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Health Implications of the Supreme Court's Obergefell vs. Hodges Marriage Equality Decision

Angela K. Perone
2015 LGBT Health  
Hodges groundbreaking marriage equality decision also created new terrain for lesbian, gay, bisexual, and transgender (LGBT) persons regarding health, healthcare, and health benefits.  ...  Hodges decision, which recognized that all states (1) must recognize marriage between two same-sex individuals within their state; and (2) must recognize marriages of same-sex couples performed in other  ... 
doi:10.1089/lgbt.2015.0083 pmid:26788668 pmcid:PMC4713052 fatcat:j3eg42qg3rdj7bw535bb4ywcsa

Research highlights

Angela K Eggleston, Joshua M Finkelstein, Maria Hodges, Sabbi Lall
2008 Nature Structural & Molecular Biology  
The authors also showed that recombinant cathepsin L, but not cathepsin B or K, could reproduce the cleavage pattern seen in the cellular experiments, lending further credence to the hypothesis that this  ...  The authors also showed that recombinant cathepsin L, but not cathepsin B or K, could reproduce the cleavage pattern seen in the cellular experiments, lending further credence to the hypothesis that this  ... 
doi:10.1038/nsmb1108-1137 fatcat:x4fmopmt7jcsdp23wso6hcqtem

Transcriptomic analysis of probable asymptomatic and symptomatic Alzheimer brains [article]

Hamel Patel, Angela K Hodges, Charles Curtis, Sang hyuck Hyuck Lee, Claire Troakes, Richard Dobson, Stephen J Newhouse
2019 biorxiv/medrxiv   pre-print
Individuals with intact cognition and neuropathology consistent with Alzheimer's disease (AD) are referred to as asymptomatic AD (AsymAD). These individuals are highly likely to develop AD, yet transcriptomic changes in the brain which might reveal mechanisms for their AD vulnerability are currently unknown. Entorhinal cortex, frontal cortex, temporal cortex and cerebellum tissue from 27 control, 33 AsymAD and 52 AD human brains were microarray expression profiled. Differential expression
more » ... is identified a significant increase of transcriptomic activity in the frontal cortex of AsymAD subjects, suggesting fundamental changes in AD may initially begin within the frontal cortex region prior to AD diagnosis. Co-expression analysis identified an overactivation of the brain glutamate-glutamine cycle, and disturbances in the brain energy pathways in both AsymAD and AD subjects, while connectivity of key hub genes in this network indicates a shift from an already increased cell proliferation in AsymAD subjects to stress response and removal of amyloidogenic proteins in AD subjects. This study provides new insight into the earliest biological changes occurring in the brain prior to the manifestation of clinical AD symptoms and provides new potential therapeutic targets for early disease intervention.
doi:10.1101/621912 fatcat:bkrymaf56nczbhxahhoz6rna5u

Pathways linking Alzheimer's disease risk genes expressed highly in microglia

Angela K. Hodges, Thomas M. Piers, David Collier, Oliver Cousins, Jennifer M. Pocock
2021 Neuroimmunology and Neuroinflammation  
Authors' contributions Made substantial contributions to conception and design of the study and performed data analysis and interpretation and drafted the manuscript: Hodges AK Made substantial contributions  ... 
doi:10.20517/2347-8659.2020.60 fatcat:m4m3fsz65nd43a7a626pyefv3y

This Week in Science

Pamela J. Hines, Jelena Stajic, Leslie K. Ferrarelli, Brent Grocholski, Phil Szuromi, Kristen L. Mueller, Julia Fahrenkamp-Uppenbrink, Kip Hodges, Stella M. Hurtley, Nicholas S. Wigginton, Paula A. Kiberstis, Angela Colmone
2015 Science  
doi:10.1126/science.2015.350.6257.twis fatcat:awncktqe5fb67jfsuyr6cmaeke

Transcriptomic analysis of probable asymptomatic and symptomatic Alzheimer brains

