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Metacontrol of decision-making strategies in human aging

Florian Bolenz, Wouter Kool, Andrea Reiter, Ben Eppinger
2019 eLife  
This effect replicates previous findings (Eppinger et al., 2013) .  ...  Older adults show reduced model-based control during decision making compared to younger adults (Eppinger et al., 2013) .  ... 
doi:10.7554/elife.49154 pmid:31397670 pmcid:PMC6703898 fatcat:vnqc2w6xw5fvphdxfwsafnyteq

Developmental Changes in Learning: Computational Mechanisms and Social Influences

Florian Bolenz, Andrea M. F. Reiter, Ben Eppinger
2017 Frontiers in Psychology  
., 2008; Eppinger et al., 2009) .  ...  capacity (Eppinger et al., 2013b) .  ...  Copyright © 2017 Bolenz, Reiter and Eppinger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fpsyg.2017.02048 pmid:29250006 pmcid:PMC5715389 fatcat:oo7whj6fqrhrhczh3ktbphhbpe

Fulminante Myokarditis bei Influenza

Eleonora Lupi, Mattia Arrigo, Matthias P. Hilty, Nina Eppinger, Frank Ruschitzka, Hans Rickli, Andreas J. Flammer
2018 Swiss Medical Forum = Schweizerisches Medizin-Forum  
Andreas Flammer andreas.flammer[at]usz.ch SWISS MEDICAL FORUM -SCHWEIZERISCHES MEDIZIN-FORUM 2018;18(16):355-358 rikarderguss durch eine Perikardpunktion entlastet werden.  ... 
doi:10.4414/smf.2018.03216 fatcat:rptg6qgeurgotamfmptwfpxn24

Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes

Thomas Reiner, Dominik Jantke, Alexander N. Marziale, Andreas Raba, Jörg Eppinger
2013 ChemistryOpen  
Dedicated to Professor Wolfgang A. Herrmann on the occasion of his 65 th birthday Incorporation of artificial metal centers into proteins and peptides has emerged as an important tool in chemical and biological research. [1] Current applications include pharmaceuticals, [2] probes for molecular imaging [3] and contrast agents, [4] tools for biophysical studies targeting metalloprotein functions, [5] metal-directed protein assembly, [6] electrochemical biosensors, [7] and altered electrochemical
more » ... potential of electron transporting proteins, [8] as well as the synthesis of functional metalloenzymes with non-natural catalytic activity. [9] Particularly artificial metalloenzymes received great interest, since they hold the promise to greatly expand the range of reactions accessible by biocatalysis. A variety of methods to generate artificial metal sites were developed including domain-based directed evolution strategies, [10] engineering of transition-metal binding sites through introduction of coordinating amino acids at geometrically appropriate positions [11] or site-directed in vivo incorporation of artificial metal-chelating amino acids. [12] However, the site-directed anchoring of artificial cofactors representing appropriate ligands or metal complexes has so far been the most successful strategy to achieve good catalytic activities and enantioselectivities. Inspired by the pioneering work of Wilson and Whitesides, [13] Ward revealed the potential of the supramolecular biotin-(strept)avidin technology, which in combination with directed or rationally guided evolution [14] can deliver highly enantioselective organometallic enzyme hybrid (OMEH) catalysts. [15] Such biotin-(strept)avidin-metal conjugates were subsequently tested in a variety of catalytic transformations. [16] In contrast to this supramolecular approach, covalent anchoring of artificial cofactors on proteins can utilize a variety of protein hosts and hence is not limited by the stability range of the biotin-(strept)avidin complex. Originally introduced by Kaiser, [18] covalent attachment of artificial cofactors has been applied to convert proteases, [19] lipases [20] or other non-metal proteins [21] into organometallic enzyme hybrids. However, none of the covalent approaches could so far achieve the enantioselectivities reached by biotin-(strept)avidin conjugates. [9d, 21e] Although metals are introduced site-specifically, most systems generated through a covalent approach possess a flexible linker and hence lack a well-defined localization of the metal center on the surface of the host protein, which is a prerequisite to achieve chiral induction. We reasoned that a well-defined orientation of the metal center in the binding pocket of a protease could be achieved, if the specific binding-affinity pattern of the pocket is utilized to position a suitable artificial cofactor. Correspondingly, we decided to synthesize and test metal-conjugated affinity labels (m-ALs), which consist of 1) an achiral, catalytically active metal complex linked to 2) a protease-specific reactive group able to form a covalent bond with the active center and 3) a peptidic tail to direct the binding orientation of the m-AL (Figure 1) . To test the hydrogenation of ketones, we chose a system based on cysteine proteases of the papain family as host proteins. This class of proteases is efficiently inhibited by epoxysuccinyl ester derivatives of the known calpain inhibitor E64c through S-alkylation of the reactive epoxide group by the active site cysteine. [17, 22] Hence, these well-suited, family-wide affinity labels [23] were chosen to incorporate catalytically active rhodium-or ruthenium-half-sandwich complexes into the enzymatic host. M-ALs were synthesized starting from E64c derivatives (1-3), which were first converted to the corresponding pentafluorophenyl esters (1-OPf-3-OPf) and subsequently coupled to monomeric amino-functionalized half-sandwich complexes of ruthenium and rhodium [25] (1 Ru , 2 Ru and 1 Rh -3 Rh , respectively; see Scheme 1). Cysteine proteases of the papain family are readily converted into organometallic enzyme hybrids through conjugation with m-ALs 1 Rh , 1 Ru or 2 Rh (Figure 1 C) . Because this system is modular, combination of different affinity labels, metal complexes and proteases allows a straightforward generation of OMEH catalyst libraries, from which promising candidates can be selected based on their performance in asymmetric catalysis. In this study, we generated a variety of OMEH catalysts originating from three affinity labels (1, 2 and 3), two metal complexes (Rh and Ru) and three cysteine proteases (papain, bromelain and cathepsin L). MALDI-TOF MS was used to confirm selective formation of the desired enzyme hybrids. Upon addition of m-AL 1 Rh to papain a new signal at 23.976 kDa appeared, indicating formation of the desired organometallic enzyme hybrid (1 Rh @papain, Figure 2 ). After incubating papain with one equivalent of m-AL 1 Rh for two hours the signal of [a] D.
doi:10.1002/open.201200044 pmid:24551533 pmcid:PMC3646430 fatcat:ebi3fwkhpzbnlebkrzcfis6524

Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes

Thomas Reiner, Dominik Jantke, Alexander N. Marziale, Andreas Raba, Jörg Eppinger
2013 ChemistryOpen  
Jçrg Eppinger. The cover picture illustrates the concept of using metalconjugated affinity labels (m-ALs) to convert proteases into well-defined and catalytically active artificial metalloenzymes.  ...  The Group of Jçrg Eppinger Division of Physical Sciences and Engineering and KAUST Catalysis Center, KCC King Abdullah University of Science and Technology, KAUST Thuwal 23955-6900 (Saudi Arabia) E-mail  ... 
doi:10.1002/open.201300015 pmid:24551528 pmcid:PMC3646425 fatcat:ewzhndulvzajzormp4imliy4zq

The Aging of the Social Mind - Differential Effects on Components of Social Understanding

Andrea M. F. Reiter, Philipp Kanske, Ben Eppinger, Shu-Chen Li
2017 Scientific Reports  
Research in younger adults dissociates cognitive from affective facets of social information processing, rather than promoting a monolithic view of social intelligence. An influential theory on adult development suggests differential effects of aging on cognitive and affective functions. However, this dissociation has not been directly tested in the social domain. Employing a newly developed naturalistic paradigm that disentangles facets of the social mind within an individual, we show
more » ... ectionality of age-related differences. Specifically, components of the sociocognitive route -Theory of Mind and metacognition -are impaired in older relative to younger adults. Nevertheless, these social capacities are still less affected by aging than factual reasoning and metacognition regarding non-social content. Importantly, the socio-affective route is wellfunctioning, with no decline in empathy and elevated compassion in the elderly. These findings contribute to an integrated theory of age-related change in social functioning and inform interventions tailored to specifically reinstate socio-cognitive skills in old age.
doi:10.1038/s41598-017-10669-4 pmid:28887491 pmcid:PMC5591220 fatcat:rugfwhvut5fh7ofsqpzxfnbtoy

Spontaneous release of fluoride during the dioxygenolytic cleavage of 5-fluorosalicylate by the salicylate 1,2-dioxygenase fromPseudaminobacter salicylatoxidansBN12

Erik Eppinger, Sibylle Bürger, Andreas Stolz, Dieter Jahn
2015 FEMS Microbiology Letters  
,b, 2013 Eppinger et al. 2015) .  ... 
doi:10.1093/femsle/fnv211 pmid:26538576 fatcat:stffo3e7lnal7kfdy3ned7wfti

Wenn die Grippe aufs Herz schlägt Fulminante Myokarditis bei Influenza

Eleonora Lupi, Mattia Arrigo, P Matthias, Hilty, Nina Eppinger, Med Ruschitzka, Med Rickli, J Andreas, Flammer
unpublished
Andreas Flammer andreas.flammer[at]usz.ch SWISS MEDICAL FORUM -FORUM MÉDICAL SUISSE 2018;18(16):355-358 rikarderguss durch eine Perikardpunktion entlastet werden.  ... 
fatcat:cuk7cj7ej5ey7itbk3qbc3oju4

