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Assessing data quality from the Clinical Practice Research Datalink: a methodological approach applied to the full blood count blood test

Pradeep S. Virdee, Alice Fuller, Michael Jacobs, Tim Holt, Jacqueline Birks
2020 Journal of Big Data  
The Test dataset from the Clinical Research Practice Datalink (CPRD) was accessed, which contains results of tests performed in primary care, such as FBC blood tests.  ...  A Full Blood Count (FBC) is a common blood test including 20 parameters, such as haemoglobin and platelets.  ...  Authors' contributions PSV, TH, and JB developed the study. AF extracted the data from the CPRD database. PSV performed the quality check of the CPRD data.  ... 
doi:10.1186/s40537-020-00375-w fatcat:ynsizjo2fndsjiyigykh2bqzby

Fidelity Assessment of a Clinical Practice Research Datalink Conversion to the OMOP Common Data Model

Amy Matcho, Patrick Ryan, Daniel Fife, Christian Reich
2014 Drug Safety  
Key Points A transformation of the Clinical Practice Research Datalink (CPRD) into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) was performed Quality assessments indicated  ...  The unique structure and coding of the Clinical Practice Research Datalink (CPRD) presents challenges for epidemiologic analysis and for comparisons with other databases.  ...  Hershel Jick for their assistance in understanding changes in the CPRD database over time and key details of the methods that may have contributed to differences between the original and raw data studies  ... 
doi:10.1007/s40264-014-0214-3 pmid:25187016 pmcid:PMC4206771 fatcat:qiwseo4zf5ffhjg5igtthywvoi

Clinical profile of predefined asthma phenotypes in a large cohort of UK primary care patients (Clinical Practice Research Datalink)

Francis Nissen, Ian J. Douglas, Hana Müllerová, Neil Pearce, Chloe Bloom, Liam Smeeth, Jennifer K. Quint
2019 Journal of Asthma and Allergy  
We used linked primary and secondary care data from the Clinical Practice Research Datalink, Hospital Episode Statistics and Office for National Statistics.  ...  A population-based cohort study identified 193,999 asthma patients in UK primary care from 2007 to 2017.  ...  Author contributions All authors contributed to data analysis, drafting and revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the  ... 
doi:10.2147/jaa.s182013 pmid:30662273 pmcid:PMC6329349 fatcat:zyj7zy2g4zgtzpbpehq7hzbfcm

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink

D F Carr, H O'Meara, A L Jorgensen, J Campbell, M Hobbs, G McCann, T van Staa, M Pirmohamed
2013 Clinical Pharmacology and Therapeutics  
This study aimed to determine whether patients with statin-induced myopathy could be identified using the United Kingdom Clinical Practice Research Datalink, whether DNA could be obtained, and whether  ...  Our data replicate the association of SLCO1B1 variants with statin-induced myopathy.  ...  The UK Clinical Practice Research Datalink (CPRD), formerly the General Practice Research Database, is a computerized database of anonymized longitudinal medical records from primary care.  ... 
doi:10.1038/clpt.2013.161 pmid:23942138 pmcid:PMC3831180 fatcat:yl7gfqg5ijgsnb3k7225bztdkm

A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems

Spiros Denaxas, Anoop D Shah, Bilal A Mateen, Valerie Kuan, Jennifer K Quint, Natalie Fitzpatrick, Ana Torralbo, Ghazaleh Fatemifar, Harry Hemingway
2020 JAMIA Open  
The aims of our research were to: (a) develop a semi-supervised approach for bootstrapping EHR phenotyping algorithms in UKB EHR, and (b) to evaluate our approach by implementing and evaluating phenotypes  ...  Data are extracted from four sources, recorded using five clinical terminologies and stored in different schemas.  ...  CALIBER, led from the UCL Institute of Health Informatics, is a research resource consisting of anonymized, coded variables extracted from linked electronic health records, methods and tools, specialized  ... 
doi:10.1093/jamiaopen/ooaa047 pmid:33619467 pmcid:PMC7717266 fatcat:ayiqgv5rwfd7tirnw3k4eikpku

A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems [article]

