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Molecular mechanism of aggregation‐induced emission

Qian Peng, Zhigang Shuai
2021 Aggregate  
or minimum energy crossing point (RNR-MECP) beyond harmonic region in a variety of AIE aggregates.  ...  Our theoretical work not only justifies a plethora of experimental results but also makes reliable predictions on molecular design and mechanism that can be experimentally verified.  ...  Different from DSB, the emission spectrum of HPS is a broad band without fine structure owing to the participation of a large number of vibration states, namely 2-8, 2-9, and 2-10 transitions of the 2nd  ... 
doi:10.1002/agt2.91 fatcat:g3idcbnw2zbozoxjdijjv3uhem

DNA methylation in states of cell physiology and pathology

Anetta Sulewska, Wieslawa Niklinska, Miroslaw Kozlowski, Lukasz Minarowski, Wojciech Naumnik, Jacek Niklinski, Katarzyna Dabrowska, Lech Chyczewski
2007 Folia Histochemica et Cytobiologica  
Such methylation has been observed in non-small cell lung cancer, in three regions of the exon 5 of the p53 gene (so-called "non-CpG" methylation).  ...  The changes in the methylation pattern, which may appear as the organism age and in early stages of cancerogenesis, may lead to the silencing of over ninety endogenic genes.  ...  Krzysztof Bielawski for substantial assessment of the manuscript.  ... 
pmid:17951162 fatcat:xq3b75qplfc4tnz6e6lhgbxe4y

In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment

Muhamad Fahmi, Gen Yasui, Kaito Seki, Syouichi Katayama, Takako Kaneko-Kawano, Tetsuya Inazu, Yukihiko Kubota, Masahiro Ito
2019 International Journal of Molecular Sciences  
Rett syndrome (RTT), a neurodevelopmental disorder, is mainly caused by mutations in methyl CpG-binding protein 2 (MECP2), which has multiple functions such as binding to methylated DNA or interacting  ...  We also predicted the structural order–disorder propensity and assessed the evolutionary rates per site of MeCP2, CDKL5, and FOXG1 to investigate the relationships between disordered structure and other  ...  Conflicts of Interest: The authors declare no competing interest.  ... 
doi:10.3390/ijms20225593 pmid:31717404 pmcid:PMC6888432 fatcat:oo7uqwug5ndg7aptzykhpmmj64

Abstracts of papers presented at the fourth Mammalian Genetics and Development Workshop held at the Wellcome Trust Building, Euston Road, London on 1–3 November 1993

1994 Genetics Research  
Many hypotheses imply nondisjunction of whole bivalents at meiosis I but analysis of 140 reject oocytes at second meiotic metaphase from women undergoing in-vitro fertilization treatment for their infertility  ...  Less common were abnormalities with one single chromatid extra (23 + 1/2), or missing (22 +1 /2).  ...  These mutations provide tools for studying the structure and function of the gene involved.  ... 
doi:10.1017/s0016672300032250 fatcat:iu5sztnaa5gkvcgnwmaisaiwjm

Investigation of Organic Bulk Heterojunction Solar Cells from Optical Aspect [chapter]

Chunfu Zhang, Yue Hao, Dazheng Chen, Zhizhe Wang, Zhenhua Li
2013 Solar Cells - Research and Application Perspectives  
Author details Maria Puiu , * , Simona Dumitriu , , "dela Chiriță-Emandi , , Raluca Grădinaru and Smaranda "rghirescu , *"ddress all correspondence to University of Medicine and Pharmacy  ...  . -% of all known and predicted genes. The majority of known mutations in X-linked genes are loss-of-function mutations.  ...  Rett syndrome Was described as a form of nonsyndromal XLMR. Mutation in gene MECP maps on chromosome Xq .Rett syndrome it is frequently due to the deletion or insertion mutation in MECP gene.  ... 
doi:10.5772/52819 fatcat:e75kz7hqjzfh5nmy4arryx2nnq

