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Simultaneous trimodal PET-MR-EEG imaging: Do EEG caps generate artefacts in PET images?

Ravichandran Rajkumar, Elena Rota Kops, Jörg Mauler, Lutz Tellmann, Christoph Lerche, Hans Herzog, N. Jon Shah, Irene Neuner, Kewei Chen
2017 PLoS ONE  
Building on this, this study aims to investigate the influence of the EEG cap on the quality and quantification of PET images acquired during simultaneous PET-MR measurements.  ...  In the hybrid BrainPET-MR scanner, the attenuation correction is performed by using an MR based attenuation correction method [25] .  ...  We thank Andrea Muren, Cornelia Frey, Silke Frensch, and Suzanne Schaden for their technical assistance. We appreciate Mrs. Claire Rick for proof reading the manuscript.  ... 
doi:10.1371/journal.pone.0184743 pmid:28902890 pmcid:PMC5597218 fatcat:d7f43mothzeilcrin4culteika

MR-Based PET Motion Correction Procedure for Simultaneous MR-PET Neuroimaging of Human Brain

Marcus Görge Ullisch, Jürgen Johann Scheins, Christoph Weirich, Elena Rota Kops, Abdullah Celik, Lutz Tellmann, Tony Stöcker, Hans Herzog, Nadim Jon Shah, Chin-Tu Chen
2012 PLoS ONE  
Recently, simultaneous magnetic resonance imaging (MRI) and PET have become available in the first generation of Hybrid MR-PET scanners.  ...  In this work, the elimination of artefacts due to head motion in PET neuroimages is achieved by a new approach utilising MR-based motion tracking in combination with PET list mode data motion correction  ...  Vincent Gras and Dr. Daniel Pflugfelder for helpful discussions. Author Contributions  ... 
doi:10.1371/journal.pone.0048149 pmid:23189127 pmcid:PMC3495949 fatcat:yux75qgmvfethgqwx53lqg5m3i

Simultaneous PET-MR-EEG: Technology, Challenges and Application in Clinical Neuroscience

I. Neuner, R. Rajkumar, C. Regio Brambilla, S. Ramkiran, A. Ruch, L. Orth, E. Farrher, J. Mauler, C. Wyss, E. Rota Kops, J. Scheins, L. Tellmann (+10 others)
2019 IEEE Transactions on Radiation and Plasma Medical Sciences  
Due to technological developments in positron emission tomography (PET) detectors and PET-MR integration, the simultaneous measurement of PET-MR-EEG has become feasible, offering the possibility of exploring  ...  Studies have already shown the benefits of simultaneous measurement using PET-MR, however, such achievements come with different technical and practical challenges.  ...  Ruch (Dr. med) and of the Master's thesis of S. Ramkiran (M.Sc. Biomedical Engineering) at the Medical Faculty of the RWTH Aachen University, Germany.  ... 
doi:10.1109/trpms.2018.2886525 fatcat:ue7ol5n7dnbkll7wx36p6kngr4

A 31-channel MR brain array coil compatible with positron emission tomography

Christin Y. Sander, Boris Keil, Daniel B. Chonde, Bruce R. Rosen, Ciprian Catana, Lawrence L. Wald
2014 Magnetic Resonance in Medicine  
Purpose-Simultaneous acquisition of MR and PET images requires the placement of the MR detection coil inside the PET detector ring where it absorbs and scatters photons.  ...  Implementing attenuation correction of the 31-channel array successfully removed PET artifacts, which were comparable to those of the 8-channel array.  ...  This research was supported by grants from the National Institute of Health (R90DA023427, P41EB015896).  ... 
doi:10.1002/mrm.25335 pmid:25046699 pmcid:PMC4500638 fatcat:w77tjrjyc5g6zd4kthobhmfz4m

Bias evaluation and reduction in 3D OP-OSEM reconstruction in dynamic equilibrium PET studies with 11C-labeled for binding potential analysis

