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Multitarget Search of Swarm Robots in Unknown Complex Environments

You Zhou, Anhua Chen, Hongqiang Zhang, Xin Zhang, Shaowu Zhou
2020 Complexity  
When searching for multiple targets in an unknown complex environment, swarm robots should firstly form a number of subswarms autonomously through a task division model and then each subswarm searches for a target in parallel. Based on the probability response principle and multitarget division strategy, a closed-loop regulation strategy is proposed, which includes target type of member, target response intensity evaluation, and distance to the corresponding individuals. Besides, it is
more » ... to make robots avoid other robots and convex obstacles with various shapes in the unknown complex environment. By decomposing the multitarget search behavior of swarm robots, a simplified virtual-force model (SVF-Model) is developed for individual robots, and a control method is designed for swarm robots searching for multiple targets (SRSMT-SVF). The simulation results indicate that the proposed method keeps the robot with a good performance of collision avoidance, effectively reducing the collision conflicts among the robots, environment, and individuals.
doi:10.1155/2020/8643120 doaj:d31fdb18c94a4e4db5fc1de3044805ea fatcat:5y6bbzbx4nbq5nn4abff2w32g4

Neural stemness contributes to cell tumorigenicity

Liyang Xu, Min Zhang, Lihua Shi, Xiaoli Yang, Lu Chen, Ning Cao, Anhua Lei, Ying Cao
2021 Cell & Bioscience  
Shuai Chen, Xiang Gao, Jinzhong Qin, Jianghuai Liu and Minsheng Zhu for their generous helps.  ... 
doi:10.1186/s13578-021-00531-6 pmid:33468253 fatcat:3g6gdqrepjg55kviaeggejxwfq

Contactless Measurement of Hypervelocity Projectile Wake Velocity Distribution

Bixiao Jiang, Xianqing Yang, Ping Ma, Bo Chen, Jing Tian, Anhua Shi, Pu Tang
2019 IEEE Access  
ANHUA SHI is currently a Researcher of the China Aerodynamics Research and Development Center, Hypervelocity Institute.  ...  BO CHEN received the B.S. degree from the University of Electronic Science and Technology of China, where he is currently an Associate Professor.  ... 
doi:10.1109/access.2019.2894175 fatcat:oz32g5rjgbdlbht65kycac26i4

Multiomics Profiling and Clustering of Low-Grade Gliomas Based on the Integrated Stress Status

Xiaolin Ren, Xin Chen, Chen Zhu, Anhua Wu, R. K. Tripathy
2021 BioMed Research International  
Xiaolin Ren and Xin Chen contributed equally to this work and share the first authorship. Supplementary Materials Supplementary 1. Table 1 : integrated stress response-related genes.  ... 
doi:10.1155/2021/5554436 pmid:34368351 pmcid:PMC8343268 fatcat:rc76kncjgrbmpkqbdecowr4ive

Long non-coding RNA, HOTAIRM1, promotes glioma malignancy by forming a ceRNA network

Qingyu Liang, Xue Li, Gefei Guan, Xiaoyan Xu, Chen Chen, Peng Cheng, Wen Cheng, Anhua Wu
2019 Aging  
Long non-coding RNAs play critical roles in tumorigenesis and the immune process. In this study, RNA sequencing data for 946 glioma samples from The Cancer Genome Atlas and the Chinese Glioma Genome Atlas databases were analyzed to evaluate the prognostic value and function of homeobox A transcript antisense RNA myeloid-specific (HOTAIRM)1. HOTAIRM1 expression was associated with clinical and molecular features of glioma: patients with high HOTAIRM1 expression were more likely to be classified
more » ... s malignant cases, and elevated HOTAIRM1 level was associated with shorter survival time in subgroups stratified by clinical and molecular features. A multivariate Cox regression analysis showed that HOTAIRM1 was an independent prognostic factor for patient outcome. In vitro experiments revealed that HOTAIRM1 knockdown suppressed the malignant behavior of glioma and increased tumor sensitivity to temozolomide. The results of an in silico analysis indicated that HOTAIRM1 promotes the malignancy of glioma by acting as a sponge for microRNA (miR)-129-5p and miR-495-3p. HOTAIRM1 overexpression was also associated with immune activation characterized by enhanced T cell-mediated immune and inflammatory responses. These results suggest that HOTAIRM1 is a prognostic biomarker and potential therapeutic target in glioma.
doi:10.18632/aging.102205 pmid:31477638 pmcid:PMC6756894 fatcat:646x5ij27vdepg45mpna23yunm

Femtosecond Z-scan measurement of third-order nonlinear refractive indices of BaMgF4

