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Tox-Database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

Sebastian Polak, Barbara Wiśniowska, Anna Glinka, Miłosz Polak
2012 BMC Pharmacology and Toxicology  
The large interest in the IKr current has resulted in the development of predictive tools and informative databases describing a drug's susceptibility to interactions with the hERG channel, although there  ...  Discussion: The aim of this database development and publication was to provide a scientifically useful, easily usable and clearly verifiable set of information describing not only IKr (hERG), but also  ...  BW participated in data gathering and quality control, drafted the manuscript. AG participated in data gathering and quality control.  ... 
doi:10.1186/2050-6511-13-6 pmid:22947121 pmcid:PMC3506270 fatcat:lwsy5surjzcu7f5ougyd375nvi

An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death

Diana Mendes Freire, Claude Gutierrez, Acely Garza-Garcia, Anna D. Grabowska, Ambre J. Sala, Kanchiyaphat Ariyachaokun, Terezie Panikova, Katherine S.H. Beckham, André Colom, Vivian Pogenberg, Michele Cianci, Anne Tuukkanen (+11 others)
2019 Molecular Cell  
In the absence of MbcA, MbcT triggers rapid M. tuberculosis cell death, which reduces mycobacterial survival in macrophages and prolongs the survival of infected mice.  ...  To investigate the mechanism, we solved the 1.8 Å-resolution crystal structure of the MbcTA complex.  ...  These results indicate that MbcT is highly toxic to Mtb in vivo when not neutralized by MbcA.  ... 
doi:10.1016/j.molcel.2019.01.028 pmid:30792174 pmcid:PMC6436930 fatcat:ziheklharjethjvexneepn3rti

A critical assessment of regulatory triggers for products of biotechnology: Product vs. process

Alan McHughen
2016 GM crops & food  
These tensions led to vastly different approaches to safety regulation in different jurisdictions, even though the intent of regulations-to assure public and environmental safety-are common worldwide,  ...  So great are the political divisions that jurisdictions cannot even agree on the appropriate triggers for regulatory capture, whether product or process.  ...  Some of these issues were raised and discussed at a workshop held February [6] [7] 2006 in Ottawa.  ... 
doi:10.1080/21645698.2016.1228516 pmid:27813691 pmcid:PMC5161003 fatcat:7qwwwudt2fd7jk7gqllhvwc5qy

Protein over-expression in Escherichia coli triggers adaptation analogous to antimicrobial resistance

Jack James, Benjamin Yarnall, Andy Koranteng, Jane Gibson, Tahmina Rahman, Declan A. Doyle
2021 Microbial Cell Factories  
These results redefine our understanding of protein over-production and link it to the adaptive survival response seen in the development of antimicrobial resistance.  ...  Conclusions We demonstrate that it is the act of high-level over-expression of exogenous proteins in E. coli that sets in motion a chain of events leading to > 99.9% cell death.  ...  Acknowledgements We thank Mark Chapman, Phil Williamson and Nullin Divecha for helpful discussions and comments. We also thank Louise Shek for help with research support. 1  ... 
doi:10.1186/s12934-020-01462-6 pmid:33430875 fatcat:exmevmyqtjhirbpxyu46m23umm

ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet mediated degeneration [article]

Sonia Muliyil, Clemence Levet, Stefan Düsterhöft, Iqbal Dulloo, Sally Cowley, Matthew Freeman
2020 biorxiv/medrxiv   pre-print
Finally, we demonstrate the existence of a conserved pathway in human iPS-derived microglia-like cells, which are central players in neurodegeneration.  ...  Overall, we have discovered a pathway mediated by TNF signalling acting not as a trigger of inflammation, but as a cytoprotective factor in the retina.  ...  Conflict of interest The authors declare that they have no conflict of interest.  ... 
doi:10.1101/2020.01.09.900209 fatcat:jrupixwhdzgtzj5elliapns2ka

