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Segmentation of Dynamic Contrast-Enhanced Magnetic Resonance Images of the Prostate [article]

Wuilian Torres, Leonardo Cordero, Miguel Martín-Landrove, Antonio Rueda-Toicen
2017 arXiv   pre-print
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is a valuable tool to localize, characterize, and evaluate anomalous prostate tissue. Ultrafast gradient-echo acquisitions of MRI volumes are generated at regular time intervals while the patient receives a paramagnetic contrast agent. The result is a time series where each voxel exhibits a particular behavior of contrast uptake (wash-in) and posterior wash-out. In this work, a segmentation method is proposed that groups together
more » ... ghboring voxels with similar contrast wash-out responses, using a variant of the region growing GrowCut cellular automaton algorithm, that evolves iteratively according to the relationship of a cell to its neighboring cells. Initially, seed cells are determined through morphological filters that identify homogeneous regions in the volume that are representatives of the clinically relevant types of tissues in the prostate. Each cell is characterized by three parameters: a label that identifies the type of tissue in the associated voxel, a vector with the values of the DCE-MRI time series, and a strength coefficient with values between 0 and 1 that represents the probability with which the cell belongs to its assigned label. Every non-seed cell can modify its state; this occurs when each cell is attacked by its neighbors with a strength of attack that is inversely proportional to the similarity of the values of the time series between the cells. If the strength of the attacked cell is less than the strength of the attack of one of its neighbors, its state changes to the one of the attacking cell. The attacked cell also updates its strength making it equal to the strength of the attack with which it was conquered. To perform a clinical validation of the resulting segmentations, we used various cases from the database of The Cancer Imaging Archive (TCIA), National Cancer Institute (NCI).
arXiv:1710.03396v1 fatcat:h74keg7tuzcjrh5i3cisg2xa2y

The Effect of Globalization on Economic Development Indicators: An Inter-Regional Approach

Pedro Antonio Martín Cervantes, Nuria Rueda López, Salvador Cruz Rambaud
2020 Sustainability  
The analysis of the problems derived from globalization has become one of the most densely studied topics at the beginning of this millennium, as they can have a crucial impact on present and future sustainable development. This paper analyzes the differential patterns of globalization in four worldwide areas predefined by The World Bank (namely, High-, Upper-Middle-, Lower-Middle-, and Low-Income countries). The main objective of this work is to estimate the effect of globalization on some
more » ... omic development indicators (specifically per capita income and public expenditure on health) in 217 countries over the period 2000–2016. Methods: Our empirical approach is based on the implementation of a novel econometric methodology: The so-called Toda–Yamamoto procedure, which has been used to analyze the possible causal relationships between the involved variables. We employ World Development Indicators, provided by The World Bank, and the KOF Globalization Index, elaborated by the KOF Swiss Economic Institute. Results: The results show that there is a causal relationship in the sense of Granger between globalization and public expenditure on health, except in High-Income countries. This can be interpreted both negatively and positively, confirming the double character of globalization, as indicated by Stiglitz.
doi:10.3390/su12051942 fatcat:2v2zi3pqgzhibfoh74g3727noq

Abordajes quirúrgicos de aorta: visión práctica para residentes

Iván Martín-González, Alberto Doménech-Dolz, María Ascaso-Arbona, Cristina Rueda, Antonio García-Valentín
2015 Cirugía Cardiovascular  
doi:10.1016/j.circv.2014.10.006 fatcat:vn35i7fcmjagzbgerggdrwuqyi

miRNAgFree: prediction and profiling of novel microRNAs without genome assembly [article]