Chemoenzymatic enantioselective synthesis of phenylglycine and phenylglycine amide by direct coupling of the Strecker synthesis with a nitrilase reaction [article]

Erik Eppinger, Janosch Alexander David Gröning, Andreas Stolz, Universität Stuttgart
2022
., 2014a, b; Eppinger and Stolz, 2019; Mareya et al., 2020) .  ...  The cells formed (R)-PGA with 93% ee (Eppinger and Stolz, 2019) .  ... 
doi:10.18419/opus-12371 fatcat:24v33jdh6japplqujjpx46yyua

Desarrollo de modelo integral de autoevaluación en una institución de educación superior

Andrea Del Pilar Vera Silva, Ivonne Angelica Castiblanco Jimenez, Joan Paola Cruz Gonzalez
2019 Praxis & Saber  
El concepto del modelo fue seleccionado a través de la metodología de desarrollo de producto de Eppinger y Ulrich (2012) .  ...  Estos principios serán aplicados al modelo que resulte mejor evaluado mediante el concept scoring de Eppinger y Ulrich (2012) .  ...  con los parámetros y la selección del modelo mediante el concept scoring de Eppinger y Ulrich (2012) , se concluye que el modelo integrado debe abordar los siguientes factores y principios: Cuadro 6  ... 
doi:10.19053/22160159.v9.n21.2018.8047 fatcat:kkgpts3e5nbq3hbgveg7xkb3eq

Reviewer List

2018 Digital Health  
Benoît Durbin, Anna Dusheiko, Geoffrey Duthie, Malcolm Eastwood, Gillian Ebel, Gregory Eberhard, Mark Eckels, Kenneth Eckmann, Lars Emile, Charles Emina, Jacques Engman, David Enwonwu, Cyril Eppinger  ...  Adela Van Borm, Steven van den Hurk, Andrew van der Hoek, Wim van Griensven, Johan Van Kerkhove, Maria Van Panhuis, Willem Varela-Stokes, Andrea Vasilakis, Nikolaos Vaz da Silva, Susana Vazquez, Gonzalo  ... 
doi:10.1177/2055207618760925 fatcat:grkxllmd6zc7rimjx3qbimvlq4

Von Tätern und Opfern der NS-"Euthanasie" im Bregenzerwald

Wolfgang Weber
2020 VIRUS - Beiträge zur Sozialgeschichte der Medizin  
Albrich folgte seinem akademischen Mentor Eppinger in manchen Dingen: 1933 trat er der NSDAP und der SA bei, in letzterer hatte er den Rang eines Hauptsturmführers inne. 13 Während Eppinger 1936 Josef  ...  zurückschreckte: So war Eppinger etwa in Dachau an einer Versuchsreihe beteiligt, in der bei 90 Roma und Sinti die Trinkbarkeit von Meerwasser erforscht wurde. 1946 sollte Eppinger im Nürnberger Ärzteprozess  ... 
doi:10.1553/virus08s181 fatcat:isai7ax5hndhvll2px3etbli7a

Modelling and Simulation of Knowledge-Intensive Service Systems with Design Structure Matrices

Sönke Duckwitz, Andreas Petz, Christopher M. Schlick
2015 Enterprise Modelling and Information Systems Architectures - An International Journal  
Gebala and Eppinger (1991); Maurer (2007) ).  ...  Following the work of Smith and Eppinger (1997) more comprehensive simulation models were developed by Browning and Eppinger (2000) , Yassine et al.  ... 
doi:10.18417/emisa.10.1.3 dblp:journals/emisaij/DuckwitzPS15 fatcat:6mojwy3c6vfezfboo2cfzv232i

Page 511 of Engineering and Mining Journal Vol. 80, Issue 11 [page]

1905 Engineering and Mining Journal  
Reed and Eppinger claim that Stillwell did not give them what they had coming. Reed received 116 bonds and Eppinger 86 for his share, according to the complaint.  ...  A mining deal of importance, to the region about San Andreas, Calaveras county, is the bonding of the Chapman property to L. C. Hunter.  ... 

Page 408 of Bulletin of the History of Medicine Vol. 1, Issue 9 [page]

1933 Bulletin of the History of Medicine  
Aneurism Vesalius (Andreas) [Diagnosis and description of aneurysm of the thoracic and abdominal aorta] —— (G. H.) Sylloge. 8°. Augsb., 1667, pt. 4, 46.  ...  Eppinger (Hans) [1846-1916] Pathogenesis (His- togenesis und Aetiologie) der Aneurysmen. Arch. f. klin. Chir., Berl., 1887, xxxv, Suppl. Heft, 1-563, 9 pl. Helter (A.)  ... 
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