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Assessing data quality from the Clinical Practice Research Datalink: a methodological approach applied to the full blood count blood test
2020
Journal of Big Data
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The Test dataset from the Clinical Research Practice Datalink (CPRD) was accessed, which contains results of tests performed in primary care, such as FBC blood tests. ...
A Full Blood Count (FBC) is a common blood test including 20 parameters, such as haemoglobin and platelets. ...
Authors' contributions PSV, TH, and JB developed the study. AF extracted the data from the CPRD database. PSV performed the quality check of the CPRD data. ...
doi:10.1186/s40537-020-00375-w
fatcat:ynsizjo2fndsjiyigykh2bqzby
Fidelity Assessment of a Clinical Practice Research Datalink Conversion to the OMOP Common Data Model
2014
Drug Safety
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Key Points A transformation of the Clinical Practice Research Datalink (CPRD) into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) was performed Quality assessments indicated ...
The unique structure and coding of the Clinical Practice Research Datalink (CPRD) presents challenges for epidemiologic analysis and for comparisons with other databases. ...
Hershel Jick for their assistance in understanding changes in the CPRD database over time and key details of the methods that may have contributed to differences between the original and raw data studies ...
doi:10.1007/s40264-014-0214-3
pmid:25187016
pmcid:PMC4206771
fatcat:qiwseo4zf5ffhjg5igtthywvoi
Clinical profile of predefined asthma phenotypes in a large cohort of UK primary care patients (Clinical Practice Research Datalink)
2019
Journal of Asthma and Allergy
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We used linked primary and secondary care data from the Clinical Practice Research Datalink, Hospital Episode Statistics and Office for National Statistics. ...
A population-based cohort study identified 193,999 asthma patients in UK primary care from 2007 to 2017. ...
Author contributions All authors contributed to data analysis, drafting and revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the ...
doi:10.2147/jaa.s182013
pmid:30662273
pmcid:PMC6329349
fatcat:zyj7zy2g4zgtzpbpehq7hzbfcm
SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink
2013
Clinical Pharmacology and Therapeutics
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This study aimed to determine whether patients with statin-induced myopathy could be identified using the United Kingdom Clinical Practice Research Datalink, whether DNA could be obtained, and whether ...
Our data replicate the association of SLCO1B1 variants with statin-induced myopathy. ...
The UK Clinical Practice Research Datalink (CPRD), formerly the General Practice Research Database, is a computerized database of anonymized longitudinal medical records from primary care. ...
doi:10.1038/clpt.2013.161
pmid:23942138
pmcid:PMC3831180
fatcat:yl7gfqg5ijgsnb3k7225bztdkm
A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems
2020
JAMIA Open
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The aims of our research were to: (a) develop a semi-supervised approach for bootstrapping EHR phenotyping algorithms in UKB EHR, and (b) to evaluate our approach by implementing and evaluating phenotypes ...
Data are extracted from four sources, recorded using five clinical terminologies and stored in different schemas. ...
CALIBER, led from the UCL Institute of Health Informatics, is a research resource consisting of anonymized, coded variables extracted from linked electronic health records, methods and tools, specialized ...
doi:10.1093/jamiaopen/ooaa047
pmid:33619467
pmcid:PMC7717266
fatcat:ayiqgv5rwfd7tirnw3k4eikpku
A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems
[article]
2020
biorxiv/medrxiv
pre-print
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The aims of our research were to: a) develop a semi-supervised approach for bootstrapping EHR phenotyping algorithms in UKB EHR, and b) to evaluate our approach by implementing and evaluating phenotypes ...
Data are extracted from four sources, recorded using five clinical terminologies and stored in different schemas. ...
CALIBER, led from the UCL Institute of Health Informatics, is a research resource consisting of anonymized, coded variables extracted from linked electronic health records, methods and tools, specialized ...
doi:10.1101/2020.05.14.20101626
fatcat:zmwgv7gyvrh2lknrn3xghnb62e
Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case–control analysis
2014
BMJ Open
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Acknowledgements This study is based on data from the Clinical Practice Research Datalink (CPRD) obtained under licence from the UK Medicines and Healthcare products Regulatory Agency. ...
DR is the guarantor of this work and takes responsibility for the integrity of the data and the accuracy of the data analysis. ...
The three major UK PCDs are the CPRD 1 (Clinical Practice Research Datalink; formerly the general practice research database (GPRD)), QResearch 2 and The Health Improvement Network 3 (THIN). ...
doi:10.1136/bmjopen-2014-004952
pmid:24760353
pmcid:PMC4010839
fatcat:xfp7puiyajeufievmdjjxploru
Linking e-health records, patient-reported symptoms and environmental exposure data to characterise and model COPD exacerbations: protocol for the COPE study
2016
BMJ Open
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COPD, chronic obstructive pulmonary disease; CPRD, Clinical Practice Research Datalink; RH,
relative humidity. ...
associated with statin-induced myopathy: a proof-of-concept study 26. Halpin DM, Laing-Morton T, Spedding S, et al. A randomised
using the clinical practice research datalink. ...
doi:10.1136/bmjopen-2016-011330
pmid:27412104
pmcid:PMC4947745
fatcat:czi3bldk2rc6ddn7rwk4lrzloa
Angiotensin receptor blocker use and gastro-oesophageal cancer survival: a population-based cohort study
2017
Alimentary Pharmacology and Therapeutics
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We linked to prescription and clinical records from the Clinical Practice Research Datalink, and to death records from the Office for National Statistics. ...
