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Economic Evaluation of a Universal Childhood Pneumococcal Conjugate Vaccination Strategy in Ireland

Lesley Tilson, Cara Usher, Karina Butler, John Fitzsimons, Fiona O'Hare, Suzanne Cotter, Darina O'Flanagan, Howard Johnson, Michael Barry
2008 Value in Health  
of the herd immunity effect.  ...  In a separate submodel, the effect of herd immunity was investigated.  ...  [7] , using administrative data, have provided further evidence of the herd immunity effect from routine pneumococcal vaccination of children and infants, where a reduction in hospitalized [11] Reduction  ... 
doi:10.1111/j.1524-4733.2008.00341.x pmid:18489504 fatcat:4ilf4ktd4fanteqytxqx44kcga

Impact of vaccination on the COVID-19 pandemic: Evidence from U.S. states [article]

Xiao Chen, Hanwei Huang, Jiandong Ju, Ruoyan Sun, Jialiang Zhang
2021 medRxiv   pre-print
In this study, we evaluated the effectiveness of the COVID-19 vaccination program and predicted the path to herd immunity in the U.S.  ...  Using data from 12 October 2020 to 7 March 2021, we estimated that vaccination reduced the total number of new cases by 4.4 million (from 33.0 to 28.6 million), prevented approximately 0.12 million hospitalizations  ...  Warner and S. Mennemeyer for their feedback. Funding: H.H. is supported by the startup grant from the City University of Hong Kong (grant no. 7200689).  ... 
doi:10.1101/2021.05.08.21256892 fatcat:r2u2qcri6bcqdhbyl355vxrgh4

A review of economic evaluations of 13-valent pneumococcal conjugate vaccine (PCV13) in adults and the elderly

S Dirmesropian, JG Wood, CR MacIntyre, AT Newall
2015 Human Vaccines & Immunotherapeutics  
Key uncertainties included the efficacy of PCV13 against non-invasive pneumonia and the herd immunity effect of childhood vaccination programs.  ...  The 13-valent pneumococcal conjugated vaccine (PCV13) is already recommended for some adult groups and is being considered for wider use in many countries.  ...  against IPD and NPP, the effectiveness of PPV23 used to estimate the "no vaccination" baseline and the assumed herd immunity of PCV13 immunization in infants.  ... 
doi:10.1080/21645515.2015.1011954 pmid:25933180 pmcid:PMC4514194 fatcat:2ild3hgs25c4thadcmnys4hl7a

Streamlined Analysis for Evaluating the Use of Preharvest Interventions Intended to Prevent Escherichia coli O157:H7 Illness in Humans

James Withee, Michael Williams, Terry Disney, Wayne Schlosser, Nate Bauer, Eric Ebel
2009 Foodborne pathogens and disease  
The production functions are then used for marginal economic analysis to assess the cost=benefit ratio of using the vaccine to prevent foodborne illness.  ...  A combination of quantitative risk assessment methods and marginal economic analysis are used to describe the maximum cost per unit that would still allow the vaccine to be a cost-effective intervention  ...  If decision makers were to consider the use of a real vaccine, the efficacy, required coverage for herd immunity, and cost per vaccinated animal would be known.  ... 
doi:10.1089/fpd.2008.0255 pmid:19737060 fatcat:uboyv34iu5bjzlob5wgkuy7smy

Attainment of Herd Immunity: Mathematical Modelling of Survival Rate [article]

Sayantan Mondal, Saumyak Mukherjee, Biman Bagchi
2020 arXiv   pre-print
We study the influence of the rate of the attainment of herd immunity (HI), in the absence of an approved vaccine, on the vulnerable population.  ...  Our results quantify the adverse effects on the recovery rates of vulnerables in the course of attaining the herd immunity.  ...  The authors thank the Department of Science and Technology (DST), India for financial support. BB thanks sir J. C. Bose fellowship for partial financial support. S.  ... 
arXiv:2005.14496v1 fatcat:abxvdzkn75esrcdjzu3mn42xz4

Endemic foot and mouth disease: pastoral in-herd disease dynamics in sub-Saharan Africa