Cláudia Régio Brambilla, Jürgen Scheins, Ahlam Issa, Lutz Tellmann, Hans Herzog, Elena Rota Kops, N. Jon Shah, Irene Neuner, Christoph W. Lerche, Pierpaolo Alongi
2021 PLoS ONE  
This is especially relevant in the case of neuro-receptor studies with simultaneous PET/MR when a bolus-infusion protocol is applied to allow the comparison of pre- and post-task effects.  ...  However, it is known to contribute to quantitation bias and is particularly pronounced during dynamic studies with 11C-labeled radiotracers where count rates become low towards the end of the acquisition  ...  Andreas Matusch for the implementation of the metabolite correction method and support in the equilibrium analysis for the human study which is indicated in S1 File.  ... 
doi:10.1371/journal.pone.0245580 pmid:33481896 fatcat:3b3vnagjkbgchefnrre43u7b5e

Current Trends in PET and Combined (PET/CT and PET/MR) Systems Design

Habib Zaidi, Abass Alavi
2007 PET Clinics  
Illustration of the reduction of parallax or depth-of-interaction error when using the phoswich detector approach with depth-of-interaction measurement capability.  ...  Nevertheless, significant progress has been made, resulting in the design of a few preclinical PET scanners and one human prototype dedicated for simultaneous PET/MR brain imaging [8] .  ... 
doi:10.1016/j.cpet.2007.10.004 pmid:27157869 fatcat:tlec447fvjcpligu5cevpfjgvm

Influence of the partial volume correction method on18F-fluorodeoxyglucose brain kinetic modelling from dynamic PET images reconstructed with resolution model based OSEM

Spencer L Bowen, Larry G Byars, Christian J Michel, Daniel B Chonde, Ciprian Catana
2013 Physics in Medicine and Biology  
We explored the influence of the PVC method and implementation on kinetic parameters estimated by fitting 18 F-fluorodeoxyglucose dynamic data acquired on a dedicated brain PET scanner and reconstructed  ...  As both count density and background-to-target values for a brain structure can change during a dynamic scan, the local image resolution may also concurrently vary.  ...  Jacob Hooker and Steve Carlin for tracer synthesis, Grae Arabasz and Shirley Hsu for technical assistance and subject scanning, Patricia McCarthy for subject scanning, and Andrea Ferrero for use of the  ... 
doi:10.1088/0031-9155/58/20/7081 pmid:24052021 pmcid:PMC4234075 fatcat:dfro3z3kyrhixb36keorsyj7y4

MR/PET quantification tools: Registration, segmentation, classification, and MR-based attenuation correction

Baowei Fei, Xiaofeng Yang, Jonathon A. Nye, John N. Aarsvold, Nivedita Raghunath, Morgan Cervo, Rebecca Stark, Carolyn C. Meltzer, John R. Votaw
2012 Medical Physics (Lancaster)  
A human MR/PET prototype system consisting of a Siemens 3T Trio MR and brain PET insert was installed and tested at our institution.  ...  Attenuation correction results from the ten subjects show that the difference between the MR and TX-based methods was <6.5%.  ...  PET scans of the coil were collected on three scanners, i.e., BrainPET, GE DST, and SiemensFIG. 11.  ... 
doi:10.1118/1.4754796 pmid:23039679 pmcid:PMC3477199 fatcat:y4yfo5wvaze6vkj7e4jsidcz64

PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Nonhuman Primates

Benjamin H. Rotstein, Hsiao-Ying Wey, Timothy M. Shoup, Alan A. Wilson, Steven H. Liang, Jacob M. Hooker, Neil Vasdev
2014 Molecular Pharmaceutics  
The distribution and pharmacokinetics were quantified following a 2 h dynamic imaging session using a simultaneous PET/MR scanner.  ...  at 60 min and a reduced rate of metabolism after pretreatment with URB597.  ...  Ronald Borra, Shirley Hsu, Grae Arabasz, and Helen Deng for assistance with PET/MR imaging experiments, and Dr. Ramesh Neelamegam for assistance with plasma−protein binding experiments. We  ... 
doi:10.1021/mp500316h pmid:25004399 pmcid:PMC4224570 fatcat:a53ejsdu3jeuzh6v5jmhi3ywb4