Despite this, epidemiological studies have yet to assess the impact of ARB use on gastrooesophageal cancer survival. ...
Acknowledgements: This study is based in part on data from the Clinical Practice Research Datalink ...
doi:10.1111/apt.14388
pmid:29105106
fatcat:l6eeqywwrbelvmbs5m2wxji6me
The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal
2020
Cancers
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A full blood count (FBC) blood test includes 20 components. ...
We systematically reviewed studies that assessed the association of the FBC and diagnosis of colorectal cancer to identify components as risk factors. ...
The authors would also like to thank patient and public involvement representatives, Julian Ashton, Margaret Ogden, and Pete Wheatstone for their input in the interpretation of results and development ...
doi:10.3390/cancers12092348
pmid:32825191
pmcid:PMC7564785
fatcat:kmdkh7f27bfgxh4kr4kykqvkku
Artificial intelligence techniques that may be applied to primary care data to facilitate the earlier diagnosis of cancer: a systematic review (Preprint)
2020
Journal of Medical Internet Research
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A total of 13 studies described the initial development and testing of AI algorithms, and 3 studies described the validation of an AI algorithm in independent data sets. ...
Risk of bias assessment highlighted a wide range of study quality. The additional scoping review of commercial AI technologies identified 21 technologies, only 1 meeting our inclusion criteria. ...
HS is additionally supported by the Houston Veterans Administration Health Services Research and Development Center for Innovations in Quality, Effectiveness, and Safety (CIN13-413) and the Agency ...
doi:10.2196/23483
pmid:33656443
fatcat:4dbujhdqhrea3c6jcsn7b2dnsm
Identifying COPD in routinely collected electronic health records: a systematic scoping review
2021
ERJ Open Research
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We systematically examine and summarise approaches from the recent literature.MEDLINE via EBSCOhost was searched for COPD-related studies using EHR published from January 1, 2018 to November 30, 2019. ...
Various proxies of disease severity were used since spirometry results and patient-reported outcomes were not often available.To enable the research community to draw reliable insights from electronic ...
study using the Clinical Practice Research Datalink (CPRD). ...
doi:10.1183/23120541.00167-2021
pmid:34527726
pmcid:PMC8435805
fatcat:n2lsln2e2vhddajdzrjolmn3pe
Data management and data analysis techniques in pharmacoepidemiological studies using a pre-planned multi-database approach: a systematic literature review
2015
Pharmacoepidemiology and Drug Safety
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Six studies performed an aggregate meta-analysis (27%), while a semi-aggregate approach was applied in three studies (14%). ...
The number of databases used per study ranged from 2 to 17 (median = 4.0). Most studies used a cohort design (82%) instead of a case-control design (18%). ...
ACKNOWLEDGEMENTS The research leading to the results of this study has received funding from the European Community's Seventh Framework Programme (FP-7) under grant ...
doi:10.1002/pds.3828
pmid:26175179
pmcid:PMC5034829
fatcat:evdaofoe4rcrzjqsg43fpk4hyq
Managing glycaemia in older people with type 2 diabetes: A retrospective, primary care-based cohort study, with economic assessment of patient outcomes
2017
Diabetes, obesity and metabolism
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Materials and methods: The Clinical Practice Research Datalink database was used to inform a retrospective observational cohort study of patients with type 2 diabetes treated with metformin monotherapy ...
Conclusions: With respect to treatment choice, data from the present study support the notion of prescribing beyond metformin + SU, as alternative regimens have been shown to be associated with reduced ...
ACKNOWLEDGMENTS The authors thank Daniel Sugrue, Samantha Webster and Karina Hamilton (HEOR Ltd) for writing services in the development of this manuscript.
Conflict of interest ...
doi:10.1111/dom.12867
pmid:28026911
pmcid:PMC5412932
fatcat:6gryejhe4zbytnlrayisd77p4m
Protocol for an observational cohort study investigating personalised medicine for intensification of treatment in people with type 2 diabetes mellitus: the PERMIT study
2021
BMJ Open
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risk profiles.Methods and analysisThe study includes people with T2DM prescribed one of the second-line treatments-of-interest between 2014 and 2020 within the UK Clinical Practice Research Datalink linked ...
The primary outcome to assess short-term effectiveness will be change in haemoglobin A1c (%) 12 months after treatment initiation. ...
METHODS AND ANALYSIS Data resources We will identify the study population using the UK Clinical Practice Research Datalink (CPRD), 20 21 a pseudonymised primary care database which includes detailed ...
doi:10.1136/bmjopen-2020-046912
pmid:34580091
fatcat:quxiqhscavdalg24x3gfwwipx4
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