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Such a procedure is more powerful than the corresponding procedure based on Wilks' theorem. ... We show that the application of the classical Wilks' theorem may be affected by the arbitrary choice of the "origin of time", in connection with P1). ... Wilks' theorem on large sample asymptotics for LR statistics (Wilks (1938) and Wald (1943) ) may be applied to devise a testing procedure fulfilling principles P1) and P2). ...arXiv:1802.01715v3 fatcat:5ejf74dhlrenzbsffa4r3ln7hi
or angioplasty Yes 12 17.9 No 55 82.1 Angina Yes 7 10.5 No 60 89.5 Hypercholesterolemia Yes 28 58.2 No 39 41.8 Total 67 100 Patient Preferences for LTAD vs STAD/Wilke ... whether, if they could avoid blindness but at the price of having to give up some life, they would choose 1) living for 16 years with blindness or 2) living for 1 year Patient Preferences for LTAD vs STAD/Wilke ...doi:10.1002/cncr.24905 pmid:20162716 fatcat:d7rqxrissvh3tnzo5cx3bypzo4
PURPOSE. To describe the retinal dystrophy phenotype associated with mutations in RDH12, the gene encoding a retinoid dehydrogenase/reductase expressed in the photoreceptor cells. METHODS. Sixteen persons from 12 families with pathogenic RDH12 mutations on both alleles were studied. Retinal phenotypes were characterized by ophthalmic examination, including psychophysical and standardized electrophysiological methods and multifocal electroretinography (mfERG). was diagnosed initially as Leberdoi:10.1167/iovs.06-0628 pmid:17389517 fatcat:ssrv7vvz3jgllbowctwndrcnfe
more »... genital amaurosis (LCA) or early-onset retinitis pigmentosa. These individuals appeared to share a common clinical picture, independent of the type of mutation, characterized by poor, yet useful visual function in early life, followed by progressive decline due to both rod and cone degeneration. Marked pigmentary retinopathy, including bone spicules in the peripheral retina, was present in all persons older than age 6, and pronounced maculopathy was evident in persons older than 7 years. A unique view into the progressive nature of the disorder was achieved by evaluation of seven affected persons from three consanguineous families, all carrying the homozygous p.Y226C mutation. CONCLUSIONS. Ophthalmic findings in persons with RDH12 mutations suggest that RDH12 loss-of-function results in a characteristic form of early and progressive rod-cone degeneration distinct from that caused by mutations in other LCA genes. From our data, it seems likely that various clinical designations appropriately describe the diagnosis in these persons, including early-onset retinitis pigmentosa, LCA type II, and childhood retinal dystrophy. (Invest Ophthalmol Vis Sci.
Jürgen Wilke, Mainz Martin Welke/Jürgen Wilke (Hg.): 400 Jahre Zeitung. Die Entwicklung der Tagespresse im internationalen Kontext. ... Basisdaten und Pro- grammprofile) und Andrea Dürager (Fernsehnutzung in Österreich) . ...doi:10.5771/0010-3497-2009-3-324 fatcat:vhuyyit7wbcypmuekzurf7hmii
Mass spectrometry based peptide mass fingerprints (PMFs) offer a fast, efficient, and robust method for protein identification. A protein is digested (usually by trypsin) and its mass spectrum is compared to simulated spectra for protein sequences in a database. However, existing tools for analyzing PMFs often suffer from missing or heuristic analysis of the significance of search results and insufficient handling of missing and additional peaks. Results: We present an unified framework fordoi:10.1186/1471-2105-8-102 pmid:17386090 pmcid:PMC1851022 fatcat:3nt26ogdovbedlc7vex3ilabhy
more »... yzing Peptide Mass Fingerprints that offers a number of advantages over existing methods: First, comparison of mass spectra is based on a scoring function that can be custom-designed for certain applications and explicitly takes missing and additional peaks into account. The method is able to simulate almost every additive scoring scheme. Second, we present an efficient deterministic method for assessing the significance of a protein hit, independent of the underlying scoring function and sequence database. We prove the applicability of our approach using biological mass spectrometry data and compare our results to the standard software Mascot. Conclusion: The proposed framework for analyzing Peptide Mass Fingerprints shows performance comparable to Mascot on small peak lists. Introducing more noise peaks, we are able to keep identification rates at a similar level by using the flexibility introduced by scoring schemes.
