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Mechanical blood-tissue interaction in contracting muscles

W.J. Vankana, J.M. Huyghe, C.C. van Donkelaar, M.R. Drost, J.D. Janssen, A. Huson
1998 Journal of Biomechanics  
A finite element (FE) model of blood perfused biological tissue has been developed.  ...  The FE model used in this simulation contains a transversely isotropic, non-linearly elastic description of deforming muscle tissue, in which local contraction stress is prescribed as a function of time  ...  Slaaf of the Cardiovascular Research Institute, Department of Biophysics, Maastricht University, for the fruitful discussions about the physiological aspects of the study. The research of Dr J.M.  ... 
doi:10.1016/s0021-9290(98)00014-1 pmid:9727337 fatcat:ajjzkv5sp5fmxea4owv5zj3ukq

Artery active mechanical response: High order finite element implementation and investigation

Zohar Yosibash, Elad Priel
2012 Computer Methods in Applied Mechanics and Engineering  
The active mechanical response of an artery wall resulting from the contraction of the smooth muscle cells (SMCs) is represented by a strain energy function (SEDF) that augments the passive SEDF recently  ...  reported in Yosibash Z. and Priel E., "p-FEMs for hyperelastic anisotropic nearly incompressible materials under finite deformations with applications to arteries simulation", Int.  ...  Acknowledgements The authors gratefully acknowledge the anonymous referees for their valuable and constructive comments, leading to improvements in the presentation and context.  ... 
doi:10.1016/j.cma.2012.05.001 fatcat:ctwvpibblrhxtdukpfgnwzb7nm

p-FEMs in biomechanics: Bones and arteries

Zohar Yosibash
2012 Computer Methods in Applied Mechanics and Engineering  
The p-version of the finite element method (p-FEM) is extended to problems in the field of biomechanics: the mechanical response of bones and arteries.  ...  The complex combined passive-active mechanical response of human arteries is considered in the second part and the enhancement of p-FEMs to these non-linear problems is detailed.  ...  of Health, Israel, for their financial support for the research on bones.  ... 
doi:10.1016/j.cma.2012.09.006 fatcat:lgp6rtftrfcwtaruelnd5p47be

Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator

Seiryo Sugiura, Takumi Washio, Asuka Hatano, Junichi Okada, Hiroshi Watanabe, Toshiaki Hisada
2012 Progress in Biophysics and Molecular Biology  
Recent advancements in computational science and the development of high-performance computers have enabled the creation of multi-scale, multi-physics simulation heart models using the finite element method  ...  Such an approach is crucial to understanding the complexity of hierarchical biological systems increasingly revealed by active researches in molecular and cellular biology.  ...  FEM meshed for solid (ventricular wall) and fluid (blood) elements are shown with their electrical analogs of afterload (systemic arterial tree) and preload (pulmonary circulation with active LA).  ... 
doi:10.1016/j.pbiomolbio.2012.07.001 pmid:22828714 fatcat:vyl6dgvirvczrlvytrmmircb4u

Biomechanical relevance of the microstructure in artery walls with a focus on passive and active components

Gerhard A. Holzapfel, Ray W. Ogden
2018 American Journal of Physiology. Heart and Circulatory Physiology  
layers; artery tissue modeling; artery wall biomechanics; artery wall microstructure; passive-active modeling  ...  Biomechanical relevance of the microstructure in artery walls with a focus on passive and active components.  ...  The fibers are the main load-bearing elements of artery walls and render the material properties anisotropic. They turn over continuously with a half-life on the order of 15Ϫ90 days (39) .  ... 
doi:10.1152/ajpheart.00117.2018 pmid:29799274 fatcat:zgcba4x6ojdtheolhgw6krgi5e

Parallel multiscale simulations of a brain aneurysm

Leopold Grinberg, Dmitry A. Fedosov, George Em Karniadakis
2013 Journal of Computational Physics  
We also discuss the computational challenges involved and present scalability results of our coupled solver on up to 300K computer processors.  ...  Acknowledgment Computations were performed on the IBM Blue-Gene/P computers of Argonne National Laboratory (ANL) and Jülich Supercomputing Centre, and also on the CRAY XT5 of National Institute for Computational  ...  We would like to thank Vitali Morozov and Joseph Insley of ANL for their help in computational and visualization issues.  ... 
doi:10.1016/ pmid:23734066 pmcid:PMC3668797 fatcat:isv2plx6j5a6ji462ux2hzox7q

Microstructure-based biomechanics of coronary arteries in health and disease

Huan Chen, Ghassan S. Kassab
2016 Journal of Biomechanics  
The microstructural constitutive models of healthy coronary arteries consist of three major mechanical components: collagen, elastin, and smooth muscle cells, while the models of atherosclerotic arteries  ...  Microstructure-based models of blood vessels can provide predictions of arterial mechanical response at the macro-and micromechanical level for each constituent structure.  ...  Acknowledgments This work was supported by the National Institute of Health National Heart, Lung, and Blood Institute Grant 1 R01 HL117990.  ... 
doi:10.1016/j.jbiomech.2016.03.023 pmid:27086118 pmcid:PMC5028318 fatcat:ajsmydy5hfgi5l57hz6pmrakay

A computational study of turbulent flow separation for a circular cylinder using skin friction boundary conditions [chapter]

Johan Hoffman, Niclas Jansson
2011 ERCOFTAC Series  
Basic aspects of turbulent flow from applications point of view thus show to be computable by stabilized finite element methods without turbulence modeling referred to as Direct FEM-Simulation, which opens  ...  The well known second order solid dynamics formulation, where the primary variable is the displacement, is typically discretised in space by using the Finite Element Method (FEM) and discretised in the  ...  of the Extended Abstracts and Full Contributions, and the organization of ADMOS 2013, VI International Conference on Adaptive Modeling and Simulation: Acknowledgments The authors thank the financial  ... 
doi:10.1007/978-94-007-0231-8_5 fatcat:f6ll6iawcbeo7pbj4rb7t4o2tq

