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Die Wertungen des BVerfG lassen sich nicht durchweg spannungsfrei mit anderen Gesetzes-Spengler A, Koller M. Zwingend ohne Zwang? ... ... Die Wertungen des BVerfG lassen sich nicht durchweg spannungsfrei mit anderen Gesetzes-Spengler A, Koller M. Zwingend ohne Zwang? ...doi:10.1055/s-0032-1305330 pmid:23044842 fatcat:iytvzxtl2rcglplnbjmo2elsg4
Andrea Niesert, Fritz M. Koller, Rosi Haarer-Becker Pamela C. ... Das Gespräch führten Rosi Haarer-Becker und Andrea Niesert. P "Therapeuten in anderen Ländern mit den gleichen Problemen umgehen, die wir haben." ...doi:10.1055/s-0032-1308105 fatcat:d3vukjmwijcqljkean6ejbwdom
The retinal pigment epithelium (RPE), which is among the tissues in the body that are exposed to the highest levels of phagocytosis and oxidative stress, is dependent on autophagy function. Impaired autophagy and continuous cellular stress are associated with various disorders, such as dry age-related macular degeneration (AMD), a disease for which effective therapies are lacking. Cysteinyl leukotriene receptor (CysLTR) 1 is a potential modulator of autophagy; thus, the aim of this study was todoi:10.1038/s41598-020-74755-w pmid:33077798 fatcat:qzy2xqnno5fmri7cznwazljjc4
more »... investigate the role of CysLTR1 in autophagy regulation in the RPE cell line ARPE-19. The polarized ARPE-19 monolayer exhibited expression of CysLTR1, which was colocalized with β-tubulin III. In ARPE-19 cells, autophagic activity was rhythmically regulated and was increased upon CysLTR1 inhibition by Zafirlukast (ZK) treatment. H2O2 affected the proautophagic regulatory effect of ZK treatment depending on whether it was applied simultaneously with or prior to ZK treatment. Furthermore, mRNA levels of genes related to the leukotriene system, autophagy and the unfolded protein response were positively correlated. As CysLTR1 is involved in autophagy regulation under basal and oxidative stress conditions, a dysfunctional leukotriene system could negatively affect RPE functions. Therefore, CysLTR1 is a potential target for new treatment approaches for neurodegenerative disorders, such as AMD.
Boulder: Paradigm.Contact: email@example.com (Craig Calhoun) and firstname.lastname@example.org (Andreas Koller). . Oxford: Oxford University Press. -----(2008). ... Introduction Marc Helbling and andreas Koller WZB Berlin and Social Science Research Council / New York University Charles Tilly (1929 Tilly ( -2008 was not only one of the world's preeminent social ...doi:10.1002/j.1662-6370.2009.tb00131.x fatcat:qm3xyadeozg6dlwo2iqpgqikkq
In the present study, the effective thermal conductivity of nanoparticle dispersions, so-called nanofluids, is investigated experimentally and theoretically. For probing the influence of the nanoparticles on the effective thermal conductivity of dispersions with water as liquid continuous phase, nearly spherical and monodisperse titanium dioxide (TiO 2 ), silicon dioxide (SiO 2 ), and polystyrene (PS) nanoparticles with strongly varying thermal conductivities were used as model systems. For thedoi:10.1007/s10765-020-2621-2 fatcat:hnksgr4glnb5zfxy6chphkzhra
more »... measurement of the effective thermal conductivity of the nanofluids with particle volume fractions up to 0.31, a steady-state guarded parallel-plate instrument was applied successfully at temperatures between (298 and 323) K. For the same systems, dynamic light scattering (DLS) was used to analyze the collective translational diffusion, which provided information on the dispersion stability and the distribution of the particle size as essential factors for the effective thermal conductivity. The measurement results for the effective thermal conductivity show no temperature dependency and only a moderate change as a function of particle volume fraction, which is positive or negative for particles with larger or smaller thermal conductivities than the base fluid. Based on these findings, our theoretical model for the effective thermal conductivity originally developed for nanofluids containing fully dispersed particles of large thermal conductivities was revisited and also applied for a reliable prediction in the case of particles of relatively low thermal conductivities.
