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Magnetic resonance imaging in pediatric migraine

Megan E Webb, Farnaz Amoozegar, Ashley D Harris
2019 Canadian Journal of Neurological Sciences  
, Agarwal, A., Ascadi, G., Luat, A. & Tapos, D.  ...  studies Reference number Authors Study Type of study No. of participants with migraine Participant ages in years Type of migraine if specified Type of MRI Conclusions 62 Altinok, D.  ... 
doi:10.1017/cjn.2019.243 pmid:31309904 fatcat:fbddikty5fbr7jdqptcaw2bcla

GABA and glutamate in pediatric migraine

Tiffany Bell, Mehak Stokoe, Akashroop Khaira, Megan Webb, Melanie Noel, Farnaz Amoozegar, Ashley D Harris
2020 Pain  
Migraine is one of the top 5 most prevalent childhood diseases; however, effective treatment strategies for pediatric migraine are limited. For example, standard adult pharmaceutical therapies are less effective in children and can carry undesirable side effects. To develop more effective treatments, improved knowledge of the biology underlying pediatric migraine is necessary. One theory is that migraine results from an imbalance in cortical excitability. Magnetic resonance spectroscopy (MRS)
more » ... udies show changes in GABA and glutamate levels (the primary inhibitory and excitatory neurotransmitters in the brain, respectively) in multiple brain regions in adults with migraine; however, they have yet to be assessed in children with migraine. Using MRS and GABA-edited MRS, we show that children (7-13 years) with migraine and aura had significantly lower glutamate levels in the visual cortex compared to controls, the opposite to results seen in adults. In addition, we found significant correlations between metabolite levels and migraine characteristics; higher GABA levels were associated with higher migraine burden. We also found that higher glutamate in the thalamus and higher GABA/Glx ratios in the sensorimotor cortex were associated with duration since diagnosis, i.e., having migraines longer. Lower GABA levels in the sensorimotor cortex were associated with being closer to their next migraine attack. Together, this indicates that GABA and glutamate disturbances occur early in migraine pathophysiology and emphasizes that evidence from adults with migraine cannot be immediately translated to pediatric sufferers. This highlights the need for further mechanistic studies of migraine in children, to aid in development of more effective treatments.
doi:10.1097/j.pain.0000000000002022 pmid:33326202 pmcid:PMC7737876 fatcat:c6sm2nzhc5gpxiczz2ltngpzsu

Risk Factors for Postoperative Mediastinitis Due to Methicillin-Resistant Staphylococcus aureus

E. S. D. Ashley, D. N. Carroll, J. J. Engemann, A. D. Harris, V. G. Fowler, D. J. Sexton, K. S. Kaye
2004 Clinical Infectious Diseases  
Risk factors for developing postoperative mediastinitis (POM) due to methicillin-resistant Staphylococcus aureus (MRSA) were analyzed in a case-case control study of patients who underwent median sternotomy during the period from 1994 through 2000. Three patient groups were studied. The first consisted of 64 patients with POM due to MRSA; the second consisted of 79 patients with POM due to methicillin-susceptible S. aureus (MSSA); and the third consisted of 80 uninfected control patients. In
more » ... tivariable analysis, patients who were diabetic (adjusted OR, 2.86; 95% CI, 1.22-6.70), female (OR, 2.70; 95% CI, 1.25-5.88), and 170 years old (OR, 3.43; 95% CI, 1.53-7.71) were more likely to develop POM due to MRSA. In contrast, the only independent risk factor associated with POM due to MSSA was obesity (OR, 2.49; 95% CI, 1.25-4.96). Antimicrobial prophylaxis consisted primarily of cephalosporin antibiotics (administered to 97% of the patients). Changes in perioperative antimicrobial prophylaxis, in addition to other interventions, should be considered for prevention of POM due to MRSA in targeted, high-risk populations.
doi:10.1086/420819 pmid:15156442 fatcat:3r3ccpskyvb7tmgpvio4kjvrym

Edited1H magnetic resonance spectroscopy in vivo: Methods and metabolites

Ashley D. Harris, Muhammad G. Saleh, Richard A.E. Edden
2017 Magnetic Resonance in Medicine  
D. MEGA (MEscher-GArwood): Similar to the dual BASING scheme, a pair of frequency-selective editing pulses refocus the evolution of the coupling in half of the transients, the 'On' condition.  ... 
doi:10.1002/mrm.26619 pmid:28150876 pmcid:PMC5352552 fatcat:fic2u6mcjjb5thrrapzs6txclq

Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample

Tiffany Bell, Mehak Stokoe, Ashley D. Harris
2021 Scientific Reports  
(d) GM ratio. Lines represent mean ± standard deviation. Figure 3 . 3 Correlations between the three versions of MM-supp GABA levels and age. (a) Correlation between MM-supp GABA and age.  ... 
doi:10.1038/s41598-020-80530-8 pmid:33436899 fatcat:zq7yo2fycngrxlelnz2nnb2lwu

Simultaneous edited MRS of GABA and glutathione

Muhammad G. Saleh, Georg Oeltzschner, Kimberly L. Chan, Nicolaas A.J. Puts, Mark Mikkelsen, Michael Schär, Ashley D. Harris, Richard A.E. Edden
2016 NeuroImage  
B) The Hadamard spectra show a GSH-edited signal at 2.95 ppm in the A-B+C-D combination and a GABA-edited spectrum in the A+B-C-D combination.  ...  Experiments A-D show the intended multiplet patterns, as described above, and qualitatively resemble simulations.  ... 
doi:10.1016/j.neuroimage.2016.07.056 pmid:27534734 pmcid:PMC5159266 fatcat:37qydj276jga5nujc5spzh66im

Crystallite Size Evaluation of ZnO Nanoparticles via Transmission Electron Microscopy and X-ray Powder Diffraction

Jonathan E. Cowen, Ashley E. Harris, Cecelia C. Pena, Stephen C. Bryant, Allison J. Christy, Jerry D. Harris
2016 Microscopy and Microanalysis  
Zinc Oxide has received a considerable amount of attention over the past decades due to its unique electronic and optical properties. The material is readily available, inexpensive, and environmentally friendly compared to other semiconducting materials 1 . These properties make ZnO an excellent candidate material for applications such as: photovoltaic devices 2 , gas sensors 3 , transparent conductive oxides (TCO) 4 , biomedical devices 5 , and photocatalysis 6 among many others. Zinc oxide
more » ... synthesized by alkali precipitation using aqueous solutions of zinc acetate, various amines, and precipitated with the addition of NaOH. The resulting materials were characterized with Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), and the Brunauer-Emmett-Teller (BET) method. The optical band gap of the material was determined with Ultraviolet-visible reflectance spectroscopy. 1610
doi:10.1017/s1431927616008898 fatcat:rryyjzsfqrcgtffj632ekrmsbq

The effect of movie-watching on electroencephalographic responses to tactile stimulation

Svenja Espenhahn, Tingting Yan, Winnica Beltrano, Sakshi Kaur, Kate Godfrey, Filomeno Cortese, Signe Bray, Ashley D. Harris
2020 NeuroImage  
Ashley D. Harris: Conceptualization, Resources, Writing -original draft, Writing -review & editing, Supervision, Funding acquisition.  ...  d ¼ 0.09] nor Inscapes and Movies [alpha: t (32) ¼ -1.69, p ¼ 0.305, effect size d ¼ 0.29; beta: t (32) ¼ -2.36, p ¼ 0.074, effect size d ¼ 0.40].  ... 
doi:10.1016/j.neuroimage.2020.117130 pmid:32622982 fatcat:csoemnedebcnrj5ih7kjkarn74

Optically-Controlled "Living Electrodes" with Long-Projecting Axon Tracts for a Synaptic Brain-Machine Interface [article]

Dayo O Adewole, Laura A Struzyna, James P Harris, Ashley D Nemes, Justin C Burrell, Dmitriy Petrov, Reuben H Kraft, H. Issac Chen, Mijail D Serruya, John A Wolf, D. Kacy Cullen
2018 bioRxiv   pre-print
(D) Conceptual schematic of the µTENN and cranial window.  ...  (E) The RCaMPpositive aggregate from (D) under fluorescent microscopy during recording (16 fps). (F) Confocal reconstruction of (D) post-stimulation.  ... 
doi:10.1101/333526 fatcat:wztutaop5jebvi7mijor6jxmam

Psychometric Evaluation of the Lower Extremity Computerized Adaptive Test, the Modified Harris Hip Score, and the Hip Outcome Score

Man Hung, Shirley D. Hon, Christine Cheng, Jeremy D. Franklin, Stephen K. Aoki, Mike B. Anderson, Ashley L. Kapron, Christopher L. Peters, Christopher E. Pelt
2014 Orthopaedic Journal of Sports Medicine  
Purpose: To compare the psychometric properties of the modified Harris Hip Score (mHHS), the Hip Outcome Score activities of daily living subscale (HOS-ADL) and sports (HOS-sports), and the Lower Extremity  ...  The modified Harris Hip Score (mHHS) is a commonly used joint-specific outcomes measure for hip osteoarthritis, arthroscopic, and arthroplasty procedures. 1, 3, 25, 26 The Hip Outcome Score (HOS) was  ...  Derived from the Harris Hip Score, the mHHS has 8 items that cover 8 areas: pain, limp, support, distance walked, stairs, shoes/socks, sitting, and public transportation. 6, 24 The mHHS is scored on  ... 
doi:10.1177/2325967114562191 pmid:26535291 pmcid:PMC4555528 fatcat:sx7mjjieencvpnkh3ulvpbrlfe

