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ZAHVALA Vovk, M., Beličič, A., & Šernek, M.: Sestava, lastnosti, uporaba in reciklaža Kerrocka ... V drugem članku avtorji ponudijo rešitev za izboljšanje strižne trdnosti lepilnega spoja med Kerrockom (PMMA/ATH kompozit) in lesom z uporabo lepila za les in silanov (Vovk et al., 2014) . ...doi:10.26614/les-wood.2017.v66n02a06 fatcat:5pdjlgtw6vf45m5dkyaj4o6pu4
Functional studies show that our brain has a remarkable ability to reorganize itself in the absence of one or more sensory modalities. In this review, we gathered all the available articles investigating structural alterations in congenitally deaf subjects. Some concentrated only on specific regions of interest (e.g., auditory areas), while others examined the whole brain. The majority of structural alterations were observed in the auditory white matter and were more pronounced in the rightdoi:10.1016/j.neuroimage.2020.117042 pmid:32534128 fatcat:aipg3co4uzbane4ozau66xk6jq
more »... sphere. A decreased white matter volume or fractional anisotropy in the auditory areas were the most common findings in congenitally deaf subjects. Only a few studies observed alterations in the auditory grey matter. Preservation of the grey matter might be due to the cross-modal plasticity as well as due to the lack of sensitivity of methods used for microstructural alterations of grey matter. Structural alterations were also observed in the frontal, visual, and other cerebral regions as well as in the cerebellum. The observed structural brain alterations in the deaf can probably be attributed mainly to the cross-modal plasticity in the absence of sound input and use of sign instead of spoken language.
Hepatic encephalopathy (HE) is a complex disorder associated with increased ammonia levels in the brain. Although astrocytes are believed to be the principal cells affected in hyperammonemia (HA), endothelial cells (ECs) may also play an important role by contributing to the vasogenic effect of HA. Methods: Following acute application and removal of NH 4 Cl on astrocytes and endothelial cells, we analyzed pH changes, using fluorescence imaging with BCECF/ AM, and changes in intracellular Ca 2+doi:10.1186/s11658-016-0011-3 pmid:28536616 pmcid:PMC5414667 fatcat:ajd6zzpxbzeo3bxjtmfv7qcclm
more »... oncentration ([Ca 2+ ] i ), employing fluorescence imaging with Fura-2/AM. Using confocal microscopy, changes in cell volume were observed accompanied by changes of [Ca 2+ ] i in astrocytes and ECs. Results: Exposure of astrocytes and ECs to 1 -20 mM NH 4 Cl resulted in rapid concentration-dependent alkalinization of cytoplasm followed by slow recovery. Removal of the NH 4 Cl led to rapid concentration-dependent acidification, again followed by slow recovery. Following the application of NH 4 Cl, a transient, concentration-dependent rise in [Ca 2+ ] i in astrocytes was observed. This was due to the release of Ca 2+ from intracellular stores, since the response was abolished by emptying intracellular stores with thapsigargin and ATP, and was still present in the Ca 2+ -free bathing solution. The removal of NH 4 Cl also led to a transient concentration-dependent rise in [Ca 2+ ] i that resulted from Ca 2+ release from cytoplasmic proteins, since removing Ca 2+ from the bathing solution and emptying intracellular Ca 2+ stores did not eliminate the rise. Similar results were obtained from experiments on ECs. Following acute application and removal of NH 4 Cl no significant changes in astrocyte volume were detected; however, an increase of EC volume was observed after the administration of NH 4 Cl, and EC shrinkage was demonstrated after the acute removal of NH 4 Cl. Conclusions: This study reveals new data which may give a more complete insight into the mechanism of development and treatment of HE.
In Parkinson's disease (PD), there is a reduction of neuromelanin (NM) in the substantia nigra (SN). Manual quantification of the NM volume in the SN is unpractical and time-consuming; therefore, we aimed to quantify NM in the SN with a novel semi-automatic segmentation method. Twenty patients with PD and twelve healthy subjects (HC) were included in this study. T1-weighted spectral pre-saturation with inversion recovery (SPIR) images were acquired on a 3T scanner. Manual and semi-automaticdoi:10.3390/brainsci9120335 pmid:31766668 pmcid:PMC6956028 fatcat:vhoba52g6nck7m3hfceomkfykm
more »... s-free local statistics signature-based segmentations measured the surface and volume of SN, respectively. Midbrain volume (MV) was calculated to normalize the data. Receiver operating characteristic (ROC) analysis was performed to determine the sensitivity and specificity of both methods. PD patients had significantly lower SN mean surface (37.7 ± 8.0 vs. 56.9 ± 6.6 mm2) and volume (235.1 ± 45.4 vs. 382.9 ± 100.5 mm3) than HC. After normalization with MV, the difference remained significant. For surface, sensitivity and specificity were 91.7 and 95 percent, respectively. For volume, sensitivity and specificity were 91.7 and 90 percent, respectively. Manual and semi-automatic segmentation methods of the SN reliably distinguished between PD patients and HC. ROC analysis shows the high sensitivity and specificity of both methods.
