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L. A. Marco, T. F. Reed, L. D. Aides, R. B. Chronister, C. B. Brown, L. E. White
1989 Clinical and Experimental Pharmacology and Physiology  
M. (1958a) Cortico-bulbar connections to the pons and lower brain-stem in man. An anatomical study. Brain Research, 81, 364-388. Kuypers, H. G. J.  ...  . & Albe-Fessard, D. (1981) Relationship between input and output of cells in motor and somatosensory cortices of the chronic awake rat. A study using glass micropipettes.  ... 
doi:10.1111/j.1440-1681.1989.tb01577.x pmid:2766581 fatcat:feb2fxoumnb2zd7ragkwsjzmxi

Cell Class-Dependent Intracortical Connectivity and Output Dynamics of Layer 6 Projection Neurons of the Rat Primary Visual Cortex

Florence Cotel, Lee N Fletcher, Simon Kalita-de Croft, John Apergis-Schoute, Stephen R Williams
2017 Cerebral Cortex  
To address this we combined anatomical tracing techniques with high-resolution patchclamp recording to identify morphological and functional distinct classes of layer 6 projection neurons in the rat primary  ...  Multisite whole-cell recordings in brain slices revealed that cortico-claustral and cortico-thalamic layer 6 projection neurons were sparsely and reciprocally synaptically inter-connected, but exhibited  ...  The authors declare no conflicts of interest. Cotel, F. et al.  ... 
doi:10.1093/cercor/bhx134 pmid:28591797 fatcat:wr4rtq5tbfdadk5g6ifylpvnki

Neural signatures of pathological hyperdirect pathway activity in Parkinson's disease [article]

Ashwini Oswal, Chien-Hung Yeh, Wolf-Julian Neumann, James Gratwicke, Harith Akram, Andreas Horn, Ludvic Zrinzo, Tom Foltynie, Patricia Limousin, Rafal Bogacz, Masud Husain, Peter Brown (+1 others)
2020 bioRxiv   pre-print
Finally, computational modelling revealed that exaggerated hyperdirect cortical inputs to the STN in the upper beta frequency range can provoke the generation of widespread pathological synchrony at lower  ...  Additionally within the STN, non-linear waveform features suggestive of cortical synchronisation correlated with cortico-STN fibre densities.  ...  The clusters include SMA and mesial primary motor cortex.  ... 
doi:10.1101/2020.06.11.146886 fatcat:kydgdnb3wnfgrmi6ze3d7xxpzu

The Relationship Between Zebrin Expression and Cerebellar Functions: Insights From Neuroimaging Studies

Yi-Cheng Lin, Chih-Chin Heather Hsu, Pei-Ning Wang, Ching-Po Lin, Li-Hung Chang
2020 Frontiers in Neurology  
The zebrin stripe receives input from climbing fibers and project to different parts of the cerebral cortex through its cerebrocerebellar connection.  ...  The cerebellum has long been known to play an important role in motor and balance control, and accumulating evidence has revealed that it is also involved in multiple cognitive functions.  ...  The afferent inputs to the cerebellar cortex consist of mossy and climbing fibers.  ... 
doi:10.3389/fneur.2020.00315 pmid:32390933 pmcid:PMC7189018 fatcat:dmrdcptyyzcivnraki6zr7h6vq

Long-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile

Alex T. L. Leong, Russell W. Chan, Patrick P. Gao, Ying-Shing Chan, Kevin K. Tsia, Wing-Ho Yung, Ed X. Wu
2016 Proceedings of the National Academy of Sciences of the United States of America  
The cerebral cortex contains long-range axonal projections of pyramidal neurons reciprocally connected to the thalamus by cortico-thalamic and thalamo-cortical projections and within the cortex via cortico-cortical  ...  One challenge in contemporary neuroscience is to achieve an integrated understanding of the large-scale brain-wide interactions, particularly the spatiotemporal patterns of neural activity that give rise  ...  Instead, robust and diffuse BOLD activation was detected in ipsilateral primary motor cortex (M1), in addition to ipsilateral S1BF, S2, and S1ULp.  ... 
doi:10.1073/pnas.1616361113 pmid:27930323 pmcid:PMC5187697 fatcat:yq22i5ktcvdm5fa2abkiycxjhe

