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Effects of renal impairment on the pharmacokinetics of orally administered deferiprone

Caroline Fradette, Vincent Pichette, Éric Sicard, Anne Stilman, Shalini Jayashankar, Yu Chung Tsang, Michael Spino, Fernando Tricta
2016 British Journal of Clinical Pharmacology  
AIMS In light of the growing recognition of renal disease in thalassemia, it is important to understand the impact of renal impairment on the pharmacokinetics of iron chelators. This study evaluated the pharmacokinetics and safety of the iron chelator deferiprone (DFP) in subjects with renal impairment in comparison with healthy volunteers (HVs). METHODS Thirty-two subjects were categorized into four groups based on degree of renal impairment: none, mild, moderate or severe, as determined by
more » ... imated glomerular filtration rate (eGFR). All subjects received a single oral dose of 33 mg kg À1 DFP, provided serum and urine samples for pharmacokinetic assessment over 24 h and were monitored for safety. RESULTS Renal clearance of DFP decreased as renal impairment increased. However, based on C max , AUC(0,t) and AUC(0,∞), there were no significant group differences in systemic exposure, because less than 4% of the drug was excreted unchanged in the urine. DFP is extensively metabolized to a renally excreted, pharmacologically inactive metabolite, deferiprone 3-O-glucuronide (DFP-G), which exhibited higher C max , AUC(0,t), AUC(0,∞) and longer t max and t 1/2 in the renally impaired groups compared with HVs. The C max and AUCs of DFP-G increased as eGFR decreased. Overall, 75%-95% of the dose was retrieved in urine, either as DFP or DFP-G, regardless of severity of renal impairment. With respect to safety, DFP was well tolerated. CONCLUSIONS These data suggest that no adjustment of the DFP dosage regimen in patients with renal impairment is necessary, as there were no significant changes in the systemic exposure to the drug. British Journal of Clinical Pharmacology Br J Clin Pharmacol (2016) 82 994-1001 994
doi:10.1111/bcp.13037 pmid:27276421 pmcid:PMC5137824 fatcat:dbycjwdjfjfhxejynnmfbaq7ee

Page 168 of National Union Catalog Vol. 43, Issue [page]

1958 National Union Catalog  
TT518.S76 62-42959 Stilson, Donald Wyman, 1:2 A psychophysical investigation of triangular shape, Ann Arbor, University Microfilms 1957, rofilins, Ann Arbor, Mich.  ...  A historical and comparative study of four State-sup- ported institutes of industrial and labor relations, Ann Ar- bor, University Microfilms ,1957, {University Microfilms, Ann Arbor, Mich.  ... 

Page 274 of Maine Farmer Vol. 3, Issue [page]

1833 Maine Farmer  
Samuel Stilman In Quincey, Fas, Sanmel Stilman Low, of Rath, 26.-----August 5, 1841. Solomon In Worridgewock, Mr. Solomon Low, aged 45. -----Feb. 9, 1839.  ...  274 Love jo WE item Augustua---In Livermore, Jan. 6th, William Augustus, aged 6 years, and on Jan. llth, Tabitha Ann, aged 16 months, only children of Mr. Jonathan and Mre, Ruth Lovejoy.  ... 

Page 553 of National Union Catalog Vol. 22, Issue [page]

1953 National Union Catalog  
Title. 5T7-41078 Stilman, Leon, Nikolai Gogol, historical and biographical elements in his creative personality. Ann Arbor, University Microfilms, 1953.  ...  Ann Arbor, University Microfilms 957, qu versity Micraitees, Ann Arbor, Mids Publication no. 19,718) ipt. de by University of Michigan Library ice.  ... 

Page 128 of The New England Historical and Genealogical Register Vol. 20, Issue 2 [page]

1866 The New England Historical and Genealogical Register  
Stilman, Nathanaell, and Anne, dau. of Wm. Southmayd, of Middle. town, were m. March 3, 1715, Is. Nathanieil, b. March 10, ’20, Mrs A. S. d. Jan. 6,’30. Mr. N. S. and Sarah, dau. of Capt.  ...  Stilman, Benjamin, and Sarah, dau. of Capt. Samuel Doty, were m. Aug. 29,’1727. Is. George, b. Nov. 24, ’29; Samuel, b. Nov. 28, 731. Mrs. S. S. d.  ... 

Page 67 of The New England Historical and Genealogical Register Vol. 59, Issue [page]

1905 The New England Historical and Genealogical Register  
Bensamin’ Wivmor and his wife Ann settled early in New Haven, Conn.  ...  ANN,? m. William Bunnel. 3. ii. BENJAMIN. 4, fii. WILLIAM. 2. Ann? Witmot (Benjamin') married William Bunnel. She died be- fore May, 1654. Children : i. Lyp1a BUNNEL, m.  ... 

