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An investigation of statistical power for continuous arterial spin labeling imaging at 1.5 T

Iris Asllani, Ajna Borogovac, Clinton Wright, Ralph Sacco, Truman R. Brown, Eric Zarahn
2008 NeuroImage  
arterial spin labeling (CASL) imaging on 52 elderly subjects (age = 70.5 ± 7.9 years, 29 males).  ...  Estimated ROI-wise power was computed for various numbers of acquired CBF images, numbers of subjects, and CBF effect sizes for two experimental designs: independent samples t-test and paired t-test.  ...  Eric Zarahn was supported by a NARSAD Young Investigator Award.  ... 
doi:10.1016/j.neuroimage.2007.10.015 pmid:18036834 pmcid:PMC2665307 fatcat:iqmsa7fwzbeu3ixw7xkn6oh7c4

Quantitative basal CBF and CBF fMRI of rhesus monkeys using three-coil continuous arterial spin labeling

Xiaodong Zhang, Tsukasa Nagaoka, Edward J. Auerbach, Robbie Champion, Lei Zhou, Xiaoping Hu, Timothy Q. Duong
2007 NeuroImage  
A three-coil continuous arterial-spin-labeling technique with a separate neck labeling coil was implemented on a Siemens 3T Trio for quantitative cerebral blood flow (CBF) and CBF fMRI measurements in  ...  The optimal labeling power was 2 W, labeling efficiency was 92 ± 2%, and optimal postlabeling delay was 0.8 s. Gray matter (GM) and white matter (WM) were segmented based on T 1 maps.  ...  The Yerkes Imaging Center is supported in part by a base grant from the NIH/NCRR (P51 RR000165).  ... 
doi:10.1016/j.neuroimage.2006.10.011 pmid:17126036 pmcid:PMC2943966 fatcat:x4lkbhromjashdd3eospyuqipm

Functional perfusion imaging using continuous arterial spin labeling with separate labeling and imaging coils at 3 T

Toralf Mildner, Robert Trampel, Harald E. Möller, Andreas Schäfer, Christopher J. Wiggins, David G. Norris
2003 Magnetic Resonance in Medicine  
Functional perfusion imaging with a separate labeling coil located above the common carotid artery was demonstrated in human volunteers at 3 T.  ...  A helmet resonator and a spin-echo echo-planar imaging (EPI) sequence were used for imaging, and a circular surface coil of 6 cm i.d. was employed for labeling.  ...  We also thank Wolfgang Driesel and Manfred Weder for technical assistance, and Anke Mempel, Mandy Naumann, and Claudia Buschendorf for support in the experiments.  ... 
doi:10.1002/mrm.10438 pmid:12704759 fatcat:axjet5n6qbd5pbsntzg76hg5qq

Perfusion Based Functional MRI [chapter]

Luis Hernandez-Garcia, Hesamoddin Jahanian
2014 Advanced Brain Neuroimaging Topics in Health and Disease - Methods and Applications  
Author details Luis Hernandez-Garcia and Hesamoddin Jahanian University of Michigan, FMRI Laboratory, USA  ...  The first class of arterial spin labeling pulse sequences is "Continuous arterial spin labeling" (CASL).  ...  Since noise spectrum of arterial spin labeling signal contains relatively less power at low frequencies, it is particularly useful for phMRI studies in which a change in brain activity is expected over  ... 
doi:10.5772/58259 fatcat:ep36ddgqnrd6hlptp42mvm7lsi

Quantification of cerebral arterial blood volume and cerebral blood flow using MRI with modulation of tissue and vessel (MOTIVE) signals

Tae Kim, Seong-Gi Kim
2005 Magnetic Resonance in Medicine  
Blood signal is changed either by injection of a contrast agent or by arterial spin labeling (ASL).  ...  Regional cerebral arterial blood volume (CBVa) and blood flow (CBF) can be quantitatively measured by modulation of tissue and vessel (MOTIVE) signals, enabling separation of tissue signal from blood.  ...  ASL efficiency at the carotid arteries ␣ o was determined before and after the injection of MION using an 8-s continuous spin labeling pulse (17) .  ... 
doi:10.1002/mrm.20550 pmid:16032688 fatcat:7wb7t5r22je57k6o4tsi7siidu

