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Anatomy of enzyme channels

Lukáš Pravda, Karel Berka, Radka Svobodová Vařeková, David Sehnal, Pavel Banáš, Roman A Laskowski, Jaroslav Koča, Michal Otyepka
2014 BMC Bioinformatics  
Conclusions: The majority of enzymes have buried active sites accessible via a network of access channels.  ...  We find that over 64% of enzymes contain two or more long channels, their typical length being 28 Å.  ...  Table 1 1 Number of enzyme entries in each EC class, and numbers of channels of different lengths EC Enzyme class Number of enzymes Enzymes with channels of length ≥ 5 Å ≥10 Å ≥ 15 Å ≥ 20 Å EC1  ... 
doi:10.1186/s12859-014-0379-x pmid:25403510 pmcid:PMC4245731 fatcat:7m2avekmengythpacvbwkao2s4

Bile Duct Drainage Using a Short Double-Balloon Endoscope for a Hematoma due to Hepatocellular Carcinoma After Roux-en-Y Reconstruction

Yoshie Kondo, Satoshi Shinozaki, Hisashi Hatanaka, Tomonori Yano, Shunji Watanabe, Kiichi Tamada, Alan Kawarai Lefor, Hironori Yamamoto
2015 Journal of Gastroenterology and Hepatology Research  
Double-balloon ERCP enabled biliary drainage in a patient with surgically altered anatomy and cirrhosis, and provided effective relief of symptoms. CASE REPORT  ...  A short double-balloon endoscope with a 2.8 mm working channel enabled metal stent placement.  ...  [4] Third, the use of a short double-balloon endoscope with a wide working channel enables metal stent placement despite surgically altered anatomy.  ... 
doi:10.17554/j.issn.2224-3992.2015.04.567 fatcat:3gnutqrtyvb4vbwxe5sbmpxjvq

Proof of C4 photosynthesis without Kranz anatomy in Bienertia cycloptera (Chenopodiaceae)

Elena V. Voznesenskaya, Vincent R. Franceschi, Olavi Kiirats, Elena G. Artyusheva, Helmut Freitag, Gerald E. Edwards
2002 The Plant Journal  
Our results show Bienertia utilizes strict compartmentation of organelles and enzymes within a single cell to effectively mimic the spatial separation of Kranz anatomy, allowing it to function as a C 4  ...  Kranz anatomy, with its separation of elements of the C 4 pathway between two cells, has been an accepted criterion for function of C 4 photosynthesis in terrestrial plants.  ...  We also thank the Electron Microscope Center of Washington State University for use of their facilities and staff assistance.  ... 
doi:10.1046/j.1365-313x.2002.01385.x pmid:12207654 fatcat:nuzoa4iuczewxlmc4uglgn6bpu

Benign biliary strictures treated with biodegradable stents in patients with surgically altered anatomy using double balloon enteroscopy

Outi Lindström, Marianne Udd, Mia Rainio, Hannu Nuutinen, Kalle Jokelainen, Leena Kylänpää
2020 Scandinavian Journal of Gastroenterology  
Surgically altered anatomy complicates endoscopical procedures of pancreatobiliary tree.  ...  The biodegradable stent, which can be passed through working channel of a long enteroscope, seems promising in the treatment of these strictures. The benefit is that no stent removal is needed.  ...  The Archimedes stents were easily deployed through the long working channel (200 cm) of DBE. However, use of currently available ERCP devices is limited because of the long working channel.  ... 
doi:10.1080/00365521.2020.1806351 pmid:32794409 fatcat:6mkfglrlxnhjdp6exsqqdewgbe

C4 photosynthesis in terrestrial plants does not require Kranz anatomy

Rowan F Sage
2002 Trends in Plant Science  
Acknowledgements I am grateful for the assistance of Gerry Edwards and Helmut Freitag who provided advanced information about their work on Bienertia and valuable discussions regarding the biology of single-cell  ...  Interestingly, B. aralocaspica had low activities of decarboxylating enzymes. The total activity of NAD-malic enzyme was 25% of that observed in S. laricina [4] .  ...  Superficially, B. aralocaspica exhibits an internal anatomy resembling the salsoloid type of Kranz anatomy common in the Salsoloideae.  ... 
doi:10.1016/s1360-1385(02)02293-8 pmid:12119158 fatcat:cgzy5ght3rfgncj3c6hcc2ddfe

Pancreaticobiliary Ductal Anatomy in the Normal Population

Jakrapan Jirasiritham, Chumpon Wilasrusmee, Napaphat Poprom, Noppadol Larbcharoensub
2016 Asian Pacific Journal of Cancer Prevention  
The common channel was found in 75.60% and its length varied from just a common junction (so-called "V-type" anatomy) to 15 mm (Y-type-b).  ...  The complex anatomy of the pancreaticobiliary duct was crucial in management of pancreatic and biliary tract disease.  ...  Discussion In this study, length of the pancreas, the location of the pancreatic ducts in relation to the surface of the pancreas, the length and types of the common channels, as well as the anatomy of  ... 
pmid:27797245 fatcat:df6ptvbrzzcxrmzp7snzjmanka

Electrohydraulic lithotripsy for hepatolithiasis in a stenotic intrahepatic bile duct after Roux-en-Y hepaticojejunostomy

