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Health Implications of the Supreme Court's Obergefell vs. Hodges Marriage Equality Decision
2015
LGBT Health
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Hodges groundbreaking marriage equality decision also created new terrain for lesbian, gay, bisexual, and transgender (LGBT) persons regarding health, healthcare, and health benefits. ...
Hodges decision, which recognized that all states (1) must recognize marriage between two same-sex individuals within their state; and (2) must recognize marriages of same-sex couples performed in other ...
doi:10.1089/lgbt.2015.0083
pmid:26788668
pmcid:PMC4713052
fatcat:j3eg42qg3rdj7bw535bb4ywcsa
Research highlights
2008
Nature Structural & Molecular Biology
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The authors also showed that recombinant cathepsin L, but not cathepsin B or K, could reproduce the cleavage pattern seen in the cellular experiments, lending further credence to the hypothesis that this ...
The authors also showed that recombinant cathepsin L, but not cathepsin B or K, could reproduce the cleavage pattern seen in the cellular experiments, lending further credence to the hypothesis that this ...
doi:10.1038/nsmb1108-1137
fatcat:x4fmopmt7jcsdp23wso6hcqtem
Transcriptomic analysis of probable asymptomatic and symptomatic Alzheimer brains
[article]
2019
biorxiv/medrxiv
pre-print
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Individuals with intact cognition and neuropathology consistent with Alzheimer's disease (AD) are referred to as asymptomatic AD (AsymAD). These individuals are highly likely to develop AD, yet transcriptomic changes in the brain which might reveal mechanisms for their AD vulnerability are currently unknown. Entorhinal cortex, frontal cortex, temporal cortex and cerebellum tissue from 27 control, 33 AsymAD and 52 AD human brains were microarray expression profiled. Differential expression
doi:10.1101/621912
fatcat:bkrymaf56nczbhxahhoz6rna5u
more »
... is identified a significant increase of transcriptomic activity in the frontal cortex of AsymAD subjects, suggesting fundamental changes in AD may initially begin within the frontal cortex region prior to AD diagnosis. Co-expression analysis identified an overactivation of the brain glutamate-glutamine cycle, and disturbances in the brain energy pathways in both AsymAD and AD subjects, while connectivity of key hub genes in this network indicates a shift from an already increased cell proliferation in AsymAD subjects to stress response and removal of amyloidogenic proteins in AD subjects. This study provides new insight into the earliest biological changes occurring in the brain prior to the manifestation of clinical AD symptoms and provides new potential therapeutic targets for early disease intervention.
Pathways linking Alzheimer's disease risk genes expressed highly in microglia
2021
Neuroimmunology and Neuroinflammation
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Authors' contributions Made substantial contributions to conception and design of the study and performed data analysis and interpretation and drafted the manuscript: Hodges AK Made substantial contributions ...
doi:10.20517/2347-8659.2020.60
fatcat:m4m3fsz65nd43a7a626pyefv3y
This Week in Science
2015
Science
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Transcriptomic analysis of probable asymptomatic and symptomatic Alzheimer brains
2019
Brain, behavior, and immunity
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Individuals with intact cognition and neuropathology consistent with Alzheimer's disease (AD) are referred to as asymptomatic AD (AsymAD). These individuals are highly likely to develop AD, yet transcriptomic changes in the brain which might reveal mechanisms for their AD vulnerability are currently unknown. Entorhinal cortex, frontal cortex, temporal cortex and cerebellum tissue from 27 control, 33 AsymAD and 52 AD human brains were microarray expression profiled. Differential expression
doi:10.1016/j.bbi.2019.05.009
pmid:31063847
fatcat:yyngiay3jva77pv7wvsdgyqlp4
more »
... is identified a significant increase of transcriptomic activity in the frontal cortex of AsymAD subjects, suggesting fundamental changes in AD may initially begin within the frontal cortex region prior to AD diagnosis. Co-expression analysis identified an overactivation of the brain "glutamate-glutamine cycle", and disturbances in the brain energy pathways in both AsymAD and AD subjects, while the connectivity of key hub genes in this network indicates a shift from an already increased cell proliferation in AsymAD subjects to stress response and removal of amyloidogenic proteins in AD subjects. This study provides new insight into the earliest biological changes occurring in the brain prior to the manifestation of clinical AD symptoms and provides new potential therapeutic targets for early disease intervention.
Interactions between an arbuscular mycorrhizal fungus and a soil microbial community mediating litter decomposition
2012
FEMS Microbiology Ecology
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., 2011) , but not all (Hodge, 2003a; Reynolds et al., 2005) , conditions. ...
