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Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells

Ronny Falk, Anna Falk, Michael R. Dyson, Anna N. Melidoni, Kothai Parthiban, Joyce L. Young, Wendy Roake, John McCafferty
2012 Methods  
N terminus.  ...  During antigen purification there is the potential for loss of the N terminal fragment of the NRR, since cleavage at the S1 site means there is a reliance on non-covalent association to retain the untagged  ... 
doi:10.1016/j.ymeth.2012.07.008 pmid:22842086 pmcid:PMC3502869 fatcat:yeigvwddffe5lnpzec7nousupy

The complex portal - an encyclopaedia of macromolecular complexes

Birgit H.M. Meldal, Oscar Forner-Martinez, Maria C. Costanzo, Jose Dana, Janos Demeter, Marine Dumousseau, Selina S. Dwight, Anna Gaulton, Luana Licata, Anna N. Melidoni, Sylvie Ricard-Blum, Bernd Roechert (+6 others)
2014 Nucleic Acids Research  
The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/ complex), through which protein complexes from major model organisms are being collated and made available for search, viewing and download. It has been built in close collaboration with other bioinformatics services and populated with data from ChEMBL, MatrixDB, PDBe, Reactome and UniPro-tKB. Each entry contains information about the participating
more » ... molecules (including small molecules and nucleic acids), their stoichiometry, topology and structural assembly. Complexes are annotated with details about their function, properties and complex-specific Gene Ontology (GO) terms. Consistent nomenclature is used throughout the resource with systematic names, recommended names and a list of synonyms all provided. The use of the Evidence Code Ontology allows us to indicate for which entries direct experimental evidence is available or if the complex has been inferred based on homology or orthology. The data are searchable using standard identifiers, such as UniProt, ChEBI and GO IDs, protein, gene and complex names or synonyms. This reference resource will be maintained and grow to encompass an increasing number of organisms. In-put from groups and individuals with specific areas of expertise is welcome.
doi:10.1093/nar/gku975 pmid:25313161 pmcid:PMC4384031 fatcat:afmhddxkfbg7rm2rp5yjgj4fyi

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing

Sandra G. Gonzalez Malagon, Anna N. Melidoni, Diana Hernandez, Bilal A. Omar, Lyndsey Houseman, Sunil Veeravalli, Flora Scott, Dorsa Varshavi, Jeremy Everett, Yugo Tsuchiya, John F. Timms, Ian R. Phillips (+1 others)
2015 Biochemical Pharmacology  
: n = 6 (WT), 10 (KO).  ...  = 7; WT, 0.89 AE 0.07 mmol/l, n = 10), nonesterified fatty acids (NEFA) (KO, 0.88 AE 0.09 mmol/l, n = 4; WT, 0.74 AE 0.07 mmol/l, n = 4) or glycerol (KO, 0.35 AE 0.02 mmol/l, n = 4; WT, 0.38 AE 0.01 mmol  ... 
doi:10.1016/j.bcp.2015.05.013 pmid:26049045 pmcid:PMC4509511 fatcat:jjem2zf54vcz5grz2ceuq3dsry

The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

Sandra Orchard, Mais Ammari, Bruno Aranda, Lionel Breuza, Leonardo Briganti, Fiona Broackes-Carter, Nancy H. Campbell, Gayatri Chavali, Carol Chen, Noemi del-Toro, Margaret Duesbury, Marine Dumousseau (+23 others)
2013 Nucleic Acids Research  
IntAct (freely available at http://www.ebi.ac.uk/ intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMExand MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate
more » ... s of training, perform quality control on entries and take responsibility for long-term data maintenance. Recently, the MINT and IntAct databases decided to merge their separate efforts to make optimal use of limited developer resources and maximize the curation output. All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. Both IntAct and MINT are active contributors to the IMEx consortium
doi:10.1093/nar/gkt1115 pmid:24234451 pmcid:PMC3965093 fatcat:5qemzevwgzdjln3y4pxvgfz7aa

Effects of therapist exceptions questions on blaming and positive statements in families with adolescent behavior problems

Greer G. Melidonis, Brenna H. Bry
1995 Journal of family psychology  
Melidonis and Brenna H.  ...  Levant, EdD; James N. Butcher, PhD; and Timothy A. Salthouse, PhD, respectively, are the incumbent editors.  ... 
doi:10.1037/0893-3200.9.4.451 fatcat:vafwtiw22vfqrblqe42bugeyby

An expanded evaluation of protein function prediction methods shows an improvement in accuracy