I. McLachlan, G. Marion, I. J. McKendrick, T. Porphyre, I. G. Handel, B. M. deC. Bronsvoort
2019 Scientific Reports  
We address this knowledge gap using stochastic, compartmental modelling to explore FMD virus (FMDV) persistence, outbreak dynamics and disease burden in individual cattle herds within an endemic setting  ...  Our analysis suggests repeated introduction of virus from outside the herd is required for long-term viral persistence, irrespective of carrier presence.  ...  Furthermore, varying levels of immunity and greater movement and interaction between herds are generally not relevant in FMD-free settings but need to be considered in endemic settings.  ... 
doi:10.1038/s41598-019-53658-5 pmid:31757992 pmcid:PMC6874544 fatcat:ay2fc64szfauhkj5iu4tnjz2t4

Optimising Assessments of the Epidemiological Impact in the Netherlands of Paediatric Immunisation with 13-Valent Pneumococcal Conjugate Vaccine Using Dynamic Transmission Modelling

Elisabetta De Cao, Alessia Melegaro, Rogier Klok, Maarten Postma, Shamala Devi Sekaran
2014 PLoS ONE  
Using available Dutch data, a dynamic transmission model for the spread of pneumococci and potential subsequent invasive pneumococcal disease has been adapted to the Dutch setting.  ...  The results are quite robust for the sensitivity analyses performed on the parameters that regulate herd immunity and competition between vaccine and non-vaccine types.  ...  Acknowledgments The authors would like to thank Drs Mark Rozenbaum, Albert van Hoek, Yoon Choi, and Raymond Farkouh for very useful discussions and feedback on the topic.  ... 
doi:10.1371/journal.pone.0089415 pmid:24694656 pmcid:PMC3973563 fatcat:d5g25623rfbddaapmgczwjwhxq

Ebola could be eradicated through voluntary vaccination

Andrew Brettin, Rosa Rossi–Goldthorpe, Kyle Weishaar, Igor V. Erovenko
2018 Royal Society Open Science  
We found that if a population adopts selfishly optimal vaccination strategies, then the population vaccination coverage falls negligibly short of the herd immunity level.  ...  We conducted uncertainty and sensitivity analysis to demonstrate that our findings do not depend on the choice of the epidemiological model parameters.  ...  Leshowitz and P. Waiker, who served as graduate assistants during the REU program where this research was conducted, and F. Agusto for sharing her methodology for performing sensitivity analysis.  ... 
doi:10.1098/rsos.171591 pmid:29410863 pmcid:PMC5792940 fatcat:dp3ynaskdbb6rcc7byqpugzynq

Meningococcal Serogroup A, C, W135 and Y Conjugated Vaccine: A Cost-Effectiveness Analysis in the Netherlands

Hiltsje Hepkema, Koen B. Pouwels, Arie van der Ende, Tjalke A. Westra, Maarten J. Postma, Ray Borrow
2013 PLoS ONE  
Despite its success, herd immunity may wane over time. Recently, a serogroup A,C,W135,Y meningococcal conjugate vaccine (MenACWY) was licensed for use in subjects of 12 months of age and above.  ...  Methods: A decision analysis cohort model, with 185,000 Dutch newborns, was used to evaluate the cost-effectiveness of different immunization strategies.  ...  Because this method uses data on the amount of cases in the population [38] , a part of the herd immunity effect might be included in our VE estimate, possibly leading to an underestimation of the initial  ... 
doi:10.1371/journal.pone.0065036 pmid:23741448 pmcid:PMC3669019 fatcat:adcx3roiwbbv5afeabgtjazn5m

Inducing Herd Immunity against Seasonal Influenza in Long-Term Care Facilities through Employee Vaccination Coverage: A Transmission Dynamics Model

Aaron M. Wendelboe, Carl Grafe, Micah McCumber, Michael P. Anderson
2015 Computational and Mathematical Methods in Medicine  
We used influenza surveillance data from all LTCFs in New Mexico to validate a transmission dynamics model developed to investigate herd immunity induction.Material and Methods.  ...  Vaccinating healthcare workers (HCWs) in long-term care facilities (LTCFs) may effectively induce herd immunity and protect residents against influenza-related morbidity and mortality.  ...  Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.  ... 
doi:10.1155/2015/178247 pmid:26101542 pmcid:PMC4458543 fatcat:cgr44bgx5zdd7ppptlzwov5xga

Cost-effectiveness of a potential Zika vaccine candidate: a case study for Colombia

