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Knowledge encapsulation framework for technosocial predictive modeling
2012
Security Informatics
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Analysts who use predictive analytics methods need actionable evidence to support their models and simulations. Commonly, this evidence is distilled from large data sets with significant amount of culling and searching through a variety of sources including traditional and social media. The time/cost effectiveness and quality of the evidence marshaling process can be greatly enhanced by combining component technologies that support directed content harvesting, automated semantic annotation, and
doi:10.1186/2190-8532-1-10
fatcat:q5t52u5gfrfztfsyquxp4fekkq
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... content analysis within a collaborative environment, with a functional interface to models and simulations. Existing evidence extraction tools provide some, but not all, the critical components that would empower such an integrated knowledge management environment. This paper describes a novel evidence marshaling solution that significantly advances the state of the art. Its embodiment, the Knowledge Encapsulation Framework (KEF), offers a suite of semi-automated and configurable content harvesting, vetting, annotation and analysis capabilities within a wiki-enabled and user-friendly visual interface that supports collaborative work across distributed teams of analysts. After a summarization of related work, our motivation, and the technical implementation of KEF, we will explore the model for using KEF and results of our research.
Outbreak of Cryptosporidium linked to drinking unpasteurised milk
2002
Communicable diseases intelligence quarterly report
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The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides
2020
mBio
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Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic enzyme, phosphofructokinase (PfPFK9), are associated with in vitro resistance to a primary sulfonamide glycoside (PS-3). Flux through the upper glycolysis pathway was significantly reduced in PS-3-resistant parasites, which was associated with reduced ATP
doi:10.1128/mbio.02842-20
pmid:33293381
fatcat:cyfk6j45srb3bi47moz3rwjkom
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... vels but increased flux into the pentose phosphate pathway. PS-3 may directly or indirectly target enzymes in these pathways, as PS-3-treated parasites had elevated levels of glycolytic and tricarboxylic acid (TCA) cycle intermediates. PS-3 resistance also led to reduced MEP pathway intermediates, and PS-3-resistant parasites were hypersensitive to the MEP pathway inhibitor, fosmidomycin. Overall, this study suggests that PS-3 disrupts core pathways in central carbon metabolism, which is compensated for by mutations in PfPFK9, highlighting a novel metabolic drug resistance mechanism in P. falciparum. IMPORTANCE Malaria, caused by Plasmodium parasites, continues to be a devastating global health issue, causing 405,000 deaths and 228 million cases in 2018. Understanding key metabolic processes in malaria parasites is critical to the development of new drugs to combat this major infectious disease. The Plasmodium glycolytic pathway is essential to the malaria parasite, providing energy for growth and replication and supplying important biomolecules for other essential Plasmodium anabolic pathways. Despite this overreliance on glycolysis, no current drugs target glycolysis, and there is a paucity of information on critical glycolysis targets. Our work addresses this unmet need, providing new mechanistic insights into this key pathway.
Arapaho Stories, Songs, and Prayers a Bilingual Anthology (Andrew Cowell, Alonzo Moss, Sr. and William J. C'Hair eds)
2015
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The combined efforts of Andrew Cowell, Alonzo Moss and William C'Hair have produced an exceptional work on the Arapaho language. ...
This story, as Cowell explains, also gives reference to traditional medicinal practices at the end. ...
doi:10.22024/unikent/03/tm.180
fatcat:575icrpq7vc2tmayxd6hahiq5u
PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
[article]
2021
bioRxiv
pre-print
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J Neurosci 34, 15208-15222. 538 Graham, R.T., Parrish, R.R., Allberio, L., E.L., J., and Trevelyan, A.J. (2021). ...
parts of the brain, where its expression is enriched in GABAergic neurons (Cowell et al., 2007) . 56 Within cortical networks, PGC-1α appears particularly to affect parvalbumin-expressing (PV) 57 chlorhexidine ...
doi:10.1101/2021.06.25.449915
fatcat:g3supjao7vboxefwf3hn4a2uuq
Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1
2015
Journal of Investigative Dermatology
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CONFLICT OF INTEREST Andrew Harrison is an employee of Bioventus LLC. The remaining authors state no conflict of interest. Figure 1 . 1 Figure 1. ...