Crosstalk between Calcium and ROS Signaling during Flg22-Triggered Immune Response in Arabidopsis Leaves

Matthew J. Marcec, Kiwamu Tanaka
2021 Plants  
The rise and sequestration of these messengers in the cytosol and apoplast are formed by various channels, transporters, and enzymes that are required for proper defense responses.  ...  Calcium and reactive oxygen species (ROS) are two of the earliest second messengers in response to environmental stresses in plants.  ...  Acknowledgments: We are grateful to Jeremy Jewell at Washington State University for critical comments on the manuscript. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/plants11010014 pmid:35009017 pmcid:PMC8747291 fatcat:45fus5tnafdgrgnbknupzl6h5a

Hepatic Metabolic Derangements Triggered by Hyperthermia: An In Vitro Metabolomic Study

Ana Margarida Araújo, Maria Enea, Félix Carvalho, Maria de Lourdes Bastos, Márcia Carvalho, Paula Guedes de Pinho
2019 Metabolites  
and aims: Liver toxicity is a well-documented and potentially fatal adverse complication of hyperthermia.  ...  Metabolomic profiling of both intracellular metabolites and volatile metabolites in the extracellular medium of PMH was performed.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/metabo9100228 pmid:31618919 pmcid:PMC6835778 fatcat:47tx3knxc5egrgoxyjqpro7nla

The Ubiquitin Ligase PUB22 Targets a Subunit of the Exocyst Complex Required for PAMP-Triggered Responses in Arabidopsis

M. Stegmann, R. G. Anderson, K. Ichimura, T. Pecenkova, P. Reuter, V. Zarsky, J. M. McDowell, K. Shirasu, M. Trujillo
2012 The Plant Cell  
), which acts in concert with PUB23 and PUB24 as a negative regulator of PAMP-triggered responses.  ...  We show that Exo70B2 is required for both immediate and later responses triggered by all tested PAMPs, suggestive of a role in signaling.  ...  These clones define the interaction site to the first 144 amino acids of Exo70B2 (see Supplemental Figure 1A online).  ... 
doi:10.1105/tpc.112.104463 pmid:23170036 pmcid:PMC3531861 fatcat:4ahniy7yone4rboe2rtrysdgz4

HSB-1 inhibition and HSF-1 overexpression trigger overlapping transcriptional changes to promote longevity in Caenorhabditis elegans [article]

Surojit Sural, Tzu-Chiao Lu, Seung Ah Jung, Ao-Lin Hsu
2019 bioRxiv   pre-print
In addition, genes that are upregulated via both HSB-1 inhibition and HSF-1 overexpression include numerous DAF-16 targets that have known functions in longevity regulation.  ...  In addition to its role in stress response, HSF-1 also acts as a key regulator of the rate of organismal aging.  ...  and prevent the toxic aggregation of misfolded cytosolic proteins (Richter et al. 2010) .  ... 
doi:10.1101/535864 fatcat:qxsi67ngczbl5ftzkq3uf26n2y

sj-pdf-1-ctj-10.1177_1740774520972650 – Supplemental material for Assessing the potential for prevention or earlier detection of on-site monitoring findings from randomised controlled trials: Further analyses of findings from the prospective TEMPER triggered monitoring study

William J Cragg, Caroline Hurley, Victoria Yorke-Edwards, Sally P Stenning
2020 Figshare  
of findings from the prospective TEMPER triggered monitoring study by William J Cragg, Caroline Hurley, Victoria Yorke-Edwards and Sally P Stenning in Clinical Trials  ...  Supplemental material, sj-pdf-1-ctj-10.1177_1740774520972650 for Assessing the potential for prevention or earlier detection of on-site monitoring findings from randomised controlled trials: Further analyses  ...  If you know us and would rather discuss in person, please feel free to get in touch.  ... 
doi:10.25384/sage.13284238.v1 fatcat:6jdjlufs5nc2xfyxupci6jevie

