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Structure determination of oligomeric alkannin and shikonin derivatives
2005
Biomedical chromotography
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Peak not observed due to low S/N of quarternary carbons. * , † Peaks with the same symbol may be interchanged. See Schemes 1 and 2 for numbering. Position ...
., 2002; Assimopoulou and Papageorgiou, 2004a) in order for the structure of the dimeric A/S to be elucidated.
SEC experiments. ...
doi:10.1002/bmc.470
pmid:15651092
fatcat:ftr2viubkjeuvkvfu5ob3jofd4
Green Extracts from Coffee Pulp and Their Application in the Development of Innovative Brews
2020
Applied Sciences
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Acknowledgments: Andrena N. Assimopoulou and Konstantinos N. ...
doi:10.3390/app10196982
fatcat:gtbdkxbf5zes5pwnmn5k5b4ixe
Spent Coffee Grounds' Valorization towards the Recovery of Caffeine and Chlorogenic Acid: A Response Surface Methodology Approach
2021
Sustainability
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Accelerated Solvent Extraction
Solvent
n-Hexane
EtOH
EtOH: H 2 O (50:50 v/v)
Solvent vol. ...
Its absorbance was measured immediately after preparation at 517 n ultraviolet (UV-vis) spectrophotometer. ...
doi:10.3390/su13168818
fatcat:5uklzymxanawhcoeeyec7wor6y
Chimeric advanced drug delivery nano systems (chi-aDDnSs) for shikonin combining dendritic and liposomal technology
2012
International Journal of Pharmaceutics
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., 2003; Assimopoulou and Papageorgiou, 2004b) , cyclodextrins (Assimopoulou and Papageorgiou, 2004a) , liposomes (Kontogiannopoulos et al., 2011a) and electrospun fiber mats (Kontogiannopoulos et ...
: chloroform) followed by recrystallization (n-hexane), according to the procedure proposed by Prof. ...
doi:10.1016/j.ijpharm.2011.09.031
pmid:21979251
fatcat:wkijwtnwn5bgtjfyznmdi47nza
Novel electrospun poly-hydroxybutyrate scaffolds as carriers for the wound healing agents alkannins and shikonins
2021
Regenerative Biomaterials
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N, N-dimethylformamide (DMF) and diethyl ether were obtained from Honeywell (Charlotte, NC). ...
The n parameter varies, non-systematically, between 0.44 and 0.51. ...
doi:10.1093/rb/rbab011
fatcat:sal6yoye2nb6dcloytnnzioi34
Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells
2015
OncoTarget
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Data are represented as mean values ± SEM of three independent experiments (n = 3). a , p < 0.01 vs. control; b , p < 0.05 vs. control, calculated by two-tailed Student's t test. ...
Data are represented as mean values ± SEM of three independent experiments (n = 3). a , p < 0.01 vs. control; b , p < 0.05 vs. control, calculated by two-tailed Student's t test. B. ...
doi:10.18632/oncotarget.5380
pmid:26472107
pmcid:PMC4770748
fatcat:e6t2ngxtevetxkuuqgugukmm54
Endophytic Bacteria From the Roots of the Medicinal Plant Alkanna tinctoria Tausch (Boraginaceae): Exploration of Plant Growth Promoting Properties and Potential Role in the Production of Plant Secondary Metabolites
2021
Frontiers in Microbiology
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The extraction of A/S was conducted overnight with 8 mg of dried roots in 250 µL of methanol and the OD was read at 520 nm (Assimopoulou et al., 2009 ). ...
A mixture of alkannin/shikonin and their derivatives (A/S mixture) was isolated after extraction and further fractionation steps from A. tinctoria roots, as described in Assimopoulou et al. (2008) and ...
Copyright © 2021 Rat, Naranjo, Krigas, Grigoriadou, Maloupa, Alonso, Schneider, Papageorgiou, Assimopoulou, Tsafantakis, Fokialakis and Willems. ...
