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Applicability and reproducibility of 2D multi-slice GRASE myelin water fraction with varying acquisition acceleration

Gerhard S. Drenthen, Walter H. Backes, Albert P. Aldenkamp, Jacobus F.A. Jansen
2019 NeuroImage  
We investigated the applicability and reproducibility of whole brain multi-slice GRASE myelin-water imaging with post-acquisition slice-profile correction in healthy volunteers (aged 25-32y).  ...  Hence, a multi-slice GRASE acquisition with parallel acceleration factor 2 and a scan time of 7:30 min still provides an excellent reproducibility.  ...  In this study, we have shown the applicability and reproducibility of MWF estimation using fast whole brain multi-slice GRASE imaging with post-acquisition slice-profile correction for varying acceleration  ... 
doi:10.1016/j.neuroimage.2019.04.011 pmid:30965132 fatcat:tvwpciu32na2halngr32x4vy3a

Gradient- and spin-echo (GRASE) MR imaging: a long-existing technology that may find wide applications in modern era

Mei-Lan Chu, Cheng-Ping Chien, Wen-Chau Wu, Hsiao-Wen Chung
2019 Quantitative Imaging in Medicine and Surgery  
Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.  ...  Myelin water fraction is another example where T2 mapping with GRASE finds usefulness (50) .  ...  Technical variations on GRASE to attempt a direct visualization of the myelin water component have also been documented (51) .  ... 
doi:10.21037/qims.2019.09.13 pmid:31667134 pmcid:PMC6785504 fatcat:u3tmszsq4zcihc4usoxzfuohui

Exploring Generalization Capacity of Artificial Neural Network for Myelin Water Imaging

Jieun Lee, Joon Yul Choi, Dongmyung Shin, Eung Yeop Kim, Se-Hong Oh, Jongho Lee
2020 Investigative Magnetic Resonance Imaging  
Results: The results of ANN-MWI showed high reliability in generating myelin water fraction maps from the datasets with different resolutions.  ...  Materials and Methods: ANN-MWI was trained to generate a T 2 distribution, from which the myelin water fraction value was measured.  ...  Acknowledgments This work was supported by the Creative-Pioneering Researchers Program and the Institute of Engineering  ... 
doi:10.13104/imri.2020.24.4.207 fatcat:sk2nzmvri5bolmr7mfdivkl3sq

Inferring brain tissue composition and microstructure via MR relaxometry

Mark D. Does
2018 NeuroImage  
MRI relaxometry has been established as a tool for characterizing neural tissue, particular with respect to myelination, and the potential for further development exists. size of axons.  ...  This article reviews the development and current state of the most common types of water proton relaxometry, measures of T 1 , T 2 , and T 2 * .  ...  Harkins, and Daniel F. Gochberg. Does Page 18 Neuroimage. Author manuscript; available in PMC 2019 November 15.  ... 
doi:10.1016/j.neuroimage.2017.12.087 pmid:29305163 pmcid:PMC6028317 fatcat:lvdwsxiy7zfhzifvj66rawrqeu

Imaging outcomes for trials of remyelination in multiple sclerosis

Shahrukh Mallik, Rebecca S Samson, Claudia A M Wheeler-Kingshott, David H Miller
2014 Journal of Neurology, Neurosurgery and Psychiatry  
The ratio of the short T 2 (myelin water) signal to the total water signal, termed the myelin water fraction (MWF), 14 has been shown to correlate with histological measures of myelin content, 15 and  ...  compared with traditional multi-component T 2 relaxometry using 2D multi-spin echo (MSE) sequences.  ... 
doi:10.1136/jnnp-2014-307650 pmid:24769473 pmcid:PMC4335693 fatcat:3bpko63xuje35byq7h7v55a7ji

Revisiting the T2 Spectrum Imaging Inverse Problem: Bayesian Regularized Non-Negative Least Squares