Page 211 of The New England Historical and Genealogical Register Vol. 59, Issue [page]

1905 The New England Historical and Genealogical Register  
Sept 138" Frances Anne, adopted daughter of Lebbeus P. Tinker—27" Edward, son of Francis M*Lean.  ...  July 4% Elizabeth Warburton Adult—Mary Anne Chapman Adult. Dec. 28 Leander, son of Obadiah K. Smith Private baptism. Baptisms 1820.  ... 

Page 580 of English Journal Vol. 50, Issue 8 [page]

1961 English Journal  
JAMAICA OR THE INNOCENT VOYAGE by Rich- ard Hughes Foreword by Vernon Wat- kins CP67 60¢ DIARY OF A MADMAN AND OTHER STORIES by Nikolai Gogol A New Translation by Andrew MacAndrew, Afterword by Leon Stilman  ...  Cable Foreword by Shirley Ann Grau CP84 60¢ BILLY BUDD AND OTHER TALES by Herman Melville Afterword by Willard Thorp CT75 75¢ TWENTY YEARS AT HULL-HOUSE by Jane Addams Foreword by Henry Steele Commager  ... 

Page 548 of Graham's Illustrated Magazine Vol. 5, Issue 12 [page]

1830 Graham's Illustrated Magazine  
Stilman entered from an adjoining room, where he had been all the while reading and smoking.  ...  I would bid good bye to geography and history, and these tiresome nouns and verbs,— And now | think of it, Anne, I have heard that your father never made a wish in his life with- out getting it.  ... 

Page 113 of PMLA. Publications of the Modern Language Association of America Vol. 67, Issue 3 [page]

1952 PMLA. Publications of the Modern Language Association of America  
., 92 Stilman, Galina, 98 Stilman, Leon, 96 Stillwell, Gardiner, 23 Stirling, Brents, 30 (2) Stock, Irvin, 63, 70 Stoeffler, E. E., 94 Stoll, E.  ...  O., 47 Tjomsland, Anne, 86 Todd, M. L., 59 Todd, W. B., 36, 37 (2), 38 (2), 41 (2), 45 Tolles, F. B., 53 (2) Tomkinson, Constance, 48 Tomlinson, M.  ... 

Page 567 of Annals of Internal Medicine Vol. 38, Issue 3 [page]

1953 Annals of Internal Medicine  
S$ 7 Stilman, N } 31: 481, 1942 sence oft i  ...  in and of adreno ne, Ann. Int. Med. 34: 1041 omfort, M. W., Wollaeger, E Je nd we The ettect cal sprue, J. Clin.  ... 

Page 51 of PMLA. Publications of the Modern Language Association of America Vol. 71, Issue 2 [page]

1956 PMLA. Publications of the Modern Language Association of America  
Whitfield. 1956 Officers: Chairman, Leon Stilman, Columbia Univ.; Secretary, Herbert E. Bowman, Univ. of Oregon. Conference 5: Problems in the Study of Southern Literature.  ...  “The Image of Nature in Wallace Stevens,’’ Anne King, Adelphi Coll. (15 min.) 7. “The Concept of Nature in Modern Southern Poetry,” Louis D. Rubin, Jr., Univ. of Pennsylvania. (15 min.) 8.  ... 

Page 636 of National Union Catalog Vol. 2, Issue [page]

1963 National Union Catalog  
The practical harmonist at the harpsichord, Stilman, Eduardo, joint comp. see Gobello, José, 1919- comp. Las letras del tango de Villoldo a Borges, Stilman, Leon.  ...  Christmas m 1 Kunz, Erich, 1900- R 65-3595 Stiller, Anne (Meara) ee Presenting Jerry Stiller & Anne Meara, (Phonodisc) Stiller, Gtinther, illus. see Der Butzemann. Kirsch, Hans Christian, 1934- comp.  ... 

Colons and Hyphens and Commas, Oh My! An Examination of Recreational Punctuation

Robin Watson
2005 Language Arts Journal of Michigan  
KERRY-ANNE: They're freckles, Philip. How many more times?  ...  (Stilman 157) At breakfast we consumed a reprehensible smorgasbord of assorted Nordic things.  ... 
doi:10.9707/2168-149x.1211 fatcat:xidkjnlozvhydfzdf74ag4oixy

Page 8 of Boston Commonwealth Vol. 35, Issue 32 [page]

1895 Boston Commonwealth  
Stilman Smith & Co., 3 Hamilton Place, BOSTON. J.  ...  New England Magazine so strong a local interest Articles which wil ippeal to the same class of readers are those by Miss Hallowell on The Streets of an Old Town, the old town being An nisquam on Cape Ann  ... 
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