doi:10.3389/fmicb.2021.633488
pmid:33633713
pmcid:PMC7901983
fatcat:igcxj3kkljfgddxyoj7lv5e5xi
A Review on Xerostomia and Its Various Management Strategies: The Role of Advanced Polymeric Materials in the Treatment Approaches
2022
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The medical term xerostomia refers to the subjective sensation of oral dryness. The etiology seems to be multifactorial with the most frequently reported causes being the use of xerostomic medications, neck and head radiation, and systematic diseases (such as Sjögren's syndrome). Xerostomia is associated with an increased incidence of dental caries, oral fungal infections, and difficulties in speaking and chewing/swallowing, which ultimately affect the oral health-related quality of life. The
doi:10.3390/polym14050850
pmid:35267672
pmcid:PMC8912296
fatcat:c5qusuvufnhgvmzsz642yy3kzm
more »
... velopment of successful management schemes is regarded as a highly challenging project due to the complexity of saliva. This is why, in spite of the fact that there are therapeutic options aiming to improve salivary function, most management approaches are alleviation-oriented. In any case, polymers are an integral part of the various formulations used in every current treatment approach, especially in the saliva substitutes, due to their function as thickening and lubricating agents or, in the case of mucoadhesive polymers, their ability to prolong the treatment effect. In this context, the present review aims to scrutinize the literature and presents an overview of the role of various polymers (or copolymers) on either already commercially available formulations or novel drug delivery systems currently under research and development.
Structure/Antileishmanial Activity Relationship Study of Naphthoquinones and Dependency of the Mode of Action on the Substitution Patterns
2011
Planta Medica
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A portion (42 g) was sequentially partitioned into n-hexane (6.6 g), CH 2 Cl 2 (6 g), EtOAc (9.7 g), n-butanol (13.2 g), and finally H 2 O (7 g). ...
The content of test tubes 20-23 (47 mg) (n-hexane -EtOAc, 97:3 V/V) and 31-33 (12 mg) (n-hexane -EtOAc, 95:5 ) was further purified by HPLC to afford plumbagin (5) (38 mg, Rt 34.6 min) and 3,3'-biplumbagin ...
doi:10.1055/s-0031-1280092
pmid:21800278
fatcat:dblohnh75ng5pioghacqwl6ztu
Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin
2018
Fluids
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Papageorgiou and Andreana N. Assimopoulou had the initial conception of this work; Konstantinos N. Kontogiannopoulos designed the experiments; Stella K. ...
Tsermentseli performed the experiments and acquired the data; Konstantinos N. Kontogiannopoulos analyzed the data, performed the visualization and wrote the original draft; Andreana N. ...
doi:10.3390/fluids3020036
fatcat:m2qdckognjayllndtskfknz5na
Spatial and ecological drivers of population structure in Alkanna tinctoria (Boraginaceae), a polyploid medicinal herb
[article]
2021
bioRxiv
pre-print
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We thank Angela Sessitsch and our partners in MICROMETABOLITE project for obtaining the funding, Eleni Maloupa, Andreana Assimopoulou and Nikolas Fokialakis for provision of plant material used in this ...
CC-BY-NC-ND 4.0 International license
available under a
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doi:10.1101/2021.05.06.442843
fatcat:s43wbfqdfjbh7gjob6icwbiuh4
A Study of Blood Fatty Acids Profile in Hyperlipidemic and Normolipidemic Subjects in Association with Common PNPLA3 and ABCB1 Polymorphisms
2021
Metabolites
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Genotype
Group
p 1
PNPLA3 I148M
Normolipidemics (n)
Hyperlipidemics (n)
CC (II)
7.59 ± 2.463 (21)
9.44 ± 3.374 (26)
0.041
CG (IM)
8.08 ± 2.262 (15)
8.25 ± 1.946 (27)
0.795
GG (MM)
6.70 ...
The hexane extract was dried under a stream of N 2 and the dried residue was reconstituted with 0.5 mL of hexane. ...
doi:10.3390/metabo11020090
pmid:33557317
pmcid:PMC7915980
fatcat:pdyyzyomznhqpmbtfmyqgq4po4
Experimental and Numerical Studies in Biomedical Engineering
2019
Fluids
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Papageorgiou and Andreana N. Assimopoulou had the initial conception of this work; Konstantinos N. Kontogiannopoulos designed the experiments; Stella K. ...
Tsermentseli performed the experiments and acquired the data; Konstantinos N. Kontogiannopoulos analyzed the data, performed the visualization and wrote the original draft; Andreana N. ...
doi:10.3390/fluids4020106
fatcat:d5byyvgg2vgrjktajjjai77mj4
Absolute Viscosity Measurements of High Viscosity Liquids:
2014
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Jiannakoudakis and Assistant Professor Andreana N. Assimopoulou for their
cooperation, special scientific knowledge and advice, during this work. ...
, n-heptane, n-octane, n-decane, n-dode- sane). ...
doi:10.26262/heal.auth.ir.134049
fatcat:rqubwwx5svcwxlhqjx5y6qfbgy