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Are glutamate and lactate increases ubiquitous to physiological activation? A 1H functional MR spectroscopy study during motor activation in human brain at 7Tesla

Benoît Schaller, Lijing Xin, Kieran O'Brien, Arthur W. Magill, Rolf Gruetter
2014 NeuroImage  
a r t i c l e i n f o 1 H MR spectroscopy Cerebral metabolic rate Neurotransmitter Glutamate Recent studies at high field (7 Tesla) have reported small metabolite changes, in particular lactate and glutamate  ...  The aim of this study was to extend functional MRS (fMRS) to investigate for the first time the metabolite changes during motor activation at 7 T.  ...  the Leenaards and the Jeantet Foundations and by a SNF grant No 131087 to R.  ... 
doi:10.1016/j.neuroimage.2014.02.016 pmid:24555953 fatcat:r5iyogp6xnd77oijjrmm5ondfi

The Future is 2D: Spectral-Temporal Fitting of Dynamic Magnetic Resonance Spectroscopy Data Provides Exponential Gains in Precision Over Conventional Approaches [article]

Assaf Tal
2022 bioRxiv   pre-print
Conclusion: Our results strongly support a 2D approach to MRS fitting where applicable, and particularly in nuclei such as 1H and 2H, which exhibit substantial spectral overlap.  ...  Methods: We derived a Cramer Rao Lower Bound for the temporal parameters for both 1D and 2D approaches, for two experiments: A multi-echo (MTE) experiment, designed to estimate metabolite T2s; And a functional  ...  A 1H functional MR spectroscopy study during motor 2021;11:2094 doi: 10.1038/s41598-021-81193-9. activation in human brain at 7Tesla. Neuroimage 2014;93:138-145 doi: 48.  ... 
doi:10.1101/2022.06.23.497318 fatcat:6hyrnmrypzca3ph2h5ilre2cbm

Speaker Abstracts

2006 International journal of psychiatry in clinical practice  
Patients with HE are believed to have profound disturbances in brain hemodynamic and energy metabolism, but no studies have yet compared cerebral blood flow and oxygen consumption during HE in cirrhosis  ...  In this study, we identified functional HCN channels in  ...  The initial increase in activity was observed at 5-30 min, followed by a decrease at 1 h, and returning to an increase at 4-24 h.  ... 
doi:10.1080/13651500601027547 pmid:24941153 fatcat:zsibfd337rdzrj4dizujozsmbu

Society of biological psychiatry 2001 annual meeting

2001 Biological Psychiatry  
Long-lasting, activity-dependent changes in synaptic strength at excitatory synapses in the mammalian brain are thought to play critical roles in brain development and many forms of experiencedependent  ...  Activation of these intracellular signaling cascades in turn appear to bi-directionally control synaptic strength, at least in part, by regulation of the trafficking of glutamate receptors to (LTP) and  ...  useful doses did not change significantly the 1H MRS brain metabolite values measured at 1.5T.  ... 
doi:10.1016/s0006-3223(01)01102-7 fatcat:iyjyq4h4qjavffdvbmr3vlfwj4

Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts

2022 Molecular Imaging and Biology  
resolution parameters (to maximize SNR/CNR) and a corresponding number of iterations for each resolution subset are taken in turn.  ...  are taken in turn.  ...  At 6h p.i., the corresponding tumor-to-organ activity ratios (T:NT) for blood, non-tumored liver and kidney were respectively 17. 6 ± 6.3, 19.4 ± 5.3, and 6.3 ± 1.3, and at 48h p.i.  ... 
doi:10.1007/s11307-021-01693-y pmid:34982365 pmcid:PMC8725635 fatcat:4sfb3isoyfdhfbiwxfr55gvqym

Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012

2012 International Journal of Neuropsychopharmacology  
We further assessed the contributing effects of HIV and cortisol, known to be elevated in MDD, in primary human neuronal-glial in vitro cultures exposed to 6000 pg/ml HIV (BaL) and/or 500 nM cortisol after  ...  Results : Post-mortem FGF2 was increased in both HIV and HIV/ MDD compared to controls (p<0.01) but was significantly lower in HIV/MDD compared to HIV alone (p<0.01).  ...  and synchronization), neurochemical profile (1H-MRS at 14.1Tesla) were assessed, as well as behavior.  ... 
doi:10.1017/s1461145712000508 fatcat:ft6ipgmb45azzjxouthbqdn43i

BNA Festival of Neuroscience 2019

2019 Brain and Neuroscience Advances  
This study aimed to investigate the effect of stress on brain connectivity in an adolescent population using a graph theory approach.  ...  Introduction: Stressful life experiences are thought to affect normal brain development.  ...  To investigate AMPK activity in a more physiological setting we exposed the distal axon to lactate and induced localised nutrient deprivation in this region by inhibition of lactate uptake (AR-C155858,  ... 
doi:10.1177/2398212819855490 fatcat:y4b5r7rpdnblzoxvb2crpzqhee

Panel Session Co-Morbid Pain and Addiction: Novel Treatments

2006 Neuropsychopharmacology  
Following 7 days of abstinence in the home cage, rats were re-exposed to the self-administration environment in the response-contingent presence of the conditioned light and tone stimuli during a 2-hour  ...  and human models which may be informative in early proof of principle/concept studies.  ...  The Time Course of Antipsychotics Versus Placebo: On Overall Efficacy, Positive, Negative and Cognitive Symptoms John M. Davis*  ... 
doi:10.1038/sj.npp.1301265 fatcat:6odqjmshuncm5muxk5g5knprui

