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Optimizing resource allocation for analytical workloads is vital for reducing costs of cloud-data services. At the same time, it is incredibly hard for users to allocate resources per query in serverless processing systems, and they frequently misallocate by orders of magnitude. Unfortunately, prior work focused on predicting peak allocation while ignoring aggressive trade-offs between resource allocation and run-time. Additionally, these methods fail to predict allocation for queries that havearXiv:2107.08594v1 fatcat:dl355rb6w5h5bk7oyfvmv4vava
more »... not been observed in the past. In this paper, we tackle both these problems. We introduce a system for optimal resource allocation that can predict performance with aggressive trade-offs, for both new and past observed queries. We introduce the notion of a performance characteristic curve (PCC) as a parameterized representation that can compactly capture the relationship between resources and performance. To tackle training data sparsity, we introduce a novel data augmentation technique to efficiently synthesize the entire PCC using a single run of the query. Lastly, we demonstrate the advantages of a constrained loss function coupled with GNNs, over traditional ML methods, for capturing the domain specific behavior through an extensive experimental evaluation over SCOPE big data workloads at Microsoft.
ANISH SARKAR ET AL. ... For any (jo, jl) ELt, consider the event (jo,jl) 340 ANISH SARKAR ET AL. A(k+2(r-1)+kt) 0, This completes the proof.  -- jo! jl! ... This situation is different from the previous cases, since, in this case, there is no upper bound on how far the run, 344 ANISH SARKAR ET AL. starting at time n, can go. ...doi:10.1007/bf02530548 fatcat:fci42q7qlfgybdzni5cvlwwvvq
Sen, A. P. Annachhatre. Published by Elsevier B.V. Peer-review under responsibility of the Scientific Committee of HK-ICONS 2014. ...doi:10.1016/j.proche.2015.03.011 fatcat:os6ypy4ikjbutefzwb7k4g3otu
Osteonecrosis (ON) is caused by inadequate blood supply leading to bone death, which results in the collapse of the architectural bony structure. Femoral head is the most common site involved in ON. Magnetic resonance imaging (MRI) is a commonly used imaging modality to detect early ON. When MRI is inconclusive, bone scan is helpful in detecting ON during early phase of the disease. As newer nuclear medicine equipment, like single photon emission computed tomography/computed tomography (CT) anddoi:10.5312/wjo.v8.i10.747 pmid:29094004 pmcid:PMC5656489 fatcat:ddwdxed6zrd4zkefagt37sadbm
more »... positron emission tomography/CT, are emerging in medical science, we review the role of these imaging modalities in ON of femoral head.
In many negotiation and bargaining scenarios, a particular agent may need to interact repeatedly with another agent. Typically, these interactions take place under incomplete information, i.e., an agent does not know exactly which offers may be acceptable to its opponent or what other outside options are available to that other agent. In such situations, an agent can benefit by learning its opponent's decision model based on its past experience. In particular, being able to accurately predictdoi:10.1145/1082473.1082534 dblp:conf/atal/SahaBS05 fatcat:x2e3gfb4bvcu3jwhp7mt3gxbua
more »... ponent decisions can enable an agent to generate offers to optimize its own utility. In this paper, we present a learning mechanism using Chebychev's polynomials by which an agent can approximately model the decision function used by the other agent based on the decision history of its opponent. We study a repeated one-shot negotiation model which incorporates uncertainty about opponent's valuation and outside options. We evaluate the proposed modeling mechanism for optimizing agent utility when negotiating with different class of opponents.
Stem Cell Research
Human embryonic stem cells (hESCs) offer new avenues for studying human development and disease progression in addition to their tremendous potential toward development of cell-replacement therapies for various cellular disorders. We have earlier reported the derivation and characterization of Relicell ® hES1, the first fully characterized hESC line generated from the Indian subcontinent. Recent studies have demonstrated discrete differences among hESC lines, in terms of both their growthdoi:10.1016/j.scr.2010.07.001 pmid:20826120 fatcat:45s4bohl5bcqpkckyon4otvm2y
more »... ties and their differentiation propensity. To address some of these issues in the context of hESC research in India, we have recently generated two new hESC lines: Relicell ® hES2 and Relicell ® hES3. Both these cell lines were derived using a combinatorial approach of immunosurgery followed by mechanical surgery for inner cell mass isolation. The cell lines exhibit the usual hESC characteristics including their ability to differentiate both in vitro and in vivo to yield the three germinal layers. Whole genome microarray analysis of these cell lines was compared with Relicell ® hES1 and it showed that approximately 9000 genes were expressed by these lines. As expected the expression pattern of these new cell lines bore close resemblance to that of Relicell ® hES1. A majority of the pluripotency genes and the genes known to inhibit various differentiation pathways were also expressed by these cell lines. We also observed that each of these cell lines expressed a unique set of genes that are mutually exclusive from each other. These results represent the first detailed characterization of a set of hESC lines originating from India.