Ernesto L. Aparicio, Antonio Rueda, Bastian Fromm, Cristina Gómez-Martin, Ricardo Lebrón, Jose L Oliver, Juan A Marchal, Michail Kotsyfakis, Michael Hackenberg
2017 bioRxiv   pre-print
The prediction of novel miRNA genes generally requires the availability of genome sequences in order to assess important properties such as the characteristic hairpin-shaped secondary structure. However, although the sequencing costs have decreased over the last years, still many important species lack an assembled genome of certain quality. We implemented an algorithm which for the first time exploits characteristic biogenesis features like the 5' homogeneity that can be assessed without
more » ... sequences. We used a phylogenetically broad spectrum of well annotated animal genomes for benchmarking. We found that between 90-100% of the most expressed miRNA candidates (top quartile) corresponded to known miRNA sequences.
doi:10.1101/193094 fatcat:xj3iacpoabdq5c25eo42ldwavy

Life Expectancy at Birth in Europe: An Econometric Approach Based on Random Forests Methodology

Pedro Antonio Martín Cervantes, Nuria Rueda López, Salvador Cruz Rambaud
2020 Sustainability  
analysis using TS Jiang et al. (2018) [20] 31 Chinese provinces 2000 and 2010 LE CSR Hill and Jorgenson (2018) [43] 50 US states and the District of Columbia 2000, 2005, and 2010 LEAB PR Martín-Cervantes  ... 
doi:10.3390/su12010413 fatcat:x3o5mpz4dze5djuzko3jzhc7qy

Antecedentes sobre la Territorialidad en Colombia [chapter]

Luis Antonio Martín Moreno, Luis Alberto Aparicio Rueda, Oscar Orlando López Barreto
2017 El control territorial en el siglo XXI: Fundamentos teóricos  
Luis Antonio Martín Moreno 5 TC. Luis Alberto Aparicio Rueda Cr. (RA) Oscar Orlando López Barreto 6 En sí el Control Territorial para los Estados, continuará siendo un desafío.  ... 
doi:10.25062/9789585625204.02 fatcat:6a7sqtt5yvfyjfghryk6sb7np4

sRNAtoolbox: an integrated collection of small RNA research tools

Antonio Rueda, Guillermo Barturen, Ricardo Lebrón, Cristina Gómez-Martín, Ángel Alganza, José L. Oliver, Michael Hackenberg
2015 Nucleic Acids Research  
Small RNA research is a rapidly growing field. Apart from microRNAs, which are important regulators of gene expression, other types of functional small RNA molecules have been reported in animals and plants. MicroRNAs are important in host-microbe interactions and parasite microRNAs might modulate the innate immunity of the host. Furthermore, small RNAs can be detected in bodily fluids making them attractive non-invasive biomarker candidates. Given the general broad interest in small RNAs, and
more » ... n particular microRNAs, a large number of bioinformatics aided analysis types are needed by the scientific community. To facilitate integrated sRNA research, we developed sRNAtoolbox, a set of independent but interconnected tools for expression profiling from high-throughput sequencing data, consensus differential expression, target gene prediction, visual exploration in a genome context as a function of read length, gene list analysis and blast search of unmapped reads. All tools can be used independently or for the exploration and downstream analysis of sRNAbench results. Workflows like the prediction of consensus target genes of parasite mi-croRNAs in the host followed by the detection of enriched pathways can be easily established. The webinterface interconnecting all these tools is available at
doi:10.1093/nar/gkv555 pmid:26019179 pmcid:PMC4489306 fatcat:ff5jj7krwvb5xpm23xolo2f4nm

Complexity of brain tumors

Miguel Martín-Landrove, Francisco Torres-Hoyos, Antonio Rueda-Toicen
2019 Physica A: Statistical Mechanics and its Applications  
Tumor growth is a complex process characterized by uncontrolled cell proliferation and invasion of neighboring tissues. The understanding of these phenomena is of vital importance to establish appropriate diagnosis and therapeutic strategy and starts with the evaluation of their complexity with suitable descriptors, such as those produced by scaling analysis. In the present work, scaling analysis is used for the extraction of dynamic parameters that characterize tumor growth processes in brain
more » ... umors. The emphasis in the analysis is on the assessment of general properties of tumor growth, such as the Family-Vicsek ansatz, which includes a great variety of ballistic growth models. Results indicate in a definitive way that gliomas strictly behave as it is proposed by the ansatz, while benign tumors behave quite differently. As a complementary view, complex visibility networks derived from the tumor interface support these results and its use is introduced as a possible descriptor in the understanding of tumor growth dynamics.
doi:10.1016/j.physa.2019.122696 fatcat:djdwgr3e2zhapijll6aek4qydi