Analyzing Uncivil Speech Provocation and Implicit Topics in Online Political News [article]

Rijul Magu, Nabil Hossain, Henry Kautz
2018 arXiv   pre-print
Finally, we devise a technique to "read between the lines" --- finding the topics of discussions that an article triggers among its readers without frequent, explicit mentions of these topics in its content  ...  First, we create a dataset of political news articles and their reader comments from partisan news sites. Then, we train classifiers to predict different aspects of uncivil speech in comments.  ...  Results from running the two classifiers are shown in Table 2 which suggest that these classifiers predict whether an article would trigger substantial incivility in its comments much better than chance  ... 
arXiv:1807.10882v1 fatcat:dn6m2gxdjzgndjxgj22xenpdm4

A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA

Agnieszka Tudek, Manfred Schmid, Marius Makaras, J. David Barrass, Jean D. Beggs, Torben Heick Jensen
2018 Cell Reports  
Genomes are promiscuously transcribed, necessitating mechanisms that facilitate the sorting of RNA for function or destruction.  ...  More generally, we suggest that nuclear RNA decay, negotiated by Nab2p availability, aids in balancing cellular transcript supply with demand.  ...  STAR+METHODS Detailed methods are provided in the online version of this paper and include the following: d KEY RESOURCES DECLARATION OF INTERESTS Hodge, C.A., Colot, H.V., Stafford, P., and Cole,  ... 
doi:10.1016/j.celrep.2018.07.103 pmid:30157437 pmcid:PMC6130047 fatcat:km6pgp4hhvc37j2pef2zndmsjm

Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase

Marcus C. Tatum, Felicia K. Ooi, Madhusudana Rao Chikka, Laetitia Chauve, Luis A. Martinez-Velazquez, Harry W.M. Steinbusch, Richard I. Morimoto, Veena Prahlad
2015 Current Biology  
activate HSF1 in another cell, even in the absence of temperature increase.  ...  in the metazoan C. elegans.  ...  Colon-Ramos for helpful comments.  ... 
doi:10.1016/j.cub.2014.11.040 pmid:25557666 pmcid:PMC4840938 fatcat:txtaowvk4zbsrlxooepys6ci2u

Effectors with chitinase activity (EWCAs), a family of conserved, secreted fungal chitinases that suppress chitin-triggered immunity

Jesús Martínez-Cruz, Diego Romero, Jesús Hierrezuelo, Michael Thon, Antonio de Vicente, Alejandro Pérez-García
2021 The Plant Cell  
In this work, we examine the role of these candidates in the infection of melon (Cucumis melo L.) plants, using gene expression analysis, RNAi silencing assays, protein modeling and protein-ligand predictions  ...  Our results show that these proteins are chitinases that are released at pathogen penetration sites to break down immunogenic chitin oligomers, thus preventing the activation of chitin-triggered immunity  ...  Linares (University of Malaga, Spain) for her technical assistance. We also thank three anonymous reviewers for their comments and criticism.  ... 
doi:10.1093/plcell/koab011 pmid:33793825 fatcat:guydhdqtujcd7ac73bphted5xe

Stress in NHS staff triggers defensive inward-focussing and an associated loss of connection with colleagues: this is reversed by Schwartz Rounds

Melanie S. George
2016 Journal of Compassionate Health Care  
Discussion: Attendance at the Schwartz Rounds helped staff to recognise that their feelings were normal in the context of a highly-pressured healthcare system.  ...  Results: Analysis of the results revealed a significant reduction in attendees' appraisal of emotional labour and an increase in reflection.  ...  Acknowledgements I am grateful to the intuitive and compassionate frontline clinicians who participated in this study. I am also indebted to Dr Jane Keep, my tutor from the NHS Leadership Academy.  ... 
doi:10.1186/s40639-016-0025-8 fatcat:a7bav7qherh2ddwshx42p7wi5y
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