Yuxiang Jiang, Tal Ronnen Oron, Wyatt T. Clark, Asma R. Bankapur, Daniel D'Andrea, Rosalba Lepore, Christopher S. Funk, Indika Kahanda, Karin M. Verspoor, Asa Ben-Hur, Da Chen Emily Koo, Duncan Penfold-Brown (+135 others)
2016 Genome Biology  
The remaining uncertainty (ru), misinformation (mi), and the resulting minimum semantic distance (S min ) are defined as ru(τ ) = 1 n e n e i=1 f ic(f ) · 1 f / ∈ P i (τ ) ∧ f ∈ T i , mi(τ ) = 1 n e n  ...  Note that here, n e = n in the full evaluation mode and n e = m(0) in the partial evaluation mode applies to both ru and mi. In addition to the main metrics, we used two secondary metrics.  ... 
doi:10.1186/s13059-016-1037-6 pmid:27604469 pmcid:PMC5015320 fatcat:xgwbfeflxbhhhi2kqxjc626nkm

Page 2504 of Psychological Abstracts Vol. 83, Issue 6 [page]

1996 Psychological Abstracts  
Stan, 1 Leventhal, Howard, , 17789, 17793 17982 ; av iuuie 333333 3 5 “oF HD : N. 17173 , 18036 LY cr 3 Looijestin Paul L., i. N.  ...  I., 17585 Meleis, Afaf I., 17170 Melek, Stephen P., Melidonis, Greer G., Mellers, J., 17331 Mello, Nancy K., 16758 Mellor, Steven, , 18570 Melton, Beth, 1 eee 18239 Melton, Gary B., Melton, L.  ... 

Auithor Index Suppl 2 - 2003 Abstract Book

2003 Diabetologia  
G. 882 Swennen, Geertje N.  ...  Rebecca 246 Mei, Jie 76 Meier, Georg 937 Meier, Juris J. 219, 825 Mein, Charles A. 388 Meinders, Arend E. 753 Melandri, Piero 1293 Melchiorre, Mariangela 634 Melczer, Zsolt 720 Melegh, Béla 395 Melidonis  ... 
doi:10.1007/s00125-003-1191-8 fatcat:xbtfc3horrcvrgbjwg2ten2k2m

Supplemental Material for Proceedings of the American Psychological Association for the Legislative Year 2014 : Minutes of the Annual Meeting of the Council of Representatives, February 21–23, 2014, Washington, DC, and August 6 and August 8, 2014, Washington, DC, and Minutes of the February, June, August, and December 2014 Meetings of the Board of Directors

2015 American Psychologist  
McMillan, Ines Melidonis, Greer G. Michelson, Pamula K. Miller, Laura E. Mills, Patrick D. Milo, Elizabeth Moulton Mingee, Catherine M. Moore, John N. Moore, Mary E. Moore, Sally A.  ...  Sonnekalb, Andrew Paul Soper, Richard Graves Sordahl, Jeffrey Alan Soto, Sylvia Ana Sottomayor, Diogo Manuel Southern, Douglas Stephen Sparks, Anna L. Spear, Owen N.  ... 
doi:10.1037/a0039369.supp fatcat:uawfjspuybevrgatrvaitctbde

An expanded evaluation of protein function prediction methods shows an improvement in accuracy

Yuxiang Jiang, Tal Ronnen Oron, Wyatt T. Clark, Asma R. Bankapur, Daniel D'Andrea, Rosalba Lepore, Christopher S. Funk, Indika Kahanda, Karin M. Verspoor, Asa Ben-Hur, Da Chen E. Koo, Duncan Penfold-Brown (+135 others)
2016
The remaining uncertainty (ru), misinformation (mi), and the resulting minimum semantic distance (S min ) are defined as ru(τ ) = 1 n e n e i=1 f ic(f ) • 1 f / ∈ P i (τ ) ∧ f ∈ T i , mi(τ ) = 1 n e n  ...  Note that here, n e = n in the full evaluation mode and n e = m(0) in the partial evaluation mode applies to both ru and mi. In addition to the main metrics, we used two secondary metrics.  ... 
doi:10.3929/ethz-b-000120396 fatcat:bikqq6bgvrcnzjgc7bqahvklsm

NEW FAUNISTIC DATA ON THE CAVE-DWELLING SPIDERS IN THE BALKAN PENINSULA (ARANEAE)