Erick Jorge Canales-Rodríguez, Marco Pizzolato, Thomas Yu, Gian Franco Piredda, Tom Hilbert, Joaquim Radua, Tobias Kober, Jean-Philippe Thiran
2021 NeuroImage  
the myelin water fraction (MWF).  ...  Multi-echo T2 magnetic resonance images contain information about the distribution of T2 relaxation times of compartmentalized water, from which we can estimate relevant brain tissue properties such as  ...  Canales-Rodríguez] and by the European Union's Horizon 2020 research and innovation program under the Marie Sk ł odowska-Curie Actions [grant agreement No  ... 
doi:10.1016/j.neuroimage.2021.118582 pmid:34536538 fatcat:xznxrdqq4nc6hbe3wjng2hwnre

Promise and pitfalls of g-ratio estimation with MRI

Jennifer S.W. Campbell, Ilana R. Leppert, Sridar Narayanan, Mathieu Boudreau, Tanguy Duval, Julien Cohen-Adad, G. Bruce Pike, Nikola Stikov
2017 NeuroImage  
The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a myelinated axon.  ...  This manuscript reviews the growing g-ratio imaging literature and speculates on future applications.  ...  of Canada (NS, 2016-06774, and JCA, 435897-2013), the Montreal Heart Institute Foundation, the Fonds de  ... 
doi:10.1016/j.neuroimage.2017.08.038 pmid:28822750 fatcat:wlhlcxpi2vhazbnmntlletlgc4

Myocardial T2 mapping reveals age- and sex-related differences in volunteers

Florian Bönner, Niko Janzarik, Christoph Jacoby, Maximilian Spieker, Bernhard Schnackenburg, Felix Range, Britta Butzbach, Sebastian Haberkorn, Ralf Westenfeld, Mirja Neizel-Wittke, Ulrich Flögel, Malte Kelm
2015 Journal of Cardiovascular Magnetic Resonance  
Conclusion: GRASE-derived T2 maps are highly reproducible. However, female sex and aging with typical prevalence of hypertension and diabetes were accompanied by increased myocardial T2 values.  ...  Therefore, the aim of the study was to investigate the effects of age and sex on quantitative T2 mapping with a turbo gradient-spin-echo (GRASE) sequence at 1.5 T.  ...  While GRASE was already investigated in the brain for the respective myelin-water environment [20] , we showed that this sequence was also sensitive in the detection of global and local water changes  ... 
doi:10.1186/s12968-015-0118-0 pmid:25656484 pmcid:PMC4318191 fatcat:ynakhnmvdfb5rdrqvexohlphp4

Rapid simultaneous high-resolution mapping of myelin water fraction and relaxation times in human brain using BMC-mcDESPOT

Mustapha Bouhrara, Richard G. Spencer
2017 NeuroImage  
Among the methods applied for measurement of myelin water fraction (MWF) and relaxation times, the multicomponent driven equilibrium single pulse observation of T 1 and T 2 (mcDESPOT) approach is of particular  ...  interest. mcDESPOT permits whole brain mapping of multicomponent T 1 and T 2 , with data acquisition accomplished within a clinically realistic acquisition time.  ...  Reiter and Christopher Bergeron for assistance with data acquisition.  ... 
doi:10.1016/j.neuroimage.2016.09.064 pmid:27729276 pmcid:PMC5303643 fatcat:44iczxemv5cddiuuos2sy2zsry

Multi-parametric neuroimaging reproducibility: A 3-T resource study

Bennett A. Landman, Alan J. Huang, Aliya Gifford, Deepti S. Vikram, Issel Anne L. Lim, Jonathan A.D. Farrell, John A. Bogovic, Jun Hua, Min Chen, Samson Jarso, Seth A. Smith, Suresh Joel (+5 others)
2011 NeuroImage  
reproducibility of 3.5%.  ...  Additionally, it establishes a baseline for continuing development and optimization of multi-parametric imaging protocols.  ...  This arrangement has been approved by Johns Hopkins University in accordance with its conflict of interest policies.  ... 
doi:10.1016/j.neuroimage.2010.11.047 pmid:21094686 pmcid:PMC3020263 fatcat:t7k6n2dlfvcmhgs56vwed5ao6y

