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Current and Future Management of Bilateral Loss of Vestibular Sensation — An Update on the Johns Hopkins Multichannel Vestibular Prosthesis Project

Charles Della C Santina, Americo A Migliaccio, Russell Hayden, Thuy-Ahn Melvin, Gene Y Fridman, Bryce Chiang, Natan S Davidovics, Chenkai Dai, John P Carey, Lloyd B Minor, Iee-Ching Anderson, HongJu Park (+2 others)
2010 Cochlear Implants International  
An implantable neuroelectronic vestibular prosthesis that emulates the normal labyrinth by sensing head movement and modulating activity on appropriate branches of the vestibular nerve could significantly  ...  surgical trauma during cochlear implantation.  ...  We thank Howard Hoffmann, of the NIDCD Translational Research Branch, for his invaluable contributions to epidemiology of BVD through his oversight of the balance segment of the National Health Interview  ... 
doi:10.1179/146701010x12726366068454 pmid:21756683 pmcid:PMC3270064 fatcat:dhasvu4jzfgplkrovphyydnw5q

Progress Toward Development of a Multichannel Vestibular Prosthesis for Treatment of Bilateral Vestibular Deficiency

Gene Y. Fridman, Charles C. Della SAntina
2012 The Anatomical Record  
In bilaterally vestibulardeficient rodents and rhesus monkeys, the Johns Hopkins multichannel vestibular prosthesis (MVP) partially restores the three-dimensional (3D) VOR for head rotations about any  ...  A vestibular prosthesis analogous to cochlear implants but designed to modulate vestibular nerve activity during head movement should improve quality of life for these chronically dizzy individuals.  ...  Della Santina is the CEO and an owner of Labyrinth Devices, LLC, a start-up company he founded to support commercialization of vestibular prosthesis technology.  ... 
doi:10.1002/ar.22581 pmid:23044664 pmcid:PMC4058831 fatcat:bv5xwelq7vbgra264u2iz7ulqe

IMPLANTABLE PROSTHESES FOR THE INNER EAR

Christina Goodvin, Edward J. Park
2011 Proceedings of the Canadian Engineering Education Association (CEEA)  
Epic and the University of Victoria (UVic) are now investigating the concept of applying both Epic and MEMS technology towards building a vestibular prosthesis, i.e. vestibular equivalent a cochlear implant  ...  In this paper, the feasibility of a vestibular prosthesis is reviewed.  ...  Currently, the most promising hope for hair cell death seems to be a vestibular prosthesis, i.e., vestibular equivalent of a cochlear implant.  ... 
doi:10.24908/pceea.v0i0.4000 fatcat:xheaziofdraivdd6g25fb2ufuu

An electronic prosthesis mimicking the dynamic vestibular function

Andrei M. Shkel, Masayoshi Tomizuka, Chung-Bang Yun, Victor Giurgiutiu
2006 Smart Structures and Materials 2006: Sensors and Smart Structures Technologies for Civil, Mechanical, and Aerospace Systems  
This paper presents a functional architecture, system level design, and electronic evaluation of a unilateral vestibular prosthesis.  ...  Electronic properties of the vestibular prosthesis prototype have been systematically evaluated and found to meet the design specifi cations.  ...  We thank Hongbin Chen, Abby Copeland, and two anonymous reviewers for their helpful comments on an earlier version of the manuscript.  ... 
doi:10.1117/12.659293 fatcat:seduxsqhb5e25igmhk5fwmv5fy

An Electronic Prosthesis Mimicking the Dynamic Vestibular Function

Andrei M. Shkel, Fan-Gang Zeng
2006 Audiology & neuro-otology  
This paper presents a functional architecture, system level design, and electronic evaluation of a unilateral vestibular prosthesis.  ...  Electronic properties of the vestibular prosthesis prototype have been systematically evaluated and found to meet the design specifi cations.  ...  We thank Hongbin Chen, Abby Copeland, and two anonymous reviewers for their helpful comments on an earlier version of the manuscript.  ... 
doi:10.1159/000090684 pmid:16439834 fatcat:mwxdgfntlzdaxmybh4vfpldab4

Guest Editorial: Sense and Sensibility in Neuroengineering

Fan-Gang Zeng, Silvestro Micera
2007 IEEE Transactions on Biomedical Engineering  
restore 3-D vestibular sensations.  ...  Sodagar, Wise, and Najafi developed a fully integrated, highly-flexible, mixed-signal, 64-channel, neural processor for use in an implantable neural recording microsystem.  ... 
doi:10.1109/tbme.2007.894853 pmid:17554815 fatcat:kfvuyr7pmvfrhllmgay4qq3l5u

Research Highlights

2012 Nature Biotechnology  
It will also be useful to adapt the device for use in mice, a common animal-model in auditory and vestibular research.  ...  In considering the future potential of the work of Mercier et al. 3 , it is worth recalling the history of the cochlear implant 9 , a revolutionary neural prosthesis that has restored auditory perception  ...  Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways  ... 
doi:10.1038/nbt.2451 fatcat:rwhl6lyqmredfb33wm5mg2osiu

Milestones in the development of a vestibular implant

Jean-Philippe Guyot, Angelica Perez Fornos
2019 Current Opinion in Neurology  
Bilateral vestibular deficits exist and their prevalence is more important than believed by the medical community.  ...  Their severe impact has inspired several teams to develop technical solutions in an attempt to rehabilitate patients. A particularly promising pathway is the vestibular implant.  ...  Their contribution to the work on vestibular implant in humans is invaluable and fundamental. We also thank the patients for their enthusiasm, time, contribution and investment.  ... 
doi:10.1097/wco.0000000000000639 pmid:30566413 pmcid:PMC6343951 fatcat:hga3i5mvi5eztjarxbm6ifrgwi