Hamel Patel, Angela K. Hodges, Charles Curtis, Sang Hyuck Lee, Claire Troakes, Richard J.B. Dobson, Stephen J Newhouse
2019 Brain, behavior, and immunity  
Individuals with intact cognition and neuropathology consistent with Alzheimer's disease (AD) are referred to as asymptomatic AD (AsymAD). These individuals are highly likely to develop AD, yet transcriptomic changes in the brain which might reveal mechanisms for their AD vulnerability are currently unknown. Entorhinal cortex, frontal cortex, temporal cortex and cerebellum tissue from 27 control, 33 AsymAD and 52 AD human brains were microarray expression profiled. Differential expression
more » ... is identified a significant increase of transcriptomic activity in the frontal cortex of AsymAD subjects, suggesting fundamental changes in AD may initially begin within the frontal cortex region prior to AD diagnosis. Co-expression analysis identified an overactivation of the brain "glutamate-glutamine cycle", and disturbances in the brain energy pathways in both AsymAD and AD subjects, while the connectivity of key hub genes in this network indicates a shift from an already increased cell proliferation in AsymAD subjects to stress response and removal of amyloidogenic proteins in AD subjects. This study provides new insight into the earliest biological changes occurring in the brain prior to the manifestation of clinical AD symptoms and provides new potential therapeutic targets for early disease intervention.
doi:10.1016/j.bbi.2019.05.009 pmid:31063847 fatcat:yyngiay3jva77pv7wvsdgyqlp4

Interactions between an arbuscular mycorrhizal fungus and a soil microbial community mediating litter decomposition

Donald J. Herman, Mary K. Firestone, Erin Nuccio, Angela Hodge
2012 FEMS Microbiology Ecology  
., 2011) , but not all (Hodge, 2003a; Reynolds et al., 2005) , conditions.  ...  Bottner et al., 1999; Dijkstra et al., 2009; Bird et al., 2011) , which in turn are influenced by a wide range of abiotic and biotic factors including AM colonization (see Hodge et al., 1997; Hodge &  ... 
doi:10.1111/j.1574-6941.2011.01292.x pmid:22224699 fatcat:gu26crsmi5bhhgjzzg27asr6my

Conservation of Regional Gene Expression in Mouse and Human Brain

Andrew D. Strand, Aaron K. Aragaki, Zachary C. Baquet, Angela Hodges, Philip Cunningham, Peter Holmans, Kevin R. Jones, Lesley Jones, Charles Kooperberg, James M. Olson
2007 PLoS Genetics  
Citation: Strand AD, Aragaki AK, Baquet ZC, Hodges A, Cunningham P, et al. (2007) Conservation of regional gene expression in mouse and human brain. PLoS Genet 3(4): e59.  ...  protein 2 Efcbp2 205330_at meningioma (disrupted in balanced translocation) 1 MN1 1427038_at preproenkephalin 1 Penk1 215506_s_at DIRAS family, GTP-binding RAS-like 3 DIRAS3 1417680_at K  ... 
doi:10.1371/journal.pgen.0030059 pmid:17447843 pmcid:PMC1853119 fatcat:gsi7237vefgfpkjxc4o5z3ttse

ALSgeneScanner: a pipeline for the analysis and interpretation of DNA NGS data of ALS patients [article]

Alfredo Iacoangeli, Ahmad Al Khleifat, William Sproviero, Aleksey Shatunov, Ashley R Jones, Sarah Opie-Martin, Ersilia Naselli, Isabella Fogh, Angela K Hodges, Richard J Dobson, Stephen J Newhouse, Ammar Al-Chalabi
2018 bioRxiv   pre-print
Amyotrophic lateral sclerosis (ALS, MND) is a neurodegenerative disease of upper and lower motor neurons resulting in death from neuromuscular respiratory failure, typically within two years of first symptoms. Genetic factors are an important cause of ALS, with variants in more than 25 genes having strong evidence, and weaker evidence available for variants in more than 120 genes. With the increasing availability of Next-Generation sequencing data, non-specialists, including health care
more » ... onals and patients, are obtaining their genomic information without a corresponding ability to analyse and interpret it. Furthermore, the relevance of novel or existing variants in ALS genes is not always apparent. Here we present ALSgeneScanner, a tool that is easy to install and use, able to provide an automatic, detailed, annotated report, on a list of ALS genes from whole genome sequence data in a few hours and whole exome sequence data in about one hour on a readily available mid-range computer. This will be of value to non-specialists and aid in the interpretation of the relevance of novel and existing variants identified in DNA sequencing data.
doi:10.1101/378158 fatcat:465qxbd5bfhtnmokwdwmhajfgi