Zeitschrift für Mittelmeerstudien
. * Andreas Eckl is Managing Editor to this Journal, e-mail: email@example.com; **Markus Koller is Professor for History of the Ottoman Empire and Modern Turkey at Ruhr-University Bochum (RUB) and Executive ...doi:10.46586/zfm.v2021.1-4 fatcat:llqef25furc43apaerd73ilmmm
Andrea Koller, Neuropsychologie im Zentrum für Kinderneurologie, Entwicklung und Rehabilitation, St. ... In 60-80% handelt es KOMPLEX, ABER NICHT KOMPLIZIERT: INTERDISZIPLINÄRE THERAPIE PRIMÄRER KOPFSCHMERZEN Katrin Lengnick, Andrea Koller Kopfschmerzen sind ein häufiger Vorstellungsgrund in der kinderärztlichen ...doi:10.35190/d2021.4.8 fatcat:6og222j6h5ewjm53gvkg4b2pyy
Carrageenan has been widely used as food additive for decades and therefore, an extended oral data set is available in the public domain. Less data are available for other routes of administration, especially intranasal administration. The current publication describes the nonclinical safety and toxicity of native (non-degraded) iota-carrageenan when applied intranasally or via inhalation. Intranasally applied iota-carrageenan is a topically applied, locally acting compound with no need ofdoi:10.1371/journal.pone.0122911 pmid:25875737 pmcid:PMC4395440 fatcat:roloyaqa3fc65ddjqf2fcxvz74
more »... mic bioavailability for the drug's action. Animal experiments included repeated dose local tolerance and toxicity studies with intranasally applied 0.12% iota-carrageenan for 7 or 28 days in New Zealand White rabbits and nebulized 0.12% iota-carrageenan administered to F344 rats for 7 days. Permeation studies revealed no penetration of iota-carrageenan across nasal mucosa, demonstrating that iotacarrageenan does not reach the blood stream. Consistent with this, no relevant toxic or secondary pharmacological effects due to systemic exposure were observed in the rabbit or rat repeated dose toxicity studies. Data do not provide any evidence for local intolerance or toxicity, when carrageenan is applied intranasally or by inhalation. No signs for immunogenicity or immunotoxicity have been observed in the in vivo studies. This is substantiated by in vitro assays showing no stimulation of a panel of pro-inflammatory cytokines by iota-carrageenan. In conclusion, 0.12% iota-carrageenan is safe for clinical use via intranasal application.
(15) reported a dependence on a long U-tail on the gRNAs whereas Köller et al. (16) found cross-linking even with a tail-less gRNA substrate. ...doi:10.1074/jbc.272.6.3749 pmid:9013632 fatcat:uz3savyz6jaerfkx6zdu7ysxjm
For a given Wind Resource Assessment (WRA) project, the modeller is faced with a difficult choice of simulation tools and calculation steps with varying accuracies, complexities and costs. The most cost-effective choice is expected to be a compromise between performance and cost (Figure 1). In order to help modellers choose the most suitable workflow for a given project, a new method for estimating the accuracy, or skill, and cost of a given workflow was developed previously (Barber et al.doi:10.5281/zenodo.4876982 fatcat:k3a7unbgqjhkjo6kplcmui54vy
more »... . This method involves estimating scores for a range of weighted parameters relating to the skill and cost of the workflow, using a pre-defined template. The method was shown to work well for various tools at the Bolund Hill site (Berg et al., 2011), but further tests are required on different sites. For the present work, therefore, the method is tested at two further complex terrain sites as follows: Firstly, at the complex terrain site of Stoetten in southern Germany (Schulz et al., 2016), workflows are developed for carrying out WRAs using various simulation tools: ANSYS CFX and ANSYS Fluent as well as the commercial tools WindSIM and WindPro and the PALM (Raasch and Schröter, 2001). The skill and cost scores are estimated for each workflow according to (Barber et al. 2019) and (Barber et al. 2020a). WRAs are then carried out for each workflow based on input measurement data from a met mast, and the Annual Energy Production (AEP) of a fictive wind turbine positioned at a second location is estimated. Measurement data from a lidar at this second location is used to assess the accuracy of both the wind speed and AEP predictions from each workflow, allowing the actual skill score of each workflow to be determined. The actual costs of each workflow are determined from the real costs after completing the calculations. Secondly, at the complex terrain site of Perdigão in Portugal (Fernando et al., 2019), a new simulation challenge was designed and run (Barber et al., 2020b). The goal of this challenge was to collect data rega [...]