.; Sen, A. Intracranial Venous Sinus Stenting in Idiopathic Intracranial Hypertension: A Case Report and Review of the Literature. ...doi:10.3390/brainsci11030382 pmid:33802706 pmcid:PMC8002446 fatcat:acoskqr7n5bdnlwrflixux2leq
Objective: Prehospital use of antiplatelet agents has been associated with an increased risk for ICH as well as a secondary increase in ICH volume after the initial hemorrhage. Strategies to reestablish platelet aggregation are used in clinical practice, but without any established guidelines or recommendations. This article serves to evaluate the literature regarding "reversal" of antiplatelet agents in neurosurgical populations. Methods: PUBMED and MEDLINE databases were searched fordoi:10.1016/j.wneu.2010.05.030 pmid:21492561 fatcat:nalzklnaobcyxgdyvqaksdw5pa
more »... ons from 1966 to 2009 relating to intracranial hemorrhage and antiplatelet agents. The reference sections of recent articles, guidelines and reviews were reviewed and pertinent articles identified. Studies were classified by two broad subsets; those describing intracranial hemorrhage relatable to a traumatic mechanism and those with a spontaneous intracranial hemorrhage. Two independent auditors recorded and analyzed study design and the reported outcome measures. Results: For the spontaneous intracranial hemorrhage group, 9 reports assessing antiplatelet effects on various outcome measures were identified. Eleven studies evaluating the use of prehospital antiplatlets prior to a traumatic intracranial hemorrhage were examined. Conclusion: The data assessing the relationship between outcome and prehospital antiplatelet agents in the setting of ICH is conflicting in both the trauma and the stroke literature. Only one retrospective review specifically addressed outcomes after attempted reversal with platelet transfusion. Further study is needed to determine whether platelet transfusion ameliorates hematoma enlargement and/or improves outcome in the setting of acute ICH.
Despite several efforts by the Government of India, the national burden of anaemia remains high and its growing prevalence (between 2015-2016 and 2019-2021) is concerning to India's public health system. This article reviews existing food-based and clinical strategies to mitigate the anaemia burden and why they are premature and insufficient. In a context where multiple anaemia control programmes are in play, this article proposes a threefold strategy for consideration. First, except thedoi:10.1017/s0007114522000927 pmid:35383547 fatcat:2qzvk5m6arafbeyjkxpbkrzx3m
more »... ensive National Nutrition Survey, 2016-2018, which measured haemoglobin (Hb) concentration among children and adolescents aged 1-19 years using venous blood samples, all national surveys use capillary blood samples to determine Hb levels, which could be erroneous. The Indian government should prioritize conducting a nationwide survey for estimating the burden of anaemia and its clinical determinants for all age groups using venous blood samples. Second, without deciding the appropriate dose of iron needed for an individual, food fortification programmes which are often compounded with layering of other micronutrients could be harmful and further research on this issue is needed. Same is true for the pharmacological intervention of iron tablet or syrup supplementation programmes which is given to individuals without assessing its need. In addition, there is a dire need for robust research to understand both the long-term benefit and side-effects of iron supplementation programmes. Third and final, the World Health Organization is in process of reviewing the Hb threshold for defining anaemia, therefore the introduction of new anaemia control programmes should be restrained.
Near-infrared spectroscopy (NIRS) is a technique by which the interaction between light in the nearinfrared spectrum and matter can be quantitatively measured to provide information about the particular chromophore. Study into the clinical application of NIRS for traumatic brain injury (TBI) began in the 1990s with early reports of the ability to detect intracranial hematomas using NIRS. We highlight the advances in clinical applications of NIRS over the past two decades as they relate to TBI.doi:10.1117/1.nph.3.3.031409 pmid:27226973 pmcid:PMC4874161 fatcat:vjublsccwnchzpnttlimkgq23e
more »... e discuss recent studies evaluating NIRS techniques for intracranial hematoma detection, followed by the clinical application of NIRS in intracranial pressure and brain oxygenation measurement, and conclude with a summary of potential future uses of NIRS in TBI patient management. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Autologous fat grafting for soft tissue reconstruction is challenged by unpredictable long-term graft survival. Fat derived stromal vascular fraction (SVF) is gaining popularity in tissue reconstruction as SVF-enriched fat grafts demonstrate improved engraftment. SVF also has potential in regenerative medicine for remodeling of ischemic tissues by promoting angiogenesis. Since SVF cells do not require culture expansion, attempts are being made to develop automated devices to isolate SVF at thedoi:10.1155/2015/109353 pmid:26167182 pmcid:PMC4475713 fatcat:7i3nibn5k5gkxgqcmodp5te4ui
more »... oint of care. We report development of a closed, automated system to process up to 500 mL lipoaspirate using cell size-dependent filtration technology. The yield of SVF obtained by automated tissue digestion and filtration (1.17 ± 0.5 × 105 cells/gram) was equivalent to that obtained by manual isolation (1.15 ± 0.3 × 105;p= 0.8), and the viability of the cells isolated by both methods was greater than 90%. Cell composition included CD34+CD31− adipose stromal cells, CD34+CD31+ endothelial progenitor cells, and CD34−CD31+ endothelial cells, and their relative percentages were equivalent to SVF isolated by the manual method. CFU-F capacity and expression of angiogenic factors were also comparable with the manual method, establishing proof-of-concept for fully automated SVF isolation, suitable for use in reconstructive surgeries and regenerative medicine applications.
Acquisition of data: Campbell, Sen. Analysis and interpretation of data: Campbell, Sen, Yadla, Sharan. Drafting the article: Campbell, Sen. Critically revising the article: all authors. ...doi:10.3171/2010.4.focus1096 pmid:20672916 fatcat:wbt6lujfvzdhhoup5mqtrhl6cm
doi:10.1007/s00259-011-1794-0 pmid:21448700 fatcat:n2djjw3p7jcqflwu5worvnqqlu
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