Humanization of SRGAP2C expression increases cortico-cortical connectivity and reliability of sensory-evoked responses in the mouse brain

Ewoud R.E. Schmidt, Hanzhi T. Zhao, Elizabeth M. C. Hillman, Franck Polleux
2019 biorxiv/medrxiv  
cortico-cortical inputs received by layer 2/3 cortical PNs.  ...  Our results suggest that the emergence of during human evolution led to increased local and long-range cortico-cortical connectivity and improved reliability of sensory-evoked cortical coding.  ...  We also consistently observed traced neurons in the ipsilateral secondary motor cortex (M2), ipsilateral secondary somatosensory cortex (S2), and the primary sensory cortex contralateral to the injection  ... 
doi:10.1101/852970 fatcat:qju27axg7jestled2kgxwulzvy

A study of parietal-motor connectivity by intraoperative dual cortical stimulation [article]

Luigi Cattaneo, Davide Giampiccolo, Pietro Meneghelli, Vincenzo Tramontano, Francesco Sala
2019 bioRxiv   pre-print
For the first time in humans, the present data show direct evidence in favour of a distributed system of connections from the posterior parietal cortex to the ipsilateral primary motor cortex.  ...  Well-established models indicate that the posterior parietal cortex influences motor output indirectly, by means of connections to the premotor cortex, which in turn is directly connected to the motor  ...  Test stimuli are delivered to the motor cortex and produce a measurable motor evoked potential via the corticospinal tract (green arrow).  ... 
doi:10.1101/747337 fatcat:vp3daampajgqtj3es4kd4dnuau

Intrinsic coupling modes reveal the functional architecture of cortico-tectal networks

I. Stitt, E. Galindo-Leon, F. Pieper, G. Engler, E. Fiedler, T. Stieglitz, A. K. Engel
2015 Science Advances  
Despite displaying a high degree of spatial specificity, cortico-tectal coupling in lower-frequency bands did not match patterns of cortex-to-SC anatomical connectivity.  ...  In the absence of sensory stimulation or motor output, the brain exhibits complex spatiotemporal patterns of intrinsically generated neural activity.  ...  In addition to reflecting Na + action potentials, high-frequency cortical surface potentials result from the superposition of several ionic processes that coincide with neuronal firing, such as synaptic  ... 
doi:10.1126/sciadv.1500229 pmid:26601226 pmcid:PMC4643805 fatcat:mpwsdx2hgbftrem2tq4g54nfya

The contribution of transcranial magnetic stimulation in the functional evaluation of microcircuits in human motor cortex

Vincenzo Di Lazzaro, Ulf Ziemann
2013 Frontiers in Neural Circuits  
The anatomical and computational characteristics of a canonical microcircuit model of cerebral cortex composed of layer II and III and layer V excitatory pyramidal cells, inhibitory interneurons, and cortico-cortical  ...  In summary, simple canonical microcircuits of neocortex can explain activation of corticospinal neurons in human motor cortex by TMS.  ...  One way of assessing the effects of TMS is to directly record the synaptic activity evoked by stimulation of those cortical areas that produce a measureable readout, such as the primary motor cortex (M1  ... 
doi:10.3389/fncir.2013.00018 pmid:23407686 pmcid:PMC3570771 fatcat:lmmsmw55pzazdec6wtrpfpuy34

Colocalized Structural and Functional Changes in the Cortex of Patients with Trigeminal Neuropathic Pain

Alexandre F. DaSilva, Lino Becerra, Gautam Pendse, Boris Chizh, Shannon Tully, David Borsook, William Giannobile
2008 PLoS ONE  
Acknowledgments We wish to thank Bruce Fischl PhD for help with initial data evaluation for cortical thickness methods, and Eric Moulton for his help with some of the functional data analysis.  ...  Motor Cortex. Significant thinning of the primary motor cortex (MI) sections 3 and 4 contralateral to the neuropathic pain were observed (Figure 2) .  ...  Additional studies should be pursued to accurately define the anatomical and functional attributes of the primary motor cortex. Posterior Insula.  ... 
doi:10.1371/journal.pone.0003396 pmid:18923647 pmcid:PMC2561059 fatcat:qzcvf2l4nfgsdc4at4erfokwl4