2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions

Rafał Szabla, Magdalena Zdrowowicz, Paulina Spisz, Nicholas J Green, Petr Stadlbauer, Holger Kruse, Jiří Šponer, Janusz Rak
2021 Nature Communications  
This substantial self-repairing activity originates from excellent electron donating properties of 2,6-diaminopurine in nucleic acid strands.  ...  Considering that 2,6-diaminopurine was previously shown to increase the rate of nonenzymatic RNA replication, this nucleobase could have played critical roles in the formation of functional and photostable  ...  .), the project SYMBIT (reg. number: CZ.02.1.01/0.0/0.0/15_003/0000477 to J.S. and H.K.) financed by the ERDF and a grant from the Ministry of Science and Higher Education in Poland (DS/531-T080-D494-20  ... 
doi:10.1038/s41467-021-23300-y pmid:34021158 pmcid:PMC8139960 fatcat:ap2p2oax7ndfvo2vk6l2dis2mu

Silencing of CD44 Expression in Prostate Cancer by Hypermethylation of the CD44 Promoter Region

Nicole S Verkaik, Gert J van Steenbrugge, Wytske M van Weerden, Marion J Bussemakers, Theodorus H van der Kwast
2000 Laboratory Investigation  
Similarly, in 6 out of 12 in vivo-growing human prostate carcinoma xenograft models, hypermethylation of the CD44 gene was found.  ...  In the xenografts lacking hypermethylation of the CD44 gene, high levels of CD44 mRNA and protein were expressed in some models, whereas in others CD44 mRNA expression was only detectable by RT-PCR and  ...  Instead of a direct effect, it is likely that CD44 expression is suppressed by the indirect effect of the chromatin structure changes mediated by binding of MeCPs close to the Sp1.  ... 
doi:10.1038/labinvest.3780137 pmid:10950120 fatcat:6irm7tt4wnc2dejmx5h5kgri74

Exploring the Landscape of the Genome [chapter]

Michael R. Barnes
2010 Msphere  
Genome analysis can be carried out at different levels of detail -at a macro level; it improves understanding of issues like genome structure and species evolution.  ...  The comprehensive range of information presented in tools such as the UCSC genome browser and Ensembl enables integrated queries of data that are otherwise reserved to the most skilled computational biologists  ...  For more sophisticated analysis of large datasets on a genomic scale, see (3) . A list of genomic tools and databases mentioned and used in this review is given in Table 1 .  ... 
doi:10.1007/978-1-60327-367-1_2 pmid:20238074 fatcat:d37ygpseorcgnjfhsvtvbv4tey

Spine Morphology and Plasticity in X-linked Mental Retardations

Jyothi Arikkath
2009 Open Neuroscience Journal  
In this review we discuss aberrations in spine and synapse structure and function in X-linked human mental retardations and corresponding mouse models with mutations in genes that modulate synaptic structure  ...  An emerging idea is that structural and functional abnormalities in spines and synapses are a common feature of mental retardations.  ...  Gerard Beaudoin for the EM image of the synapse in Fig. (1) .  ... 
doi:10.2174/1874082000903020134 fatcat:huuteapxyjhnjcidkdqr3rl3vm

Spine Morphology and Plasticity in X-linked Mental Retardations

Jyothi Arikkath
2014 Open Neuroscience Journal  
In this review we discuss aberrations in spine and synapse structure and function in X-linked human mental retardations and corresponding mouse models with mutations in genes that modulate synaptic structure  ...  An emerging idea is that structural and functional abnormalities in spines and synapses are a common feature of mental retardations.  ...  Gerard Beaudoin for the EM image of the synapse in Fig. (1) .  ... 
doi:10.2174/1874082000903010134 fatcat:dakqglcy5raqfmxnf3oyumsdoi

Genetic basis for natural variation in seed vitamin E levels in Arabidopsis thaliana