Precision medicine in human heart modeling : Perspectives, challenges, and opportunities

M Peirlinck, F Sahli Costabal, J Yao, J M Guccione, S Tripathy, Y Wang, D Ozturk, P Segars, T M Morrison, S Levine, E Kuhl
2021 Biomechanics and Modeling in Mechanobiology  
However, the exact role in precision medicine for human heart modeling has not yet been fully explored.  ...  Here, we discuss the challenges and opportunities for personalized human heart simulations, from diagnosis to device design, treatment planning, and prognosis.  ...  of Health and Human Services or the Food and Drug Administration.  ... 
doi:10.1007/s10237-021-01421-z pmid:33580313 pmcid:PMC8154814 fatcat:yt4jb7s445fdri6l4r65o47tba

A Review on Damage and Rupture Modelling for Soft Tissues

Sai Naga Sri Harsha Chittajallu, Ashutosh Richhariya, Kwong Ming Tse, Viswanath Chinthapenta
2022 Bioengineering  
The current article reviews the recently developed damage models and rupture models that considered the microstructure of the tissues.  ...  Some key challenges of damage and rupture models are outlined in the article, which helps extend the present damage and rupture models to various soft tissues.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/bioengineering9010026 pmid:35049735 pmcid:PMC8773318 fatcat:v73jb2hymfdzbbxfbw4esmx634

Multiscale modeling in computational biomechanics

M. Tawhai, J. Bischoff, D. Einstein, A. Erdemir, T. Guess, J. Reinbolt
2009 IEEE Engineering in Medicine and Biology Magazine  
Tethering of the arteries and veins extends to the level of the pulmonary capillaries that essentially form the walls of the alveoli.  ...  This can be seen in multilevel finite element models of tissue-cell interactions [68] and in musculoskeletal modeling where rigid body movement simulations requesting simulations of a tissue-level finite  ... 
doi:10.1109/memb.2009.932489 pmid:19457733 pmcid:PMC2854014 fatcat:borkynrfcrckpgagzoi4rs47ua

Modeling Pathologies of Diastolic and Systolic Heart Failure

M. Genet, L. C. Lee, B. Baillargeon, J. M. Guccione, E. Kuhl
2015 Annals of Biomedical Engineering  
This makes it virtually impossible to predict the time line of heart failure for a diseased individual.  ...  Heart failure is classified into two categories: diastolic heart failure, a thickening of the ventricular wall associated with impaired filling; and systolic heart failure, a dilation of the ventricles  ...  To create the finite element model, we import the SolidWorks NURBS surface model as solid geometry into Abaqus/ CAE (SIMULIA, Dassault Syste`mes; Providence, Rhode Island) and generate the tetrahedral  ... 
doi:10.1007/s10439-015-1351-2 pmid:26043672 pmcid:PMC4670609 fatcat:iv4hxlzz3vag5afddpurj435ma

On a phase-field approach to model fracture of small intestine walls

Sindhu Nagaraja, Kay Leichsenring, Marreddy Ambati, Laura De Lorenzis, Markus Böl
2021 Acta Biomaterialia  
From a modeling point of view, the observed anisotropic elastic response is studied with a continuum mechanical model stemming from a strain energy density with a neo-Hookean component and an anisotropic  ...  The presented model can reproduce the mechanical failure behaviour of the small intestine in an excellent way and is thus a promising tool for the future mechanical description of diseased small intestinal  ...  Acknowledgements The authors would like to thank Stephan Kohn for data preparation. Manuscript submitted to 'Acta Biomaterialia'  ... 
doi:10.1016/j.actbio.2021.06.002 pmid:34119714 fatcat:tua2biew6jbnpmf3s5u7gulaq4

Toward a Digital Twin for Arthroscopic Knee Surgery: A Systematic Review

Oystein Bjelland, Bismi Rasheed, Hans Georg Schaathun, Morten D. Pedersen, Martin Steinert, Alf Inge Hellevik, Robin T. Bye
2022 IEEE Access  
In arthroscopic surgery education, the paradigm shift from apprenticeship to simulation training has driven the need for better simulators, and the current focus is on improving simulators with respect  ...  This paper introduces the digital twin concept for arthroscopic surgery, and explores its potential in light of the existing scientific literature.  ...  For mesh-based finite element methods, achieving real-time simulation rates for large models remains difficult.  ... 
doi:10.1109/access.2022.3170108 fatcat:m4j42uybibhu5iorfepxyetfze

Palabos: Parallel Lattice Boltzmann Solver

Jonas Latt, Orestis Malaspinas, Dimitrios Kontaxakis, Andrea Parmigiani, Daniel Lagrava, Federico Brogi, Mohamed Ben Belgacem, Yann Thorimbert, Sébastien Leclaire, Sha Li, Francesco Marson, Jonathan Lemus (+7 others)
2020 Computers and Mathematics with Applications  
The software proposes a very broad modeling framework, capable of addressing a large number of applications of interest in the Lattice Boltzmann community, yet exhibits solid computational performance.  ...  Palabos is a C++ software platform developed since 2010 for Computational Fluid Dynamics simulations and Lattice Boltzmann modeling, which specifically targets applications with complex, coupled physics  ...  Palabos supports the simulation of passive and active Lagrangian point-like particles, and the simulation of arbitrary shaped immersed bodies, with a DEM-like model for the resolution of the body motion  ... 
doi:10.1016/j.camwa.2020.03.022 fatcat:y3n7gxmvjbatrnbwmcbjzcrjou
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