Differentiation of Glioblastoma from Brain Metastasis: Qualitative and Quantitative Analysis Using Arterial Spin Labeling MR Imaging

Leonard Sunwoo, Tae Jin Yun, Sung-Hye You, Roh-Eul Yoo, Koung Mi Kang, Seung Hong Choi, Ji-hoon Kim, Chul-Ho Sohn, Sun-Won Park, Cheolkyu Jung, Chul-Kee Park, Jeroen Hendrikse
2016 PLoS ONE  
Purpose To evaluate the diagnostic performance of cerebral blood flow (CBF) by using arterial spin labeling (ASL) perfusion magnetic resonance (MR) imaging to differentiate glioblastoma (GBM) from brain  ...  Conclusion ASL perfusion MR imaging can aid in the differentiation of GBM from brain metastasis. Differentiation of GBM from Brain Metastasis Using ASL PLOS ONE |  ...  While the majority of patients with brain metastasis underwent MR imaging at a 1.5 T scanner, the majority of patients with GBM underwent MR imaging at a 3 T scanner (p < 0.001).  ... 
doi:10.1371/journal.pone.0166662 pmid:27861605 pmcid:PMC5115760 fatcat:xbhrhxf2u5dypdt2dp4sntfb6e

Quantitative regional cerebral blood flow MRI of animal model of attention-deficit/hyperactivity disorder

Jared F. Danker, Timothy Q. Duong
2007 Brain Research  
The spontaneously hypertensive rat (SHR) has been widely used as an animal model for attention-deficit/hyperactivity disorder (AD/HD), a developmental disorder that affects 3-5% of school-age children.  ...  Regional CBF of the SHR were statistically different from those of the WKY rats in all structures analyzed (P < 0.05) except for the caudate putamen (P = 0.09) and the globus pallidus (P = 0.12).  ...  The Yerkes Imaging Center is supported by an NIH/NCRR base grant (P51RR000165).  ... 
doi:10.1016/j.brainres.2007.02.082 pmid:17391651 pmcid:PMC2074876 fatcat:kwh72xstifa5ppmjfhnht6wf3m

Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods

THOMAS T. LIU, GREGORY G. BROWN
2007 Journal of the International Neuropsychological Society  
Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) method that provides a highly repeatable quantitative measure of cerebral blood flow (CBF).  ...  for more accurate estimation of the location and magnitude of neural function.  ...  For example, the CNR of close-tag continuous CASL at 1.5 T has been shown to approach that of the BOLD signal for a finger-tapping experiment .  ... 
doi:10.1017/s1355617707070646 pmid:17445301 fatcat:jjd57u2lpfagll7befcvxvjdci

Increased Cerebral Vascular Reactivity in the Tau Expressing rTg4510 Mouse: Evidence against the Role of Tau Pathology to Impair Vascular Health in Alzheimer's Disease

Jack A Wells, Holly E Holmes, James M O'Callaghan, Niall Colgan, Ozama Ismail, Elizabeth MC Fisher, Bernard Siow, Tracey K Murray, Adam J Schwarz, Michael J O'Neill, Emily C Collins, Mark F Lythgoe
2015 Journal of Cerebral Blood Flow and Metabolism  
Imaging of cerebral vascular reactivity (CVR) is a powerful tool to investigate vascular health in clinical populations although the cause of reduced CVR in AD patients is not fully understood.  ...  We investigated the specific role of tau pathology in CVR derangement in AD using the rTg4510 mouse model. We observed an increase in CVR in cortical regions with tau pathology.  ...  Arterial spin labelling MRI can yield whole brain maps of CVR non-invasively with good spatial and temporal resolution, and as such is a powerful and clinically relevant approach to estimate CVR.  ... 
doi:10.1038/jcbfm.2014.224 pmid:25515210 pmcid:PMC4348392 fatcat:sn3gaxp5cfa6vb2c6pqkhemsbe

Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$-prepared whole brain pCASL