Kenji Nakamura, Takeshi Okamoto, Tadashi Katayama, Yutaka Takigawa, Katsuyuki Fukuda, Hiroshi Kishikawa, Jiro Nishida
2021 Endoscopy  
The authors declare that they have no conflict of interest.  ...  through a colonoscope with a large working channel.  ...  We therefore inserted a cholangioscope through the channel of the colonoscope, which revealed intrahepatic biliary stenosis in addition to multiple stones (▶ Fig. 3) .  ... 
doi:10.1055/a-1381-6152 pmid:33682898 fatcat:7enun4m64nh6hewuehcjubwbei

Association of an Abnormal Pancreaticobiliary Junction with Biliary Tract Cancers

Nick E. Roukounakis, Joseph A. Kuhn, Todd M. McCarty
2000 Baylor University Medical Center Proceedings  
(a) Normal anatomy with a short common channel (arrow) and biliopancreatic junction within the duodenal wall.  ...  A variety of associated conditions have been shown to increase the incidence of malignancy. The underlying mechanism has been attributed to stasis, pancreatic enzymes, and bacteria.  ... 
doi:10.1080/08998280.2000.11927636 pmid:16389319 pmcid:PMC1312207 fatcat:i2uehhaicjexjnhymif2uhqn5m

Effects of shea oil on the histology and enzymes of the liver

Madu Nom Gadzama
2018 Anatomy journal of Africa  
The study was carried out to investigate the effect of Shea oil on the histology and enzymes of liver of Albino Wistar rats.  ...  Further investigations should be carried out.Keywords: Vitellaria Paradoxa, Enzymes and Liver  ...  Effects of Shea oll on enzymes and histology of the liver. Anatomy Journal of Africa. 7 (2): 1309 -1313.  ... 
doi:10.4314/aja.v7i2.177642 fatcat:np55cex75fchld23gj4oxdx5cy

Page 155 of Biological Reviews Vol. 79, Issue 2 [page]

2004 Biological Reviews  
American Journal of Anatomy 174, 949-968.  ...  A perspective on the control of mammalian ferti- lization by egg-activated ion channels in sperm: a tale of two channels. Biology of Reproduction 59, 12-16. Foster, J. A., Fripay, B. B., Mauurr, M.  ... 

DDESC: Dragon database for exploration of sodium channels in human

Sunil Sagar, Mandeep Kaur, Adam Dawe, Sundararajan Seshadri, Alan Christoffels, Ulf Schaefer, Aleksandar Radovanovic, Vladimir B Bajic
2008 BMC Genomics  
and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links.  ...  Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels.  ...  ", "disease concepts" and "human anatomy".  ... 
doi:10.1186/1471-2164-9-622 pmid:19099596 pmcid:PMC2631582 fatcat:ch4vigfp2bay3kjaguowpciqlm

Antiseizure Medications in Gastric Bypass and Other Post-Surgical Malabsorptive States

Caitlin S. Brown, Alejandro A. Rabinstein, Erin M. Nystrom, Jeffrey W. Britton, Tarun D. Singh
2021 Epilepsy & Behavior Reports  
valproic acid have reduced absorption due to effects of bariatric surgery based on the pharmacokinetic properties of these medications.  ...  of the ASMs throughout the pre-surgical and post-surgical periods.  ...  in three intestinal limbs or channels.  ... 
doi:10.1016/j.ebr.2021.100439 pmid:33997757 pmcid:PMC8093413 fatcat:6veyjcdodrfzvouuzexyeq43hm

Elevated plasma pancreatic enzyme concentrations after Roux-en-Y gastric bypass may indicate closed loop obstruction

K Arapis, P Tammaro, G Goujon, H Becheur, P Augustin, JP Marmuse
2017 Annals of the Royal College of Surgeons of England  
Laparoscopic Roux-en-Y gastric bypass is one of the most commonly performed bariatric procedures and most patients are women of reproductive age.  ...  Consequently, general surgeons and obstetricians need to be aware that these patients are at risk of bariatric specific surgical complications during their pregnancy.  ...  Intussusception of the proximal common channel. Reduction.  ... 
doi:10.1308/rcsann.2016.0334 pmid:27791421 pmcid:PMC5392841 fatcat:qvnn5uzdajbyrk5ruu47euqxk4

Roux-en-Y gastric bypass alters small intestine glutamine transport in the obese Zucker rat

Brynn S. Wolff, Katia Meirelles, Qinghe Meng, Ming Pan, Robert N. Cooney
2009 American Journal of Physiology - Gastrointestinal and Liver Physiology  
The metabolic effects of Roux-en-Y gastric bypass (RYGB) are caused by postsurgical changes in gastrointestinal anatomy affecting gut function.  ...  the common channel (Fig. 1) .  ...  This work was supported in part by National Institute of Health Grants DK062165 (to M. Pan).  ... 
doi:10.1152/ajpgi.00104.2009 pmid:19556357 pmcid:PMC2739821 fatcat:bx2wpl624bdzri3aps6vu5taqq

Page 169 of Biological Reviews Vol. 77, Issue 4 [page]

2002 Biological Reviews  
the ingested mic robiota were not killed by the digestive enzymes of Philoscia muscorum (see section ITT.1). in part due to the tvphlosole channels directing the endogenous enzymes to the papillate region  ...  Digestive enzymes are produced in the hepatopancreas, and are secreted into the proventricular chamber of the foregut and the typhlosole channels to be mixed with the food Hassall & Jennings, 1975: Lane  ... 
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