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Picolyl Porphyrin Nanostructures as a Functional Drug Entrant for Photodynamic Therapy in Human Breast Cancers

Betsy Marydasan, Rajshree R. Nair, P. S. Saneesh Babu, Danaboyina Ramaiah, S. Asha Nair
2019 ACS Omega  
Working in this direction, we synthesized a picolylamine-functionalized porphyrin conjugate, compound 1, and its zinc complex compound 2.  ...  Compared to the existing PSs like foscan and photofrin, compound 2 exhibited a high singlet oxygen generation efficiency and triplet quantum yield.  ...  Cell proliferation is a tightly regulated process following a cyclic pattern and hence termed as the cell cycle.  ... 
doi:10.1021/acsomega.9b01380 pmid:31460405 pmcid:PMC6682089 fatcat:oisvfspwt5ac7blrobrswwqksy

Folic Acid Conjugated δ-Valerolactone-Poly(ethylene glycol) Based Triblock Copolymer as a Promising Carrier for Targeted Doxorubicin Delivery

Lekha Nair K, Sankar Jagadeeshan, Asha Nair S, G. S. Vinod Kumar, Chris Lorenz
2013 PLoS ONE  
Citation: Nair K L, Jagadeeshan S, Nair S A, Kumar GSV (2013) Folic Acid Conjugated d-Valerolactone-Poly(ethylene glycol) Based Triblock Copolymer as a Promising Carrier for Targeted Doxorubicin Delivery  ...  Moreover, a significant G2/M arrest was induced by DOX loaded VEV-FOL micelles at a concentration where free drug failed to show any activity.  ...  Polymeric micelles are made of amphiphilic copolymers having a hydrophobic as well as a hydrophilic end.  ... 
doi:10.1371/journal.pone.0070697 pmid:23990912 pmcid:PMC3749165 fatcat:xrmc3nbhf5enbfyf5tyvylngdy

Evaluation of triblock copolymeric micelles of δ- valerolactone and poly (ethylene glycol) as a competent vector for doxorubicin delivery against cancer

Lekha Nair K, Sankar Jagadeeshan, S Asha Nair, G S Vinod Kumar
2011 Journal of Nanobiotechnology  
Doxorubicin entrapped micelles (VEVDMs) prepared using a modified single emulsion method were obtained with a mean diameter of 90 nm and high encapsulation efficiency showing a pH dependent sustained doxorubicin  ...  Furthermore, our results launch VEV as a promising nanocarrier for an effective controlled drug delivery in cancer chemotherapy.  ...  Acknowledgements Authors are thankful to National Institute of Interdisciplinary Sciences and Technology, Kerala for NMR studies and CSIR, New Delhi for providing Research Fellowship to Lekha Nair K.  ... 
doi:10.1186/1477-3155-9-42 pmid:21943300 pmcid:PMC3213063 fatcat:qrpsq2rvjrhqja5gtwgao3e7iq

A CASE F UTERINE FIBROSARARCMA IN CATTLE

Asha Merina Kuriakose, G. Jeba Sujana Dhas, Vandana Vijayachandran, G. Ajithkumar, N.D . Nair
2005 Journal of Veterinary and Animal Sciences  
A case of uterine fibrosarcoma in cattle is placed on record.  ...  A pedunculated pear shaped soft mass weighing 40 g and having a. circumference and thickness of 1 S cm and S.7 cm respectivelywas noticed anteriodorsally on the right horn of a bovine uterus collected  ...  Based on these observatiol2s, the tumour was histologically characterized as a fibrosarcoma (Fig. 2 ).  ... 
doaj:e61e6876c25e42ee92aeb03ec02c2e17 fatcat:vsa6m4kov5hnjdgnomfghrq5ga

Nuclear Factor-κB: A Holy Grail in Cancer Prevention and Therapy

Bharat Aggarwal, Gautam Sethi, Asha Nair, Haruyo Ichikawa
2006 Current Signal Transduction Therapy  
The development of a drug that can specifically suppress NF-B activation requires a full understanding of the mechanism by which NF-B is activated in response to these various stimuli.  ...  Nuclear factor-B (NF-B) is a transcription factor that is activated in response to various inflammatory stimuli such as cytokines, growth factors, hormones, mitogens, carcinogens, chemotherapeutic agents  ...  Whereas NF-B provides a proliferative signal, p53 is a mediator of antiproliferation.  ... 
doi:10.2174/157436206775269235 fatcat:swjphs3manfivls7guczphcvja