L. U. Gilliland, M. Magallanes-Lundback, C. Hemming, A. Supplee, M. Koornneef, L. Bentsink, D. DellaPenna
2006 Proceedings of the National Academy of Sciences of the United States of America  
Understanding the basis of the QVE loci in Arabidopsis promises to provide insight into the regulation and͞or metabolism of vitamin E in plants and has clear ramifications for improving the nutritional  ...  As a complement to such approaches we have used quantitative trait loci analysis with two sets of Arabidopsis thaliana recombinant inbred lines and have identified 14 QVE (quantitative vitamin E) loci  ...  Agency for International Development, HarvestPlus, and the Grand Challenges in Global Health initiative.  ... 
doi:10.1073/pnas.0606221103 pmid:17077148 pmcid:PMC1693748 fatcat:qtf5q27co5huzlchrjtwg4pzzi

MECP2 variation in Rett syndrome-An overview of current coverage of genetic and phenotype data within existing databases

Gillian S. Townend, Friederike Ehrhart, Henk J. van Kranen, Mark Wilkinson, Annika Jacobsen, Marco Roos, Egon L. Willighagen, David van Enckevort, Chris T. Evelo, Leopold M. G. Curfs
2018 Human Mutation  
gene analysis.  ...  et al., 2014) , without specific reference being made (e.g., to RTT and/or MECP) in the title or abstract of an article.  ... 
doi:10.1002/humu.23542 pmid:29704307 pmcid:PMC6033003 fatcat:zv56lxpeezbb7noynqjt7bqzme

Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology

Adebola Enikanolaiye, Julie Ruston, Rong Zeng, Christine Taylor, Marijke Schrock, Christie M. Buchovecky, Jay Shendure, Elif Acar, Monica J. Justice
2020 Genome Research  
Mutations in X-linked methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome (RTT).  ...  Association analysis was successful in resolving combinatorial effects of multiple loci.  ...  Acknowledgments The Centre for Applied Genomics (TCAG) generated sequence for founder animals from screen 2 and was crucial in analyzing the sequence.  ... 
doi:10.1101/gr.258400.119 pmid:32317254 pmcid:PMC7197480 fatcat:luyapseiijczdodoqyzwvoauki

DNA Repair in Drosophila : Mutagens, Models, and Missing Genes

Jeff Sekelsky
2017 Genetics  
Numerous methods have been developed to take advantage of Drosophila genetic tools to elucidate repair processes in whole animals, organs, tissues, and cells.  ...  Indeed, the first ideas about chromosome and gene repair grew out of Drosophila research on the properties of mutations produced by ionizing radiation and mustard gas.  ...  Table 2 2 Glycosylases in humans and Drosophila The largest predicted isoform of human TDG is 452 residues, but it is larger in insects-four times as large in Schizophora.  ... 
doi:10.1534/genetics.116.186759 pmid:28154196 pmcid:PMC5289830 fatcat:z27oomykkja5jbf7da6pfg5yoa

Targeting the Methyl Erythritol Phosphate (MEP) Pathway for Novel Antimalarial, Antibacterial and Herbicidal Drug Discovery: Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase (DXR) Enzyme

Nidhi Singh, Gweneal Cheve, Mitchell Avery, Christopher McCurdy
2007 Current pharmaceutical design  
This review summarizes the recent and promising developments with respect to the current knowledge of the MEP pathway with emphasis on the understanding of the structure and the catalytic mechanism of  ...  First, it is a vital enzyme for synthesis of isoprenoids in algae, plants, several eubacteria including the pathogenic bacteria like Bacillus anthracis, Helicobacter pylori, Yersinia pestis, Mycobacterium  ...  The analysis of the crystal structures of DXR from E. coli [81, 82] provides additional support to the above statement.  ... 
doi:10.2174/138161207780618939 pmid:17430177 fatcat:6gregx3labecvnzlqfgqvp3rri
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