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QSAR of anti-inflammatory drugs

Veronica R Khayrullina, H Bögel
2010 Journal of Cheminformatics  
In a second part of this paper the interrelation between structure and efficacy for anti-inflammatory drug action is carried out using traditional QSAR with descriptors from topology and from quantum-mechanical  ...  The computer analysis of relations between molecular structures and their biological activity using fragmentbased methods is very useful to draw conclusions for the understanding of drug action and for  ...  In a second part of this paper the interrelation between structure and efficacy for anti-inflammatory drug action is carried out using traditional QSAR with descriptors from topology and from quantum-mechanical  ... 
doi:10.1186/1758-2946-2-s1-p45 pmcid:PMC2867180 fatcat:zbpegve7d5h3zmttfznvmzv7ku

Anti-inflammatory and immunomodulatory effects of antibiotics and their use in dermatology

Bhushan Madke, Swetalina Pradhan, Poonam Kabra, AdarshLata Singh
2016 Indian Journal of Dermatology  
: Peroral Table 4: Indications of macrolides in dermatological diseases for their its anti-inflammatory and immunomodulatory properties Disease/condition Drug Mechanism of action for anti-inflammatory  ...  Antiviral and antifungal drugs are seldom used for their anti-inflammatory properties.  ... 
doi:10.4103/0019-5154.190105 pmid:27688434 pmcid:PMC5029230 fatcat:trwo5hgbfbbljathfi2d3xafoy

Page 624 of Arthritis & Rheumatology Vol. 4, Issue 6 [page]

1961 Arthritis & Rheumatology  
underlying their anti-inflammatory action.?  ...  In spite of the extensive documentation of numerous metabolic influences of corticcsteroids, the basic mechanisms underlying their anti-inflammatory actions have nct been elucidated.  ... 

Cytokine Storm in Head Injury Patients and its Management in COVID-19 Era

Md Moshiur Rahman, Auctores Publishing LLC
2021 Neuroscience and Neurological Surgery  
Proof of their action can be confirmed by serial evaluation in the level of inflammatory mediator's level before and after giving the drugs or by observing an alternative inflammatory outcome. [5] Drugs  ...  It has an anti-inflammatory action in a concentration higher than needed for antimicrobial action. [9] Open Access Editorial Journal of Neuroscience and Neurological Surgery anti-inflammatory drugs  ... 
doi:10.31579/2578-8868/153 fatcat:qnt34ysqpbd7jnqobutoqp2gau

Page 143 of New Jersey Medicine Vol. 82, Issue 2 [page]

1985 New Jersey Medicine  
This review highlights their proposed mechanism of action, indications, and most common toxicities.  ...  MECHANISM OF ACTION Although the mechanism of action of these drugs is complicated and probably multifactoral, the leading hypothesis is the effect on the formation of prostaglan- dins.  ... 

Page 771 of Bulletin on the Rheumatic Diseases Vol. 24, Issue 8-9 [page]

1973 Bulletin on the Rheumatic Diseases  
mechanism of the action of these drugs.  ...  Albumin binding is a more recently proposed speculation to explain the mechanism of action of anti-inflammatory drugs. Grant'? showed a strong correlation of effectiveness in vivo and in interaction.  ... 

Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs [chapter]

Newman Osafo, Christian Agyare, David Darko Obiri, Aaron Opoku Antwi
2017 Nonsteroidal Anti-Inflammatory Drugs  
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) dates back to thousands of years when man used natural sources of these agents in a lot of pain and inflammatory conditions.  ...  This chapter looks with key interest in the existing and evolving role of NSAIDs in therapeutics with emphasis on the current insights into their mechanism of action and side effect profiles associated  ...  Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of therapeutic agents with diverse structural and pharmacodynamics profiles but similar mode of action.  ... 
doi:10.5772/68090 fatcat:tvkcvgxqwvey7n3uzbrr6wczvm

Scope of inflammopharmacology

K. D. Rainsford
2010 InflammoPharmacology  
One of the central elements in understanding the modes of action of various anti-inflammatory agents is the recognition that drugs may be limited in their effectiveness, selectivity and toxicology as a  ...  The prime focus of papers considered for inclusion in the journal is concentrated on the mechanisms of action and the use of anti-inflammatory agents in the treatment of rheumatic and related painful conditions  ... 
doi:10.1007/s10787-010-0050-8 pmid:20661689 fatcat:j6aaqbffubftdgpcpz5dirc3pe

Pharmacological activity and mechanism of action of plants with anti-inflammatory properties found in brazilian flora