Inteligencia artificial en Dermatología: ¿amenaza u oportunidad?
Inteligencia artificial en dermatología: ¿amenaza u oportunidad?

Antonio Martorell, Alejandro Martin-Gorgojo, Elisa Ríos-Viñuela, Jose M Rueda-Carnero, Fernando Alfageme, Rosa Taberner
2021 Actas Dermo-Sifiliográficas  
The worldwide explosion of interest in artificial intelligence (AI) has created a before-and-after moment in our lives by generating great improvements in such sectors as the automotive and food production industries. AI has even been called the fourth industrial revolution. Machine learning through AI is helping to improve professional processes and promises to transform the health care sector as we know it in various ways: 1) through applications able to promote health in the general
more » ... n by providing high-quality information and offering advice for different segments of the population based on prediction models; 2) by developing prediction models based on anonymized clinical data, for preventive purposes in primary care; 3) by analyzing images to provide additional decision-making support for health care providers, for improving specialist care at the secondary level; and 4) through robotics applied to processes that promote health and well-being. However, the medical profession harbors doubts about whether this revolution is a threat or an opportunity owing to a lack of understanding of AI technology and the methods used to validate its applications. This article outlines basic aspects of AI as it is applied in dermatology and reviews the main advances achieved in the last 5 years.
doi:10.1016/ pmid:35249709 fatcat:f2hgv6blhbar3fhxfohz2353x4

Metallofluorescent Nanoparticles for Multimodal Applications

Antonio Delgado-Gonzalez, Emilio Garcia-Fernandez, Teresa Valero, M. Victoria Cano-Cortes, Maria J. Ruedas-Rama, Asier Unciti-Broceta, Rosario M. Sanchez-Martin, Juan J. Diaz-Mochon, Angel Orte
2018 ACS Omega  
Herein, we describe the synthesis and application of cross-linked polystyrene-based dual-function nano- and microparticles containing both fluorescent tags and metals. Despite containing a single dye, these particles exhibit a characteristic dual-band fluorescence emission. Moreover, these particles can be combined with different metal ions to obtain hybrid metallofluorescent particles. We demonstrate that these particles are easily nanofected into living cells, allowing them to be used for
more » ... ctive fingerprinting in multimodal fluorescence-based and mass spectrometry-based flow cytometry experiments. Likewise, the in situ reductions of the metal ions enable other potential uses of the particles as heterogeneous catalysts.
doi:10.1021/acsomega.7b01984 pmid:30023770 pmcid:PMC6044963 fatcat:zqf6slaw6fdwpofsiiwdscwovq

Enhancement of Chemokine Function as an Immunomodulatory Strategy Employed by Human Herpesviruses

Abel Viejo-Borbolla, Nadia Martinez-Martín, Hendrik J. Nel, Patricia Rueda, Rocío Martín, Soledad Blanco, Fernando Arenzana-Seisdedos, Marcus Thelen, Padraic G. Fallon, Antonio Alcamí, Laurent Coscoy
2012 PLoS Pathogens  
Citation: Viejo-Borbolla A, Martinez-Martín N, Nel HJ, Rueda P, Martín R, et al. (2012) Enhancement of Chemokine Function as an Immunomodulatory Strategy Employed by Human Herpesviruses.  ... 
doi:10.1371/journal.ppat.1002497 pmid:22319442 pmcid:PMC3271085 fatcat:czyp7kjvnvhojnf7mmomgtrnou