Abstracts from the Society for Neuro-Oncology Eighth Annual Meeting

2003 Neuro-Oncology  
Migration experiments, performed in modified Boyden chambers using 2024, WT11, and LN229 cells, demonstrated a 17%-60% increase in cell migration after 24 hours in hypoxia compared to normoxia (20% O 2  ...  Hypoxic cells showed a stellate morphology and expressed proteins associated with increased migration, including increased total gelatinase activity by gelatin zymography, modestly increased cellular urokinase  ...  Purpose: The aim of this work is to develop a combination of in vivo and ex vivo 1H MR Spectroscopy (MRS) methodology for a precise classification of glioblastoma multiforme (GBM) types from metabolic  ... 
doi:10.1093/neuonc/5.4.279 fatcat:ykb4vil5z5fv3oti7esqlchpxy

ACNP 57th Annual Meeting: Poster Session II

2018 Neuropsychopharmacology  
These data indicate that when limited to adulthood, high CRP loads representing physiological levels in humans do not appear to be sufficient to alter susceptibility to trauma.  ...  These results suggest that either CRP gene mutations are required to increase risk or that CRP may only be a marker of immune pathology but is not itself directly contributing to PTSD pathogenesis.  ...  in the brain were calculated. 1H-MRS data were processed with the ProFit algorithm and 2D basis sets, and estimated GABA and glutamate metabolite peaks were ratioed to water and corrected for within-voxel  ... 
doi:10.1038/s41386-018-0267-6 fatcat:febeq6uwefgdzm65ccmzrmjwjy

Poster Session III

2006 Neuropsychopharmacology  
Acute administration of cocaine has been shown to alter brain function in these regions and there are data to suggest a dysregulation of reward processing in cocaine users.  ...  Results: In a proprietary human recombinant mutant alpha7 nAchR cell line, MEM 3454 activated alpha7 nAchRs and produced concentration-dependent increases in calcium flux signals that were rightshifted  ...  In this study, we examined the left STG in young individuals at increased genetic risk for schizophrenia and healthy controls using in vivo 1H spectroscopy with a hypothesis that HR will show reduction  ... 
doi:10.1038/sj.npp.1301268 fatcat:rl22v3qzwfh4hcr2c4z3b2daoi

Integrated Physiology/Obesity

2012 Diabetes  
Beta cell function was assessed by state-of-art mathematical modeling of glucose/C-peptide curves during a 240' frequently sampled OGTT, to provide the beta cell responses to: i. the rate of increase of  ...  In order to determine which model produces a phenotype most like that of human T2D, the diet models need to be evaluated in head-to-head comparisons.  ...  In this prospective, matched case-control study, we evaluated whether the presence of BAT are associated with thyroid function, insulin resistance, infl ammation and visceral obesity in adult humans.  ... 
doi:10.2337/db12-1721-2041 fatcat:q6qkrz4nmzgorialrplvyp6egy

Solid Phase Microextraction as a Short-Term Sampling Technique for BTEX Occupational Exposure

Patrick Y. Schüpfer, Cong Khanh Huynh
2008 Journal of Occupational and Environmental Hygiene  
DNA extraction from 5 mg of fingernails from 7 volunteers using 1 h cell lysis in a standard buffer and a DNA purification on QIAamp DNA mini kit columns allowed to acquire a mean quantity of 100 ng DNA  ...  In conclusion, nails are very easy to collect and contain large amounts of good quality DNA that can be extracted within a few hours.  ...  Acknowledgements: the authors thank Christophe Bonny, Peter Clarke and Jean-François Brunet for helpful discussion. This work is supported by the CTI grant #8909.1 PFLS-LS.  ... 
doi:10.1080/15459620802177484 pmid:18569516 fatcat:bjf22zzr3beljomywn7ooqn44e

39th Meeting of the Canadian Congress of Neurological Sciences

2004 Canadian Journal of Neurological Sciences  
Each animal received an infusion of either [2-13C]acetate or [1-13C]glucose. 1H MR spectroscopic analysis and 1H{13C} Spin-echo difference (SED) MR spectroscopy was used to analyze cerebral metabolites  ...  In this study we use 13C substrates in combination with MR spectroscopy to study cerebral metabolism in the setting of TBI.  ...  Composition Active Ingredient: almotriptan malate equivalent to 6.25 or 12.5 mg of almotriptan.  ... 
doi:10.1017/s0317167100002961 fatcat:3umzmupwt5b6vc2ec5akfgbms4


2010 Epilepsia  
Purpose: To explore the causative role of PCDH19 gene, located at Xq22, in females with epilepsy.  ...  All patients were pharmacoresistent and had been exposed to 2-8 (median 3.5) AEDs without success.  ...  The most frequent AEDs used before LTG were valproate (n = 7), levetiracetame (n = 7), sulthiame (n = 6), and topiramate (n = 4).  ... 
doi:10.1111/j.1528-1167.2010.02658.x pmid:20590792 fatcat:ylmo7rjtqncydkxeudaib77noy
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