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Structure determination of oligomeric alkannin and shikonin derivatives

Apostolos Spyros, Andreana N. Assimopoulou, Vassilios P. Papageorgiou
2005 Biomedical chromotography  
Peak not observed due to low S/N of quarternary carbons. * , † Peaks with the same symbol may be interchanged. See Schemes 1 and 2 for numbering. Position  ...  ., 2002; Assimopoulou and Papageorgiou, 2004a) in order for the structure of the dimeric A/S to be elucidated. SEC experiments.  ... 
doi:10.1002/bmc.470 pmid:15651092 fatcat:ftr2viubkjeuvkvfu5ob3jofd4

Green Extracts from Coffee Pulp and Their Application in the Development of Innovative Brews

Anastasia Loukri, Petroula Tsitlakidou, Athanasia Goula, Andreana N. Assimopoulou, Konstantinos N. Kontogiannopoulos, Ioannis Mourtzinos
2020 Applied Sciences  
Acknowledgments: Andrena N. Assimopoulou and Konstantinos N.  ... 
doi:10.3390/app10196982 fatcat:gtbdkxbf5zes5pwnmn5k5b4ixe

Spent Coffee Grounds' Valorization towards the Recovery of Caffeine and Chlorogenic Acid: A Response Surface Methodology Approach

Georgia-Christina Mitraka, Konstantinos N. Kontogiannopoulos, Maria Batsioula, George F. Banias, Andreana N. Assimopoulou
2021 Sustainability  
Accelerated Solvent Extraction Solvent n-Hexane EtOH EtOH: H 2 O (50:50 v/v) Solvent vol.  ...  Its absorbance was measured immediately after preparation at 517 n ultraviolet (UV-vis) spectrophotometer.  ... 
doi:10.3390/su13168818 fatcat:5uklzymxanawhcoeeyec7wor6y

Chimeric advanced drug delivery nano systems (chi-aDDnSs) for shikonin combining dendritic and liposomal technology

Konstantinos N. Kontogiannopoulos, Andreana N. Assimopoulou, Sophia Hatziantoniou, Kostas Karatasos, Costas Demetzos, Vassilios P. Papageorgiou
2012 International Journal of Pharmaceutics  
., 2003; Assimopoulou and Papageorgiou, 2004b) , cyclodextrins (Assimopoulou and Papageorgiou, 2004a) , liposomes (Kontogiannopoulos et al., 2011a) and electrospun fiber mats (Kontogiannopoulos et  ...  : chloroform) followed by recrystallization (n-hexane), according to the procedure proposed by Prof.  ... 
doi:10.1016/j.ijpharm.2011.09.031 pmid:21979251 fatcat:wkijwtnwn5bgtjfyznmdi47nza

Novel electrospun poly-hydroxybutyrate scaffolds as carriers for the wound healing agents alkannins and shikonins

Athanasios S Arampatzis, Konstantina Giannakoula, Konstantinos N Kontogiannopoulos, Konstantinos Theodoridis, Eleni Aggelidou, Angélique Rat, Elli Kampasakali, Anne Willems, Dimitrios Christofilos, Aristeidis Kritis, Vassilios P Papageorgiou, Ioannis Tsivintzelis (+1 others)
2021 Regenerative Biomaterials  
N, N-dimethylformamide (DMF) and diethyl ether were obtained from Honeywell (Charlotte, NC).  ...  The n parameter varies, non-systematically, between 0.44 and 0.51.  ... 
doi:10.1093/rb/rbab011 fatcat:sal6yoye2nb6dcloytnnzioi34

Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells

Qiaoli Zhao, Andreana N. Assimopoulou, Sabine M. Klauck, Harilaos Damianakos, Ioanna Chinou, Nadine Kretschmer, José-Luis Rios, Vassilios P. Papageorgiou, Rudolf Bauer, Thomas Efferth
2015 OncoTarget  
Data are represented as mean values ± SEM of three independent experiments (n = 3). a , p < 0.01 vs. control; b , p < 0.05 vs. control, calculated by two-tailed Student's t test.  ...  Data are represented as mean values ± SEM of three independent experiments (n = 3). a , p < 0.01 vs. control; b , p < 0.05 vs. control, calculated by two-tailed Student's t test. B.  ... 
doi:10.18632/oncotarget.5380 pmid:26472107 pmcid:PMC4770748 fatcat:e6t2ngxtevetxkuuqgugukmm54

Endophytic Bacteria From the Roots of the Medicinal Plant Alkanna tinctoria Tausch (Boraginaceae): Exploration of Plant Growth Promoting Properties and Potential Role in the Production of Plant Secondary Metabolites

Angélique Rat, Henry D. Naranjo, Nikos Krigas, Katerina Grigoriadou, Eleni Maloupa, Alicia Varela Alonso, Carolin Schneider, Vassilios P. Papageorgiou, Andreana N. Assimopoulou, Nikolaos Tsafantakis, Nikolas Fokialakis, Anne Willems
2021 Frontiers in Microbiology  
The extraction of A/S was conducted overnight with 8 mg of dried roots in 250 µL of methanol and the OD was read at 520 nm (Assimopoulou et al., 2009 ).  ...  A mixture of alkannin/shikonin and their derivatives (A/S mixture) was isolated after extraction and further fractionation steps from A. tinctoria roots, as described in Assimopoulou et al. (2008) and  ...  Copyright © 2021 Rat, Naranjo, Krigas, Grigoriadou, Maloupa, Alonso, Schneider, Papageorgiou, Assimopoulou, Tsafantakis, Fokialakis and Willems.  ... 
doi:10.3389/fmicb.2021.633488 pmid:33633713 pmcid:PMC7901983 fatcat:igcxj3kkljfgddxyoj7lv5e5xi

A Review on Xerostomia and Its Various Management Strategies: The Role of Advanced Polymeric Materials in the Treatment Approaches

Afroditi Kapourani, Konstantinos N Kontogiannopoulos, Alexandra-Eleftheria Manioudaki, Athanasios K Poulopoulos, Lazaros Tsalikis, Andreana N Assimopoulou, Panagiotis Barmpalexis
2022
The medical term xerostomia refers to the subjective sensation of oral dryness. The etiology seems to be multifactorial with the most frequently reported causes being the use of xerostomic medications, neck and head radiation, and systematic diseases (such as Sjögren's syndrome). Xerostomia is associated with an increased incidence of dental caries, oral fungal infections, and difficulties in speaking and chewing/swallowing, which ultimately affect the oral health-related quality of life. The
more » ... velopment of successful management schemes is regarded as a highly challenging project due to the complexity of saliva. This is why, in spite of the fact that there are therapeutic options aiming to improve salivary function, most management approaches are alleviation-oriented. In any case, polymers are an integral part of the various formulations used in every current treatment approach, especially in the saliva substitutes, due to their function as thickening and lubricating agents or, in the case of mucoadhesive polymers, their ability to prolong the treatment effect. In this context, the present review aims to scrutinize the literature and presents an overview of the role of various polymers (or copolymers) on either already commercially available formulations or novel drug delivery systems currently under research and development.
doi:10.3390/polym14050850 pmid:35267672 pmcid:PMC8912296 fatcat:c5qusuvufnhgvmzsz642yy3kzm

Structure/Antileishmanial Activity Relationship Study of Naphthoquinones and Dependency of the Mode of Action on the Substitution Patterns

Ahmad Ali, Andreana Assimopoulou, Vassilios Papageorgiou, Herbert Kolodziej
2011 Planta Medica  
A portion (42 g) was sequentially partitioned into n-hexane (6.6 g), CH 2 Cl 2 (6 g), EtOAc (9.7 g), n-butanol (13.2 g), and finally H 2 O (7 g).  ...  The content of test tubes 20-23 (47 mg) (n-hexane -EtOAc, 97:3 V/V) and 31-33 (12 mg) (n-hexane -EtOAc, 95:5 ) was further purified by HPLC to afford plumbagin (5) (38 mg, Rt 34.6 min) and 3,3'-biplumbagin  ... 
doi:10.1055/s-0031-1280092 pmid:21800278 fatcat:dblohnh75ng5pioghacqwl6ztu

Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin

Stella Tsermentseli, Konstantinos Kontogiannopoulos, Vassilios Papageorgiou, Andreana Assimopoulou
2018 Fluids  
Papageorgiou and Andreana N. Assimopoulou had the initial conception of this work; Konstantinos N. Kontogiannopoulos designed the experiments; Stella K.  ...  Tsermentseli performed the experiments and acquired the data; Konstantinos N. Kontogiannopoulos analyzed the data, performed the visualization and wrote the original draft; Andreana N.  ... 
doi:10.3390/fluids3020036 fatcat:m2qdckognjayllndtskfknz5na

Spatial and ecological drivers of population structure in Alkanna tinctoria (Boraginaceae), a polyploid medicinal herb [article]

Muhammad Ahmad, Thibault Leroy, Nikos Krigas, Eva M. Temsch, Hanna Weiss-Schneeweiss, Christian Lexer, Eva Maria Sehr, Ovidiu Paun
2021 bioRxiv   pre-print
We thank Angela Sessitsch and our partners in MICROMETABOLITE project for obtaining the funding, Eleni Maloupa, Andreana Assimopoulou and Nikolas Fokialakis for provision of plant material used in this  ...  CC-BY-NC-ND 4.0 International license available under a 643 644 645 646 647 648 649 650 651 B e r l i n : 895 B o t a n i c G a r d e n a n d B o t a n i  ... 
doi:10.1101/2021.05.06.442843 fatcat:s43wbfqdfjbh7gjob6icwbiuh4

A Study of Blood Fatty Acids Profile in Hyperlipidemic and Normolipidemic Subjects in Association with Common PNPLA3 and ABCB1 Polymorphisms

Thomai Mouskeftara, Antonis Goulas, Despoina Ioannidou, Charikleia Ntenti, Dimitris Agapakis, Andreana Assimopoulou, Helen Gika
2021 Metabolites  
Genotype Group p 1 PNPLA3 I148M Normolipidemics (n) Hyperlipidemics (n) CC (II) 7.59 ± 2.463 (21) 9.44 ± 3.374 (26) 0.041 CG (IM) 8.08 ± 2.262 (15) 8.25 ± 1.946 (27) 0.795 GG (MM) 6.70  ...  The hexane extract was dried under a stream of N 2 and the dried residue was reconstituted with 0.5 mL of hexane.  ... 
doi:10.3390/metabo11020090 pmid:33557317 pmcid:PMC7915980 fatcat:pdyyzyomznhqpmbtfmyqgq4po4

Experimental and Numerical Studies in Biomedical Engineering

Spiros V. Paras, Athanasios G. Kanaris
2019 Fluids  
Papageorgiou and Andreana N. Assimopoulou had the initial conception of this work; Konstantinos N. Kontogiannopoulos designed the experiments; Stella K.  ...  Tsermentseli performed the experiments and acquired the data; Konstantinos N. Kontogiannopoulos analyzed the data, performed the visualization and wrote the original draft; Andreana N.  ... 
doi:10.3390/fluids4020106 fatcat:d5byyvgg2vgrjktajjjai77mj4

Absolute Viscosity Measurements of High Viscosity Liquids:

Σοφία Κ. Μυλωνά
2014
Jiannakoudakis and Assistant Professor Andreana N. Assimopoulou for their cooperation, special scientific knowledge and advice, during this work.  ...  , n-heptane, n-octane, n-decane, n-dode- sane).  ... 
doi:10.26262/heal.auth.ir.134049 fatcat:rqubwwx5svcwxlhqjx5y6qfbgy