Circular RNAs and their associations with breast cancer subtypes

Asha A. Nair, Nifang Niu, Xiaojia Tang, Kevin J. Thompson, Liewei Wang, Jean-Pierre Kocher, Subbaya Subramanian, Krishna R. Kalari
2016 OncoTarget  
Based on existing bioinformatics approaches, we developed a comprehensive workflow called Circ-Seq to identify and report expressed circRNAs.  ...  We believe that Circ-Seq will be a valuable tool to identify circRNAs useful in the diagnosis and treatment of other cancers and complex diseases.  ...  ACKNOWLEDGMENTS We thank Matthew A. Bockol for packaging the Circ-Seq workflow to make it available to the research community.  ... 
doi:10.18632/oncotarget.13134 pmid:27829232 pmcid:PMC5348369 fatcat:uqoooqt3nfatljlqb2qhxf4rki

BBBomics-Human Blood Brain Barrier Transcriptomics Hub

Krishna R. Kalari, Kevin J. Thompson, Asha A. Nair, Xiaojia Tang, Matthew A. Bockol, Navya Jhawar, Suresh K. Swaminathan, Val J. Lowe, Karunya K. Kandimalla
2016 Frontiers in Neuroscience  
Information of distance of a lincRNA to its corresponding protein-coding gene (upstream indicated by a negative number and downstream indicated by a positive number) can be found in the BBBomics hub.  ...  A detailed protocol has been included in the Supplementary Methods.  ...  Copyright © 2016 Kalari, Thompson, Nair, Tang, Bockol, Jhawar, Swaminathan, Lowe and Kandimalla.  ... 
doi:10.3389/fnins.2016.00071 pmid:26973449 pmcid:PMC4771746 fatcat:olouith5svfnzmdqkl2tv7li6u

Cyclosporin A Promotes Translational Silencing of Autocrine Interleukin-3 via Ribosome-Associated Deadenylation

Asha P. K. Nair, Hans H. Hirsch, Marco Colombi, Christoph Moroni
1999 Molecular and Cellular Biology  
Cyclosporin A (CsA), a calcineurin antagonist and blocker of interleukin-2 (IL-2) transcription in T cells, was found to inhibit translation of IL-3 mRNA in autocrine mast cell tumor lines.  ...  The mechanism involved ribosome-associated poly(A) shortening and required an intact AU-rich element in the 3′ untranslated region. FK506, another calcineurin inhibitor, shared the effect.  ...  (a) Northern blot analysis of poly(A) ϩ RNA (RNA was extracted by method A) from PB-3c, V2, V4D6, and V2D1 cells.  ... 
doi:10.1128/mcb.19.1.889 pmid:9858612 pmcid:PMC83946 fatcat:ifqpzmcsq5hs3aerdvcarwtjmi

A microRNA cluster downstream of the selector gene Fezf2 coordinates fate specification with dendritic branching in cortical neurons [article]

Asha Iyer, Verl B Siththanandan, Victoria Lu, Ramesh V Nair, Lee O Vaasjo, Maria J Galazo, Suzanne Tharin
2021 bioRxiv   pre-print
A network of transcription factors, including the selector gene Fezf2, is central to specifying cortical projection neuron fates.  ...  corticospinal projection neurons - involved in motor function and implicated in paralysis - and callosal projection neurons - involved in cognitive function and implicated in autism - develop represents a  ...  IDR can operate on peaks across a pair of true replicates resulting in a "conservative" output peak set, or across a pair of pseudoreplicates resulting in an "optimal" output peak set.  ... 
doi:10.1101/2021.11.03.467176 fatcat:7jmfqxnpvrarldj2nldnyl3bve

A Study on Student's Perception towards Online Classes and Effectiveness in Enhancing Active Participation and Communication Skills

Asha Nair Ganeser
2020 Universal Journal of Educational Research  
Cite This Paper in the following Citation Styles (a): [1] Abstract Online classes are now in demand, which fit the needs of today's 21st-century skills.  ...  This study conducted in a private higher education institution based in Kuala Lumpur and the participants were (N=50). Data were analyzed using SPSS.  ...  In the end, it is to give a positive reflection as said that it is a good practice.  ... 
doi:10.13189/ujer.2020.082231 fatcat:b3m4jg42rngpvg57e7thdtfxy4

Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner

Diana David, Sankar Jagadeeshan, Ramkumar Hariharan, Asha Nair, Radhakrishna Pillai
2014 Cell Division  
Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to respond to TGF-β/BMP signaling pathway.  ...  Conclusions: Our results therefore suggest a novel relation between Smurf2 and CNKSR2 thereby regulating AKT-dependent cell proliferation and invasion.  ...  a PPxY-motif.  ... 
doi:10.1186/1747-1028-9-2 pmid:25191523 pmcid:PMC4154384 fatcat:j4nxulrrdfa4ndtyfn6gqd23wy

Long non-coding RNA profile in mantle cell lymphoma identifies a functional lncRNA ROR1-AS1 associated with EZH2/PRC2 complex

Guangzhen Hu, Shiv K. Gupta, Tammy P. Troska, Asha Nair, Mamta Gupta
2017 OncoTarget  
Geisler CH, Kolstad A, Laurell A, Jerkeman M, Raty R, Andersen NS, Pedersen LB, Eriksson M, Nordstrom M, Kimby E, Bentzen H, Kuittinen O, Lauritzsen GF, et al.  ...  Taken together, this study identified a functional lncRNA ROR-AS1 involved with regulation of gene transcription via associating with PRC2 complex, and may serve as a novel biomarker in MCL patients.  ...  A.-D.  ... 
doi:10.18632/oncotarget.17956 pmid:29113297 pmcid:PMC5655192 fatcat:23ga47drojautm6q7v3piut3za

Enabling a Freely Accessible Open Source Remotely Controlled Robotic Articulator with a Neuro-Inspired Control Algorithm

Asha Vijayan, Chaitanya Nutakki, Dhanush Kumar, Krishnashree Achuthan, Bipin Nair, Shyam Diwakar
2017 International Journal of Online Engineering (iJOE)  
We developed an online laboratory for bioinspired robotics using a low-cost 6 degree-of-freedom robotic articulator with a neuro-inspired controller.  ...  With over 210000 registered users, the remote lab has been perceived as an interactive online learning tool and a practice platform.  ...  (Nair et al. 2008) in order to understand fundamental concepts in bio-inspired robotics.  ... 
doi:10.3991/ijoe.v13i01.6288 fatcat:hfbf7birtvg6tnel7fylls32ti

Functional crosstalk in culture between macrophages and trigeminal sensory neurons of a mouse genetic model of migraine

Alessia Franceschini, Asha Nair, Tanja Bele, Arn MJM Maagdenberg, Andrea Nistri, Elsa Fabbretti
2012 BMC Neuroscience  
Recurrent headache attacks might establish a chronic neuroinflammatory ganglion profile contributing to the hypersensitive phenotype.  ...  KI ganglion cultures constitutively contained a larger number of active macrophages, although no difference in P2X3 receptor expression was found.  ...  supported by the Telethon Foundation (grant GGP10082 to AN), the Cariplo Foundation (2011-0505 to AN), the Italian Institute of Technology (IIT to A.Nistri), and by an ARRS grant J3-2376-1540 (to EF) and a  ... 
doi:10.1186/1471-2202-13-143 pmid:23171280 pmcid:PMC3511260 fatcat:pypqgjtd6rcqpin5horlzol4mi

STIL a novel link in Shh and Wnt signaling, endowing oncogenic and stem like attributes to colorectal cancer [article]

Tapas Pradhan, Vikas Panchal, Evangeline Surya H, Krishna R, Samu John, Jissa V T, Anjana S, Chandramohan K, S. ASHA NAIR
2020 bioRxiv   pre-print
Cells were treated with RNase A (Sigma-aldrich, USA) at a concentration of 100µg/ml for 1 hr at 37ºC in a heat block (Thermo mixer, Eppendorf, Germany).  ...  Absorbance was measured at 570 nm in a microtiter plate reader. A graph was plotted with concentration on X axis and absorbance on y axis.  ... 
doi:10.1101/2020.07.30.226654 fatcat:mwxdrdduyfbl5bnloi7cnmhfqu
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