Record breaking mushroom yields in Spain

Josu G. Alday, José Antonio Bonet, Juan Andrés Oria-de-Rueda, Juan Martínez-de-Aragón, Jorge Aldea, Pablo Martín-Pinto, Sergio de-Miguel, María Hernández-Rodríguez, Fernando Martínez-Peña
2017 Fungal ecology  
., Oria-de-Rueda, J.A., Martín-Pinto, P., 2015. Climate-sensitive models for mushroom yields and diversity in Cistus ladanifer scrublands. Agric. For. Meteorol. 213, 173-182.  ... 
doi:10.1016/j.funeco.2017.01.004 fatcat:xtnc2xeg5nd2tg4fbetpv3xaxq

Anthracosis Mimicking Metastatic Melanoma in a Sentinel Lymph Node

Almudena Nuno Gonzalez, Jose Luis Lopez Estebaranz, Jose Antonio Rueda Orgaz, Mercedes Mitjavila, Fernando Pinedo Moraleda, Francisco Javier Vicente Martin
2016 Journal of Pigmentary Disorders  
Sentinel lymph node (SLN) biopsy provides a pathological lymph node staging in patients with clinical stage I/II melanoma. In most cases, we will find melanoma metastases if SLN is brown or black. But there are other entities that give black color to SLN, the most frequent is tattoo pigment. We report the first case of anthracosis in a SLN biopsy of melanoma mimicking melanoma metastases. We also review other causes of black pigment in SLN.
doi:10.4172/2376-0427.1000240 fatcat:eru5yilkqbegpm6f6ixweuqta4

A Causal Analysis of Life Expectancy at Birth. Evidence from Spain

Pedro Antonio Martín Cervantes, Nuria Rueda López, Salvador Cruz Rambaud
2019 International Journal of Environmental Research and Public Health  
From a causal point of view, there exists a set of socioeconomic indicators concerning life expectancy. The objective of this paper is to determine the indicators which exhibit a relation of causality with life expectancy at birth. Methods: Our analysis applies the Granger causality test, more specifically its version by Dumitrescu–Hurlin, starting from the information concerning life expectancy at birth and a set of socioeconomic variables corresponding to 17 Spanish regions, throughout the
more » ... iod 2006–2016. To do this, we used the panel data involving the information provided by the Spanish Ministry of Health, Consumer Affairs and Social Welfare (MHCSW) and the National Institute of Statistics (NIS). Results: Per capita income, and the rate of hospital beds, medical staff and nurses Granger-cause the variable "life expectancy at birth", according to the Granger causality test applied to panel data (Dumitrescu–Hurlin's version). Conclusions: Life expectancy at birth has become one of the main indicators able to measure the performance of a country's health system. This analysis facilitates the identification of those factors which exhibit a unidirectional Granger-causality relationship with life expectancy at birth. Therefore, this paper provides useful information for the management of public health resources from the point of view of the maximization of social benefits.
doi:10.3390/ijerph16132367 pmid:31277340 pmcid:PMC6650812 fatcat:pbrr7n5tsff4ndov4mxormel5i

Novel ortho-OPE metallofoldamers: binding-induced folding promoted by nucleating Ag(i)–alkyne interactions

Ana Martín-Lasanta, Luis Álvarez de Cienfuegos, Alice Johnson, Delia Miguel, Antonio J. Mota, Angel Orte, Maria Jose Ruedas-Rama, Maria Ribagorda, Diego J. Cárdenas, M. Carmen Carreño, Antonio M. Echavarren, Juan M. Cuerva
2014 Chemical Science  
Ag(i)–alkyne interactions induce the folding of o-OPE foldamers, yielding a new class of metallofoldamers.
doi:10.1039/c4sc01988a fatcat:bcmbs2ymj5gbbgzqzwj22ihn5q
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