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2019
Fachtagung "e-Learning" der Gesellschaft für Informatik
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Zeitschrift für Pädagogische Psychologie, 23(2), 105-115, 2009. 336 Anja Hawlitschek et al. Lernenden auf relevante Fakten, Prozeduren und Ansätze aufmerksam machen sollen [Th09]. ...
doi:10.18420/delfi2019_342
dblp:conf/delfi/HawlitschekDZ19
fatcat:nr6fifkusrhgdghxlanqv4d2cy
Le long chemin d'une charte vers l'ère multimédiale
[chapter]
2011
Lexikon, Varietät, Philologie
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Early rectal stenosis following stapled rectal mucosectomy for hemorrhoids
2004
BMC Surgery
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Within the last years, stapled rectal mucosectomy (SRM) has become a widely accepted procedure for second and third degree hemorrhoids. One of the delayed complications is a stenosis of the lower rectum. In order to evaluate the specific problem of rectal stenosis following SRM we reviewed our data with special respect to potential predictive factors or stenotic events. Methods: A retrospective analysis of 419 consecutive patients, which underwent SRM from December 1998 to August 2003 was
doi:10.1186/1471-2482-4-6
pmid:15153248
pmcid:PMC420246
fatcat:h3fmyh6wdvenvp3ahlnscqkpuu
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... med. Only patients with at least one follow-up check were evaluated, thus the analysis includes 289 patients with a mean follow-up of 281 days (±18 days). For statistic analysis the groups with and without stenosis were evaluated using the Chi-Square Test, using the Kaplan-Meier statistic the actuarial incidence for rectal stenosis was plotted. Results: Rectal stenosis was observed in 9 patients (3.1%), eight of these stenoses were detected within the first 100 days after surgery; the median time to stenosis was 95 days. Only one patient had a rectal stenosis after more than one year. 8 of the 9 patients had no obstructive symptoms, however the remaining patients complained of obstructive defecation and underwent surgery for transanal strictureplasty with electrocautery. A statistical analysis revealed that patients with stenosis had significantly more often prior treatment for hemorrhoids (p < 0.01). According to the SRM only severe postoperative pain was significantly associated with stenoses (p < 0.01). Other factors, such as gender (p = 0.11), surgical technique (p = 0.25), revision (p = 0.79) or histological evidence of squamous skin (p = 0.69) showed no significance. Conclusion: Rectal stenosis is an uncommon event after SRM. Early stenosis will occur within the first three months after surgery. The majority of the stenoses are without clinical relevance. Only one of nine patients had to undergo surgery for a relevant stenosis. The predictive factor for stenosis in the patient-characteristics is previous interventions for hemorrhoids, severe postoperative pain might also predict rectal stenosis.
Compensatory versus noncompensatory models for predicting consumer preferences
2009
Judgment and Decision Making
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and estimated responses r i is minimal. 1 More elaborate methods that ask for self-explicated attribute preferences such as ACA (Johnson, 1987; Green, Krieger & Agarwal, 1991) and HILCA (Wildner, Dietrich ...
doaj:32567cc327604660bceb0c46ad2b35c3
fatcat:zukiwf5cgnhc5nc3fwaruevqzi
Tidal gravity variations revisited at Vostok Station, Antarctica
2009
Polar Science
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., 1996) ; indeed, Dietrich et al. (2001) attributed these discrepancies to the effect of tides in Lake Vostok. ...
doi:10.1016/j.polar.2008.11.001
fatcat:ecmmug6gprejhi2y52ll2duekm
Ein national gefördertes Onlinelabor als Infrastruktur für die psychologische Forschung
2014
Psychologische Rundschau
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Standard-Nutzungsbedingungen: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen
doi:10.1026/0033-3042/a000198
fatcat:ftuc62mea5gkjdeyw2t3gy4jmi
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... bedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Die RatSWD Working Papers Reihe startete Ende 2007. Seit 2009 werden in dieser Publikationsreihe nur noch konzeptionelle und historische Arbeiten, die sich mit der Gestaltung der statistischen Infrastruktur und der Forschungsinfrastruktur in den Sozial-, Verhaltens-und Wirtschaftswissenschaften beschäftigen, publiziert. Dies sind insbesondere Papiere zur Gestaltung der Amtlichen Statistik, der Ressortforschung und der akademisch getragenen Forschungsinfrastruktur sowie Beiträge, die Arbeit des RatSWD selbst betreffend. Auch Papiere, die sich auf die oben genannten Bereiche außerhalb Deutschlands und auf supranationale Aspekte beziehen, sind besonders willkommen. RatSWD Working Papers sind nicht-exklusiv, d. h. einer