Junjie Chen, Xianfeng Chen, Anhua Wu, Hongjun Li, Yuanlin Zheng, Yanzhi Ma, Linwen Jiang, Jun Xu
2011 Applied Physics Letters  
Chen, Y. Wang, Y. Xia, B. Wu, D. Tang, K. Wu, Z. Wenrong, L. Yu, and L. Mei, J. Appl. Phys. 77, 2268 ͑1995͒. Downloaded 09 May 2011 to 202.120.52.79.  ...  Crystallographic axes Subscripts of ͑3͒ tensor n 2,␣ ͑10 −19 m 2 / W͒ ijkl ͑3͒ ͑10 −13 esu͒ a 1111 2.90Ϯ 0.45 1.58Ϯ 0.24 b 2222 6.38Ϯ 0.96 3.46Ϯ 0.52 c 3333 23.5Ϯ 3.5 12.4Ϯ 1.9 191102-2 Chen  ... 
doi:10.1063/1.3587642 fatcat:bt3wvb53vjallf6y2fhfj5ftue

Characterization of ROS Metabolic Equilibrium Reclassifies Pan-Cancer Samples and Guides Pathway Targeting Therapy

Shuai Shen, Zihao Yan, Jianqi Wu, Xing Liu, Gefei Guan, Cunyi Zou, Qing Guo, Chen Zhu, Tianqi Liu, Chen Chen, Ling Chen, Peng Cheng (+2 others)
2020 Frontiers in Oncology  
Abnormal redox equilibrium is a major contributor to tumor malignancy and treatment resistance. Understanding reactive oxygen species (ROS) metabolism is a key to clarify the tumor redox status. However, we have limited methods to evaluate ROS in tumor tissues and little knowledge on ROS metabolism across human cancers. Methods: The Cancer Genome Atlas multi-omics data across 22 cancer types and the Genomics of Drug Sensitivity in Cancer data were analyzed in this study. Cell viability testing
more » ... nd xenograft model were used to validate the role of ROS modulation in regulating treatment efficacy. Results: ROS indexes reflecting ROS metabolic balance in five dimensions were developed and verified. Based on the ROS indexes, we conducted ROS metabolic landscape across 22 cancer types and found that ROS metabolism played various roles in different cancer types. Tumor samples were classified into eight ROS clusters with distinct clinical and multi-omics features, which was independent of their histological origin. We established a ROS-based drug efficacy evaluation network and experimentally validated the predicted effects, suggesting that modulating ROS metabolism improves treatment sensitivity and expands drug application scopes. Conclusion: Our study proposes a new method in evaluating ROS status and offers comprehensive understanding on ROS metabolic equilibrium in human cancers, which provide practical implications for clinical management.
doi:10.3389/fonc.2020.581197 pmid:33194713 pmcid:PMC7606976 fatcat:pfxt53y47bhfziv2qdzidfo4s4

Isolation of a new monoterpenoid glycoside from Anhua dark tea based on an NMR-guided method and its cytotoxic activity against MDA-MB-231 and SH-SY5Y cell lines

Yunqiang Zhang, Jianyu Liu, Miao Chen, Yanhua Fan, Meichen Li, Andong Wang, Gaigai Liu, Yongnan Xu, Xuhong Ren, Yan Xiao
2020 figshare.com  
Based on an NMR-guided method, one new monoterpenoid glycoside (1) was isolated from Anhua dark tea, together with five known compounds (2–6).  ... 
doi:10.6084/m9.figshare.13186970.v1 fatcat:5pz65ckbzfhc5nqqdgq54hu4pu

Development and validation of an interferon signature predicting prognosis and treatment response for glioblastoma

Chen Zhu, Cunyi Zou, Gefei Guan, Qing Guo, Zihao Yan, Tianqi Liu, Shuai Shen, Xiaoyan Xu, Chen Chen, Zhiguo Lin, Wen Cheng, Anhua Wu
2019 Oncoimmunology  
Xiaoyan Xu and Chen Chen for performing the data analysis.  ... 
doi:10.1080/2162402x.2019.1621677 pmid:31428519 pmcid:PMC6685507 fatcat:dwggh6fo7vet7gvvjfjbnynr4q

Crystal growth and frequency conversion of BaMgF4 single crystal by temperature gradient technique

Anhua Wu, Zhuo Wang, Liangbi Su, Dapeng Jiang, Yuqi Zou, Jun Xu, Junjie Chen, Yanzhi Ma, Xianfeng Chen, Zhanggui Hu
2014 Optical materials (Amsterdam)  
The BaMgF 4 single crystal was grown by the temperature gradient technique. Highly pure MgF 2 and BaF 2 powders were used as raw materials and CaF 2 single crystal was chosen as a seed to induce BaMgF 4 single crystal grow along h0 0 1i orientation. The short cut-off wavelength of BaMgF 4 single crystal was determined to be 130 nm which is consistent with the previously reported result. We realized second harmonic generation from 1064 nm to 532 nm laser, and 800 nm to 400 nm femtosecond laser
more » ... single domain BaMgF 4 by using birefringent phase matching. 355-nm-wavelength laser was produced by Sum-Frequency Generation from 1064-nm-and 532-nm-wavelength laser, which is the shortest coherent radiation obtained in the UV in the BaMgF 4 crystal.
doi:10.1016/j.optmat.2014.10.038 fatcat:td55py52ebhqldjhpsenr2cs3i