Recommendations and guidelines from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 2 - Ex vivo imaging [article]

Kurt G Schilling, Francesco Grussu, Andrada Ianus, Brian Hansen, Manisha Aggarwal, Stijn Michielse, Fatima Nasrallah, Warda Syeda, Nian Wang, Jelle Veraart, Alard Roebroeck, Andrew F Bagdaserian (+38 others)
2022 arXiv   pre-print
An overarching goal herein is to enhance the rigor and reproducibility of ex vivo dMRI acquisitions and analyses, and thereby advance biomedical knowledge.  ...  The steps from tissue preparation, image acquisition and processing, and interpretation of results are complex, with many decisions that not only differ dramatically from in vivo imaging, but ultimately  ...  Indeed, very high spatial resolutions in the third dimension may not be achievable in 2D multi-slice acquisitions, as very thin slices may not be feasible depending on the slice-selection gradient strength  ... 
arXiv:2209.13371v1 fatcat:3i3ky5etrjeotc4pmnat3t4nd4

The Human Connectome Project's neuroimaging approach

Matthew F Glasser, Stephen M Smith, Daniel S Marcus, Jesper L R Andersson, Edward J Auerbach, Timothy E J Behrens, Timothy S Coalson, Michael P Harms, Mark Jenkinson, Steen Moeller, Emma C Robinson, Stamatios N Sotiropoulos (+4 others)
2016 Nature Neuroscience  
Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease.  ...  , blurring, and temporal artifacts; (4) represent data using the natural geometry of cortical and subcortical structures; (5) accurately align corresponding brain areas across subjects and studies; (6)  ...  We thank the other investigators and staff members of the Human Connectome Project consortium for invaluable contributions to data acquisition, analysis, and sharing.  ... 
doi:10.1038/nn.4361 pmid:27571196 fatcat:wwg4h7gmw5eshc5bc3zsmt6zmy

Characterization of myelin water imaging using a gradient and spin echo sequence in human brain and spinal cord

Emil Ljungberg
Results from the two scanners were found to be highly correlated but with a significant offset in myelin water fraction of 4.3%.  ...  In 2007, a paradigm shift took place when the standard sequence for myelin water imaging changed from a multi-echo spin echo sequence to a gradient and spin echo (GRASE) sequence.  ...  I have extended the scope of applications for GRASE to spinal cord imaging and initiated the study of multi-vendor reproducibility.  ... 
doi:10.14288/1.0228626 fatcat:tbowqe7vvffrnnkhnmmk2kaasi

Analysis strategies for high-resolution UHF-fMRI data

Jonathan R. Polimeni, Ville Renvall, Natalia Zaretskaya, Bruce Fischl
2018 NeuroImage  
Functional MRI (fMRI) benefits from both increased sensitivity and specificity with increasing magnetic field strength, making it a key application for Ultra-High Field (UHF) MRI scanners.  ...  These include strategies designed to mitigate distortion and artifacts associated with higher fields in ways that attempt to preserve spatial resolution of the fMRI data, as well as recently introduced  ...  s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies.  ... 
doi:10.1016/j.neuroimage.2017.04.053 pmid:28461062 pmcid:PMC5664177 fatcat:dcrrvh4sgfcb5diw62bgbeng2a

Myelin Water Imaging Using Transverse Relaxation

Nima Mehdizadeh
This ratio is typically called the myelin water fraction (MWF) value.  ...  Multi-component analysis of multi-echo data has shown promising results in the field of myelin water imaging (MWI).  ...  Acknowledgements In the first year of this M.Sc. program, we were focusing on ME-GRE based MWI projects; and I was wondering whether the path we were on had any justifications  ... 
doi:10.7939/r3-x9xx-fz04 fatcat:sy64xbsfuzbgxdwbczhsgxtuwm
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