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"Naked" FACT is unstable

Anton A Komar
2013 Cell Cycle  
Cell Cycle 2013; 12; In this issue PMID:23839038; http://dx.doi.org/10.4161/cc.25452 Anton A Komar; Center for Gene Regulation in Health and Disease; Department of Biological, Geological and Environmental  ...  Comment on:Safina A, et al.  ... 
doi:10.4161/cc.25661 pmid:23856583 pmcid:PMC3841312 fatcat:ycdgafow5zh5hl4ajyyabgfram

Cellular IRES-mediated translation

Anton A Komar, Maria Hatzoglou
2011 Cell Cycle  
complex or eIF4F. 3, 6, 7 This complex consists of the cap-binding protein eIF4E, the scaffolding protein Correspondence to: Anton A.  ...  Komar and Maria Hatzoglou; Email: a.komar@csuohio.edu and mxh8@case.edu Submitted: 12/10/10; Accepted: 12/10/10 DOI: 10 .4161/cc. 10.2.14472 Translation of cellular mRNAs via initiation at internal  ... 
doi:10.4161/cc.10.2.14472 pmid:21220943 pmcid:PMC3048795 fatcat:fgdb2ihbk5dtraxwag2fosn5q4

Unraveling co-translational protein folding: Concepts and methods

Anton A. Komar
2018 Methods  
Ultimately, studies using these techniques will facilitate development of a unified concept of protein folding, a process that is essential for proper cell function and organism viability.  ...  Komar Page 22 Author Manuscript Author Manuscript Author Manuscript Author Manuscript Methods. Author manuscript; available in PMC 2019 March 15.  ...  A combination of a small fluorophore incorporated via a modified aa-tRNA and a large fluorophore (like GFP) can be also used for FRET studies.  ... 
doi:10.1016/j.ymeth.2017.11.007 pmid:29221924 pmcid:PMC5866750 fatcat:txytteem3bgdzfcxw2uzzfnvqq

A new framework for understanding IRES-mediated translation

Anton A. Komar, Barsanjit Mazumder, William C. Merrick
2012 Gene  
It will become apparent that a mixture of descriptions is likely to become the norm in the near future (i.e. m 7 G-assisted internal initiation).  ...  From individual studies of a number of mRNAs encoding proteins that are regulatory in nature (i.e. likely to be needed in small amounts such as transcription factors, protein kinases, etc.), it is now  ...  (Lewis and Holcik, 2008; Komar and Hatzoglou, 2011) .  ... 
doi:10.1016/j.gene.2012.04.039 pmid:22555019 pmcid:PMC3361623 fatcat:2dtd3swq4jcspemowzhtdlvm7y

Cotranslational Folding of Globin

Anton A. Komar, Aigar Kommer, Igor A. Krasheninnikov, Alexander S. Spirin
1997 Journal of Biological Chemistry  
Globin synthesis in a wheat germ cell-free translation system was performed in the presence of [ 3 H]hemin and [ 35 S]methionine to determine the minimal length of the nascent ribosome-bound globin chain  ...  This indicates that the ribosome-bound nascent chain of 86 amino acid residues has already acquired a spatial structure that allows its interaction with the heme group or that heme attachment promotes  ...  The alternative case could be that a ribosomal tunnel or channel hides the C-terminal section of a growing polypeptide (64, 65) .  ... 
doi:10.1074/jbc.272.16.10646 pmid:9099713 fatcat:psm6565bd5fo7eke4c37qbsuby

Exploring Internal Ribosome Entry Sites as Therapeutic Targets

Anton A. Komar, Maria Hatzoglou
2015 Frontiers in Oncology  
Initiation of eukaryotic mRNA translation may proceed via several different routes, each requiring a different subset of factors and relying on different and specific interactions between the mRNA and  ...  initiation, which requires all canonical initiation factors and is responsible for about 95-97% of all initiation events in eukaryotic cells; and (ii) cap-independent internal initiation, which requires a  ...  Komar and Hatzoglou IRESs as therapeutic targets Frontiers in Oncology | www.frontiersin.org suppress cap-dependent translation of their own mRNAs (95) .  ... 
doi:10.3389/fonc.2015.00233 pmid:26539410 pmcid:PMC4611151 fatcat:7uoo7ywtovebje74lschekzhya

Birth, life and death of nascent polypeptide chains

Sujata Jha, Anton A. Komar
2011 Biotechnology Journal  
Anton A. Komar received his PhD degree in molecular biology from Lomonosov Moscow State University in Moscow, Russia.  ...  Komar is also serving as a Graduate Program Director) between the Cleveland State University and the Lerner Research Institute of the Cleveland Clinic.  ... 
doi:10.1002/biot.201000327 pmid:21538896 pmcid:PMC3130931 fatcat:sbq7vzfx6ffbtm7uylcpuiarjm

Cotranslational heme binding to nascent globin chains

Anton A. Komar, Aigar Kommer, Igor A. Krasheninnikov, Alexander S. Spirin
1993 FEBS Letters  
Komar, Department of Molecular Biology, Faculty of Biology, Moscow State University, 119899 Moscow, Russian Federation. Fig. 1 . 1 e'~o-o-. e~ lb..e,::l.-4t,, .A..Q.,e.. e f-a--t,.,i..o.  ...  buffer A.  ... 
doi:10.1016/0014-5793(93)81803-8 pmid:8325375 fatcat:5bat3nkem5b3bog3ou3pvvpnwq