. − = no expression detected. n = 3-10 (GALP: T cells CD4 + , n = 2; T cells CD8 + , n = 1). a Reported in Locker, et al. 37 . b Reported in Koller, et al. 36 . www.nature.com/scientificreports www.nature.com ...doi:10.1038/s41598-019-43704-7 pmid:31076613 pmcid:PMC6510899 fatcat:muf4rmp45fhzphgkmgwr2bnkpe
A theoretical model of a single molecule coupled to many vibronic modes is presented. At low energies, transport is dominated by electron-vibron processes where transfer of an electron through the dot is accompanied by the excitation/emission of quanta (vibrons). Because the frequency of the nth mode is taken as an nth multiple of the frequency of the fundamental mode, several energetically degenerate or quasi-degenerate vibronic configurations can contribute to transport. We investigate thearXiv:1108.0814v2 fatcat:vjwawpe4nffcpmqep4sr2tnnjq
more »... sequences of strong electron-vibron coupling in a fully symmetric set-up. Several striking features are predicted. In particular, a gate-asymmetry and pronounced negative differential conductance features are observed. We attribute these features to the presence of slow channels originating from the interplay of Franck-Condon suppression of transport channels and spin/orbital degeneracies.
When shopping for apparel, many consumers seek advice from friends and family or store personnel. In-store kiosk systems might serve as an alternative decision support system. In the present study we address the key question of how such kiosk systems are evaluated by consumers. We conducted three focus group discussions with regular apparel shoppers aged between 23 and 39 years. In sum, qualitative information from 15 participants was subject to a qualitative content analysis with the aim ofdoi:10.1590/s0034-75902012000600008 fatcat:qz4hrqla6vgwhfxr3qzfjrw24i
more »... ning a more comprehensive understanding of how apparel shoppers experience the shopping process. Getting a more in-depth understanding of the needs and wishes associated with the apparel shopping process gives a basis for evaluating the potential acceptance of electronic decision support systems in apparel shopping. Although our study is exploratory in nature, we are able to draw an initial picture of how kiosk systems could be used in apparel shopping.
Current research into neuropeptides is bringing to light many remarkable functions of these endocrine/neurocrine/paracrine factors, such as their roles in modulating immune responses. Galanin is a neuropeptide expressed in both neural and non-neural tissues and exerts its effects through three G protein-coupled receptors, GAL1,2,3 -R. It has been demonstrated that galanin has modulatory effects on immune cells, including neutrophils and natural killer cells. Because monocytes express GAL2 -R,doi:10.1111/nyas.14111 pmid:31074091 pmcid:PMC6899851 fatcat:iwjcxjthj5ffplolgggtucq7g4
more »... d therefore are expected to be a target of galanin, we analyzed the effect of galanin on the expression of cytokines and chemokines by monocytes. Galanin increased the expression of IL-1β up to 1.5-fold, TNF-α, IL-10, IL-18, and CCL3 up to twofold, and CXCL8 up to fourfold in nonactivated monocytes, but had no major effect on activated monocytes. A cross-correlation analysis of cytokine expression profiles, irrespective of the activation status of the monocytes, revealed that galanin changed the cross-correlation of the expression of certain cytokines. Galanin abolished several significant correlations in IFN-γ-stimulated monocytes. For example, treatment with 10 nM galanin changed the Spearman's rank coefficient of IL-18 and CXCL8 from 0.622 (P ≤ 0.01) to 0.126. These results further emphasize the importance of neuroregulatory peptides, such as galanin and their therapeutic potential to treat inflammatory diseases.
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