Affan Shoukat, Thomas Vilches, Seyed M. Moghadas
2018 BMC Medicine  
Methods: Using an agent-based simulation model of ZIKV transmission dynamics in a Colombian population setting, we conducted cost-effectiveness analysis with and without pre-existing herd immunity.  ...  vaccine is cost-saving (with negative incremental cost-effective ratio; ICER) for vaccination costs up to US$6 per individual without herd immunity, and up to US$4 per individual with 8% herd immunity.  ...  Availability of data and materials The computational modeling framework used for this study is available at: https://github.com/affans/zika/tree/publication.  ... 
doi:10.1186/s12916-018-1091-x pmid:29966516 pmcid:PMC6029035 fatcat:bdd2jb3dfjdffi7bpca44mplcm

Mathematical model of hepatitis B in the Bosomtwe district of Ashanti region, Ghana

Isaac Kwasi Adu, Anthony Yaw Aidoo, Isaac Owusu Darko, Emmanuel Osei-Frimpong
2014 Applied Mathematical Sciences  
A combination of increased vaccination of newborns and immunization of susceptible adults appears to reduce HB prevalence in Bosomtwe District to the minimum.  ...  We use SIR model to predict the prevalence and incidence of Hepatitis B in Bosomtwe District of Ghana. The study is made up of two sections.  ...  Sensitivity Analysis of the Endemic Equilibrium State The Herd Immunity Threshold The Herd Immunity Threshold (H1) is the percentage of the population that needs to be immune to control transmission  ... 
doi:10.12988/ams.2014.44263 fatcat:oqgznohkhvcefk7mfdssyh7myi

Vaccine Induced Herd Immunity for Control of Respiratory Syncytial Virus Disease in a Low-Income Country Setting

Timothy M. Kinyanjui, Thomas A. House, Moses C. Kiti, Patricia A. Cane, David J. Nokes, Graham F. Medley, Cecile Viboud
2015 PLoS ONE  
Development of vaccines for young infants is complicated by the presence of maternal antibodies and immunological immaturity, but vaccines targeted at older children avoid these problems.  ...  viral cause of respiratory morbidity and mortality in young children.  ...  Acknowledgments The authors acknowledge the contribution of the laboratory, field and data team at KEMRI-Wellcome Research Programme, Kenya.  ... 
doi:10.1371/journal.pone.0138018 pmid:26390032 pmcid:PMC4577090 fatcat:hgu67l255bhrphbgnjwg4x366a

Sex-Specific Immunization for Sexually Transmitted Infections Such as Human Papillomavirus: Insights from Mathematical Models

Johannes A. Bogaards, Mirjam Kretzschmar, Maria Xiridou, Chris J. L. M. Meijer, Johannes Berkhof, Jacco Wallinga, Jeremy D. Goldhaber-Fiebert
2011 PLoS Medicine  
Methods and Findings: We use a range of two-sex transmission models with varying detail to identify general criteria for allocating a prophylactic vaccine between both sexes.  ...  Exceptions arise only when the higher prevaccine prevalence is due to a substantially lower rate of natural immunity, or when natural immunity is lifelong, and a prolonged duration of infectiousness coincides  ...  of vaccine-preventable disease (herd immunity).  ... 
doi:10.1371/journal.pmed.1001147 pmid:22205887 pmcid:PMC3243713 fatcat:2kt53dc4xffmxenbzdhtgmsxum

How to Understand "Herd Immunity" in COVID-19 Pandemic

Yuanqing Xia, Lumin Zhong, Jingcong Tan, Zhiruo Zhang, Jiajun Lyu, Yiting Chen, Anda Zhao, Lili Huang, Zichong Long, Ning-Ning Liu, Hui Wang, Shenghui Li
2020 Frontiers in Cell and Developmental Biology  
Different countries are adopting varied response strategy in terms of their public health system to prevent the spread. Herd immunity has been a hot topic since the outbreak of COVID-19 pandemic.  ...  immunity, and discuss its feasibility in COVID-19 prevention.  ...  ZZ, JL, YC, AZ, LH, and ZL contributed to the acquisition of data for the work. All authors contributed to manuscript revision, read and approved the submitted version.  ... 
doi:10.3389/fcell.2020.547314 pmid:33072741 pmcid:PMC7543944 fatcat:nacl4x7isrc6dlumwprogvq5em
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