The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord

Yunuen Moreno-Lopez, Charlotte Bichara, Gilles Delbecq, Philippe Isope, Matilde Cordero-Erausquin
2021 eLife  
In contrast, the cortex conveys the motor command via a relay in the upper spinal cord or supraspinal motor centers.  ...  At lumbar level, the main role of the CST is thus the modulation of sensory inputs, which is an essential component of the selective tuning of sensory feedback used to ensure well-coordinated and skilled  ...  potentials as an index of primary afferent depolarization) versus recruitment of tibialis anterior ankle flexor motor neurons (measured electromyographically).  ... 
doi:10.7554/elife.65304 pmid:34497004 fatcat:ctkdlxrcsvbdnn3dzmnj6xzvi4

Distinct and Overlapping Functional Zones in the Cerebellum Defined by Resting State Functional Connectivity

Jill X. O'Reilly, Christian F. Beckmann, Valentina Tomassini, Narender Ramnani, Heidi Johansen-Berg
2009 Cerebral Cortex  
The cortical connectivity of the supramodal zone was driven by regions of frontal and parietal cortex which are not directly involved in sensory or motor processing, including dorsolateral prefrontal cortex  ...  However, the topography of the connections between the cerebellar and cerebral cortices remains largely unmapped, as it is relatively unamenable to anatomical methods.  ...  Given the difficulty of tracing cortico-cerebellar anatomical connections ''cortex to cortex,'' it is at present difficult to relate our knowledge of the connectivity of the cerebellar input and output  ... 
doi:10.1093/cercor/bhp157 pmid:19684249 pmcid:PMC2837094 fatcat:ku6ptg5jjbaq7pirl4ue7xrbma


D M Feeney, J C Baron
1986 Stroke  
Acknowledgments We wish to express our gratitude to Elise Scott and Dr. Irene Meissner for assistance in the preparation of this manuscript.  ...  Pharmacological Studies of an Animal Model of Hemiplegia In an attempt to explain the mechanisms of hemiplegia following motor cortex damage, Von Monakow described "diaschisis cortico-spinalis", a reversible  ...  Normalization of the evoked potentials in intact cortex adjacent to the lesions paralleled recovery of behavior. 133 -134 In contrast, enhancement of evoked responses recorded in intact cortex adjacent  ... 
doi:10.1161/01.str.17.5.817 pmid:3532434 fatcat:4ggnpbn5zzhgzg6t2jxm5tosji

Parieto-frontal network in humans studied by cortico-cortical evoked potential

Riki Matsumoto, Dileep R. Nair, Akio Ikeda, Tomoyuki Fumuro, Eric LaPresto, Nobuhiro Mikuni, William Bingaman, Susumu Miyamoto, Hidenao Fukuyama, Ryosuke Takahashi, Imad Najm, Hiroshi Shibasaki (+1 others)
2011 Human Brain Mapping  
We investigated inter-areal connections of the lateral parieto−frontal network in vivo by means of cortico-cortical evoked potentials (CCEPs).  ...  = afterdischarge; AIP = anterior intraparietal area; BA = Brodmann's area; CCEP = cortico-cortical evoked potential; DCR = direct cortical response; ECoG = electrocorticogram; FCD = focal cortical dysplasia  ...  Hiroki Yamamoto for his assistance in standardization of the CCEP connectivity findings. This work was supported by Cleveland Clinic (the Advanced  ... 
doi:10.1002/hbm.21407 pmid:21928311 fatcat:3t45uwe2kjdarm24lisiittkzu

Hyperdirect connectivity of opercular speech network to the subthalamic nucleus [article]

Ahmed Jorge, Witold J Lipksi, Dengyu Wang, Donald J Crammond, Robert S. Turner, Robert Mark Richardson
2021 bioRxiv   pre-print
In addition, we observed evoked potentials consistent with the presence of monosynaptic projections from areas of opercular speech cortex that are primarily sensory, including auditory cortex, to the STN  ...  in the STN and examining antidromic evoked activity in the left temporal, parietal and frontal opercular cortex.  ...  , yet no models of speech production consider the cortico-subthalamic hyperdirect pathway for cortical input to basal ganglia.  ... 
doi:10.1101/2021.07.02.450909 fatcat:q6wmljmg7vbx5fxxwqls2f6ygm
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