CD48 is a key molecule of immunomodulation affecting prognosis in glioma

Cunyi Zou, Chen Zhu, Gefei Guan, Qing Guo, Tianqi Liu, Shuai Shen, Zihao Yan, Xiaoyan Xu, Zhiguo Lin, Ling Chen, Anhua Wu, Wen Cheng
2019 OncoTargets and Therapy  
Acknowledgments We thank all the members of Dr Anhua Wu's laboratory for help with our study.  ... 
doi:10.2147/ott.s198762 pmid:31213836 pmcid:PMC6549391 fatcat:hqvdtm2xjbfjzbt2gp2ib3wsbm

Measurement of second-order nonlinear optical coefficients of BaMgF_4

Junjie Chen, Xianfeng Chen, Yanzhi Ma, Yuanlin Zheng, Anhua Wu, Hongjun Li, Linwen Jiang, Jun Xu
2012 Journal of the Optical Society of America. B, Optical physics  
B / Vol. 29, No. 4 / April 2012 Chen et al.  ... 
doi:10.1364/josab.29.000665 fatcat:g656l4llarghhiqpypsebp2hki

A Method of Modal Parameter Identification for Wind Turbine Blade Based on Binocular Dynamic Photogrammetry

Wenyun Wang, Xuejun Li, Anhua Chen
2019 Shock and Vibration  
The identification of operational modal parameters of a wind turbine blade is fundamental for online damage detection. In this paper, we use binocular photogrammetry technology instead of traditional contact sensors to measure the vibration of blade and apply the advanced stochastic system identification technique to identify the blade modal frequencies automatically when only output data are available. Image feature extraction and target point tracking (PT) are carried out to acquire the
more » ... cement of labeled targets on the wind turbine blade. The vibration responses of the target points are obtained. The data-driven stochastic subspace identification (SSI-Data) method based on the Kalman filter prediction sequence is explored to extract modal parameters from vibration response under unknown excitation. Hankel matrixes are reconstructed with different dimensions, so different modal parameters are produced. Similarity of these modal parameters is compared and used to cluster modes into groups. Under appropriate tolerance thresholds, spurious modes can be eliminated. Experiment results show that good effects and stable accuracy can also be achieved with the presented photogrammetry vibration measurement and automatic modal identification algorithm.
doi:10.1155/2019/7610930 fatcat:xljxzor5xfgplnlvybpfyukhsu

IFI30 Is a Novel Immune-Related Target with Predicting Value of Prognosis and Treatment Response in Glioblastoma

Chen Zhu, Xin Chen, Gefei Guan, Cunyi Zou, Qing Guo, Peng Cheng, Wen Cheng, Anhua Wu
2020 OncoTargets and Therapy  
Xin Chen; Methodology, Cunyi Zou, Xin Chen; Project administration, Chen Zhu, Xin Chen; Supervision, Anhua Wu, Wen Cheng; Validation, Chen Zhu; Writingoriginal draft, Chen Zhu and Xin Chen; Writingreview  ...  & editing, Anhua Wu.  ... 
doi:10.2147/ott.s237162 pmid:32103982 pmcid:PMC7008640 fatcat:4pdnxf2tjra2nl5pfn2kv43ifq

TERT Promoter Mutations Lead to High Transcriptional Activity under Hypoxia and Temozolomide Treatment and Predict Poor Prognosis in Gliomas

Chen Chen, Sheng Han, Lingxuan Meng, Zhonghua Li, Xue Zhang, Anhua Wu, Marta M. Alonso
2014 PLoS ONE  
Objective: This study explored the effects of telomerase reverse transcriptase (TERT) promoter mutations on transcriptional activity of the TERT gene under hypoxic and temozolomide (TMZ) treatment conditions, and investigated the status and prognostic value of these mutations in gliomas. Methods: The effect of TERT promoter mutations on the transcriptional activity of the TERT gene under hypoxic and TMZ treatment conditions was investigated in glioma cells using the luciferase assay. TERT
more » ... er mutations were detected in 101 glioma samples (grades I-IV) and 49 other brain tumors by sequencing. TERT mRNA expression in gliomas was examined by real-time PCR. Hazard ratios from survival analysis of glioma patients were determined relative to the presence of TERT promoter mutations. Results: Mutations in the TERT promoter enhanced gene transcription even under hypoxic and TMZ treatment conditions, inducing upregulation of TERT mRNA expression. Mutations were detected in gliomas, but not in meningiomas, pituitary adenomas, cavernomas, intracranial metastases, normal brain tissues, or peripheral blood of glioma patients. Patients with TERT promoter mutations had lower survival rates, even after adjusting for other known or potential risk factors, and the incidence of mutation was correlated with patient age. Conclusion: TERT promoter mutations were specific to gliomas. TERT promoter mutations maintained its ability of inducing high transcriptional activity even under hypoxic and TMZ treatment conditions, and the presence of mutations was associated with poor prognosis in glioma patients. These findings demonstrate that TERT promoter mutations are novel prognostic markers for gliomas that can inform prospective therapeutic strategies.
doi:10.1371/journal.pone.0100297 pmid:24937153 pmcid:PMC4061075 fatcat:ctspeodpafc77ciyyt7wwhp66y
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