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CIS Publication Spotlight [Publication Spotlight]

Haibo He, Jon Garibaldi, Kay Chen Tan, Graham Kendall, Yaochu Jin, Yew Soon Ong
2018 IEEE Computational Intelligence Magazine  
Broad Learning System: An Effective and Efficient Incremental Learning System Without the Need for Deep Architecture, by C. L. P. Chen and Z.  ...  Digital Object Identifier: 10.1109 / TNNLS.2017.2716952 "Broad Learning System (BLS) that aims to offer an alternative way of learning in deep structure is proposed in this paper.  ... 
doi:10.1109/mci.2018.2806987 fatcat:3apj5rvntzhavfkbqpzjrrdehu

Cloud-based genomics pipelines for ophthalmology: reviewed from research to clinical practice

David C.S. Wong, Maximiliano Olivera, Jing Yu, Anita Szabo, Ismail Moghul, Konstantinos Balaskas, Robert Luben, Anthony P. Khawaja, Nikolas Pontikos, Pearse A. Keane
2021 Modeling and Artificial Intelligence in Ophthalmology  
A broad overview of these fields is provided, followed by key examples of their integration.Results: Cloud computing could benefit clinical genomics due to scalability of resources, potentially lower costs  ...  , and ease of data sharing between multiple institutions.  ...  Pontikos would like to thank the Archer family in memory of Marion Woods.  ... 
doi:10.35119/maio.v3i1.115 fatcat:wjxxoar6kfhufmrkw6tj53spna


Dheeraj S, Goutham GS, Jayasurya R, Sanjay G, Rakshitha R
2022 Zenodo  
Selected features from Genetic algorithm are used to train machine learning classifiers and their capability in identification of Malware before and after feature selection is compared.  ...  on computational complexity of learning classifiers.  ...  In contrast to signature-based approach which requires regular update of signature database, machine-learning based approach in combination with static and dynamic analysis can be used to detect new variants  ... 
doi:10.5281/zenodo.6790358 fatcat:iqdtv756brdkhj5g3sqqzxojtu

In This Issue

2018 Proceedings of the National Academy of Sciences of the United States of America  
Young birds tutored on a medium-tempo synthetic song sang learned songs with a broad range of tempos and with learned tempos that strongly correlated with paternal birds' tempos, despite never having heard  ...  Whole-brain atlas of the mouse cholinergic system The cholinergic system modulates neuronal activity tied to critical functions, including memory, learning, behavior, sensory processing, and sleep-wake  ...  Image courtesy of the CDC/James Gathany. Bengalese finch.  ... 
doi:10.1073/iti0218115 fatcat:4irdgvpxcfdrrnqyklpwzvm36y

Malware Classification Based on the Behavior Analysis and Back Propagation Neural Network

Zhi-Peng Pan, Chao Feng, Chao-Jing Tang, T. Gong, T. Yang, J. Xu
2016 ITM Web of Conferences  
In order to deal with the diversity and amount of the variants, a number of automated behavior analysis tools have emerged as the time requires.  ...  With the development of the Internet, malwares have also been expanded on the network systems rapidly.  ...  For example, all variants of the Allaple worm acquire and lock of particular mutexes on infected systems [8] .  ... 
doi:10.1051/itmconf/20160702001 fatcat:zvqj2t4zrrfjldljdy5retlfza

CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum

Enrico D. H. Konrad, DDD Study, Niels Nardini, Almuth Caliebe, Inga Nagel, Dana Young, Gabriella Horvath, Stephanie L. Santoro, Christine Shuss, Alban Ziegler, Dominique Bonneau, Marlies Kempers (+52 others)
2019 Genetics in Medicine  
Pathogenic variants in the chromatin organizer CTCF were previously reported in seven individuals with a neurodevelopmental disorder (NDD).  ...  We especially thank Laila Distel and Christine Suchy for excellent technical assistance; André Reis, Arif Ekici, and Fulvia Ferrazzi at the next-generation sequencing core facility at the Institute of  ...  Human Genetics in Erlangen; and Felix Engel for help with the confocal microscope, which was supported by the German Research Foundation ( DISCLOSURE The authors declare no conflicts of interest.  ... 
doi:10.1038/s41436-019-0585-z pmid:31239556 pmcid:PMC6892744 fatcat:qjol2zg5ovf47osgcvfkgu2tou

Automated Metabolic Phenotyping of Cytochrome Polymorphisms Using PubMed Abstract Mining

Luoxin Chen, Carol Friedman, Joseph Finkelstein
2018 AMIA Annual Symposium Proceedings  
This system is promising as it achieved a precision of 85.71% in a preliminary proof-of-concept evaluation and is expected to automatically provide up-to-date metabolic information for cytochrome polymorphisms  ...  In this paper, we present a novel rule-based text-mining system to extract metabolic phenotypes of polymorphisms from PubMed abstracts with a focus on cytochrome P450.  ...  Analysis tool of TAPoR 3 22 .  ... 
pmid:29854118 pmcid:PMC5977704 fatcat:ouhnlpgpyrbxbdsiwfkddnc6ra

Broad Learning-Based Optimization and Prediction of Questionnaire Survey: Application to Mind Status of College Students

Lin Yu, Shejiao Ding
2018 Complexity  
Thirdly, for each pair of the question and the answer, the score is obtained and considered as data training of the system.  ...  This paper focused on the data analysis using the recent developed broad learning method to obtain the learning model and then the prediction can be done.  ...  In [12] , the feature nodes are replaced with Takagi-Sugeno fuzzy system and the fuzzy broad learning system is proposed. For data analysis and system control, NN is widely studied in [13, 14] .  ... 
doi:10.1155/2018/5736030 fatcat:qzjugp6jrnhxbb7kbo2w7n7w2y

Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report

Mohammad M. Al-Qattan, Abdulaziz Jarman, Atif Rafique, Zuhair N. Al-Hassnan, Heba M. Al-Qattan
2019 BMC Medical Genetics  
Rubinstein-Taybi syndrome (RSTS) Type 1 (OMIM 180849) is characterized by three main features: intellectual disability; broad and frequently angulated thumbs and halluces; and characteristic facial dysmorphism  ...  Funding None Availability of data and materials The datasets used and analyzed in the current study are available from the corresponding author upon request.  ...  Acknowledgements We would like to thank the parents of our patient who agreed to participate in the study.  ... 
doi:10.1186/s12881-019-0747-5 pmid:30635043 pmcid:PMC6330443 fatcat:x3fi7s4tczg5ngjv5l4n4v2bsu

The spectrum of phenotypes in females with Rett Syndrome

Peter Huppke, Melanie Held, Franco Laccone, Folker Hanefeld
2003 Brain & development (Tokyo. 1979)  
We found a broad spectrum of phenotypes in females. At the severest end we have females with primary developmental delay who never learned to turn, sit or walk and who developed severe epilepsy.  ...  As a result of molecular genetic analysis a broad spectrum of phenotypes in RTT females has evolved. We found evidence that the defect in MeCP2 influences the somatic growth before birth. q  ...  Molecular genetic analysis enables us to diagnose RTT in the absence of characteristic symptoms and in the presence of uncharacteristic features. A broad spectrum of phenotypes has evolved.  ... 
doi:10.1016/s0387-7604(03)00018-4 pmid:12850514 fatcat:ka235lqipzhk7mk4p7ejyidleu

Special Issue on High Performance Computing in Bio-medical Informatics

Luping Zhou, Islem Rekik, Chenggang Yan, Guorong Wu
2018 Neuroinformatics  
, though not time-consuming, neurocomputing methods, including machine learning, neural networks and its variant architectures, deep networks and multi-source healthcare data representation and learning  ...  The topics covered in this special issue reflect an ongoing evolution of the field of bio-medicine, and span a broad range from the prediction of dementia or analysis of neuronal activity, through the  ...  , though not time-consuming, neurocomputing methods, including machine learning, neural networks and its variant architectures, deep networks and multi-source healthcare data representation and learning  ... 
doi:10.1007/s12021-018-9393-x pmid:30022314 fatcat:ba7p3znanzgovaalq2lkelfalq

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

Kyle Ellrott, Matthew H. Bailey, Gordon Saksena, Kyle R. Covington, Cyriac Kandoth, Chip Stewart, Julian Hess, Singer Ma, Kami E. Chiotti, Michael McLellan, Heidi J. Sofia, Carolyn Hutter (+728 others)
2018 Cell Systems  
Highlights d Exome sequencing-based variant calls from 10,000 individuals d Samples from 33 cancer types  ...  This resulted in the 500GB of VCF files representing all detected variants. 3.Broad Firehose -The Broad Firehose is a system to deploy automated pipeline analysis on all the TCGA data.  ...  some lessons learned, and considerations of performance when looking across widely varied cohorts.  ... 
doi:10.1016/j.cels.2018.03.002 pmid:29596782 pmcid:PMC6075717 fatcat:ncvcedl6qfdijfdo47cmqh5ury

Page 10 of Sage Family Studies Abstracts Vol. 21, Issue 1 [page]

1999 Sage Family Studies Abstracts  
Psychologists commonly espouse some variant of learning theory (classical conditioning, operant conditioning, or social learning theory) as an explanatory framework and a source of hypotheses and methodology  ...  Systems theory and its application to research on human sexuality. Journal of Sex Research 35(1):72-87, 1998. RESEARCH TRENDS. SEXUAL BEHAVIOR. SEXUAL DYSFUNCTION. SYSTEMS ANALYSIS.  ... 

De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila

Dorien Lugtenberg, Margot R F Reijnders, Michaela Fenckova, Emilia K Bijlsma, Raphael Bernier, Bregje W M van Bon, Eric Smeets, Anneke T Vulto-van Silfhout, Danielle Bosch, Evan E Eichler, Heather C Mefford, Gemma L Carvill (+18 others)
2016 European Journal of Human Genetics  
fissures, and a broad mouth and chin.  ...  To investigate the role of WAC in ID, we studied the importance of the Drosophila WAC orthologue (CG8949) in habituation, a non-associative learning paradigm.  ...  the Interuniversity Attraction Pole program by BELSPO, the research fund KU Leuven, a Methusalem grant of the Flemish government and VIB.  ... 
doi:10.1038/ejhg.2015.282 pmid:26757981 pmcid:PMC4970694 fatcat:k4722jxqjjho5cgtfbp34sstcm

The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis

A. Hargreaves, R. Anney, C. O'Dushlaine, K. K. Nicodemus, M. Gill, A. Corvin, D. Morris, Gary Donohoe
2013 Psychological Medicine  
Genetic studies of single gene variants have been criticized as providing a simplistic characterization of the genetic basis of illness risk that ignores the effects of other variants within the same biological  ...  as the polygenic risk analysis.  ...  and analysis of the individual SNPs considered.  ... 
doi:10.1017/s0033291713002663 pmid:24284030 fatcat:snjh5mncyzcwtle6yusn2czfra
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