Vestibular assistance systems: promises and challenges

Jean-Philippe Guyot, A. Perez Fornos, N. Guinand, R. van de Berg, R. Stokroos, H. Kingma
2016 Journal of Neurology  
Currently, efforts are being made towards the development of a vestibular implant, conceptually similar to the cochlear implant for the rehabilitation of deaf patients.  ...  Once the diagnosis is made there is no biological way to "repair" the deficient vestibular apparatus and vestibular exercises are mildly effective.  ...  Acknowledgments Funded in part by the European Community (7th framework programme, theme 3, Information and Communication Technologies; (CLOsed-loop Neural prostheses for vestibular disorderS 225929) approved  ... 
doi:10.1007/s00415-015-7922-1 pmid:27083882 pmcid:PMC4833784 fatcat:2i7mgt5birdgndgktrv5ts7cgm

Towards an Implantable Vestibular Prosthesis: The Surgical Challenges

Timothy G. Constandinou, Julius Georgiou, Charalambos C. Doumanidis, Chris Toumazou
2007 2007 3rd International IEEE/EMBS Conference on Neural Engineering  
Restoring the sensation of inertia in individuals with balance-related impairments is achievable through development of an artificial vestibular prosthesis, based on the cochlear implant paradigm.  ...  This work aims to support research in developing surgical technology for precisely accessing inside the vestibular organ.  ...  VESTIBULAR IMPLANT SURGERY The concept behind this implantable prosthesis is to restore vestibular balance cues by overriding the fluid-mechanic transduction within the semicircular canals and otolith  ... 
doi:10.1109/cne.2007.369606 fatcat:xxfkllgnwfea5benxmj3qprl3i

Designing artificial senses: steps from physiology to clinical implementation

Anglica Prez Fornos, Raymond Van de Berg, Jrg Sommerhalder, Nils Guinand
2019 Swiss Medical Weekly  
, (ii) transmission of relevant information to primary sensory areas in the brain by sensory afferents, and (iii) analysis and integration of the information at multiple levels in the central nervous system  ...  If the prosthesis is able to deliver enough consistent information, the brain will be able to correctly interpret it and useful rehabilitation can be achieved.  ...  Acknowledgements The authors thank Marco Pelizzone, Jean-Philippe Guyot and Herman Kingma for their comments, help and support.  ... 
doi:10.4414/smw.2019.20061 pmid:31154660 fatcat:mjm5eefk2neqdi3jv247d4kf44

ON DEVELOPMENT OF TOTALLY IMPLANTABLE VESTIBULAR PROSTHESIS

Andrei M. Shkel
2006 IFAC Proceedings Volumes  
This paper presents a functional architecture, system level design, and preliminary experimental evaluation of a unilateral vestibular prosthesis.  ...  The proposed design is scalable; the sensing unit, pulse generator, and the current source can be potentially implemented on a single chip using integrated MEMS technology.  ...  For example, cochlear implants use electrical stimulation to restore hearing and provide some relief for patients suffering profound sensorineural hearing loss S.U. Ay, F.-G. Zeng, and Shen (1997) .  ... 
doi:10.3182/20060912-3-de-2911.00006 fatcat:mtitoht3ofawxbj63qb6il7noe

Chronic Electrical Stimulation of the Otolith Organ: Preliminary Results in Humans with Bilateral Vestibulopathy and Sensorineural Hearing Loss

Angel Ramos Macias, Angel Ramos de Miguel, Isaura Rodriguez Montesdeoca, Silvia Borkoski Barreiro, Juan Carlos Falcón González
2019 Audiology & neuro-otology  
The clinical management of patients with bilateral vestibular loss remains difficult as there is no clear evidence for an effective treatment.  ...  In this paper, we try to analyze the effect of chronic electrical stimulation and adaptation to electrical stimulation of the vestibular system in humans when stimulating the otolith organ with a constant  ...  Funding Sources No institutional or private funding was obtained for the present research. Author Contributions  ... 
doi:10.1159/000503600 pmid:31801137 fatcat:vglqmudpxzhc7ksvh2bde3cjey

Bilateral Vestibular Deficiency

Daniel Q. Sun, Bryan K. Ward, Yevgeniy R. Semenov, John P. Carey, Charles C. Della Santina
2014 JAMA Otolaryngology - Head and Neck Surgery  
Statistically significant between-group differences were observed for overall HUI3 score (P < .001) and for specific attributes including vision, hearing, ambulation, emotion, and pain (P < .001 for all  ...  Furthermore, they quantify the potential benefits of prosthetic restoration of vestibular function both to these individuals and to society.  ...  is from best to worst. b Base estimate of cost-utility: $37 986/QALY assuming 75% restoration by multichannel vestibular prosthesis. c Percent restoration of function for implanted labyrinth. d Based  ... 
doi:10.1001/jamaoto.2014.490 pmid:24763518 pmcid:PMC4208975 fatcat:lzpyslk4szg3nlza5yje4clylu

Extracting energy from the inner ear

Kenneth Shepard, Taku Ito, Andrew J Griffith
2012 Nature Biotechnology  
In considering the future potential of the work of Mercier et al. 3 , it is worth recalling the history of the cochlear implant 9 , a revolutionary neural prosthesis that has restored auditory perception  ...  Hearing and balance are compromised in hundreds of different human disorders 7 . Some of the most challenging to treat or rehabilitate are those in which hearing or balance function fluctuates.  ... 
doi:10.1038/nbt.2448 pmid:23222789 fatcat:a7kz4kel2jfnvpdmy7d36mn3da
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