Martin Schidlowski, Rüdiger Stirnberg, Tony Stöcker, Theodor Rüber
2020 Scientific Reports  
Arterial spin labeling (ASL) is increasingly applied for cerebral blood flow mapping, but $${\text{T}}_{{2}}$$ T 2 relaxation of the ASL signal magnetization is often ignored, although it may be clinically  ...  neuroscientific biomarker, a prospective study was performed with ten healthy volunteers (5F,28 ± 3y) at a 3 T scanner.  ...  This can be accomplished by three alternative main techniques: 9, 10 Continuous ASL inverts spins within a defined slice by applying a steady labeling pulse, whereas pulsed ASL inverts spins within a  ... 
doi:10.1038/s41598-020-74680-y pmid:33110203 fatcat:jlnb5wmpzjdypngovzv3zgvzjy

Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques

E T Petersen, I Zimine, Y-C L Ho, X Golay
2006 British Journal of Radiology  
The non-invasive nature of arterial spin labelling (ASL) has opened a unique window into human brain function and perfusion physiology.  ...  High spatial and temporal resolution makes the technique very appealing not only for the diagnosis of vascular diseases, but also in basic neuroscience where the aim is to develop a more comprehensive  ...  Alan Jackson for the opportunity to write this review article.  ... 
doi:10.1259/bjr/67705974 pmid:16861326 fatcat:x2qijx3l55e6hjhyl4zb6htoa4

Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease

T. R. Melzer, R. Watts, M. R. MacAskill, J. F. Pearson, S. Rueger, T. L. Pitcher, L. Livingston, C. Graham, R. Keenan, A. Shankaranarayanan, D. C. Alsop, J. C. Dalrymple-Alford (+1 others)
2011 Brain  
This study aimed to identify an arterial spin labelling magnetic resonance-derived perfusion network as an accessible, non-invasive alternative.  ...  There is a need for objective imaging markers of Parkinson's disease status and progression.  ...  US Patents 7,369,888 and 6,980,845: Multi-slice perfusion imaging; and may receive royalty payments through a licensing agreement with GE Healthcare for US Patent 7,545,142: Arterial spin labelling with  ... 
doi:10.1093/brain/awq377 pmid:21310726 pmcid:PMC3105489 fatcat:e65euf6exfgwfcg3lwnj3w34hy

Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: A systematic review

Audrey P Fan, Hesamoddin Jahanian, Samantha J Holdsworth, Greg Zaharchuk
2016 Journal of Cerebral Blood Flow and Metabolism  
As an alternative, arterial spin labeling is a promising magnetic resonance imaging technique that magnetically labels arterial blood as it flows into the brain to map cerebral blood flow.  ...  the accuracy and reproducibility of arterial spin labeling relative to the positron emission tomography reference standard.  ...  Jarrett Rosenberg for insightful discussion on data analysis, statistics, and presentation.  ... 
doi:10.1177/0271678x16636393 pmid:26945019 pmcid:PMC4853843 fatcat:kdn34nwrszbxpmqptf667puksq

Predicting Very Early Stage Mild Cognitive Impairment Based on a Voxel-wise Arterial Spin Labeling Analysis [chapter]

Gloria Díaz, Pablo García-Polo, Virginia Mato, Eva Alfayate, Juan Antonio Hernández-Tamames, Norberto Malpica
2014 Lecture Notes in Computer Science  
In this paper, we present an image processing and pattern recognition strategy that allows to predict short-term conversion to Mild Cognitive Impairment (MCI) based on the analysis of Arterial Spin Labeling  ...  In recent years, medical images have been increasingly used as an objective method for the diagnosis of neurodegenerative diseases.  ...  Therefore, arterial spin labeling (ASL) data also begin to be used as biomarker for diagnosing probable Alzheimer's disease [10] , even in an early stage [3] .  ... 
doi:10.1007/978-3-319-12568-8_87 fatcat:ybiyvcv3dbhzfo37vlzotgifj4

A Primer on Functional Magnetic Resonance Imaging

Gregory G. Brown, Joanna E. Perthen, Thomas T. Liu, Richard B. Buxton
2007 Neuropsychology Review  
Arterial spin labeling inverts or saturates the magnetization of flowing spins to measure the rate of delivery of blood to capillaries.  ...  The physiological complexity of the BOLD signal is emphasized. In the third section, arterial spin labeling (ASL) measures of cerebral blood flow are presented.  ...  Continuous Arterial Spin Labeling-tagging based on location and velocity.  ... 
doi:10.1007/s11065-007-9028-8 pmid:17468956 fatcat:v4c7dkp3xvantedcmh62kmq55m
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