Functional and structural brain alterations in the absence of the auditory input have been described, but the observed structural brain changes in the deaf are not uniform. Some of the previous researchers focused only on the auditory areas, while others investigated the whole brain or other selected regions of interest. Majority of studies revealed decreased white matter (WM) volume or altered WM microstructure and preserved grey matter (GM) structure of the auditory areas in the deaf.doi:10.1016/j.heares.2014.09.008 pmid:25262621 fatcat:q3my5nxewba7zpygyuk4jgudhm
more »... preserved WM and increased or decreased GM volume of the auditory areas in the deaf have also been reported. Several structural alterations in the deaf were found also outside the auditory areas, but these regions differ between the studies. The observed differences between the studies could be due to the use of different single-analysis techniques, or the diverse population sample and its size, or possibly due to the usage of hearing aids by some participating deaf subjects. To overcome the aforementioned limitations four different image-processing techniques were used to investigate changes in the brain morphology of prelingually deaf adults who have never used hearing aids. GM and WM volume of the Heschl's gyrus (HG) were measured using manual volumetry, while whole brain GM volume, thickness and surface area were assessed by voxel-based morphometry (VBM) and surface-based analysis. The microstructural properties of the WM were evaluated by diffusion tensor imaging (DTI). The data were compared between 14 congenitally deaf adults and 14 sex-and age-matched normal hearing controls. Manual volumetry revealed preserved GM volume of the bilateral HG and significantly decreased WM volume of the left HG in the deaf. VBM showed increased cerebellar GM volume in the deaf, while no statistically significant differences were observed in the GM thickness or surface area between the groups. The results of the DTI analysis showed WM microstructural alterations between the groups in the bilateral auditory areas, including the superior temporal gyrus, the HG, the planum temporale and the planum polare, which were more extensive in the right hemisphere. Fractional anisotropy (FA) was significantly reduced in the right and axial diffusivity (AD) in the left auditory areas in the deaf. FA and AD were significantly reduced also in several other brain areas outside the auditory cortex in the deaf. The use of four different methods used in our study, although showing changes that are not directly related, provides additional information and supports the conclusion that in prelingually deaf subjects structural alterations are present both in the auditory areas and elsewhere. Our results support the findings of those studies showing that early deafness results in decreased WM volume and microstructural WM alterations in the auditory areas. As we observed WM microstructural alteration also in several other areas and increased GM volume in the cerebellum in the deaf, we can conclude that early deafness results in widespread structural brain changes. These probably reflect atrophy or degradation as well as compensatory cross-modal reorganisation in the absence of the auditory input and the use of the sign language.
In vivo visualization of kidney and liver damage by Magnetic Resonance Imaging (MRI) may offer an advantage when there is a need for a simple, non-invasive and rapid method for screening of the effects of potential nephrotoxic and hepatotoxic substances in chronic experiments. Here, we used MRI for monitoring chronic intoxication with microcystins (MCs) in rat. Male adult Wistar rats were treated every other day for eight months, either with MC-LR (10 μg/kg i.p.) or MC-YR (10 μg/kg i.p.).doi:10.3390/md11082785 pmid:23921723 pmcid:PMC3766865 fatcat:za657vkjoncd3ejblcqjpfy6vy
more »... l groups were treated with vehicle solutions. T 1 -weighted MR-images were acquired before and at the end of the eight months experimental period. Kidney injury induced by the MCs presented with the increased intensity of T 1 -weighted MR-signal of the kidneys and liver as compared to these organs from the control animals treated for eight months, either with the vehicle solution or with saline. The intensification of the T1-weighted MR-signal correlated with the increased volume density of heavily injured tubuli (R 2 = 0.77), with heavily damaged glomeruli (R 2 = 0.84) and with volume density of connective tissue (R 2 = 0.72). The changes in the MR signal intensity probably reflect the presence of
Background Preclinical studies demonstrated that glucagon-like peptide 1 (GLP-1) is locally synthesized in taste bud cells and that GLP-1 receptor exists on the gustatory nerves in close proximity to GLP-1-containing taste bud cells. This local paracrine GLP-1 signalling seems to be specifically involved in the perception of sweets. However, the role of GLP-1 in taste perception remains largely unaddressed in clinical studies. Whether any weight-reducing effects of GLP-1 receptor agonists aredoi:10.1186/s13063-021-05442-y pmid:34281590 pmcid:PMC8287101 fatcat:ocbcakdhbjeovhhvuke3ulc3um
more »... diated through the modulation of taste perception is currently unknown. Methods and analysis This is an investigator-initiated, randomized single-blind, placebo-controlled clinical trial. We will enrol 30 women with obesity and polycystic ovary syndrome (PCOS). Participants will be randomized in a 1:1 ratio to either semaglutide 1.0 mg or placebo for 16 weeks. The primary endpoints are alteration of transcriptomic profile of tongue tissue as changes in expression level from baseline to follow-up after 16 weeks of treatment, measured by RNA sequencing, and change in taste sensitivity as detected by chemical gustometry. Secondary endpoints include change in neural response to visual food cues and to sweet-tasting substances as assessed by functional MRI, change in body weight, change in fat mass and change in eating behaviour and food intake. Discussion This is the first study to investigate the role of semaglutide on taste perception, along with a neural response to visual food cues in reward processing regions. The study may identify the tongue and the taste perception as a novel target for GLP-1 receptor agonists. Ethics and disseminations The study has been approved by the Slovene National Medical Ethics Committee and will be conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. Results will be submitted for publication in an international peer-reviewed scientific journal. Trial registration ClinicalTrials.govNCT04263415. Retrospectively registered on 10 February 2020
To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). Lower spatial working memory (sWM) capacity during acute hyperglycemia anddoi:10.2337/dc20-0171 pmid:32471909 pmcid:PMC7372055 fatcat:op6qgu4oizhgthcyssa7v5v5nq
more »... nt differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed. Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.