Kessya Lanny Sousa Dantas, Kassyo Lenno Sousa Dantas, Eduardo Soares Dos Santos, Júlio Evangelista De Lucena, Milena Sousa Freitas, Francisco Monteiro da Silva Júnior, Adriano Stênio Genaro, Cristiane Santos Silva e Silva Figueiredo, Domingos Magno Santos Pereira
2021 Revista Eletrônica Acervo Saúde  
Objective: To describe the importance of medicinal plants in the social and pharmacological context, demonstrating the anti-inflammatory therapeutic potential and the mechanism of action of drugs present  ...  We discuss here the anti-inflammatory potential and the mechanism of action of the following plants: Uncaria tomentosa, Schinus terebinthifolius Raddi and Mentha piperita demonstrated through in vitro  ...  In next session, we will discuss about the anti-inflammatory action of three species of plants easily found in Brazilian flora, as well as their mechanism of action in several inflammatory disease models  ... 
doi:10.25248/reas.e5663.2021 fatcat:z7cd4clhlvfihfs7f7ibuzp4iu

Anti-inflammatory action of corticosteroids

M. W. Greaves
1976 Postgraduate medical journal  
The actions of glucocoiticoids at a biochemical level One of the most exciting developments in our knowledge of the actions of anti-inflammatory drugs has been their actions on the prostaglandin synthetizing  ...  He concluded that the analgesic and anti-pyretic actions of these nonsteroid drugs was due to their ability to inhibit prostaglandin synthetase.  ... 
doi:10.1136/pgmj.52.612.631 pmid:995788 pmcid:PMC2496363 fatcat:6m2t744vxfe4tluwa2begghd34

Page 19 of D M, Disease-A-Month Vol. 30, Issue 3 [page]

1983 D M, Disease-A-Month  
There are several other agents with clinically important anti-inflammatory effects, but these differ from aspirin-like drugs in their pharmacologic properties and mechanisms of action, and they lack important  ...  and their potencies as anti-inflam- matory drugs.”* In some cases, the subtle structural dif- ferences between enantiomers* of compounds are accom- panied by dramatic differences in anti-inflammatory  ... 

Targeting Inflammation in Cystic Fibrosis

Elisabeth Kieninger, Nicolas Regamey
2010 Respiration  
In order to find such treatment, a thorough understanding of the mechanisms of inflammation in the CF lung as well as of the mechanisms of action of anti-inflammatory drugs is warranted.  ...  We know even less about the mechanisms of anti-inflammatory drugs used in CF.  ... 
doi:10.1159/000264605 pmid:19955700 fatcat:o322qixixrdrvndass7q7afbt4

From NSAIDs to Glucocorticoids and Beyond

Ajantha Sinniah, Samia Yazid, Rod J. Flower
2021 Cells  
This review aims to recapitulate the last four decades of research on NSAIDs, GCs, and AnxA1 and their anti-inflammatory effects.  ...  The discovery of the GC-inducible endogenous anti-inflammatory protein annexin A1 (AnxA1) and other endogenous proresolving mediators has opened a new era of anti-inflammatory therapy.  ...  The principal mechanisms of AnxA1 anti-inflammatory actions.  ... 
doi:10.3390/cells10123524 pmid:34944032 pmcid:PMC8700685 fatcat:5k7ybqfgizf4xbtuki6ejmwg5u

NSAIDS (Non- Steroidal Anti- Inflammatory Drugs)- Their Effects and Side Effects in Orthodontic Therapy- A Review

Isha Gargya, Baljeet Singh, Sanjay Talnia
2017 Dental Journal of Advance Studies  
Tooth movement through the remeodelling of bone is regulated by prostaglandins(PG) which play a direct role in bone resorption and is adversely affected by the use of NSAIDs(Non- Steroidal anti-inflammatory  ...  drugs) with research and clinical experience suggesting that their use slows down tooth movement due to a reduction in the number of osteoclastic cells.  ...  NON STEROIDAL ANTI-INFLAMMATORY DRUGS: Nonsteroidal anti-inflammatory drugs (NSAIDs) are many a times used in the management of 6 pain or discomfort following mechanical force application to the teeth  ... 
doi:10.1055/s-0038-1672075 fatcat:mtgzkpmbx5ccfgqoypofsokxii


Mohammed Abdul Majeed, Choppadandi Anil, Amaravathi Amaravathi, Souris Kondaveti
2017 Journal of Evidence Based Medicine and Healthcare  
NSAIDS and statins, both of them act via different mechanisms and their actions could be additive.  ...  Statins exert anti-inflammatory action by preventing the isoprenylation of Rho proteins, a family of small G proteins and subsequent disruption of their functions.  ...  Anti-inflammatory drugs works on different aspects of the inflammatory cascade including the synthesis and action of mediators.  ... 
doi:10.18410/jebmh/2017/870 fatcat:uphprll6yzeytiibiewijoaxja
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