Veröffentlichung an anderen Orten steht nichts im Wege. Alle Arbeiten können und sollen auch in fachlich, institutionell und örtlich spezialisierten Reihen erscheinen. Die RatSWD Working Papers können nicht über den Buchhandel, sondern nur online über den RatSWD bezogen werden. Um nicht deutsch sprechenden Nutzer/innen die Arbeit mit der Reihe zu erleichtern, sind auf den englischen Internetseiten der RatSWD Working Papers nur die englischsprachigen Papers zu finden, auf den deutschen Seiten werden alle Nummern der Reihe chronologisch geordnet aufgelistet. Einige ursprünglich in der RatSWD Working Papers Reihe erschienenen empirischen Forschungsarbeiten sind ab 2009 in der RatSWD Research Notes Reihe zu finden. Die Inhalte der RatSWD Working Papers stellen ausdrücklich die Meinung der jeweiligen Autor/innen dar und nicht die des RatSWD. Das Bundesministerium für Bildung und Forschung hat die Publikationen nicht beeinflusst. Herausgeber der RatSWD Working Paper Series: Vorsitzender des RatSWD Zusammenfassung Momentan besteht hohes wissenschaftspolitisches Interesse an der Entwicklung von Forschungsinfrastrukturen in allen Wissenschaftsbereichen. Wir plädieren dafür, ein national gefördertes Onlinelabor für die psychologische Forschung in diesen Diskurs einzubringen. Dieses Labor sollte einen großen Teilnehmerpool, notwendige Software-Tools, edukative Komponenten (Methodenberatung) sowie Schnittstellen zu Datenarchiven zur Verfügung stellen. Die Vorteile einer solchen Einrichtung werden auf der Basis von Effizienzbetrachtungen sowie methodischen und forschungsethischen Überlegungen verdeutlicht. Abschließend diskutieren wir mittelfristige Entwicklungspotenziale eines Nationalen Onlinelabors. Abstract A nationally funded online laboratory as infrastructure for psychological research There currently is a high level of science policy interest in the development of research infrastructures in all scientific areas. We propose to promote the idea of a national online laboratory within this discourse. This laboratory should provide access to a large participant pool, should offer software tools, provide education on Internet-based research methodologies, and should interface with data archives. We spell out the advantages of such a facility on the basis of efficiency concerns as well as considerations concerning research methodology and research ethics. We conclude with a discussion of mid-term developmental potentials of a nationally funded online laboratory.
Vertical partitioning of CO2 production in a Dystric Cambisol
2019
Biogeosciences Discussions
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., 2010; Wordell-Dietrich et al., 2017) , suggesting that subsoils also contain a labile fraction that should be taken 15 into account as a source for soil respiration. ...
doi:10.5194/bg-2019-143
fatcat:4wmvoecxdvac5bfviocv7pohle
The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression
2019
Cancers
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Emerging evidence reveals crucial roles of wild type RAS in liver cancer. The delta subunit of rod-specific photoreceptor cGMP phosphodiesterase (PDE6D) regulates the trafficking of RAS proteins to the plasma membrane and thereby contributes to RAS activation. However, the expression and specific function of PDE6D in hepatocellular carcinoma (HCC) were completely unknown. In this study, PDE6D was newly found to be markedly upregulated in HCC tissues and cell lines. Overexpression of PDE6D in
doi:10.3390/cancers11030398
pmid:30901922
pmcid:PMC6468542
fatcat:n5wdgtij4vbs5p3lr2kc6fopxy
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... correlated with enhanced tumor stages, tumor grading, and ERK activation. PDE6D depletion significantly reduced proliferation, clonogenicity, and migration of HCC cells. Moreover, PDE6D was induced by TGF-β1, the mediator of stemness, epithelial-mesenchymal transition (EMT), and chemoresistance. In non-resistant cells, overexpression of PDE6D conferred resistance to sorafenib-induced toxicity. Further, PDE6D was overexpressed in sorafenib resistance, and inhibition of PDE6D reduced proliferation and migration in sorafenib-resistant HCC cells. Together, PDE6D was found to be overexpressed in liver cancer and correlated with tumor stages, grading, and ERK activation. Moreover, PDE6D contributed to migration, proliferation, and sorafenib resistance in HCC cells, therefore representing a potential novel therapeutic target.
Vertical partitioning of CO2 production in a forest soil
2020
Biogeosciences
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All raw data (without 14 C) can be accessed in a data package via https://doi.org/10.25532/OPARA-101 (Wordell-Dietrich, 2020). Supplement. ...
Wordell-Dietrich et al.: Vertical partitioning of CO 2 production in a forest soil
https://doi.org/10.5194/bg-17-6341-2020Biogeosciences, 17, 6341-6356, 2020 ...