Spiros Denaxas, Anoop Shah, Bilal Mateen, Valerie Kuan, Jennifer Quint, Natalie Fitzpatrick, Ana Torralbo, Ghazaleh Fatemifar, Harry Hemingway
2020 biorxiv/medrxiv   pre-print
The aims of our research were to: a) develop a semi-supervised approach for bootstrapping EHR phenotyping algorithms in UKB EHR, and b) to evaluate our approach by implementing and evaluating phenotypes  ...  Data are extracted from four sources, recorded using five clinical terminologies and stored in different schemas.  ...  CALIBER, led from the UCL Institute of Health Informatics, is a research resource consisting of anonymized, coded variables extracted from linked electronic health records, methods and tools, specialized  ... 
doi:10.1101/2020.05.14.20101626 fatcat:zmwgv7gyvrh2lknrn3xghnb62e

Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case–control analysis

David Reeves, David A Springate, Darren M Ashcroft, Ronan Ryan, Tim Doran, Richard Morris, Ivan Olier, Evangelos Kontopantelis
2014 BMJ Open  
Acknowledgements This study is based on data from the Clinical Practice Research Datalink (CPRD) obtained under licence from the UK Medicines and Healthcare products Regulatory Agency.  ...  DR is the guarantor of this work and takes responsibility for the integrity of the data and the accuracy of the data analysis.  ...  The three major UK PCDs are the CPRD 1 (Clinical Practice Research Datalink; formerly the general practice research database (GPRD)), QResearch 2 and The Health Improvement Network 3 (THIN).  ... 
doi:10.1136/bmjopen-2014-004952 pmid:24760353 pmcid:PMC4010839 fatcat:xfp7puiyajeufievmdjjxploru

Linking e-health records, patient-reported symptoms and environmental exposure data to characterise and model COPD exacerbations: protocol for the COPE study

Elizabeth Moore, Lia Chatzidiakou, Roderic L Jones, Liam Smeeth, Sean Beevers, Frank J Kelly, Jennifer K Quint, Benjamin Barratt
2016 BMJ Open  
COPD, chronic obstructive pulmonary disease; CPRD, Clinical Practice Research Datalink; RH, relative humidity.  ...  associated with statin-induced myopathy: a proof-of-concept study 26. Halpin DM, Laing-Morton T, Spedding S, et al. A randomised using the clinical practice research datalink.  ... 
doi:10.1136/bmjopen-2016-011330 pmid:27412104 pmcid:PMC4947745 fatcat:czi3bldk2rc6ddn7rwk4lrzloa

Angiotensin receptor blocker use and gastro-oesophageal cancer survival: a population-based cohort study

J. Busby, Ú. McMenamin, A. Spence, B. T. Johnston, C. Hughes, C. R. Cardwell
2017 Alimentary Pharmacology and Therapeutics  
We linked to prescription and clinical records from the Clinical Practice Research Datalink, and to death records from the Office for National Statistics.  ...  Despite this, epidemiological studies have yet to assess the impact of ARB use on gastrooesophageal cancer survival.  ...  Acknowledgements: This study is based in part on data from the Clinical Practice Research Datalink  ... 
doi:10.1111/apt.14388 pmid:29105106 fatcat:l6eeqywwrbelvmbs5m2wxji6me

The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal

Pradeep S. Virdee, Ioana R. Marian, Anita Mansouri, Leena Elhussein, Shona Kirtley, Tim Holt, Jacqueline Birks
2020 Cancers  
A full blood count (FBC) blood test includes 20 components.  ...  We systematically reviewed studies that assessed the association of the FBC and diagnosis of colorectal cancer to identify components as risk factors.  ...  The authors would also like to thank patient and public involvement representatives, Julian Ashton, Margaret Ogden, and Pete Wheatstone for their input in the interpretation of results and development  ... 
doi:10.3390/cancers12092348 pmid:32825191 pmcid:PMC7564785 fatcat:kmdkh7f27bfgxh4kr4kykqvkku

Artificial intelligence techniques that may be applied to primary care data to facilitate the earlier diagnosis of cancer: a systematic review (Preprint)