Expanding the obesity research paradigm to reach African American communities

Shiriki K Kumanyika, Melicia C Whitt-Glover, Tiffany L Gary, T Elaine Prewitt, Angela M Odoms-Young, Joanne Banks-Wallace, Bettina M Beech, Chanita Hughes Halbert, Njeri Karanja, Kristie J Lancaster, Carmen D Samuel-Hodge
2007 Preventing Chronic Disease  
Samuel-Hodge, PhD Figure: AACORN's Expanded Obesity Research Paradigm. Reprinted with permission of the African American Collaborative Obesity Research Network.  ...  Elaine Prewitt, DrPH, Angela M. Odoms-Young, PhD, Joanne Banks-Wallace, RN, PhD, Bettina M. Beech, DrPH, MPH, Chanita Hughes Halbert, PhD, Njeri Karanja, PhD, Kristie J. Lancaster, PhD, RD, Carmen D.  ... 
pmid:17875256 pmcid:PMC2099277 fatcat:r3s4i2gufbbphjiawyx42mgcwi

A Blood Gene Expression Marker of Early Alzheimer's Disease

Katie Lunnon, Martina Sattlecker, Simon J. Furney, Giovanni Coppola, Andrew Simmons, Petroula Proitsi, Michelle K. Lupton, Anbarasu Lourdusamy, Caroline Johnston, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci (+6 others)
2013 Journal of Alzheimer's Disease  
doi:10.3233/jad-2012-121363 pmid:23042217 fatcat:aaewgtwnofgglf3maqwxewolsu

A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease

A. Jennifer Morton, Mark J. Hunt, Angela K. Hodges, Paul D. Lewis, Amanda J. Redfern, Stephen B. Dunnett, Lesley Jones
2005 European Journal of Neuroscience  
Hodges and L. Jones, personal communication).  ...  72 0.000835 Myosin light chain, alkali, cardiac atria Tm4sf2 16 2528 2042 2594 2262 0.000908 Transmembrane 4 superfamily member 2 Atp1a1 17 658 504 701 485 0.000190 ATPase, Na+ ⁄ K+  ... 
doi:10.1111/j.1460-9568.2005.03895.x pmid:15787692 fatcat:tnqlxlbvr5cbdlo3qpe3ottad4

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

Nicholas J. Ashton, Marc Suárez-Calvet, Amanda Heslegrave, Abdul Hye, Cristina Razquin, Pau Pastor, Raquel Sanchez-Valle, José L. Molinuevo, Pieter Jelle Visser, Kaj Blennow, Angela K. Hodges, Henrik Zetterberg
2019 Alzheimer's Research & Therapy  
Results from recent clinical studies suggest that cerebrospinal fluid (CSF) biomarkers that are indicative of Alzheimer's disease (AD) can be replicated in blood, e.g. amyloid-beta peptides (Aβ42 and Aβ40) and neurofilament light chain (NFL). Such data proposes that blood is a rich source of potential biomarkers reflecting central nervous system pathophysiology and should be fully explored for biomarkers that show promise in CSF. Recently, soluble fragments of the triggering receptor expressed
more » ... n myeloid cells 2 (sTREM2) protein in CSF have been reported to be increased in prodromal AD and also in individuals with TREM2 rare genetic variants that increase the likelihood of developing dementia.
doi:10.1186/s13195-019-0545-5 pmid:31779670 pmcid:PMC6883551 fatcat:a6kzna7kmzgjhpsfubgeavdmmu

Loss of Trem2 in microglia leads to widespread disruption of cell co-expression networks in mouse brain [article]

Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva Wozniak, Kristie Wood, Charles A. Mein, Richard J. B. Dobson, David A. Collier, Michael J. O'Neill, Angela K. Hodges (+1 others)
2018 bioRxiv   pre-print
, A., Lovestone, S., Dobson, R., Hodges, A., 2012. Mitochondrial dysfunction and immune activation are detectable in early alzheimer's disease blood. J.  ...  Elife 5. https://doi.org/10.7554/eLife.20391 Kondo, T., Takahashi, K., Kohara, N., Takahashi, Y., Hayashi, S., Takahashi, H., Matsuo, H., Yamazaki, M., Inoue, K., Miyamoto, K., Yamamura, T., 2002.  ... 
doi:10.1101/248757 fatcat:vkb75b57uva3vagpu4gq3oogdm

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva Wozniak, Kristie Wood, Charles A. Mein, Richard J.B. Dobson, David A. Collier, Michael J. O'Neill, Angela K. Hodges (+1 others)
2018 Neurobiology of Aging  
TREM2 signaling is propagated through the adaptor protein DAP12, which activates a number of pathways including Syk, P13 K, and mitogen-activated protein kinase, which culminate in increased phagocytosis  ... 
doi:10.1016/j.neurobiolaging.2018.04.019 pmid:29906661 pmcid:PMC6075941 fatcat:vse7qeqovbg6jgbdhwvl27rj6e
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