The bias field, generated by B1-field inhomogeneity, causes MR tissue intensity to vary as a function of spatial location (Vovk et al., 2007; Sled, 1998; Van Leemput, 1999) , thus broadening the distribution ...doi:10.1016/j.neuroimage.2010.11.082 pmid:21146620 pmcid:PMC3031751 fatcat:qkhsjljrsfgutjnql3qwlemcqy
In this topic the role and place of experts work in the area of health care quality control for patients with an acute surgical disease of abdominal cavity in the big multi-profile medical clinic in St. Petersburg were reviewed. There was an analysis of some data of 2155 patients who were urgently taken to the hospital in 2017. As a result surgical care analysis of diseases included in "acute abdomen syndrome" we found the correlation between negative outcomes caused by defects in diagnosticsdoi:10.17816/mechnikov201911213-26 fatcat:adcdt3k7xzbdvco2enn7uuy5zm
more »... d treatment and insufficiency of activity in experts work in surgery. In these study groups increasing cases of post-operative mortality, delaying of surgical intervention without strong argumentation in all diseases included in "acute abdomen syndrome" were found. Nowadays there is no opportunity to change the balance between acute and planning hospitalization of patients who have abdominal cavity diseases in positive way. Some paths of improving the quality of medical assessment to patients who has abdominal surgery diseases were discussed. In average, the example of positive improvement the abdominal surgery could be given speaking about the importance of systematically estimation of results some of the surgery teams activity and managerial decisions which could be made in time.
Following his death Andrej Simcic was named administrator . ... Auxiliary Bishop Vovk assumed the administration from him in 1951, followed in 1955 by Toros and in 1961 by Albin Kjuder. ...doi:10.7152/ssj.v17i1.3984 fatcat:4rxq65qflnaf7lqlukblg3xi5y
Efficiency of Health Care Management with the Online Scheduling for Medical Services: Impact of Age and Occupation 209 Predictors of Email Communication Skills among Slovenian and Serbian Students , Maryna Vovk ... Differences Among European Countries 157 Special Session 4: Graph Theory and Algorithms 165 Timotej Hrga and Janez Povh On Using Hypermetric Inequalities in a Cutting-Plane Algorithm for Max-Cut 188 Andrej ...doi:10.5281/zenodo.5532077 fatcat:chs6ncxsfzgbxnfaxhdbracs7y
I folodin, Andrej I Volokitin, E. P. Voloshinoy, V. V. Vol'per, D. E Volynskii, VV. ... Vorobeichikova, O. A Vorovich, I. I Voudouri, Aggeliki Vovk, R. V. Vrbik, Jan Vud, D. ; Vukoslavchevich, V. ...
Additionally, in 1988 about 1800 people lived in homes for people with mental disorder (Vovk, 1993) . ...doi:10.1192/pb.24.10.385 fatcat:tbuwuue65zh2flm6b62hgljjrq
Zapise o relevantnih zbirkah so v zadnjem času zbrali Tea Štoka: Prevara ogledala, 1994; Matevž Kos: Kritike in refleksije, 2000; Peter Košek: Lepa točajka, 2003 , Urban Vovk: V teku časa, 2002 , Kruh ... Spremljevalec devetdesetih let Urban Vovk v njihovi poeziji odkriva realistično in elegično intonacijo, proti koncu tudi himnično razčustvovanost, vračanje k neposredni življenjski izkušnji in resničnosti ...doaj:9eade5c30f5d43cb8c0f6d88b1f8bd10 fatcat:6o7figkuyzhodknwra74ynzsky
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