Building a Distributed, Credible and Scalable Research and Data Infrastructure for Open Science

Anton Polishko, Artur Kiulian, Maksym Komar, Vyacheslav Tykhonov
2020 Zenodo  
Building a Distributed, Credible and Scalable Research and Data Infrastructure for Open Science https://www.youtube.com/watch?v=aeS-vzbMm7I  ...  At CoronaWhy we are building a Common Research and Data Infrastructure for Open Science that can be used by researchers coming from various scientific communities involved in COVID-19 research.  ...  , CoronaWhy; Artur Kiulian, akiulian@ gmail.com, CoronaWhy; Maksym Komar, komar@evologics.de, CoronaWhy.  ... 
doi:10.5281/zenodo.3922256 fatcat:zdgvn4qewfa6ljiwqe7ayc5elm

The eIF2A knockout mouse

Andrei Golovko, Artyom Kojukhov, Bo-Jhih Guan, Benjamin Morpurgo, William C. Merrick, Barsanjit Mazumder, Maria Hatzoglou, Anton A. Komar
2016 Cell Cycle  
KEYWORDS alternative initiation pathways; eIF2A; initiation of translation; knockout mouse; non-AUG dependent initiation CONTACT Anton A. Komar  ...  Eukaryotic initiation factor 2A (eIF2A) is a 65-kDa protein that was first identified in the early 1970s as a factor capable of stimulating initiator methionyl-tRNAi (Met-tRNA Met i ) binding to 40S ribosomal  ...  by a polyadenylation signal.  ... 
doi:10.1080/15384101.2016.1237324 pmid:27686860 pmcid:PMC5134716 fatcat:7yv3mctjqrevrmrm6lvargsgnu

Internal Ribosome Entry Sites in Cellular mRNAs: Mystery of Their Existence

Anton A. Komar, Maria Hatzoglou
2005 Journal of Biological Chemistry  
Initiation factor eIF4G functions as a scaffolding protein.  ...  Assembly of the 80 S ribosome at a start codon within the majority of eukaryotic mRNAs involves binding of the mRNA 5Ј-m 7 G cap structure to a group of proteins referred to as the cap-binding complex  ...  This study introduced a new concept of a "dynamic IRES" (65) .  ... 
doi:10.1074/jbc.r400041200 pmid:15749702 fatcat:fhj5tglbtfhl7edx63bzbskp6i

IRES-mediated translation of the pro-apoptotic Bcl2 family member PUMA

Atossa Shaltouki, Terri J. Harford, Anton A. Komar, Crystal M. Weyman
2013 Translation  
The importance of PUMA as a mediator of apoptosis cannot be understated.  ...  We have previously shown that pUMA plays a pivotal role in the apoptosis associated with skeletal myoblast differentiation and that a MyoD-dependent mechanism is responsible for the increased expression  ... 
doi:10.4161/trla.24391 pmid:26824017 pmcid:PMC4718066 fatcat:dmdkul3rqrbnnge4huvkw5zuwi

The "periodic table" of the genetic code: A new way to look at the code and the decoding process

Anton A. Komar
2016 Translation  
The new asymmetrical circular genetic code has a number of advantages over the traditional codon table and the previous circular diagrams (with a symmetrical/clockwise arrangement of the U, C, A, G bases  ...  A. KOMAR  ...  Ile is encoded by a group of 3 codons and Val, Pro, Thr, Ala, and Gly are each specified by a group of 4 codons; these also differ only at position 3 within a group.  ... 
doi:10.1080/21690731.2016.1234431 pmid:28090420 pmcid:PMC5173307 fatcat:j44mwmtoijebpdxbzpta4jjwwm

Structural Characterization ofSaccharomyces cerevisiaePrion-like Protein Ure2

Carine Thual, Anton A. Komar, Luc Bousset, Eric Fernandez-Bellot, Christophe Cullin, Ronald Melki
1999 Journal of Biological Chemistry  
Ure2p self-assembly is a cooperative process where one can distinguish a lag phase followed by an elongation phase preceding a plateau.  ...  A combination of size exclusion chromatography, sedimentation velocity, and electron microscopy demonstrates that the soluble form of Ure2p consists at least of three forms of the protein as follows: a  ...  Ure2p Is a Two-domain Protein-A number of secondary structure determination algorithms predict Ure2p to be a twodomain protein.  ... 
doi:10.1074/jbc.274.19.13666 pmid:10224139 fatcat:ehkk5ifb7fb67oal74nuhksanm

Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation

Anton A Komar, Thierry Lesnik, Claude Reiss
1999 FEBS Letters  
Rainer Jaenicke for a helpful discussion. The pUC18:IM3/CI-1 plasmid was kindly provided by Prof. Dr. W.V. Shaw. T.L. thanks ProAnima (Paris) for support.  ...  a¡ected.  ...  Codon substitutions were introduced in a region (ORF 123^145) represented in a CAT three-dimensional structure by a long loop and a beta-sheet [58, 59] .  ... 
doi:10.1016/s0014-5793(99)01566-5 pmid:10622731 fatcat:fjbinzarzndibggviaxxxtyfki
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