doi:10.5194/bg-17-6341-2020
fatcat:ja2djhugdvhflfcgx6dx7en4ty
Influence of tides and tidal current on Mertz Glacier, Antarctica
2004
Journal of Glaciology
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Mertz Glacier, East Antarctica, is characterized by a 140 km long, 25 km wide floating ice tongue. In this paper, we combine a large number of remotely sensed datasets, including in situ global positioning system measurements, satellite radar altimetry, airborne radio-echo sounding and satellite synthetic aperture radar imagery and interferometry. These various datasets allow us to study the interaction of the ice tongue with the tides and currents. However, the inverse barometer effect needs
doi:10.3189/172756504781829828
fatcat:4g6h7j3i2ncybfvbgi5rmzm3u4
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... be applied to sea-level variations affecting the tongue. We find that the tide-induced currents exert a small lateral pressure on the tongue which, when integrated over the large surface of the tongue, induce a flexure of up to 2 m amplitude per day. Simple elastic modelling of the flexure confirms the observations and helps validate the boundary conditions necessary to explain different eastward and westward tongue deflections. In addition, the along-flow velocity of the tongue does vary daily from 1.9 to 6.8 md-1 depending on the tidal current. When the current pushes the tongue toward the eastern boundary of the fjord, the tongue is retarded by the drag and the velocity decreases. The accumulated stress is released, allowing the tongue to flow very rapidly when the current pushes the tongue westward. These forcing and boundary conditions on the floating ice flow are important and must be taken into account when studying glacier discharge and calving.
Durotropic growth of pollen tubes
2020
Plant Physiology
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To reach the female gametophyte, growing pollen tubes must penetrate different tissues within the pistil, the female reproductive organ of a flower. Past research has identified various chemotropic cues that guide pollen tubes through the transmitting tract of the pistil, which represents the longest segment of its growth path. In addition, physical mechanisms also play a role in pollen tube guidance; however, these processes remain poorly understood. Here we show that pollen tubes from plants
doi:10.1104/pp.19.01505
pmid:32241878
pmcid:PMC7271775
fatcat:y2u432jdrjbsni44hxwxkzjcma
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... ith solid transmitting tracts actively respond to the stiffness of the environment. We found that pollen tubes from Nicotiana tabacum and other plant species with a solid or semi-solid transmitting tract increase their growth rate in response to an increasing matrix stiffness. By contrast, pollen tubes from Lilium longiflorum and other plant species with a hollow transmitting tract decrease their growth rate with increasing matrix stiffness, even though the forces needed to maintain a constant growth rate remain far below the maximum penetration force these pollen tubes are able to generate. Moreover, when confronted with a transition from a softer to a stiffer matrix, pollen tubes from N. tabacum display a greater ability to penetrate into a stiffer matrix compared to pollen tubes from L. longiflorum, even though the maximum force generated by pollen tubes from N. tabacum (11 µN) is smaller than the maximum force generated by pollen tubes from L. longiflorum (36 µN). These findings demonstrate a mechano-sensitive growth behavior, termed here durotropic growth, that is only expressed in pollen tubes from plants with a solid or semi-solid transmitting tract and thus may contribute to an effective pollen tube guidance within the pistil.
An efficient and pragmatic approach for regulatory aquatic mixture risk assessment of pesticides
2022
Environmental Sciences Europe
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AbstractThe current regulatory approach to address aquatic mixture toxicity for pesticides in the EU (EFSA J 11:3290, 2013) is rather complex: in typical cases it requires conducting the entire mixture risk assessment scheme for every exposure scenario separately (e.g. 6–8 ecotoxicological endpoints, for each of the nine exposure scenarios for the European Central Zone with 24 common mitigation measure combinations result in over 1700 sub-scenarios to be assessed). This article discusses the
doi:10.1186/s12302-022-00594-3
fatcat:fweq3fnpincmnndzx5cyx6zwzi
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... ilable concepts for a mixture toxicity assessment, the key questions raised and the implementation of these questions in existing risk assessment approaches. Based on this, an alternative, more efficient assessment scheme for aquatic mixture risk assessment (AMiRA) is proposed with the aim of facilitating the practical conduct and interpretation of the assessment while addressing the key questions and preserving the level of protection. The scheme assesses product risk (including a check for non-additive effects), the presence of a risk driver and gains efficiency by the straightforward use of risk quotients (RQ) to calculate mixture risk quotients (RQmix) that are equivalent to the calculation of exposure toxicity ratios for a mixture (ETRmix,CA = Exposure-Toxicity-Ratio for mixtures based on concentration addition) proposed by EFSA (EFSA J 11:3290, 2013). A case study is provided underlining the equivalence of the proposed approach to the EFSA (EFSA J 11:3290, 2013) decision tree.
Technologies Turning Future Brick-and-Mortar Stores into Data-Rich Environments
2019
NIM Marketing Intelligence Review
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Slave to habit? Obesity is associated with decreased behavioural sensitivity to reward devaluation
2015
Appetite
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1 Horstmann A, Dietrich A, Mathar D, Pössel M, Villringer A, Neumann J. Slave to habit? Obesity is associated with decreased behavioural sensitivity to reward devaluation. Appetite. 2015;87:175-83. ...
doi:10.1016/j.appet.2014.12.212
pmid:25543077
fatcat:w3dbbqxobrh75axsfnffczlb6e
Body weight status, eating behavior, sensitivity to reward/punishment, and gender: relationships and interdependencies
2014
Frontiers in Psychology
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Anja Dietrich is funded by a research grant from the Konrad Adenauer Foundation (www.kas.de). The questionnaire contains three subscales. ...
doi:10.3389/fpsyg.2014.01073
pmid:25368586
pmcid:PMC4202791
fatcat:gkxloaqjujb7llep7koewdcyfm
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