Individual differences in striatum activity to food commercials predict weight gain in adolescents

Sonja Yokum, Ashley N. Gearhardt, Jennifer L. Harris, Kelly D. Brownell, Eric Stice
2014 Obesity  
Objective: Adolescents view thousands of food commercials annually, but little is known about how individual differences in neural response to food commercials relate to weight gain. To add to our understanding of individual risk factors for unhealthy weight gain and environmental contributions to the obesity epidemic, we tested the associations between reward region (striatum and orbitofrontal cortex [OFC]) responsivity to food commercials and future change in body mass index (BMI). Methods:
more » ... olescents (N 5 30) underwent a scan session at baseline while watching a television show edited to include 20 food commercials and 20 nonfood commercials. BMI was measured at baseline and 1-year follow-up. Results: Activation in the striatum, but not OFC, in response to food commercials relative to nonfood commercials and in response to food commercials relative to the television show was positively associated with change in BMI over 1-year follow-up. Baseline BMI did not moderate these effects. Conclusions: The results suggest that there are individual differences in neural susceptibility to food advertising. These findings highlight a potential mechanism for the impact of food marketing on adolescent obesity.
doi:10.1002/oby.20882 pmid:25155745 pmcid:PMC4236252 fatcat:po3hk37blvgyvbm3is6g745usu

Cerebral blood flow response to acute hypoxic hypoxia

Ashley D. Harris, Kevin Murphy, Claris M. Diaz, Neeraj Saxena, Judith E. Hall, Thomas T. Liu, Richard G. Wise
2013 NMR in Biomedicine  
D. HARRIS ET 2.  ...  D. HARRIS ET AL. factors included.  ... 
doi:10.1002/nbm.3026 pmid:24123253 pmcid:PMC4114548 fatcat:6sbdboolovfmvcv4xdq3fduxau

Integrated stratigraphic studies of Paleocene-lowermost Eocene sequences, New Jersey Coastal Plain: Evidence for glacioeustatic control

Ashley D. Harris, Kenneth G. Miller, James V. Browning, Peter J. Sugarman, Richard K. Olsson, Benjamin S. Cramer, James D. Wright
2010 Paleoceanography  
New Jersey Paleocene sequence boundaries correlate with those in other regions and with d 18 O increases in the deep sea, suggesting Paleocene eustatic lowerings were associated with ice-growth events.  ...  HARRIS ET AL.: PALEOCENE-EOCENE SEA LEVEL PA3211 PA3211 . Preliminary comparisons with the Paleocene benthic foraminiferal d 18 O record of Berggren et al. [2000] from DSDP Site 384 (W.  ...  Thick gray lines on the d 18 O record represent the increases in d 18 O that correlate to New Jersey hiatuses.  ... 
doi:10.1029/2009pa001800 fatcat:oldtkfmzafd6taeus5jsac5sua

Effects of Transcranial Direct Current Stimulation on GABA and Glutamate in Children: A Pilot Study [article]

Chidera Nwaroh, Adrianna Giuffre, Lauran Cole, Tiffany Bell, Helen Carlson, Frank P MacMaster, Adam Kirton, Ashley D Harris
2019 bioRxiv   pre-print
Harris AD, Saleh MG, Edden R. Edited 1 H magnetic resonance spectroscopy in vivo: Methods and metabolites. Magn Reson Med. 2017;77(4):1377-89. 32.  ...  across the three intervention groups, showed a significant positive relationship between the change in left sensorimotor GABA (%GABA) and change in PPT L score ( PPT L ) (r = 0.538, p = 0.018; Fig Δ 4d)  ... 
doi:10.1101/759290 fatcat:jnxa4m2gsffzxhwvmjpjqnn434

Macromolecule-suppressed GABA measurements correlate more strongly with behavior than macromolecule-contaminated GABA+ measurements

Mark Mikkelsen, Ashley D. Harris, Richard A.E. Edden, Nicolaas A.J. Puts
2018 Brain Research  
MRS-only results showing moderate associations between MM-suppressed GABA and GABA+ are reported elsewhere (Harris et al., 2015b) .  ...  GABA estimates were tissue-corrected as per Harris et al. (2015c) , including full correction for tissue-related factors assuming a 2:1 GABA ratio between grey and white matter (α = 0.5).  ... 
doi:10.1016/j.brainres.2018.09.021 pmid:30244020 pmcid:PMC6519711 fatcat:pmc4kpejurcjto4z47rtzmzfga
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