Bottner et al., 1999; Dijkstra et al., 2009; Bird et al., 2011) , which in turn are influenced by a wide range of abiotic and biotic factors including AM colonization (see Hodge et al., 1997; Hodge & ...
doi:10.1111/j.1574-6941.2011.01292.x
pmid:22224699
fatcat:gu26crsmi5bhhgjzzg27asr6my
Conservation of Regional Gene Expression in Mouse and Human Brain
2007
PLoS Genetics
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Citation: Strand AD, Aragaki AK, Baquet ZC, Hodges A, Cunningham P, et al. (2007) Conservation of regional gene expression in mouse and human brain. PLoS Genet 3(4): e59. ...
protein 2
Efcbp2
205330_at
meningioma (disrupted in balanced
translocation) 1
MN1
1427038_at
preproenkephalin 1
Penk1
215506_s_at DIRAS family, GTP-binding RAS-like 3
DIRAS3
1417680_at
K ...
doi:10.1371/journal.pgen.0030059
pmid:17447843
pmcid:PMC1853119
fatcat:gsi7237vefgfpkjxc4o5z3ttse
ALSgeneScanner: a pipeline for the analysis and interpretation of DNA NGS data of ALS patients
[article]
2018
bioRxiv
pre-print
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Amyotrophic lateral sclerosis (ALS, MND) is a neurodegenerative disease of upper and lower motor neurons resulting in death from neuromuscular respiratory failure, typically within two years of first symptoms. Genetic factors are an important cause of ALS, with variants in more than 25 genes having strong evidence, and weaker evidence available for variants in more than 120 genes. With the increasing availability of Next-Generation sequencing data, non-specialists, including health care
doi:10.1101/378158
fatcat:465qxbd5bfhtnmokwdwmhajfgi
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... onals and patients, are obtaining their genomic information without a corresponding ability to analyse and interpret it. Furthermore, the relevance of novel or existing variants in ALS genes is not always apparent. Here we present ALSgeneScanner, a tool that is easy to install and use, able to provide an automatic, detailed, annotated report, on a list of ALS genes from whole genome sequence data in a few hours and whole exome sequence data in about one hour on a readily available mid-range computer. This will be of value to non-specialists and aid in the interpretation of the relevance of novel and existing variants identified in DNA sequencing data.
Expanding the obesity research paradigm to reach African American communities
2007
Preventing Chronic Disease
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Samuel-Hodge, PhD
Figure: AACORN's Expanded Obesity Research Paradigm. Reprinted with permission of the African American Collaborative Obesity Research Network. ...
Elaine Prewitt, DrPH, Angela M. Odoms-Young, PhD, Joanne Banks-Wallace, RN, PhD, Bettina M. Beech, DrPH, MPH, Chanita Hughes Halbert, PhD, Njeri Karanja, PhD, Kristie J. Lancaster, PhD, RD, Carmen D. ...
pmid:17875256
pmcid:PMC2099277
fatcat:r3s4i2gufbbphjiawyx42mgcwi
A Blood Gene Expression Marker of Early Alzheimer's Disease
2013
Journal of Alzheimer's Disease
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A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease
2005
European Journal of Neuroscience
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Hodges and L. Jones, personal communication). ...
72
0.000835
Myosin light chain, alkali, cardiac atria
Tm4sf2
16
2528
2042
2594
2262
0.000908
Transmembrane 4 superfamily member 2
Atp1a1
17
658
504
701
485
0.000190
ATPase, Na+ ⁄ K+ ...
doi:10.1111/j.1460-9568.2005.03895.x
pmid:15787692
fatcat:tnqlxlbvr5cbdlo3qpe3ottad4
Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers
2019
Alzheimer's Research & Therapy
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Results from recent clinical studies suggest that cerebrospinal fluid (CSF) biomarkers that are indicative of Alzheimer's disease (AD) can be replicated in blood, e.g. amyloid-beta peptides (Aβ42 and Aβ40) and neurofilament light chain (NFL). Such data proposes that blood is a rich source of potential biomarkers reflecting central nervous system pathophysiology and should be fully explored for biomarkers that show promise in CSF. Recently, soluble fragments of the triggering receptor expressed
doi:10.1186/s13195-019-0545-5
pmid:31779670
pmcid:PMC6883551
fatcat:a6kzna7kmzgjhpsfubgeavdmmu
more »
... n myeloid cells 2 (sTREM2) protein in CSF have been reported to be increased in prodromal AD and also in individuals with TREM2 rare genetic variants that increase the likelihood of developing dementia.
Loss of Trem2 in microglia leads to widespread disruption of cell co-expression networks in mouse brain
[article]
2018
bioRxiv
pre-print
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, A., Lovestone, S., Dobson, R., Hodges, A., 2012. Mitochondrial dysfunction and immune activation are detectable in early alzheimer's disease blood. J. ...
Elife 5. https://doi.org/10.7554/eLife.20391 Kondo, T., Takahashi, K., Kohara, N., Takahashi, Y., Hayashi, S., Takahashi, H., Matsuo, H., Yamazaki, M., Inoue, K., Miyamoto, K., Yamamura, T., 2002. ...
doi:10.1101/248757
fatcat:vkb75b57uva3vagpu4gq3oogdm
Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain
2018
Neurobiology of Aging
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TREM2 signaling is propagated through the adaptor protein DAP12, which activates a number of pathways including Syk, P13 K, and mitogen-activated protein kinase, which culminate in increased phagocytosis ...
doi:10.1016/j.neurobiolaging.2018.04.019
pmid:29906661
pmcid:PMC6075941
fatcat:vse7qeqovbg6jgbdhwvl27rj6e
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