Syndecan-4 wild-type and knockout C57BL/6 J mice (Ishiguro et al., 2000) generated by heterozygous (Sdc4 (+/ − ) C57BL/6 J) parental crosses were used at age 12 weeks for comparison of genotypes. ...
doi:10.1038/jid.2015.224
pmid:26079528
pmcid:PMC4902130
fatcat:tlvjd3wx5rcglekd3yybzvjovi
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons
2014
Nature Communications
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Elliott DJ. Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons. Nature Communications 2014, 5: 4760. Alternative splicing-the production of multiple messenger RNA isoforms from a single gene-is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2a) and Tra2b have both been implicated in the regulation of alternative splicing, their relative contributions to this process are not well understood. Here we find
doi:10.1038/ncomms5760
pmid:25208576
pmcid:PMC4175592
fatcat:llyrulsnnnhh5egfl5s6c2hg5y
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... multaneousbut not individual-depletion of Tra2a and Tra2b induces substantial shifts in splicing of endogenous Tra2b target exons, and that both constitutive and alternative target exons are under dual Tra2a-Tra2b control. Target exons are enriched in genes associated with chromosome biology including CHEK1, which encodes a key DNA damage response protein. Dual Tra2 protein depletion reduces expression of full-length CHK1 protein, results in the accumulation of the DNA damage marker gH2AX and decreased cell viability. We conclude Tra2 proteins jointly control constitutive and alternative splicing patterns via paralog compensation to control pathways essential to the maintenance of cell viability.
Quality of Health Care for Children in Australia, 2012-2013
2018
Journal of the American Medical Association (JAMA)
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IMPORTANCE The quality of routine care for children is rarely assessed, and then usually in single settings or for single clinical conditions. OBJECTIVE To estimate the quality of health care for children in Australia in inpatient and ambulatory health care settings. DESIGN, SETTING, AND PARTICIPANTS Multistage stratified sample with medical record review to assess adherence with quality indicators extracted from clinical practice guidelines for 17 common, high-burden clinical conditions
doi:10.1001/jama.2018.0162
pmid:29558552
pmcid:PMC5885883
fatcat:ajfenjchnzblxdv5c3mxlgbbcq
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... municable [n = 5], mental health [n = 4], acute infection [n = 7], and injury [n = 1]), such as asthma, attention-deficit/hyperactivity disorder, tonsillitis, and head injury. For these 17 conditions, 479 quality indicators were identified, with the number varying by condition, ranging from 9 for eczema to 54 for head injury. Four hundred medical records were targeted for sampling for each of 15 conditions while 267 records were targeted for anxiety and 133 for depression. Within each selected medical record, all visits for the 17 targeted conditions were identified, and separate quality assessments made for each. Care was evaluated for 6689 children 15 years of age and younger who had 15 240 visits to emergency departments, for inpatient admissions, or to pediatricians and general practitioners in selected urban and rural locations in 3 Australian states. These visits generated 160 202 quality indicator assessments. EXPOSURES Quality indicators were identified through a systematic search of local and international guidelines. Individual indicators were extracted from guidelines and assessed using a 2-stage Delphi process. MAIN OUTCOMES AND MEASURES Quality of care for each clinical condition and overall. RESULTS Of 6689 children with surveyed medical records, 53.6% were aged 0 to 4 years and 55.5% were male. Adherence to quality of care indicators was estimated at 59.8% (95% CI, 57.5%-62.0%; n = 160 202) across the 17 conditions, ranging from a high of 88.8% (95% CI, 83.0%-93.1%; n = 2638) for autism to a low of 43.5% (95% CI, 36.8%-50.4%; n = 2354) for tonsillitis. The mean adherence by condition category was estimated as 60.5% (95% CI, 57.2%-63.8%; n = 41 265) for noncommunicable conditions (range, 52.8%-75.8%); 82.4% (95% CI, 79.0%-85.5%; n = 14 622) for mental health conditions (range, 71.5%-88.8%); 56.3% (95% CI, 53.2%-59.4%; n = 94 037) for acute infections (range, 43.5%-69.8%); and 78.3% (95% CI, 75.1%-81.2%; n = 10 278) for injury. CONCLUSIONS AND RELEVANCE Among a sample of children receiving care in Australia in 2012-2013, the overall prevalence of adherence to quality of care indicators for important conditions was not high. For many of these conditions, the quality of care may be inadequate.
