers, Nayma Zaheer, Susan Quaglietti, Rupa Madhavan, Victor Froelicher, Paul Heidenreich
2006 Journal of Cardiac Failure  
These findings suggest that exercise test responses, non-exercise test estimates of physical function, and quality of life indices reflect different facets of health status in HF and one should not be  ...  Methods and Results: Forty-one patients with HF were assessed with commonly used functional, health status, and quality of life measures, including maximal cardiopulmonary exercise testing, the Duke Activity  ...  Randomized clinical trials frequently use exercise duration or workload on a standardized exercise test as a primary outcome variable when assessing the efficacy of an intervention.  ... 
doi:10.1016/j.cardfail.2006.04.004 pmid:16911910 fatcat:d7qseerq7vcunik7f3twcmyhum

Determining the Minimal Clinically Important Difference for 6-Minute Walk Distance in Fibromyalgia

Anthony S. Kaleth, James E. Slaven, Dennis C. Ang
2016 American Journal of Physical Medicine & Rehabilitation  
An anchor-based approach that used linear regression analyses was used to determine the MCID for 6MWD, using the total FIQ score (FIQ-Total) and SF36-physical function domain (SF36-PF) as clinical anchors  ...  Objective-To estimate the minimal clinically important difference (MCID) for 6-minute walk distance (6MWD) in patients with fibromyalgia (FM).  ...  Acknowledgments Funding Support: National Institute of Arthritis & Musculoskeletal and Skin Diseases (1RO1AR054324-01A1)  ... 
doi:10.1097/phm.0000000000000485 pmid:27003201 pmcid:PMC5831244 fatcat:mkmdabb32nbglpmewgliwlgwxa

"Keeping Moving": factors associated with sedentary behaviour among older people recruited to an exercise promotion trial in general practice

Ruth Heseltine, Dawn A. Skelton, Denise Kendrick, Richard W. Morris, Mark Griffin, Deborah Haworth, Tahir Masud, Steve Iliffe
2015 BMC Family Practice  
Demographic data, health status, self-rated function and physical test performance were examined for each group. 1104 participants aged 65 & over were included in the secondary analysis of trial data from  ...  Sedentary behaviour is detrimental to health, even in those who achieve recommended levels of physical activity.  ...  Acknowledgement We thank all the practices and participants who took part in the original study.  ... 
doi:10.1186/s12875-015-0284-z pmid:26018127 pmcid:PMC4446807 fatcat:oqtfaxq5bnghnnqhswqz3rry64

Clinically Meaningful Change for Physical Performance: Perspectives of the ICFSR Task Force

J. Guralnik, K. Bandeen-Roche, S.A.R. Bhasin, S. Eremenco, F. Landi, J. Muscedere, S. Perera, J.-Y. Reginster, L. Woodhouse, B. Vellas, And The ICFSR Task Force
2019 The Journal of frailty & aging  
Physical performance measures including measures of gait speed and other aspects of mobility and strength have been used in many studies, although a definition of clinically meaningful change in performance  ...  For clinical studies of sarcopenia and frailty, clinically meaningful outcome measures are needed to monitor disease progression, evaluate efficacy of interventions, and plan clinical trials.  ...  Introduction Clinical research studies in older populations have shifted over the last two decades from assessing biological indicators and disease status to measuring physical function as a primary endpoint  ... 
doi:10.14283/jfa.2019.33 pmid:32150208 pmcid:PMC7286121 fatcat:ebxmr7bxtjcyxa7mar6iol3ltu

Impact of physical activity in vascular cognitive impairment (AFIVASC): study protocol for a randomised controlled trial

Ana Verdelho, Sofia Madureira, Manuel Correia, José Manuel Ferro, Mário Rodrigues, Manuel Gonçalves-Pereira, Mafalda Gonçalves, Ana Catarina Santos, Pedro Vilela, Helena Bárrios, Mariana Borges, Helena Santa-Clara
2019 Trials  
Secondary outcomes include changes in neuro-cognitive measures, quality of life, and functional and motor status.  ...  Discussion: We aim to show whether or not moderate physical activity has a beneficial impact on cognition, quality of life, motor, and functional status in people with vascular cognitive impairment, and  ...  Funding The authors disclose receipt of the following financial support for this research: FCT (FCT-PTDC/DTP-ES/3706/2014).  ... 
doi:10.1186/s13063-019-3174-1 fatcat:e6fdptu63vg2nfwnen6pysuuhq

Multi-modal intervention to reduce cardiovascular risk among hypertensive older adults: Design of a randomized clinical trial

Thomas W. Buford, Stephen D. Anton, Anthony A. Bavry, Christy S. Carter, Michael J. Daniels, Marco Pahor
2015 Contemporary Clinical Trials  
Functional status, determined by measures of physical performance, is an important predictor of cardiovascular outcomes in older adults and declines more rapidly in seniors with hypertension.  ...  To date, physical exercise is the primary strategy for attenuating declines in functional status.  ...  The study is funded by a grant from the American Heart Association (13SDG17080033) with support from the University of Florida Claude D. Pepper Older Americans Independence Center (2P30AG028740).  ... 
doi:10.1016/j.cct.2015.06.019 pmid:26115878 pmcid:PMC4522342 fatcat:4sluo4dhcvhfxixu4jdtltsmrm

Biomarker-Calibrated Protein Intake and Physical Function in the Women's Health Initiative

Jeannette M. Beasley, Betsy C. Wertheim, Andrea Z. LaCroix, Ross L. Prentice, Marian L. Neuhouser, Lesley F. Tinker, Stephen Kritchevsky, James M. Shikany, Charles Eaton, Zhao Chen, Cynthia A. Thomson
2013 Journal of The American Geriatrics Society  
The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, and  ...  and objective measures of physical performance over an average 11.5-y time period.  ...  A stratified analysis of protein intake (% energy) by median recreational physical activity level in our sample showed that the protein associations with physical function were independent of activity  ... 
doi:10.1111/jgs.12503 pmid:24219187 pmcid:PMC3928025 fatcat:4aykmkikkvfovj775tkbrxlcyi
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