Cornerstone. Paper 17
The John Wilkes Collection • Focus on Library Faculty: Andrea Imre Page 10 CornerStone Volume 5, Number 2 Winter 2010 M any people associate the name John Wilkes with Abraham Lincoln' s assassin ... Leave a Legacy A major gift of $25,000 can create an endowed fund to ensure the funding of a subject area that is essential to the mission of Morris Library. • 10 • Focus on Library Faculty Andrea Imre ...fatcat:ajyy3obrmjatnbprxn5ysilyh4
Wilke and Peter M. ... , & Todd, 2008; Wilke, Hutchinson, Todd, & Czienskowski, 2009) . ...pmid:20100420 fatcat:h5ucnpwhanekpc3ogoqublmopi
Biological Nitrogen Fixation
Johnson, and Andreas Wilke Volume 17-Number 4Domain Specificity ... In the present study, we used the German version of the DOSPERT scale (DOSPERT-G; see Johnson, Wilke, & Weber, 2004) to provide further support of the notion that risk taking is domain-specific. ...doi:10.1111/j.1467-9280.2006.01702.x pmid:16623686 fatcat:senqokaypvbkrgqu2dfevsmeeu
Current issues in linguistic theory
We describe two major dialogue system segments: first we describe a Dialogue Manager which uses a representation of stereotypical dialogue patterns that we call Dialogue Action Frames and which, we believe, generate strong and novel constraints on later access to incomplete dialogue topics. Secondly, an analysis module that learns to assign dialogue acts from corpora, but on the basis of limited quantities of data, and up to what seems to be some kind of limit on this task, a fact we also discuss.doi:10.1075/cilt.260.04wil fatcat:sarisl33ardm3acuddc27dr5pq
Bischof, Natalia Wilke. ... and small gel domains are used as markers for observing the flow velocity of the liquid membrane. 477-Pos 478-Pos Board B264 Line Tension in Lipid Monolayers with Liquid-Liquid Phase Coexistence Andrea ...doi:10.1016/j.bpj.2011.11.539 fatcat:jiyrhxjk55gbzey7uzaj7eh3au
Lecture Notes in Computer Science
(Photo by Andreas Wilkes) FIGURE 3 3 A woman observing whether her cattle like to eat silaged cornstalks. ... (Photo by Andreas Wilkes) FIGURE 4 Project staff discussing establishment of a revolving drug fund with villagers. ...doi:10.1659/0276-4741(2006)26[209:itsali]2.0.co;2 fatcat:7cimfw22xfedzfj4ctqvbfvqau
Especially in context of critical urban infrastructures, trust in IoT data is of utmost importance. While most technology stacks provide means for authentication and encryption of device-to-cloud traffic, there are currently no mechanisms to rule out physical tampering with an IoT device's sensors. Addressing this gap, we introduce a new method for extracting a hardware fingerprint of an IoT sensor which can be used for secret-free authentication. By comparing the fingerprint against referencearXiv:2006.06296v1 fatcat:jheawy7a4za2dit3c3wyapxfmy
more »... easurements recorded prior to deployment, we can tell whether the sensing hardware connected to the IoT device has been changed by environmental effects or with malicious intent. Our approach exploits the characteristic behavior of analog circuits, which is revealed by applying a fixed-frequency alternating current to the sensor, while recording its output voltage. To demonstrate the general feasibility of our method, we apply it to four commercially available temperature sensors using laboratory equipment and evaluate the accuracy. The results indicate that with a sensible configuration of the two hyperparameters we can identify individual sensors with high probability, using only a few recordings from the target device.
Line tension was determined in lipid monolayers with a low amount of putative linactants. There are no clear rules to design molecules that decrease line tension.doi:10.1039/c5sm00022j pmid:25633226 fatcat:mdofpyxd3vh5tehjbmjhr7sjt4
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