Owain Tudor Jones, Natalia Calanzani, Smiji Saji, Stephen W Duffy, Jon Emery, Willie Hamilton, Hardeep Singh, Niek de Wit, Fiona Walter
2020 Journal of Medical Internet Research  
A total of 13 studies described the initial development and testing of AI algorithms, and 3 studies described the validation of an AI algorithm in independent data sets.  ...  Risk of bias assessment highlighted a wide range of study quality. The additional scoping review of commercial AI technologies identified 21 technologies, only 1 meeting our inclusion criteria.  ...  HS is additionally supported by the Houston Veterans Administration Health Services Research and Development Center for Innovations in Quality, Effectiveness, and Safety (CIN13-413) and the Agency  ... 
doi:10.2196/23483 pmid:33656443 fatcat:4dbujhdqhrea3c6jcsn7b2dnsm

Identifying COPD in routinely collected electronic health records: a systematic scoping review

Shanya Sivakumaran, Mohammad A. Alsallakh, Ronan A. Lyons, Jennifer K. Quint, Gwyneth A. Davies
2021 ERJ Open Research  
We systematically examine and summarise approaches from the recent literature.MEDLINE via EBSCOhost was searched for COPD-related studies using EHR published from January 1, 2018 to November 30, 2019.  ...  Various proxies of disease severity were used since spirometry results and patient-reported outcomes were not often available.To enable the research community to draw reliable insights from electronic  ...  study using the Clinical Practice Research Datalink (CPRD).  ... 
doi:10.1183/23120541.00167-2021 pmid:34527726 pmcid:PMC8435805 fatcat:n2lsln2e2vhddajdzrjolmn3pe

Data management and data analysis techniques in pharmacoepidemiological studies using a pre-planned multi-database approach: a systematic literature review

Marloes T. Bazelier, Irene Eriksson, Frank de Vries, Marjanka K. Schmidt, Jani Raitanen, Jari Haukka, Jakob Starup-Linde, Marie L. De Bruin, Morten Andersen
2015 Pharmacoepidemiology and Drug Safety  
Six studies performed an aggregate meta-analysis (27%), while a semi-aggregate approach was applied in three studies (14%).  ...  The number of databases used per study ranged from 2 to 17 (median = 4.0). Most studies used a cohort design (82%) instead of a case-control design (18%).  ...  ACKNOWLEDGEMENTS The research leading to the results of this study has received funding from the European Community's Seventh Framework Programme (FP-7) under grant  ... 
doi:10.1002/pds.3828 pmid:26175179 pmcid:PMC5034829 fatcat:evdaofoe4rcrzjqsg43fpk4hyq

Managing glycaemia in older people with type 2 diabetes: A retrospective, primary care-based cohort study, with economic assessment of patient outcomes

Jason Gordon, Phil McEwan, Marc Evans, Jorge Puelles, Alan Sinclair
2017 Diabetes, obesity and metabolism  
Materials and methods: The Clinical Practice Research Datalink database was used to inform a retrospective observational cohort study of patients with type 2 diabetes treated with metformin monotherapy  ...  Conclusions: With respect to treatment choice, data from the present study support the notion of prescribing beyond metformin + SU, as alternative regimens have been shown to be associated with reduced  ...  ACKNOWLEDGMENTS The authors thank Daniel Sugrue, Samantha Webster and Karina Hamilton (HEOR Ltd) for writing services in the development of this manuscript. Conflict of interest  ... 
doi:10.1111/dom.12867 pmid:28026911 pmcid:PMC5412932 fatcat:6gryejhe4zbytnlrayisd77p4m

Protocol for an observational cohort study investigating personalised medicine for intensification of treatment in people with type 2 diabetes mellitus: the PERMIT study

Patrick Bidulka, Stephen O'Neill, Anirban Basu, Samantha Wilkinson, Richard J Silverwood, Paul Charlton, Andrew Briggs, Amanda I Adler, Kamlesh Khunti, Laurie A Tomlinson, Liam Smeeth, Ian J Douglas (+1 others)
2021 BMJ Open  
risk profiles.Methods and analysisThe study includes people with T2DM prescribed one of the second-line treatments-of-interest between 2014 and 2020 within the UK Clinical Practice Research Datalink linked  ...  The primary outcome to assess short-term effectiveness will be change in haemoglobin A1c (%) 12 months after treatment initiation.  ...  METHODS AND ANALYSIS Data resources We will identify the study population using the UK Clinical Practice Research Datalink (CPRD), 20 21 a pseudonymised primary care database which includes detailed  ... 
doi:10.1136/bmjopen-2020-046912 pmid:34580091 fatcat:quxiqhscavdalg24x3gfwwipx4
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