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Application of Cooperative Convolution Optimization for 13C Metabolic Flux Analysis: Simulation of Isotopic Labeling Patterns Based on Tandem Mass Spectrometry Measurements [chapter]

Rohitash Chandra, Mengjie Zhang, Lifeng Peng
2012 Lecture Notes in Computer Science  
measured by tandem mass spectrometry, which essentially is an optimization problem.  ...  Research Goals • This work applies cooperative coevolution for 13 C MFA for simulating the isotopic labeling patterns of the metabolites in an example metabolic network selected from literature. • The  ...  Evaluation of Population Size and Duration of Optimisation Simulated Tandem MS Discussion The results have shown that cooperative coevolution can be used for metabolic flux analysis.  ... 
doi:10.1007/978-3-642-34859-4_18 fatcat:myyxwyxsiff3tknwjgp6zz5jue

Award Winners and Abstracts of the 31st Annual Symposium of The Protein Society, Montreal, Canada, July 24-27, 2017

2017 Protein Science  
METHODS: We developed a clinically optimized variant of ExM called Expansion Pathology (ExPath), by optimizing the ExM chemistry, labeling, and imaging methodologies.  ...  by imaging of the ACTN4 protein expression pattern with conventional light microscopy.  ...  mass spectrometry.  ... 
doi:10.1002/pro.3349 pmid:29280217 fatcat:jrxtwzblare37gxsvc5szbwuhu

Abstracts submitted for the 8th annual conference of the Society for Glycobiology

2003 Glycobiology  
The mass-labeled HS is then digested into oligosaccharides and the oligosaccharides containing the labeled isotope are identified by mass spectrometry.  ...  These were characterized by a variety of techniques as required, including 1-D 1H-and 13C-NMR, 2-D 1H-1H-NMR, and 2-D 13C-1H-NMR spectroscopy; electrospray ionization mass spectrometry (ESI-MS and tandem  ... 
doi:10.1093/glycob/cwg130 fatcat:24d74tupyvbtreziagois4yjui

Proceedings of the World Molecular Imaging Congress 2020, October 7-9, 2020: General Abstracts

2022 Molecular Imaging and Biology  
Conclusion: Tumor specific uptake of pan800 provided remarkable contrast and a flexible imaging window for fluorescence-guided identification of HGGs despite modest EGFR expression.  ...  Administered systemically, nearinfrared fluorescent dye-labeled antibody targeting EGFR may be able to detect HGGs expressing modest amount of EGFR and serve as an image-guided surgical probe.  ...  Trends of these metrics are plotted in Fig. 1i .  ... 
doi:10.1007/s11307-021-01691-0 pmid:34982363 pmcid:PMC8725637 fatcat:ipn7hwekzzh6nbsk6dr2mzuhhm

Poster Abstracts

2009 Integrative and Comparative Biology  
The power output measured for B. marinus corresponds to less than 100 W kg -1 hindlimb muscle mass (16% body mass), well below the power generating capacity of typical Bufo muscle (>200 W kg -1 ).  ...  Evidence from previous research, based on measured levels of the hormone cortisol, suggests that bridge-roosting Brazilian free-tailed bats (Tadarida brasliensis) experience lower levels of stress and  ...  to explain metabolic scaling based on the evolutionary optimization of the structure and function of resource supply networks and exchange surfaces.  ... 
doi:10.1093/icb/icp003 fatcat:ogzq66svibfcjnht5szojhqk3q

Forty-First Annual Meeting March 2-6, 1997 Ernest N. Morial Convention Center New Orleans, Louisiana. Monday Symposia and Posters, Part III

1997 Biophysical Journal  
Mass spectrometry of a partially purified fraction yielded a molecular mass of 16.95 kDa for this fragment.  ...  When free Tnl (Mr=21k) was treated with chymotrypsin (enzyme:Tnl wt ratio 1:500, 250C for -10 min) two fragments were produced with molecular masses of 11.56 and 9.53 kDa as determined by mass spectrometry  ...  Immunofluorescent analysis of the transfected cells demonstrates strong labeling at the cell surface.  ... 
doi:10.1016/s0006-3495(97)78734-4 fatcat:ughxargwkzdchefcecrdjjxitm

The Advancement of Mass Spectrometry-based Hydroxyl Radical Protein Footprinting: Application of Novel Analysis Methods to Model Proteins and Apolipoprotein E

Brian Gau
Only one isoform of ApoE is strongly associated with Alzheimer's disease; unfortunately, the structural reason for this association is not known, in part because no high resolution structure exists of  ...  The stable modifications can be detected and quantified by the same proteolysis, chromatography, and mass spectrometry techniques employed in proteomics studies; however, proteomics software does not automatically  ...  labeling visited on each peptide by mass spectrometry.  ... 
doi:10.7936/k72r3pq8 fatcat:kcqstyq4gzgkhmjq2j3ghbtjeq

Using Chemometrics and Geochemistry to Assess Heavy Oil Fluid Heterogeneity in Southeastern Mexico Heavy Oil Fields [article]

Mengsha Yin, University Of Calgary, Stephen R. Larter, Haiping Huang, Lloyd R. Snowdon, Thomas B. P. Oldenburg
These parameters are subsequently integrated by principal component analysis (PCA) to generate a whole oil composition-based biodegradation parameter that magnifies oil compositional variations and enables  ...  To deconvolve complex oil biodegradation, charging and mixing history, exploratory factor analysis is applied, incorporating fresh oil components and the biodegradation indicators for different oil fractions  ...  a mixture with an extensive mass range and complicated isotopic patterns.  ... 
doi:10.11575/prism/38537 fatcat:eejjwxdpqffwdlfj2qz277ungy

Integrating photosystem II and electroactive bacteria with three-dimensional electrodes for semi-artificial photosynthesis

Xin Fang, Apollo-University Of Cambridge Repository, Apollo-University Of Cambridge Repository, Erwin Reisner
Chapter 4 reports an inverse opal-graphene electrode as the host for photosystem II. The enzyme activity in such carbon-based ele [...]  ...  Artificial photosynthesis is at the forefront of strategies to tackle the global reliance on fossil fuels and shape the contour of a sustainable future fuelled by renewable resources.  ...  Acknowledgements This thesis is under the supervision of Prof. Erwin Reisner, to whom I extend my greatest gratitude.  ... 
doi:10.17863/cam.44736 fatcat:fltnzsilmjgyxajfpjzzbkaj5i