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Analyzing the Spatiotemporal Interaction and Propagation of ATN Biomarkers in Alzheimer's Disease using Longitudinal Neuroimaging Data [article]

Qing Liu, Defu Yang, Jingwen Zhang, Ziming Wei, Guorong Wu, Minghan Chen
2021 arXiv   pre-print
To this end, we aim to analyze the spatiotemporal associations between ATN biomarkers using large-scale neuroimaging data.  ...  Second, we propose linear mixed-effects models to quantify the pathological interactions and propagation of ATN biomarkers at each brain region.  ...  CONCLUSION In this paper, we studied the spatiotemporal interaction and propagation of ATN biomarkers using large-scale neuroimaging data from the ADNI database.  ... 
arXiv:2103.04376v1 fatcat:pam6y4cwsrgtphya4winzzasy4

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease

Dallas P. Veitch, Michael W. Weiner, Paul S. Aisen, Laurel A. Beckett, Charles DeCarli, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Susan M. Landau, John C. Morris, Ozioma Okonkwo (+9 others)
2021 Alzheimer's & Dementia  
The Alzheimer's Disease Neuroimaging Initiative (ADNI) has accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic data, and biofluid samples available to researchers,  ...  We identified 1442 publications using ADNI data by conventional search methods and selected impactful studies for inclusion.  ...  INTRODUCTION Currently in its 17th year and fourth phase, Alzheimer's Disease Neuroimaging Initiative (ADNI) 1, 2 continues in its quest to increase understanding of Alzheimer's disease (AD) pathology  ... 
doi:10.1002/alz.12422 pmid:34581485 pmcid:PMC9158456 fatcat:e5viicxp6nb2ndwwnxuy3k76cy

Poster Viewing Session III

2017 Journal of Cerebral Blood Flow and Metabolism  
of this work is to use the NIRS cerebral oxygenation data (HbD ¼ oxyhaemoglobin-deoxyhaemoglobin) combined with arterial saturation (SpO 2 ) recorded using a pulse oximeter to calculate cerebral blood  ...  The role of autophagy in adult cerebral ischemia has been studied, yet the specific role for the targeted destruction of damaged peroxisomes (pexophagy) in ischemic stroke Abstract ICAS is a disease state  ...  Acknowledgement: This research has been funded by Acknowledgements: T.Hollyer is grateful the financial and technical support for this project from SINAPSE, ReNeuron, and The University of Glasgow  ... 
doi:10.1177/0271678x17695987 pmid:28366135 pmcid:PMC5441165 fatcat:m4mfdovmpzasbh5brx26kp4ho4


2010 Epilepsia  
Purpose: To explore the causative role of PCDH19 gene, located at Xq22, in females with epilepsy.  ...  Results: We included 10 patients (8 boys) aged 2.1-7.8 (median 3.7) years at the time when LTG was started in comedication. The onset of MAE had been at 1.5-4.3 (median 2.6) years.  ...  Using electronic documentation with Epivista Ò follow up is ongoing in all patients. Acknowledgments: supported by: Italian Ministry of Health, Fondazi-  ... 
doi:10.1111/j.1528-1167.2010.02658.x pmid:20590792 fatcat:ylmo7rjtqncydkxeudaib77noy

Abstract: Symposia, Conferences, Oral communications: 14th Clinical Trials on Alzheimer's Disease (CTAD) November 9-12, 2021

This presentation will provide background related to the biology and assay methodology for biomarker measurement as well as recent examples of their use in clinical trials.  ...  Alzheimer's disease is characterized by two core pathologies, amyloid plaques and tau neurofibrillary tangles.  ...  Funding: This project was completed in partnership with the Alzheimer's Clinical Trial Consortium (ACTC) and the Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD  ... 
doi:10.14283/jpad.2021.57 pmid:34773455 pmcid:PMC8589633 fatcat:rr2dy6mzxjfa3auv3npl2gixry


2019 Stereotactic and Functional Neurosurgery  
The purpose of this study is to evaluate the safety of the MR guided focused ultrasound (MRgFUS) using ExAblate ® Model 4000 Type 2.0 used as a tool to disrupt the blood brain barrier (BBBD) in patients  ...  Methods: This is a prospective, single-arm study to establish the safety and feasibility of BBBD along the periphery of tumor resection cavity using the MRgFUS.  ...  in Alzheimer's disease (AD) pathology.  ... 
doi:10.1159/000501568 fatcat:pv2k5hzuindpdmffhvqlkl25ji

Poster Session

2020 Rinsho Shinkeigaku  
in the brains of Alzheimer's disease (AD) .  ...  All the data have been analyzed through various statistical methods to get proper correlation of Alzheimer's disease with acetylcholine level, oxidative stress, and inflammation.  ...  To reveal the pathophysiology and to develop the disease modifying therapy of PD, establishment of biomarkers in the prodromal stage is an urgent need.  ... 
doi:10.5692/clinicalneurol.60_supplement_s371 pmid:33177302 fatcat:mgiqss6lx5crlpxpn2i7haeuiq