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Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells
2012
Methods
Preserved Fulltext
N terminus. ...
During antigen purification there is the potential for loss of the N terminal fragment of the NRR, since cleavage at the S1 site means there is a reliance on non-covalent association to retain the untagged ...
doi:10.1016/j.ymeth.2012.07.008
pmid:22842086
pmcid:PMC3502869
fatcat:yeigvwddffe5lnpzec7nousupy
The complex portal - an encyclopaedia of macromolecular complexes
2014
Nucleic Acids Research
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The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/ complex), through which protein complexes from major model organisms are being collated and made available for search, viewing and download. It has been built in close collaboration with other bioinformatics services and populated with data from ChEMBL, MatrixDB, PDBe, Reactome and UniPro-tKB. Each entry contains information about the participating
doi:10.1093/nar/gku975
pmid:25313161
pmcid:PMC4384031
fatcat:afmhddxkfbg7rm2rp5yjgj4fyi
more »
... molecules (including small molecules and nucleic acids), their stoichiometry, topology and structural assembly. Complexes are annotated with details about their function, properties and complex-specific Gene Ontology (GO) terms. Consistent nomenclature is used throughout the resource with systematic names, recommended names and a list of synonyms all provided. The use of the Evidence Code Ontology allows us to indicate for which entries direct experimental evidence is available or if the complex has been inferred based on homology or orthology. The data are searchable using standard identifiers, such as UniProt, ChEBI and GO IDs, protein, gene and complex names or synonyms. This reference resource will be maintained and grow to encompass an increasing number of organisms. In-put from groups and individuals with specific areas of expertise is welcome.
The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing
2015
Biochemical Pharmacology
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: n = 6 (WT), 10 (KO). ...
= 7; WT, 0.89 AE 0.07 mmol/l, n = 10), nonesterified fatty acids (NEFA) (KO, 0.88 AE 0.09 mmol/l, n = 4; WT, 0.74 AE 0.07 mmol/l, n = 4) or glycerol (KO, 0.35 AE 0.02 mmol/l, n = 4; WT, 0.38 AE 0.01 mmol ...
doi:10.1016/j.bcp.2015.05.013
pmid:26049045
pmcid:PMC4509511
fatcat:jjem2zf54vcz5grz2ceuq3dsry
The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases
2013
Nucleic Acids Research
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IntAct (freely available at http://www.ebi.ac.uk/ intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMExand MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate
doi:10.1093/nar/gkt1115
pmid:24234451
pmcid:PMC3965093
fatcat:5qemzevwgzdjln3y4pxvgfz7aa
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... s of training, perform quality control on entries and take responsibility for long-term data maintenance. Recently, the MINT and IntAct databases decided to merge their separate efforts to make optimal use of limited developer resources and maximize the curation output. All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. Both IntAct and MINT are active contributors to the IMEx consortium
Effects of therapist exceptions questions on blaming and positive statements in families with adolescent behavior problems
1995
Journal of family psychology
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Melidonis and Brenna H. ...
Levant, EdD; James N. Butcher, PhD; and Timothy A. Salthouse, PhD, respectively, are the incumbent editors. ...
doi:10.1037/0893-3200.9.4.451
fatcat:vafwtiw22vfqrblqe42bugeyby
An expanded evaluation of protein function prediction methods shows an improvement in accuracy
2016
Genome Biology
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The remaining uncertainty (ru), misinformation (mi), and the resulting minimum semantic distance (S min ) are defined as ru(τ ) = 1 n e n e i=1 f ic(f ) · 1 f / ∈ P i (τ ) ∧ f ∈ T i , mi(τ ) = 1 n e n ...
Note that here, n e = n in the full evaluation mode and n e = m(0) in the partial evaluation mode applies to both ru and mi. In addition to the main metrics, we used two secondary metrics. ...
doi:10.1186/s13059-016-1037-6
pmid:27604469
pmcid:PMC5015320
fatcat:xgwbfeflxbhhhi2kqxjc626nkm
Page 2504 of Psychological Abstracts Vol. 83, Issue 6
[page]
1996
Psychological Abstracts
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Stan, 1 Leventhal, Howard, , 17789, 17793 17982
;
av iuuie
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5 “oF
HD :
N. 17173 , 18036
LY cr 3
Looijestin Paul L., i. N. ...
I., 17585
Meleis, Afaf I., 17170 Melek, Stephen P., Melidonis, Greer G., Mellers, J., 17331
Mello, Nancy K., 16758 Mellor, Steven, , 18570
Melton, Beth, 1 eee 18239
Melton, Gary B., Melton, L. ...
Auithor Index Suppl 2 - 2003 Abstract Book
2003
Diabetologia
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G. 882
Swennen, Geertje N. ...
Rebecca 246
Mei, Jie 76
Meier, Georg 937
Meier, Juris J. 219, 825
Mein, Charles A. 388
Meinders, Arend E. 753
Melandri, Piero 1293
Melchiorre, Mariangela 634
Melczer, Zsolt 720
Melegh, Béla 395
Melidonis ...
doi:10.1007/s00125-003-1191-8
fatcat:xbtfc3horrcvrgbjwg2ten2k2m
Supplemental Material for Proceedings of the American Psychological Association for the Legislative Year 2014 : Minutes of the Annual Meeting of the Council of Representatives, February 21–23, 2014, Washington, DC, and August 6 and August 8, 2014, Washington, DC, and Minutes of the February, June, August, and December 2014 Meetings of the Board of Directors
2015
American Psychologist
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McMillan, Ines
Melidonis, Greer G.