Technosocial Predictive Analytics in Support of Naturalistic Decision Making
2009
unpublished
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The Knowledge Encapsulation Framework (KEF) is a suite of tools that enables the acquisition of knowledge inputs to support the modeling task and provides knowledge reach-back during decision making (Cowell ...
doi:10.14236/ewic/ndm2009.13
fatcat:nl2uqanfrjcdbeavv4d6ulyp7a
Page 153 of Notes and Queries Vol. 183, Issue 6
[page]
1942
Notes and Queries
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J. Gulstone and the ...
She secondly married on 29 Jan. 1788, Andrew Cowett, of Coleshill, Co. ...
Page 353 of National Union Catalog Vol. 3, Issue
[page]
1963
National Union Catalog
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-four hand arrangement for Harvard Glee Club by Andrew Heath. Cambridge, Mass., 1950?,
Hovaness, Alan Scott, 1911- {Lake of Van sonata, piano, Sketch for Lake of Van sonata. 1947. ...
Prins, Groningen, J. B, Wolters, 1960.
Watkin, Harold. History of music, college level. Rev. and edited by Mon- tague Cantor. New York, Distributed by Monarch Press (£1965,
Watkin, Harold. ...
Page 196 of National Union Catalog Vol. 34, Issue
[page]
1942
National Union Catalog
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Comet. began td « Crommelin, Andrew Claude De la Cherois,
1866- Joint a 410-1025 Vasear college. ...
Battersby, J. Place,
A. & J. Churchil, and R. Sare, 1701 31, p. 32°. ...
Page 186 of National Union Catalog Vol. 161, Issue
[page]
1942
National Union Catalog
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Welléon, James Edward Cowell, 1854— of the Wellcome tropical research laboratories at the The English church, by J. E. C. ...
Dept. of education. 41-23117 Library of Congress 8584.E3S85 2
Welidon, James Edward Cowell, bp., 1854—
peggy rely med ed eg J. E. C. Well- don... ...
Page 221 of Criminal Law & Justice Weekly Vol. 160, Issue 13
[page]
1996
Criminal Law & Justice Weekly
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Barclay; Andrew J. Bamett; Patrick R.J. Clarkson, Q.C.; Paul J.D. Coleridge, Q.C.; Mark Evans, Q.C.; Mark A. Everall, Q.C.; Anthony Derwin Hope; James Roger Jarvis; Andrew H.R. ...
Sallon, Q.C.; Miss Pamela Scriven, Q.C.; Andrew C. Smith, Q.C.; Christopher J. Smyth; Alan C. Steynor; Michael A. Supperstone, Q.C.; Christopher J. Sutton-Mattocks; Nigel C. Van der Bijl; Graham B.N. ...
Page 634 of The Journal of American History Vol. 22, Issue Index
[page]
1935
The Journal of American History
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Cowell, Mrs. Sam, diary, 104.
Cowells in Am., Being the Diary of Mrs. Sam Cowell during Her Husband’s Concert Tour in the Years 1860-61, ed. by M. Willson Disher, revd., 104.
Cox, Isaac J. ...
., 591.
orrespondence of Andrew Jackson, VI, VII, ed. by John S. Bassett, revd., 585 87. ,
~ =~
‘orsica, and Utopian ideal, 493,
‘orwin, Edward 8., The Twilight of the Supreme Court, revd., 133-35. ...
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