Nasal neuron PET imaging quantifies neuron generation and degeneration

Genevieve C. Van de Bittner, Misha M. Riley, Luxiang Cao, Janina Ehses, Scott P. Herrick, Emily L. Ricq, Hsiao-Ying Wey, Michael J. O'Neill, Zeshan Ahmed, Tracey K. Murray, Jaclyn E. Smith, Changning Wang (+3 others)
2017 Journal of Clinical Investigation  
Taken together, these results indicate that GV1-57 is a quantitative tool for measurement of the OSN population that provides insight into fluctuations in OSN population resulting from normative development  ...  Additionally, preliminary application to nonhuman primates (NHPs) suggests that the GV1-57 radiotracer maintains good uptake and saturable binding in the primate nasal epithelium.  ...  Biostatistical analysis was conducted in part with assistance from Mark Vangel at Harvard Catalyst (NIH NCRR and National Center for Advancing Translational Sciences through grant UL1 TR001102) and financial  ... 
doi:10.1172/jci89162 pmid:28112682 pmcid:PMC5272198 fatcat:zldygnzthbbhldqf4rffuftadu

Kinetic Analysis and Quantification of [11C]Martinostat for in Vivo HDAC Imaging of the Brain

Hsiao-Ying Wey, Changning Wang, Frederick A. Schroeder, Jean Logan, Julie C. Price, Jacob M. Hooker
2015 ACS Chemical Neuroscience  
-54.4 mL/cm 3 in the brain and large changes in occupancy (up to 99%) with a blocking dose approaches full enzyme saturation.  ...  The goal of this work was to determine whether classic compartmental analysis techniques were appropriate and to further determine if arterial plasma is required for future NHP studies.  ...  by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health.  ... 
doi:10.1021/acschemneuro.5b00066 pmid:25768025 pmcid:PMC4439341 fatcat:j5x6q4646zemxhqq3icp3aam3q

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

Poster Viewing Session II

2017 Journal of Cerebral Blood Flow and Metabolism  
The BOLD data underwent spatial independent component analysis (sICA [2]) and time shift analysis (voxelwise cross-correlation with global signal [1]) after bandpass filtering to the following frequencies  ...  These results, along with the time shift analysis maps, are shown for a representative patient in the figure.  ...  No correction for metabolites was deemed necessary*. F]FDG in a 3T MR-BrainPET system), reconstructed precisely during the rs-fMRI measurement (6 minutes/eyes closed).  ... 
doi:10.1177/0271678x17695989 pmid:28366134 pmcid:PMC5441166 fatcat:no54qir44jemni3wacaipk5wxa

Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging

Cristina Lois, Ilja Bezrukov, Holger Schmidt, Nina Schwenzer, Matthias K. Werner, Jürgen Kupferschläger, Thomas Beyer
2012 European Journal of Nuclear Medicine and Molecular Imaging  
Sponsoring Institutes and Companies The 2011 Nuclear Science Symposium and Medical Imaging Conference is  ...  Motion During Simultaneous PET-MR Acquisitions G.  ...  Martinos Center for Biomedical Imaging, U.S.A MIC3-2 (14:45) Attenuation Correction in MR-BrainPET with Segmented T1-Weighted MR Images of the Patients Head -A Comparative Study with CT G.  ... 
doi:10.1007/s00259-012-2190-0 pmid:22890801 fatcat:gaikvxa6hrc2xobeyxp7gyu3ha

Design and Characterisation of an MRI Compatible Human Brain PET Insert by Means of Simulation and Experimental Studies

Mirjam Lenz, Bergische Universität Wuppertal
2020
The simulated data were matched to measured data from test detectors. This allowed the determination of an optimum thickness of a lightguide between the scintillators and the dSiPMs.  ...  At present, an MRI compatible human brain PET scanner for applications in neuroscience is being constructed in the scope of a Helmholtz Validation Fund project.  ...  UHF MRI Compatibility The feasibility of combining PET and ultra-high field MRI has already been demonstrated, e.g. in preclinical scanners [118] and with a Siemens MR-BrainPET insert located at the  ... 
doi:10.25926/d4s5-bc37 fatcat:use5uckttrac3mqdipwf4lyjl4
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