Maria V. Naumova, Stoyan P. Lazarov, Boyan P. Petrov, Christo D. Deltshev
2016 Ecologica Montenegrina  
Gasparo and N. Simov.  ...  (Continued) 102 Crete Isl., Rethymnon, Melidonion vill., Gerondospilios cave (cave of Melidoni) 75 35.34˚ 24.50˚ 237 C. Deltshev, S. Lazarov, K.  ...  Beron 121 *Mount Athos, Agia Anna monastery, The Lost Glasses cave 92 40.14˚ 24.30˚ 394 A. Zhalov 122 Pella distr., Lutraky vill., Arcudaspileo cave (Bear cave) 93 40.84˚ 22.27˚ 43 P.  ... 
doi:10.37828/em.2016.7.17 fatcat:qn6yzdmk2zfwfcc7q7fo5czmmy

PARENTAL ACCOUNTS OF BLAMING WITHIN THE FAMILY: A DIALECTICAL MODEL FOR UNDERSTANDING BLAME IN SYSTEMIC THERAPY

Ceri Bowen, Anna Madill, Peter Stratton
2002 Journal of Marital & Family Therapy  
Turpin, G., Barley, V., Beail, N., Scaife, J., Slade, P., Smith, J. A., & Walsh, S. (1997).  ...  Kagan, N. (1975). Interpersonal process recall: A method for influencing human action. Unpublished manuscript, University of Houston, Texas. Kerig, P. K. (1994).  ... 
doi:10.1111/j.1752-0606.2002.tb00351.x pmid:11977374 fatcat:xudp4acthjfmbpotyabpbyuswq

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Adrian F Hernandez, Jennifer B Green, Salim Janmohamed, Ralph B D'Agostino, Christopher B Granger, Nigel P Jones, Lawrence A Leiter, Anne E Rosenberg, Kristina N Sigmon, Matthew C Somerville, Karl M Thorpe, John J V McMurray (+796 others)
2018 The Lancet  
4717)* Placebo (n=4715)* n (%) n (%) RR (95% CI) Severe hypoglycemia 31 (0.7) 55 (1.2) 0.56 (0.36-0.87) Pancreatitis † 10 (0.2) 7 (0.1) 1.43 (0.54-3.75) Injection site reactions 86 (  ...  SC, Leiter LA, Lingvay I, Matthews D, Simó R, Helmark IC, 559 Wijayasinghe N, Larsen M. Semaglutide, reduction in glycated haemoglobin 560 and the risk of diabetic retinopathy.  ... 
doi:10.1016/s0140-6736(18)32261-x pmid:30291013 fatcat:ihm3xwmecvhprlpw4onfrytuv4

Isolation of an ES-Derived Cardiovascular Multipotent Cell Population Based on VE-Cadherin Promoter Activity

Violetta A. Maltabe, Eleonora Barka, Marianthi Kontonika, Dimitra Florou, Maria Kouvara-Pritsouli, Maria Roumpi, Simeon Agathopoulos, Theofilos M. Kolettis, Panos Kouklis
2016 Stem Cells International  
Anna Melidoni, Dr. Spyros Georgatos, and Dr. Nikos Tsigkas for helpful discussions. The CT3 and 39.4D5 monoclonal antibodies developed by Lin, J. J.  ...  EGFP coding sequence (from pEGFP-N) digested with Xho/NotI was ligated to the same sites of pPvec construct. Cell Culture. E14T Embryonic Stem Cells (ESCs) were kindly provided by Professor A.  ...  Subsequently, they were incubated with 3% BSA containing 0.2% Triton-X100 for 30 min and primary antibody labeling was performed at 4 ∘ C O/N, followed by incubation with the secondary antibody for 1 h  ... 
doi:10.1155/2016/8305624 pmid:28101109 pmcid:PMC5215608 fatcat:dpb2j7cdtnc6zogp5pfybsk2o4

Behavioral Medicine, Clinical Nutrition, Education, and Exercise

2016 Diabetes  
Results: The subjects mean BMI was 20.95Kg/m2 (SD=±1.16) in normal group (n=48), 24.13Kg/m2 (SD=±0.53) in overweight group (n=34), 27.58Kg/ m2 (SD=±2.58) in obesity group (n=45).  ...  Variables FCPD (n=35) T1DM (n=35) T2DM (n=45) M/F 1.33:1 1.33:1 1.25:1 Duration of DM in years 13.1±9.9 13.2±8.8 14.1±9.4 Retinopthy [n (%)] 8 (22.8) 12 (34) 21 (46.6) Nephropathy [n (%)  ...  GP informed 45% (n=52) DM pts, 13% (n=15) CVD pts about associated risk of road accident. 7% of pts (n=8, all T2DM) checked SMBG before driving.  ... 
doi:10.2337/db16-2192-2227 fatcat:xjd3plemnzdkhfd44odhg7ivb4
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