Michelson, Pamula K.
Miller, Laura E.
Mills, Patrick D.
Milo, Elizabeth Moulton
Mingee, Catherine M.
Moore, John N.
Moore, Mary E.
Moore, Sally A. ...
Sonnekalb, Andrew Paul
Soper, Richard Graves
Sordahl, Jeffrey Alan
Soto, Sylvia Ana
Sottomayor, Diogo Manuel
Southern, Douglas Stephen
Sparks, Anna L.
Spear, Owen N. ...
doi:10.1037/a0039369.supp
fatcat:uawfjspuybevrgatrvaitctbde
An expanded evaluation of protein function prediction methods shows an improvement in accuracy
2016
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The remaining uncertainty (ru), misinformation (mi), and the resulting minimum semantic distance (S min ) are defined as ru(τ ) = 1 n e n e i=1 f ic(f ) • 1 f / ∈ P i (τ ) ∧ f ∈ T i , mi(τ ) = 1 n e n ...
Note that here, n e = n in the full evaluation mode and n e = m(0) in the partial evaluation mode applies to both ru and mi. In addition to the main metrics, we used two secondary metrics. ...
doi:10.3929/ethz-b-000120396
fatcat:bikqq6bgvrcnzjgc7bqahvklsm
NEW FAUNISTIC DATA ON THE CAVE-DWELLING SPIDERS IN THE BALKAN PENINSULA (ARANEAE)
2016
Ecologica Montenegrina
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Gasparo and N. Simov. ...
(Continued)
102
Crete Isl., Rethymnon, Melidonion vill., Gerondospilios cave (cave
of Melidoni)
75
35.34˚ 24.50˚ 237
C. Deltshev, S.
Lazarov, K. ...
Beron
121 *Mount Athos, Agia Anna monastery, The Lost Glasses cave
92
40.14˚ 24.30˚ 394
A. Zhalov
122 Pella distr., Lutraky vill., Arcudaspileo cave (Bear cave)
93
40.84˚ 22.27˚ 43
P. ...
doi:10.37828/em.2016.7.17
fatcat:qn6yzdmk2zfwfcc7q7fo5czmmy
PARENTAL ACCOUNTS OF BLAMING WITHIN THE FAMILY: A DIALECTICAL MODEL FOR UNDERSTANDING BLAME IN SYSTEMIC THERAPY
2002
Journal of Marital & Family Therapy
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Turpin, G., Barley, V., Beail, N., Scaife, J., Slade, P., Smith, J. A., & Walsh, S. (1997). ...
Kagan, N. (1975). Interpersonal process recall: A method for influencing human action. Unpublished manuscript, University of Houston, Texas.
Kerig, P. K. (1994). ...
doi:10.1111/j.1752-0606.2002.tb00351.x
pmid:11977374
fatcat:xudp4acthjfmbpotyabpbyuswq
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
2018
The Lancet
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4717)*
Placebo
(n=4715)*
n (%)
n (%)
RR (95% CI)
Severe hypoglycemia
31 (0.7)
55 (1.2)
0.56 (0.36-0.87)
Pancreatitis †
10 (0.2)
7 (0.1)
1.43 (0.54-3.75)
Injection site reactions
86 ( ...
SC, Leiter LA, Lingvay I, Matthews D, Simó R, Helmark IC, 559 Wijayasinghe N, Larsen M. Semaglutide, reduction in glycated haemoglobin 560 and the risk of diabetic retinopathy. ...
doi:10.1016/s0140-6736(18)32261-x
pmid:30291013
fatcat:ihm3xwmecvhprlpw4onfrytuv4
Isolation of an ES-Derived Cardiovascular Multipotent Cell Population Based on VE-Cadherin Promoter Activity
2016
Stem Cells International
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Anna Melidoni, Dr. Spyros Georgatos, and Dr. Nikos Tsigkas for helpful discussions. The CT3 and 39.4D5 monoclonal antibodies developed by Lin, J. J. ...
EGFP coding sequence (from pEGFP-N) digested with Xho/NotI was ligated to the same sites of pPvec construct.
Cell Culture. E14T Embryonic Stem Cells (ESCs) were kindly provided by Professor A. ...
Subsequently, they were incubated with 3% BSA containing 0.2% Triton-X100 for 30 min and primary antibody labeling was performed at 4 ∘ C O/N, followed by incubation with the secondary antibody for 1 h ...
doi:10.1155/2016/8305624
pmid:28101109
pmcid:PMC5215608
fatcat:dpb2j7cdtnc6zogp5pfybsk2o4
Behavioral Medicine, Clinical Nutrition, Education, and Exercise
2016
Diabetes
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Results: The subjects mean BMI was 20.95Kg/m2 (SD=±1.16) in normal group (n=48), 24.13Kg/m2 (SD=±0.53) in overweight group (n=34), 27.58Kg/ m2 (SD=±2.58) in obesity group (n=45). ...
Variables
FCPD (n=35)
T1DM (n=35) T2DM (n=45)
M/F
1.33:1
1.33:1
1.25:1
Duration of DM in years
13.1±9.9
13.2±8.8
14.1±9.4
Retinopthy [n (%)]
8 (22.8)
12 (34)
21 (46.6)
Nephropathy [n (%) ...
GP informed 45% (n=52) DM pts, 13% (n=15) CVD pts about associated risk of road accident. 7% of pts (n=8, all T2DM) checked SMBG before driving. ...
doi:10.2337/db16-2192-2227
fatcat:xjd3plemnzdkhfd44odhg7ivb4
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